Abstract: An antibiofilm composition comprising a compound of formula (A1), (A2) or (A3): wherein each of R1, R2, R3, R4, R5, R6 and R7 is independently selected from hydrogen, alkyl, alkenyl, aryl, halo, alkoxy, hydroxyl, amino, nitro, sulfoxy, thiol, carboxy, alkyl carboxy and amido; and X may be O or S, wherein the composition does not comprise a compound of formula (B1) or (B2):

Abstract: The invention concerns a brace, ideally disposable, formed from a blank and, particularly but not exclusively, a neck or limb brace wherein the brace is contoured to fit about a wearer and comprises at least one, or a series of, crease line(s) that mirror(s) the contour of at least one edge of said brace and spaced from same by a selected amount whereby said edge can be folded or torn along at least one selected crease line to fit a wearer.

Abstract: A poly(methyl methacrylate) (PMMA) membrane having a highly porous, reticulated, 3-D structure suitable for lateral flow diagnostic applications is described. Also described is a method for producing a poly(methyl methacrylate) (PMMA) membrane that comprises the steps of mixing a suitable amount of PMMA, a solvent and a optionally one of either a co-solvent or a non-solvent to produce a solution, casting a thin film of the solution onto a support, and removal of the solvent from the solution to produce the PMMA membrane. A lateral flow diagnostic device comprising a highly porous PMMA membrane as a reaction membrane is also described.

Abstract: A delivery system comprising hydrogen peroxide or a hydrogen peroxide generator system, for use in a method for the treatment or prevention of inflammatory bowel disease in a mammal, is described. The method comprises a step of orally administering to the mammal the delivery system, wherein the delivery system is formulated for oral delivery and release of the hydrogen peroxide or hydrogen peroxide generator system in-situ at a target location in the mammalian gastrointestinal tract. Also described is an oral dosage delivery system comprising hydrogen peroxide or a hydrogen peroxide generator system, in which the delivery system is configured for oral administration to a mammal and release of the hydrogen peroxide or hydrogen peroxide generator system at a target location within the mammalian gastrointestinal tract thereby effecting a localised increase in hydrogen peroxide levels at the target location in the mammalian gut or airways.

Abstract: The invention concerns a brace, ideally disposable, formed from a blank and, particularly but not exclusively, a neck or limb brace wherein the brace is contoured to fit about a wearer and comprises at least one, or a series of, crease line(s) that mirror(s) the contour of at least one edge of said brace and spaced from same by a selected amount whereby said edge can be folded or torn along at least one selected crease line to fit a wearer.

Abstract: A novel and useful mm-wave frequency generation system is disclosed that takes advantage of injection locking techniques to generate an output oscillator signal with improved phase noise (PN) performance and power efficiency. Low frequency and high frequency DCOs as well as a pulse generator make up the oscillator system. A fundamental low frequency (e.g., 30 GHz) signal and its sufficiently strong higher (e.g., fifth) harmonic (e.g., 150 GHz) are generated simultaneously in a single oscillator system. The second high frequency DCO having normally poor phase noise is injected locked to the first low frequency DCO having good phase noise. Due to injection locking, the high frequency output signal generated by the second DCO exhibits good phase noise since the phase noise of the second DCO tracks that of the first DCO.

Abstract: A delayed release drug formulation includes a core and a coating. The coating includes a mixture of a first material selected from starch; amylose; amylopectin; chitosan; chondroitin sulfate; cyclodextrin; dextran; pullulan; carrageenan; scleroglucan; chitin; curdulan and levan, and a second material which has a pH threshold at about pH 5 or above. The delayed release drug formulation is used to target release of a drug from a core to the intestine, particularly the colon.

Abstract: Provided are an apparatus and system for directing power flow between multiple devices, the apparatus comprising: one or more inlet ports for connection to one or more devices; a plurality of outlet ports configured for supplying electrical power; and a computing device configured to route power from the one or more inlet ports to the outlet ports. The system comprises a plurality of the apparatus connected to each other.

Abstract: The invention relates to a high throughput method for determining telomere length of mammalian chromosomal DNA; primers for use in said method; a kit comprising said primers; use of said method to diagnose or prognose or to determine the risk of developing a telomere shortening disease such as cancer, ageing, neurological disorders including Alzheimer's disease, Parkinson's disease and other dementias, brain infarction, heart disease, chronic HIV infection, chronic hepatitis, skin diseases, chronic inflammatory bowel disease including ulcerative colitis, anaemia, atherosclerosis, Barrett's oesophagus and cancers including pre-cancerous conditions, infertility, telomere syndromes including dyskeratosis congenita, aplastic anaemia, idiopathic pulmonary fibrosis, familial myelodysplastic syndrome-acute myeloid leukaemia, Hoyeraal-Hreiderasson syndrome, Revesz syndrome, Coats plus syndrome, bone marrow failure, and cryptogenic liver cirrhosis.

Abstract: Sepsis remains a leading cause of morbidity and mortality in neonates worldwide. There is also clinically a low threshold for suspicion of infection in neonates, in particular as presentation varies greatly from very subtle to catastrophic collapse. The lack of reliably sensitive tests and the potential life-threatening consequences of delayed treatment of infection results in the widespread use of empirical antibiotics exposing many infants without infection to broad-spectrum antibiotics. The present invention provides a series of patient-invariant biomarkers for screening neonates and other subjects for infection that predicts bacterial infection with high accuracy; and is further shown to have predictive value in identifying infection in suspected cases with blood-culture negative tests.

Abstract: A novel and useful high-order discrete-time charge rotating (CR) infinite impulse response (IIR) low pass filter is presented. The filter utilizes history capacitor arrays incorporating banks of capacitors. A linear interpolation technique is used in the IIR filter with second order antialiasing filtering, whose transfer function is sinc(x)2 per stage. It also uses a gm cell, rather than operational amplifiers, and is thus compatible with digital nanoscale technology. A 7th-order charge-sampling discrete time filter is disclosed. The order of the filter is easily extendable to higher orders. The charge rotating filter is process scalable with Moore's law and amenable to digital nanoscale CMOS technology. Bandwidth of the filter is precise and robust to PVT variation. The filter exhibits very low power consumption per filter pole, low input-referred noise, wide tuning range, excellent linearity and low area per minimum bandwidth and filter pole.

Abstract: A method is provided for characterising and/or prognosing prostate cancer in a subject comprising measuring the level of at least one protein from a panel or at least one peptide thereof in a sample from the subject. The method may be used to determine the grade and stage of the prostate cancer. Also disclosed is a method for selecting a treatment for prostate cancer, together with corresponding methods of treatment. Systems and computing devices for performing the methods are also provided.

Abstract: A method for the enzymatic conversion of a phenol substrate into a corresponding catechol product comprises the step of incubating the phenol substrate with a Ralstonia solanacearum tyrosinase enzyme, or a functional derivative thereof, in a reaction mixture, for a period of time sufficient to allow the enzyme convert at least some of the phenol substrate into the catechol product.

Abstract: Embodiments for implementing intelligent classification of region of interest in an organism in a computing environment by a processor. Time series data of a contrast agent in one or more regions of interest captured from multispectral image streams may be collected. The one or more regions of interest may be classified into one of a plurality of classes by applying one or more perfusion models, representing spatio-temporal behavior of the contrast agent reflected by the time series data, and by using a machine learning operation.

Abstract: Methods of treating a subject by administering Bifidobacterium longum strain NCIMB 41676 are discussed. The method may include orally administering a formulation comprising Bifidobacterium longum strain NCIMB 41676 to improve sleep.

Abstract: A method for obtaining magnetic resonance imaging (MRI) echo-planar image (EPI) data, including providing a homogeneous, static background field; providing a gradient field to select a slice of an object for imaging; applying Radio-frequency (RF) pulses to excite magnetic resonance in the selected slice; and measuring a radio frequency signal emitted by the selected slice containing image data. The RF pulses are repeatedly applied separated by a time period shorter than a recovery time of static material in the selected slice such that the static material remains in a state of magnetic saturation, while dynamic material arriving within the slice since a previous RF pulse is not magnetically saturated.

Abstract: At least one embodiment of the invention provides a photonic subsystem for integrating onto a photonic platform. The subsystem comprises a laser source and a plurality of optical components for focusing and directing a laser beam emitted from the laser source into a photonic platform. The laser source and plurality of optical components are mounted to a substrate and encapsulated.

Abstract: A seed coating composition comprising a mixture of a fungal root endophyte isolated from a root of the plant found in low-nutrient, drought-stressed or multiply-stressed conditions and a carrier medium for application of said composition to a target seed, wherein the endophyte is characterised in having a nuclear ribosomal internal transcribed spacer (nr ITS) with at least a 90% sequence identity to any one of SEQ ID NOs: 3 to 15.

Abstract: A delayed release coating includes a mixture of a first material selected from starch; amylose; amylopectin; chitosan; chondroitin sulfate; cyclodextrin; dextran; pullulan; carrageenan; scleroglucan; chitin; curdulan and levan, and a second material which has a pH threshold at about pH 5 or above. The delayed release coating is used to target release of a drug from a core to the intestine, particularly the colon.

Abstract: Aspects of the subject disclosure may include, for example, a method in which a processing system identifies a plurality of performance indicators comprising device performance indicators for a plurality of communication devices on a cellular network and network performance indicators for the cellular network. The method also includes obtaining historical data regarding the plurality of performance indicators for each of a series of time points during a past time period; the historical data for each of the plurality of performance indicators form an array of values for that performance indicator. The method further includes generating from each array a set of inputs to an algorithm for predicting a throughput of the cellular network during a future time period; the set of inputs comprises quantiles of the array, and the algorithm comprises a machine learning algorithm. Other embodiments are disclosed.