Abstract: A novel polypeptide isolated from the cornified envelope, polypeptides similar to the latter or fragments of the polypeptide as well as a cosmetic and/or pharmaceutical composition containing same are described. The mainly cosmetic and/or therapeutic use of the polypeptide, or similar polypeptides or fragments of the amino acid sequence of the polypeptide, or an encoding nucleotide sequence for the polypeptide, to reinforce the barrier function of the epidermis and prevent and/or treat the signs of skin dryness or prevent and/or treat disorders of the barrier function or the fragilisation of the epidermis. Finally, the isolated encoding polynucleotide for the polypeptide are also disclosed.
Type:
Application
Filed:
April 27, 2011
Publication date:
February 28, 2013
Applicants:
CHANEL PARFUMS BEAUTE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S. ), UNIVERSITE PAUL SABATIER TOULOUSE III
Inventors:
Nathalie Jonca, Eve Toulza, Gaelle Saintigny, Guy Serre, Marina Weber Vivat
Abstract: A process for manufacturing a device comprising at least a support and a component, joined together by at least one braze, includes a brazing operation which is carried out starting from a metal oxalate. Advantageously, it is a silver oxalate or a mixture of silver and copper oxalates, the component and/or the support being covered with a film comprising gold or copper in contact with said braze and the component possibly being a power component.
Type:
Application
Filed:
June 29, 2012
Publication date:
January 3, 2013
Applicants:
THALES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PAUL SABATIER TOULOUSE III
Inventors:
Olivier VENDIER, Lidwine RAYNAUD, Valérie BACO, Michel GOUGEON, Hoa LE TRONG, Philippe TAILHADES
Abstract: The application relates to the use of a salt associating an ammonium cation with an alkyl H-phosphonate anion of the following formula (I) in which R is a hydrocarbon radical, the pointed bond can be present or not, the radical R3 being then present or absent, as an ionic liquid. The ammonium cation is preferably an imidazolium cation. This ionic liquid is particularly useful in the field of green chemistry as a substitute for organic solvents. The application also relates to a method for preparing such a salt by the direct dealkylation of the corresponding dialkylphosphite by the appropriate nitrated base, in one step and without any solvent. The application also relates to a method for preparing mixed methylated phosphites.
Type:
Grant
Filed:
February 15, 2008
Date of Patent:
November 13, 2012
Assignees:
Centre National de la Recherche Scientifique (CNRS), Universite Paul Sabatier Toulouse III
Abstract: A piezoelectric and/or pyroelectric composite solid hybrid material, includes: a solid dielectric matrix, a filler of at least one inorganic piezoelectric and/or pyroelectric material, wherein the filler includes filiform nanoparticles distributed throughout the volume of the solid dielectric matrix with an amount by volume of less than 50%, and in that the main directions of elongation of the filiform nanoparticles of the inorganic filler distributed in the dielectric matrix have a substantially isotropic distribution in the solid dielectric matrix.
Type:
Application
Filed:
December 3, 2010
Publication date:
October 25, 2012
Applicant:
UNIVERSITE PAUL SABATIER TOULOUSE III
Inventors:
Jean-Fabien Capsal, Charlotte David, Eric Dantras, Colette Lacabanne
Abstract: The invention relates to a solid material with the following formula (A) : (Cu+1a-u; Ag+1u; Zn+2b-v-(y/2); Cd+2v; Sn+4c-w-(y/2); 1X+4w; 2X+3y; S?2x)(A), in which the solid material: is in divided state in the form of particles having a mean equivalent diameter of 15 nm to 400 nm; has, according to X-ray diffraction analysis of the solid material, a unique crystalline structure; is suitable for forming a stable dispersion of at least one solid material with formula (A) in a liquid, referred to as dispersion liquid, made up of at least one compound with a value of ?p higher than 8 and a value of ?H higher than 5.
Type:
Application
Filed:
September 8, 2010
Publication date:
September 13, 2012
Applicants:
ECOLE SUPERIEURE DES BEAUX-ARTS DE LA REUNION, UNIVERSITE PAUL SABATIER TOULOUSE III
Abstract: The present invention relates to an intermolecular association complex of an amphiphilic carrier and an active principle G, having the following general formula (I), as well as to the compositions containing same, to the uses thereof, particularly as a drug, and to the method for preparing same.
Type:
Application
Filed:
October 4, 2010
Publication date:
August 23, 2012
Applicants:
UNIVERSITE PAUL SABATIER TOULOUSE III, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Abstract: The invention concerns particles consisting essentially of fibers of an organogelling substance in the form of xerogel (dry gel), the fibers being essentially oriented in a common direction and randomly aligned around the longest fiber. The organogelling substance is preferably 1,3: 2,4-di-O-benzylidene-D-sorbitol. Said particles, which are in the form of spindles, have interesting optical properties; they have a total light transmittance higher than 0.80, with a diffuse transmittance higher than the specular transmittance. The invention also concerns a method for preparing said particles by solvent evaporation process, by solvent diffusion/evaporation process or by shearing process. The invention finally concerns active particles consisting of said particles whereon is immobilized a dermocosmetically active principle, a dermocosmetic composition comprising said particles or said active particles and a cosmetic treatment method which consists in applying on the skin said dermocosmetic composition.
Type:
Grant
Filed:
September 29, 2006
Date of Patent:
July 31, 2012
Assignees:
Pierre Fabre Dermo-Cosmetique, Universite Paul Sabatier Toulouse III, Centre National de la Recherche Scientifique (CNRS)
Inventors:
Anne Doat, Emile Perez, Isabelle Rico-Lattes, Pascal Bordat
Abstract: Device for emitting a plasma jet at ambient pressure and temperature, includes an electric-field generator for generating discharges between an anode assembly and a cathode assembly. The cathode assembly defines an inter-cathode dielectric space that extends inside the cathode assembly and is opposite at least one cathode surface of the cathode assembly, and has at least one cathode opening extending outside the inter-cathode space, the cathode opening being defined by at least one active edge of the cathode surface, the active edge(s) extending in a cathode opening plane. The anode assembly includes at least one pointed portion that is oriented toward the outside of the inter-cathode space and is laterally and deeply placed relative to the cathode opening. The pointed portion extends up to the cathode opening plane, for causing a plasma jet emission that is spontaneously sprayed in a predetermined direction toward the outside of the inter-cathode space.
Type:
Application
Filed:
June 29, 2009
Publication date:
June 7, 2012
Applicant:
UNIVERSITE PAUL SABATIER TOULOUSE III
Inventors:
Nofel Merbahi, Mohammed Yousfi, Olivier Eichwald
Abstract: The present invention relates to a method for manufacturing a metal-oxide-based ceramic, including, in order, the step of inserting, into a flash sintering device, a nanocrystalline powder comprising crystallites and crystallite agglomerates of a ceramic of formula, Zr1-xMxO2, where M is chosen from yttrium, scandium and cerium, or Ce1-xM?xO2, where M? is chosen from gadolinium, scandium, samarium and yttrium, where x lies between 0 and 0.2, the powder having an average crystallite size of between 5 and 50 nm, an average crystallite agglomerate size of between 0.5 and 20 ?m, and a specific surface area of between 20 and 100 m2/g. The invention further includes the step of flash sintering the powder by applying a pressure of between 50 and 150 MPa, at a temperature of between 850° C. and 1400° C., for a time of between 5 and 30 minutes.
Type:
Application
Filed:
June 16, 2010
Publication date:
April 19, 2012
Applicants:
Universite Paul Sabatier Toulouse III, Electricite De France
Abstract: A method for polymerizing 1,4-dioxane-2,5-diones in the presence of a generally protic initiator and at least one catalyst including at least one metal-free organic compound. The latter is a non-metal organic catalyst most often selected from among pyridines of which DMAP is a derivative, sulfonic acids, polycyclic tertiary amines, phosphazenes, thioureas, thioureas/amines, and guanidines. The invention also relates to polymers obtained by the method.
Type:
Application
Filed:
March 8, 2010
Publication date:
February 9, 2012
Applicants:
MINASOLVE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PAUL SABATIER TOULOUSE III
Abstract: The present invention relates to a method for diagnosing aggressiveness and/or genetic instability of a cancer in a patient from a cancer sample of said patient, comprising: a) measuring in vitro the expression level of the POLQ gene and the expression level of a control gene in said patient cancer sample; b) calculating for said POLQ gene an expression level ratio of the expression level of POLQ to the expression of the said control gene in said patient cancer sample; c) comparing the said POLQ expression level ratio to a corresponding threshold value, and d) diagnosing cancer aggressiveness and genetic instability if the said POLQ expression level ratio is superior to a corresponding threshold values. Dedicated microarrays and kits are also described, as well as a method of selecting a suitable treatment.
Type:
Application
Filed:
May 18, 2011
Publication date:
January 26, 2012
Applicants:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT CLAUDIUS REGAUD, UNIVERSITE PAUL SABATIER TOULOUSE III
Inventors:
Christophe CAZAUX, Jean-Sébastien HOFFMANN, Jean-Christophe BOURDON, Alice MACHADO DA SILVA, Henri ROCHE
Abstract: The identification of compounds, strigolactones, having the ability to stimulate the growth and/or development of arbuscular mycorrhizal fungi (AM fungi). Such compounds are, for example, the natural strigolactones strigol, alectrol, sorgolactone, orobanchol, or their synthetic analogs GR7, GR24, Nijmegen-1, demethylsorgolactone. New ways of developing an agriculture that is more respectful of the environment, and permits the implementation, on a small or large scale, of advanced mycorrhization techniques aimed at optimizing the production of fungic inoculum, the use of AM fungi in soils or cultivation substrates, and intensifying the symbiotic interaction between these microorganisms and cultivated plants.
Type:
Grant
Filed:
February 9, 2005
Date of Patent:
January 24, 2012
Assignees:
Universite Paul Sabatier Toulouse III, Centre National de la Recherche Scientifique (C.N.R.S.)
Abstract: A method for manufacturing a composite material including tin oxide particles and a fibrillar carbon material, including synthesising tin hydroxide particles obtained from a tin salt by precipitation/nucleation in a water-alcohol medium, in the presence of the fibrillar carbon material and an acid, the fibrillar carbon material being nanotubes, carbon nanofibres, or a mixture of the two. The method can be used for the production of negative electrodes for lithium-ion batteries.
Type:
Application
Filed:
December 4, 2009
Publication date:
December 8, 2011
Applicants:
UNIVERSITE PAUL SABATIER ( TOULOUSE III ), ARKEMA FRANCE
Inventors:
Dominique Plee, Mohamed Chakir, Patrice Simon
Abstract: The present invention relates to the use as a sensitive material in a thin layer for bolometric detection of infrared radiation, of a material having a spinel ferrite structure of chemical composition, ignoring doping agents if any are present, satisfying empirical formula I: Fe3-(x+y)MxAyO4+?. The invention also provides a bolometric device for detecting infrared radiation or for infrared imaging, and including at least one sensor provided with a sensitive element in the form of a thin layer as defined above.
Type:
Grant
Filed:
December 15, 2004
Date of Patent:
September 13, 2011
Assignees:
Universite Paul Sabatier (Toulouse III), Centre National de la Recherche Scientifique, Commissariat a l'Energie Atomique
Inventors:
Philippe Tailhades, Lionel Presmanes, Corinne Bonningue, Jean-Louis Ouvrier-Buffet, Astrid Astier, Stephanie Capdeville, Claire Vialle, Pierre Imperinetti
Abstract: An electrically conductive solid composite material contains: a solid matrix of electrically insulating material, and—a load of an electrically conductive material, wherein the charge includes so-called filiform nanoparticles, having: a length, extending along a main elongation direction; two so-called orthogonal dimensions, extending along two directions which are transverse and orthogonal to each other and orthogonal to the main elongation direction, the orthogonal dimensions being less than the length and less than 500 nm; and two so-called form factor ratios between the length and each of the two orthogonal dimensions, the form factor ratios being greater than 50, the filiform nanoparticles being distributed within the volume of the solid matrix with an amount, by volume, of less than 10%, particularly less than 5%.
Type:
Application
Filed:
July 20, 2009
Publication date:
July 14, 2011
Applicant:
UNIVERSITE PAUL SABATIER TOULOUSE III
Inventors:
Antoine Lonjon, Eric Dantras, Philippe Demont, Colette Lacabanne
Abstract: The present invention relates to a method of preparing ceramics based on lanthanum-doped barium titanate, which comprises the following steps: (a) flash sintering of lanthanum-doped barium titanate powders; and (b) heat treatment of the material thus obtained, in an air atmosphere or in an oxidising atmosphere. The invention also relates to ceramics based on lanthanum-doped barium titanate, possessing a very high real part of the relative dielectric permittivity, and to their use for obtaining capacitors of high capacitance and high capacitance per unit volume for high-voltage withstand capability.
Type:
Grant
Filed:
April 18, 2007
Date of Patent:
May 10, 2011
Assignees:
Centre National de la Recherche Scientifique (CNRS), Universite Paul Sabatier Toulouse III
Inventors:
Sophie Guillemet, Madona Boulos, Bernard Durand, Thierry Lebey, Quang Nguyen
Abstract: The invention relates to bi-substrate inhibitor molecules associating (i) a pyridine, pyridinium or dihydropyridine-type structure allied to active metabolites of isoniazide, or related structures, and (ii) a hydrophobic substituent. The invention also relates to the method for producing said molecules, to the pharmaceutical compositions containing said molecules, and to the use thereof as inhibitors of enoyl reductase for the preparation of a medicament, especially an anti-infectious medicament for the treatment of tuberculosis.
Type:
Application
Filed:
February 6, 2009
Publication date:
April 21, 2011
Applicants:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFOQUE (C.N., UNIVERSITE PAUL SABATIER TOULOUSE III
Inventors:
Jean Bernadou, Vania Bernardes-Genisson, Tamara Delaine, Annaïck Quemard
Abstract: A composite material includes a metal matrix in which synthetic lamellar phyllosilicated mineral particles are distributed. The lamellar phyllosilicated mineral particles are particles also called synthetic phyllosilicated nanoparticles (6) that are mineral, silico/germano-metal, lamellar, synthetic and hydrophilic, and have an average size of between 10 nm and 1 ?m. A substrate that includes a lubricating coating consisting of such a material, and an electrolytic deposition preparation method are also described.
Type:
Application
Filed:
December 18, 2008
Publication date:
January 20, 2011
Applicants:
LUZENAC EUROPE SAS, UNIVERSITE PAUL SABATIER TOULOUSE III
Inventors:
Francois Martin, Jean-Pierre Bonino, Pierre Micoud, Jocelyne Ferret, Cedric Lebre, Vincent Baylac
Abstract: A method for making a porous structure, includes producing, by anodization of an aluminum substrate, an outer surface layer (3), part of the thickness of which is formed by an ordered porous structure (7), characterized in that it includes an anodization step on a smooth aluminum substrate for a duration sufficient for obtaining a thickness of ordered porous structure (7). The method further includes removing by mechanical machining a portion of the thickness of the layer (3) formed by anodization, the thickness portion extending from the outer surface of the layer (3) formed by anodization, while maintaining an ordered porous structure (7) with a non-zero thickness, so that the ordered porous structure defines the free outer surface of the residual layer.
Type:
Application
Filed:
October 23, 2008
Publication date:
October 14, 2010
Applicant:
UNIVERSITE PAUL SABATIER TOULOUSE III
Inventors:
Laurent Arurault, Francois Le Coz, Rene Bes