Patents Assigned to University of Connecticut
  • Patent number: 10517565
    Abstract: An imaging system includes a primary probe that includes a substrate; an ultrasound transducer disposed in the substrate to irradiate a first tissue with an ultrasound frequency; a first near infrared source to irradiate the first tissue with a first near infrared wavelength; and a first light detector to detect a first detected wavelength from the first tissue; an auxiliary probe that includes a second near infrared source configured to irradiate a second tissue with a second near infrared wavelength; and a second light detector configured to detect a second detected wavelength from the second tissue. The system also can include an optical tomography device; an ultrasound device; and a processor unit. A process for imaging includes disposing the primary probe on a first tissue, disposing an auxiliary probe on a second tissue, irradiating the first tissue, and irradiating the second tissue to produce an image of the first tissue.
    Type: Grant
    Filed: July 25, 2013
    Date of Patent: December 31, 2019
    Assignee: THE UNIVERSITY OF CONNECTICUT
    Inventor: Quing Zhu
  • Patent number: 10520397
    Abstract: Multiple methods and corresponding apparatuses for efficient and reliable defect diagnosis in components of mechanical systems, are described. According to one aspect, multi-scale enveloping-order spectrogram is used to diagnose, or detect, defects in a moving component of a mechanical system. According to another aspect, defect identification and diagnosis in a motor is performed based on spectral characteristics of motor current envelope. According to yet another aspect, a logic rule model, employing classification of features associated with single- or multi-sensor data, is employed for diagnosis of defects in components of mechanical systems.
    Type: Grant
    Filed: May 31, 2012
    Date of Patent: December 31, 2019
    Assignees: University of Connecticut, Canrig Drilling Technology Ltd.
    Inventors: Robert X. Gao, Jinjiang Wang, Ruqiang Yan, Brian Charles Ellis, Boone Elbert Smith, Jose Abelardo Sanchez Puente
  • Patent number: 10505853
    Abstract: Systems and methods for integrating ultra-fast programmable networks in microgrid are disclosed to provide flexible and easy-to-manage communication solutions, thus enabling resilient microgrid operations in face of various cyber and physical disturbances. The system is configured to establish a novel software-defined networking (SDN) based communication architecture which abstracts the network infrastructure from the upper-level applications to significantly expedite the development of microgrid applications, develop three functions of the SDN controller for microgrid emergency operations, including time delay guarantee, failover reconfiguration and rate limit and create a hardware-in-the-loop cyber-physical platform for evaluating and validating the performance of the presented architecture and control techniques.
    Type: Grant
    Filed: February 19, 2019
    Date of Patent: December 10, 2019
    Assignee: University of Connecticut
    Inventors: Peng Zhang, Bing Wang, Peter B. Luh, Lingyu Ren, Yanyuan Qin
  • Patent number: 10501801
    Abstract: Described herein are methods of identifying tumor-specific epitopes from the cancer tissue DNA of cancer patients using both DNA sequencing and bioinformatics techniques. The identification of tumor-specific epitopes provides pharmaceutical compositions with a limited number of tumor-specific peptides suitable for personalized genomics-driven immunotherapy of human cancer. Specifically disclosed herein is a novel index called the Differential Agretopic Index (DAI) for the epitope which allows prediction of whether immunization with a particular epitope will be protective against the tumor. Pharmaceutical compositions and methods of administration are also included.
    Type: Grant
    Filed: September 27, 2013
    Date of Patent: December 10, 2019
    Assignee: UNIVERSITY OF CONNECTICUT
    Inventors: Pramod K. Srivastava, Ion Mandoiu, Fei Duan
  • Patent number: 10488397
    Abstract: Improved sensor assemblies are provided. More particularly, the present disclosure provides improved and highly advantageous metal oxide based sensor assemblies configured to sense low concentration of specific gases, and related methods of use. The present disclosure provides improved physical forms of metal oxide films (e.g., WOx films, CeOx films). The exemplary metal oxide films can be fabricated by a Reactive Spray Deposition Technology (RSDT). The highly advantageous films/materials can be utilized in sensor assemblies to detect simple chemical components of the breath that correlate with human health conditions (e.g., the presence of acetone in diabetic patients). These films/materials demonstrate improved thermal stability under the sensor's operating conditions, as well as improved sensitivity to low concentration of the analyte, selectivity and quick responsiveness.
    Type: Grant
    Filed: April 4, 2017
    Date of Patent: November 26, 2019
    Assignee: University of Connecticut
    Inventors: Radenka Maric, Rishabh Jain
  • Patent number: 10472286
    Abstract: Embodiments of a microstructure that allows arrest of contaminant infiltration includes an inter layer and at least one highly reactive ceramic layer. The inter layer is not reactive to an infiltrating reactive species. The HRC layer includes materials that react with a reactive contaminant species to slow or arrest infiltration of such contaminant species.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: November 12, 2019
    Assignee: UNIVERSITY OF CONNECTICUT
    Inventors: Eric H Jordan, Maurice Gell, Rishi Kumar, Chen Jiang
  • Patent number: 10477097
    Abstract: Instruments, assemblies and methods are provided for undertaking imaging techniques (e.g., microscopic imaging techniques). The present disclosure provides improved imaging techniques, equipment and systems. More particularly, the present disclosure provides advantageous microscopy/imaging assemblies with single-frame sample autofocusing using multi-LED illumination. The present disclosure provides for assemblies and methods for single-frame rapid sample autofocusing without a z-scan. Potential applications for the disclosed assemblies/methods include, without limitation, whole slide imaging, optical metrology, wafer inspection, DNA sequencing and other high-throughput imaging applications where the sample may need to be scanned over a large field of view. The assemblies/methods advantageously utilize multiple LEDs for sample illumination. A captured image includes multiple copies of the sample, and one can recover the distance between these copies. The distance is directly related to the defocus distance.
    Type: Grant
    Filed: January 2, 2018
    Date of Patent: November 12, 2019
    Assignee: University of Connecticut
    Inventor: Guoan Zheng
  • Patent number: 10464993
    Abstract: The present invention relates to a therapeutic polypeptide and methods for its creation and use for modulating an immune response in a host organism in need thereof. In particular, the invention relates to the administration to an organism in need thereof, of an effective amount of a pre-coupled polypeptide complex comprising a lymphokine polypeptide portion, for example IL-15 (SEQ ID NO: 5, 6), IL-2 (SEQ ID NO: 10, 12) or combinations of both, and an interleukin receptor polypeptide portion, for example IL-15Ra (SEQ ID NO: 7, 8), IL-2Ra (SEQ ID NO: 9, 11) or combinations of both, for augmenting the immune system in, for example, cancer, SCID, AIDS, or vaccination; or inhibiting the immune system in, for example, rheumatoid arthritis, or Lupus. The therapeutic complex of the invention surprisingly demonstrates increased half-life, and efficacy in vivo.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: November 5, 2019
    Assignee: UNIVERSITY OF CONNECTICUT
    Inventors: Leo Lefrancois, Thomas A. Stoklasek
  • Patent number: 10457726
    Abstract: Described herein is an isolated antibody or antigen-binding fragment including a heavy chain variable region including three heavy chain complementary determining regions (HCDRs), wherein the sequence of HCDR1 is GYRLSELS (SEQ ID NO: 1), the sequence of HCDR2 is ISGWDGNT (SEQ ID NO: 2), and the sequence of HCDR3 is ARASGYNY(SEQ ID NO: 3), wherein the isolated antibody or antigen-binding fragment specifically binds human HSP90, specifically HSP90 beta. Also included are detection and therapeutic methods using the isolated antibodies or antigen-binding fragments.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: October 29, 2019
    Assignee: UNIVERSITY OF CONNECTICUT
    Inventors: Kevin P. Claffey, Charan Devarakonda, Daniel Kita
  • Patent number: 10458472
    Abstract: In one aspect, the present disclosure provides a sliding bearing system, comprising (a) a base plate, (b) one or more force measuring sensors, wherein each of the one or more force measuring sensors includes a top surface and a bottom surface, and wherein the bottom surface of each of the one or more force measuring sensors is coupled to the base plate, and (c) a first sliding surface coupled to the top surface of each of the one or more force measuring sensors.
    Type: Grant
    Filed: May 9, 2017
    Date of Patent: October 29, 2019
    Assignee: University of Connecticut
    Inventors: Arash Esmaili Zaghi, Kevin McMullen, Michael V. Hoagland
  • Publication number: 20190324084
    Abstract: Systems and methods for fault detection and diagnosis in a machine. The method includes selecting fault characteristic frequencies of faults, implementing the fault characteristic frequencies as modulating signals, receiving a feedback signal from at least one sensor associated with a machine, applying active modulation using the modulating signals to the feedback signal to obtain modulated signals, and monitoring for a low-frequency fault indicative component from the modulated signals.
    Type: Application
    Filed: April 18, 2019
    Publication date: October 24, 2019
    Applicant: University of Connecticut
    Inventors: Ali M. Bazzi, Yiqi Liu, Bryan Davis
  • Patent number: 10392411
    Abstract: Described herein is an enzyme-mediated approach to bioconjugation at nanoparticle (NP) surfaces. This process is enabled by a new synthetic linker compatible with the covalent attachment of alkyne modified substrates, including dyes, peptides and nucleic acids. The methods described herein specifically allow for the linkage of molecules to a DNA-functionalized nanoparticle surface. Enzymatic ligation of molecules to the terminal hydroxyl group of DNA using T4 DNA ligase is achieved through incorporation of a single monophosphate on the approaching substrate. In contrast to previous strategies, the linkers disclosed herein are compatible with alkyne modified molecules of a variety of sizes and charges indicating that the ligase minimally requires the monophosphate and the incoming hydroxyl for conjugation to be successful.
    Type: Grant
    Filed: January 10, 2019
    Date of Patent: August 27, 2019
    Assignee: University of Connecticut
    Inventor: Jessica Lynn Rouge
  • Patent number: 10383708
    Abstract: Advantageous dental analogs for dental restorations and related methods of use are provided. The present disclosure provides improved analog members for use in fabricating dental implant-supported restorations, and related methods of use. More particularly, the present disclosure provides advantageous systems/methods for the design and use of protection analog members configured to protect cuff portions of coping members during the fabrication of dental restorations. The improved analog members include an added vertical rim or collar to contact and/or protect the cuff portion of coping members when an end of the analog member is screwed/mounted into place into an end of the coping member. This way, the resin added during fabrication will not contact/adhere to the cuff portion allowing a proper seating of the finished fixed implant-supported prosthesis. Use of the improved analog member also can eliminate scratches/damage to the cuff portion (e.g., during trimming and polishing).
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: August 20, 2019
    Assignee: University of Connecticut
    Inventor: Avinash S. Bidra
  • Publication number: 20190250558
    Abstract: Portable common path shearing interferometry-based holographic microscopy systems are disclosed herein. In one embodiment, a system is configured for positioning a laser light source, a sample holder, a microscope objective lens, a shear plate and the imaging device in a common path shearing interferometry configuration. In some embodiments, the systems are relatively small and lightweight and exhibit good temporal stability. In one embodiment, a system for automatic cell identification and visualization using digital holographic microscopy using an augmented reality display device can include an imaging device mounted to an augmented reality display device, configured to capture one or more images of the hologram of the sample disposed on the sample holder illuminated by a beam. The augmented reality display device can include a display and can be configured to render a pseudo-colored 3D visualization of the sample and information associated with the sample, on the display.
    Type: Application
    Filed: February 11, 2019
    Publication date: August 15, 2019
    Applicant: University of Connecticut
    Inventors: Bahram Javidi, Adam Markman, Siddharth Rawat, Arun Anand
  • Publication number: 20190228362
    Abstract: A system and method for outage prediction for electrical distribution utilities using high-resolution weather forecasts, geographic data (e.g., land use and vegetation around overhead-lines) and utility infrastructure data (e.g., transformer fuses, etc.) to predict distributed outage occurrences (e.g., number of outages over a 2-km gridded map) in advance of a storm.
    Type: Application
    Filed: July 29, 2016
    Publication date: July 25, 2019
    Applicant: University of Connecticut
    Inventors: Emmanouil Anagnostou, David Wanik, Brian Hartman, Jichao He
  • Publication number: 20190226972
    Abstract: The present disclosure provides improved systems and methods for automated cell identification/classification. More particularly, the present disclosure provides advantageous systems and methods for automated cell identification/classification using shearing interferometry with a digital holographic microscope. The present disclosure provides for a compact, low-cost, and field-portable 3D printed system for automatic cell identification/classification using a common path shearing interferometry with digital holographic microscopy. This system has demonstrated good results for sickle cell disease identification with human blood cells. The present disclosure provides that a robust, low cost cell identification/classification system based on shearing interferometry can be used for accurate cell identification.
    Type: Application
    Filed: February 11, 2019
    Publication date: July 25, 2019
    Applicant: University of Connecticut
    Inventors: Bahram Javidi, Adam Markman, Siddharth Rawat, Arun Anand
  • Patent number: 10362080
    Abstract: Aspects of the subject disclosure may include, for example, embodiments include obtaining a first estimated bandwidth capacity of a communication network and selecting a target buffer level to temporarily store media content. Further embodiments include requesting a first portion of the media content according to the first estimated bandwidth capacity and the target buffer level and receiving the first portion of the media content. Additional embodiments include determining a current buffer level and receiving a second estimated bandwidth capacity of the communication network. Also, embodiments include requesting a second portion of the media content according to the current buffer level and the second estimated bandwidth capacity. Other embodiments are disclosed.
    Type: Grant
    Filed: April 25, 2017
    Date of Patent: July 23, 2019
    Assignees: AT&T Intellectual Property I, L.P., THE UNIVERSITY OF CONNECTICUT
    Inventors: Subhabrata Sen, Shuai Hao, Yanyuan Qin, Ruofan Jin, Krishna R. Pattipati, Bing Wang
  • Patent number: 10354462
    Abstract: A system includes an electronic device and a sensor to detect sensor data corresponding to the electronic device. The system also includes a machine learning processor that receives the sensor data and generates a model of the electronic device to determine a T squared threshold and a Q threshold using a machine learning algorithm. The machine learning processor also performs a T squared analysis of the electronic device by comparing a T squared value to the T squared threshold, and a Q analysis of the electronic device by comparing a Q value to the Q threshold. The machine learning processor also determines that the model is faulty when the T squared value is less than the T squared threshold and the Q value is greater than or equal to the Q threshold, and generates a new model or updates the model when the model is determined to be faulty.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: July 16, 2019
    Assignees: TOYOTA MOTOR ENGINEERING & MANUFACTURING NORTH AMERICA, INC., UNIVERSITY OF CONNECTICUT
    Inventors: Lingyi Zhang, Weiqiang Chen, Krishna Pattipatti, Ali M. Bazzi, Shailesh N. Joshi, Ercan M. Dede
  • Patent number: 10330906
    Abstract: Advantageous instruments, assemblies and methods are provided for undertaking imaging techniques (e.g., microscopic imaging techniques). The present disclosure provides improved imaging techniques, equipment and systems. More particularly, the present disclosure provides advantageous microscopy/imaging assemblies with rapid sample auto-focusing (e.g., microscopy/imaging assemblies having instant focusing for rapid sample imaging with auto-focusing). The present disclosure provides for high-throughput whole slide imaging with instant focal plane detection. A whole slide imaging platform/assembly that uses instant focusing systems/methods for high-speed sample autofocusing is provided. Such exemplary platforms/assemblies can be used for digital pathology or the like, and can provide improved, faster and cheaper diagnosis/prognosis of ailments/diseases.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: June 25, 2019
    Assignee: University of Connecticut
    Inventor: Guoan Zheng
  • Patent number: 10326983
    Abstract: A wearable 3D augmented reality display and method, which may include 3D integral imaging optics.
    Type: Grant
    Filed: March 5, 2015
    Date of Patent: June 18, 2019
    Assignees: THE UNIVERSITY OF CONNECTICUT, ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
    Inventors: Hong Hua, Bahram Javidi