Abstract: Disclosed is a compound of the formula (I) or (II): wherein a f are as described herein. The compounds are useful in the activation of Type II NKT cells and in treating cancer.

Abstract: Compositions that include a bupivacaine salt are provided. The compositions may include bupivacaine linoleate, bupivacaine linolenate or bupivacaine laurate, at least one thermosensitive polymer, and at least one mucoadhesive or dermoadhesive agent. Also provided are methods for the treatment of an inflammatory or ulcerative condition with the disclosed compositions.

Abstract: Described herein are apparati and methods for growing cells in a manner that mimics the native three-dimensional environment. Cell cultures grown in the apparatus can be screened for inhibition by specific chemotherapeutics or other drugs.

Abstract: The present invention relates to compositions and methods for activating expression from the paternally-inherited allele of UBE3A in human Angelman's Syndrome neurons using viral vector delivery of short hairpin RNAs, ribozymes, and/or microRNAs.

Abstract: Disclosed herein are methods for prognosing the risk of progression of a disease or disorder associated with inflammation, e.g., asthma, in a subject. Such methods include detecting levels of a fungal species comprising Malassezia globosa in the subject.

Abstract: The present disclosure provides compositions, systems, pre-filled delivery devices, and methods for developing injectable compositions useful for in situ forming solid depots for the sustained release of non-steroidal anti-inflammatory drug NSAIDs over a period of days to several months for use in treating or preventing inflammation. The compositions comprise a biodegradable polymer such as poly(lactic-co-glycolic acid) (PLGA), a solvent such as N-Methyl-2-pyrrolidone, and a NSAID such as naproxen, meloxicam. The compositions may optionally comprise an additive such as hydrogenated soy L-?-phosphatidylcholine (HSPC) or a second active agent. The depot material will be robust to exist within the desired site for a period similar to or greater than the planned period of drug delivery.

Abstract: An article includes a substrate and a coating disposed on the substrate. The coating includes a binder and a plurality of nanosheets. The plurality of nanosheets are arranged in layers and are oriented with their largest surfaces being substantially parallel to a surface of the substrate upon which they are disposed.

Abstract: A quantum-key distributed (QKD)-enabled communication architecture it devises for networked microgrids (NMGs). A real-time QKD-enabled NMGs testbed built in an RTDS environment, and a novel two-level key pool sharing (TLKPS) strategy it designs to improve the system resilience against cyberattacks. In the QKD-based microgrid testbed design there is used a real-time power system simulator, i.e., RTDS, including the QKD modeling, hardware connection, communication network design, and QKD integration. By integrating QKD features into a real-time microgrid simulator, this testbed offers a flexible and programmable testing environment for evaluating the performance of QKD-enabled microgrids under a variety of scenarios.

Abstract: The present invention provides cationic polymeric nanoparticles, and nanoparticle formulations thereof. The invention also provides methods for preparing cationic polymeric nanoparticles, and methods of treating diseases, reducing tumor growth, and increasing uptake of a therapeutic agent by a tumor cell in a subject in need thereof.

Abstract: Metal oxide nanoarrays, such as titanium oxide nanoarrays, having a platinum group metal dispersed thereon and methods of making such nanoarrays are described. The platinum group metal can be dispersed on the metal oxide nanoarray as single atoms. The nanoarrays can be used to catalyze oxidation of combustion exhaust.

Abstract: A liquid sample collection system is provided. The system includes a housing having a first layer and a second layer coupled to the first layer, one or more channels integrated into the first layer from a central region of the first layer to an edge of the first layer, and a card secured between the first layer and the second layer. The first layer is made, at least in part, from a hydrophobic polymer and the second layer is made, at least in part, from a hydrophilic polymer, and the one or more channels distribute the liquid sample on the card.

Abstract: Disclosed pharmaceutical compositions including a Beta site APP Cleaving Enzyme (BACE1) inhibitor and an metabotropic glutamate receptor (mGluR) agonist, and methods for use of such compositions to treat Alzheimer's disease (AD), Down's syndrome, Parkinson's disease, vascular dementia, Dementia with Lewy Bodies, dementia, and/or frontal temporal dementia.

Abstract: Active machine learning with model selection is used to control a printing system to efficiently, accurately, and autonomously predict jettability diagrams for different print head and ink combinations. A print system may be controlled using active machine learning to efficiently and accurately predict a jetting behavior for different combinations of ink and inkjet print heads at different settings/values for operating parameters of the print heads, such as firing voltage, pulse width/dwell time, frequency, ramp up, ramp down, meniscus pressure, heating rate, hold time, transducers' positions, geometries, and heating power, and/or other operating parameters of the print heads.

Abstract: The present invention provides cationic polymeric nanoparticles, and nanoparticle formulations thereof. The invention also provides methods for preparing cationic polymeric nanoparticles, and methods of treating diseases, reducing tumor growth, and increasing uptake of a therapeutic agent by a tumor cell in a subject in need thereof.

Abstract: A heat sink apparatus having a pair of casings hinged in a clamshell arrangement and configured to contain a portion of an electric charging cable, the casings each having an inner space which contains a phase change material for absorbing heat generated during current flow through the electric charging cable.

Abstract: Disclosed herein are “dual-priming” isothermal amplification method (including “self-priming” and “pairing-priming” strand extension, termed “DAMP”) for rapid nucleic acid detection.

Abstract: The disclosure is directed to scaffolds comprising nanofibers of graphene nanoplatelets and a biocompatible polymer, as well as methods for making and using such scaffolds.

Abstract: The present disclosure provides compositions and methods related to genetically engineered plants. In particular, the present disclosure provides novel compositions for transgenic cannabis plants that overexpress a R2R3-MYB transcription factor gene and methods related to the genetic regulation of the development of a glandular trichome in plants.

Abstract: The disclosure provides porous scaffold that include a plurality of microspheres, where the microspheres include a biodegradable polymer blended with a graphene family material (GFM), micro spheres, and methods for making and using such scaffolds and microspheres.

Abstract: A new and distinct cultivar of Prunus plant named ‘UCONNPCSDR’ is disclosed, characterized by a low, compact, mounded plant habit, and dusky pink buds opening to white flowers. Foliage is red-purple-flushed in spring, to burgundy-colored in summer. The new cultivar is a Prunus, suitable for ornamental garden purposes.