Abstract: Systems, methods, and other embodiments described herein relate to predicting anomalous operation of a device and an associated remaining useful life (RUL). In one embodiment, a method includes acquiring usage information about operation of an electronic device. The method includes selecting at least one feature from the usage information according to an optimization. The method includes determining whether the least one feature indicates a presence of an anomaly in the operation of the electronic device according to an anomaly model. The method includes, responsive to detecting the anomaly, determining a remaining useful life (RUL) for the electronic device according to a RUL model. The method includes providing the RUL.

Abstract: Disclosed herein are compositions, kits, and methods for treating a disorder of genomic imprinting in a subject. The method may include modifying a zinc-finger protein 274 (ZNF274) binding site on maternal chromosome 15 at position 15q11-q13 of the subject, such that the binding of a ZNF274 protein to the ZNF274 binding site is reduced relative to a control. The ZNF274 binding site comprises a polynucleotide having at least 90% sequence identify to SEQ ID NO: 1 or SEQ ID NO: 42. Further provided are DNA targeting systems that bind to a ZNF274 binding site or to a gene encoding a ZNF274 protein.

Abstract: A vehicle system includes a controller programmed to display a plurality of icons on a HUD of the vehicle, receive EEG data from a driver of the vehicle, perform a Fast Fourier Transform of the EEG data to obtain an EEG spectrum, input the EEG spectrum into a trained machine learning model, determine which of the plurality of icons the driver is viewing based on an output of the trained machine learning model, and perform one or more vehicle operations based on the output of the trained machine learning model.

Abstract: A multi-material printer can include a housing that is configured to be handheld. The housing can be configured to receive first and second printable materials from respective first and second containers. A nozzle can define an outlet of the multi-material printer. At least one actuator can be configured to cause first and second printable materials from the first and second containers to flow at a respective constant rate. The multi-material printer can be configured to simultaneously extrude the first and second printable materials from the outlet. The multi-material printer can be used for fabricating a scaffold from filaments comprising the first and second materials directly within the body of a human or animal.

Abstract: Systems, methods, and other embodiments described herein relate to predicting anomalous operation of a device and an associated remaining useful life (RUL) estimation. In one embodiment, a method includes acquiring usage information about the operation of an electronic device. The method includes determining whether the usage information indicates the presence of an anomaly in the operation of the electronic device according to an anomaly model. The method includes, responsive to detecting the anomaly, determining a remaining useful life (RUL) for the electronic device according to a RUL model. The method includes providing the RUL estimate.

Abstract: System and methods for the culturing of multiple independent cell types under uniform conditions.

Abstract: The present invention relates to methods and compositions for treating an LRRK2-associate disorder or condition, e.g., Parkinson's Disease, methods for reducing or preventing neuronal cell death, and methods for reducing neurodegeneration and/or neuroinflammation, in a subject in need thereof, by an agent that decreases the expression of LRRK2, e.g., an agent that induces LRRK2 mRNA decay.

Abstract: A system and method to generate flood inundation maps in near real time. The system includes a plurality of computer processing modules: a flood trigger system, a SAR data query system, and a RAPID kernel algorithm system, running in real time, to identify the potential flood zones, query SAR data, and finally compute the inundation maps, respectively. As disclosed herein, the RAPID kernel algorithm is extended to a fully automated flood mapping system that requires no human interference from the initial flood events discovery to the final flood map production.

Abstract: A compact diffuse optical tomography system for generating a functional image of a lesion region is provided. The system includes a source subsystem, a probe, a detection subsystem, and a computing device. The source subsystem includes laser diodes and a laser diode driver board. The probe is configured to emit the optical waves generated by the source subsystem toward the lesion region and detect optical waves reflected by the lesion region. The detection subsystem includes a miniaturized detection board and a miniaturized data acquisition board. The miniaturized detection board includes a photomultiplier tube configured to convert the optical waves detected by the probe to electrical signals. The miniaturized data acquisition board is configured to convert electrical signals outputted by the miniaturized detection board to digital signals. The computing device is configured to receive the digital signals, reconstruct the functional image, and display the functional image.

Abstract: The present disclosure provides a fluidic device including (a) a first channel including a first inlet and a first outlet, (b) a second channel including a second inlet and a second outlet, wherein the second inlet of the second channel is in fluid communication with the first outlet of the first channel, and (c) a sensor positioned between the first outlet and the second inlet, wherein the sensor includes a sensor configured to deflect in response to a flow between the first channel and the second channel.

Abstract: Provided herein are methods of inhibiting type 1 receptor and/or type 2 receptor signaling in subjects, optionally subjects with diseases associated with myostatin, type 1 receptor, and/or type 2 receptor signaling, or muscle loss and/or bone deterioration. Also provided are compositions for inhibition of type 1 receptor and/or type 2 receptor signaling.

Abstract: An insulating composition having a polymer resin, a nanoclay, and one or more nanofillers. The insulating composition has a thermal conductivity of greater than about 0.8 W/mK, a dielectric constant of less than about 5, a dissipation factor of less than about 3%, and a breakdown strength of greater than about 1,000 V/mil. The insulating composition has an endurance life of at least 400 hours at 310 volts per mil.

Abstract: Aspects of the subject disclosure may include a method including steps of, for each segment of a content item during presentation of a content item, obtaining current consumption context information, determining a current consumption context for the segment according to the consumption context information, selecting a filtered set of audio track and video track variants for the segment according to the current consumption context and track variant information, selecting an audio track and a video track for the segment from the filtered set of audio track and video track variants according to a dynamic network condition, receiving a data stream for the segment from a server over a network including the audio track and the video track for the segment, and presenting the segment of the content item according to the audio track and the video track via a video output and an audio output. Other embodiments are disclosed.

Abstract: A biodegradable and biocompatible piezoelectric nanofiber platform for medical implant applications, including a highly sensitive, wireless, biodegradable force sensor for the monitoring of physiological pressures, and a biodegradable ultrasonic transducer for the delivery of therapeutics or pharmaceuticals across the blood-brain barrier.

Abstract: Described herein are apparata and methods for growing cells in a manner that mimics the native three-dimensional environment. Cell cultures grown in the apparatus can be screened for inhibition by specific chemotherapeutics or other drugs.

Abstract: A therapeutic bandage includes a bandage matrix and an array of microneedles extending from the bandage matrix. Each of the microneedles includes a first layer that encapsulates a first immunomodulatory compound and a second layer that encapsulates a second immunomodulatory compound. The array of microneedles is configured to guide foreign agents affected by the first immunomodulatory compound, the second immunomodulatory compound, or the first and second immunomodulatory compounds from one or more skin layers of a user to the bandage matrix such that the bandage matrix absorbs and captures the foreign agents.

Abstract: Provided are polymers, which may be crosslinked to form a main-chain liquid crystalline (LC) hydrogel with a three-dimensional network. Also provided are methods of using the hydrogel as a substrate for tissue culture. For example, the hydrogel may organize into LC phases and encapsulate a plurality of cells within its polymeric network. In some embodiments, human stem cells are cultured using the present method with good viability and demonstrate faster proliferation in the present LC hydrogel compared to a non-LC gel.

Abstract: Systems and methods are provided that may utilize a glass substrate to selectively withdraw exfoliated graphene from a high-energy interface between immiscible solvents. The exfoliated graphene preferentially adheres to the surface of the glass substrate for withdrawal from the noted high energy interface, leaving behind the graphite (which is too large to be effectively adsorbed relative to the glass substrate). The disclosed systems and methods are easily implemented and offer significant advantages for graphene production relative to conventional systems and methods, e.g., the disclosed systems/methods do not require the input of heat or mechanical energy which translates to processes that are both cheaper to run and do not result in damage to the graphene. Still further, the disclosed systems/methods do not require chemical modification of the graphene, again lowering the cost considerably and not damaging the graphene structure.

Abstract: A permeate device includes at least one non-porous, gas permeable element configured for contact with a liquid flow and at least one element fabricated from a porous material configured to permit gas flow therethrough. The permeate device may include a vacuum chamber that surrounds an operative portion of a permeation zone. A method for processing a liquid flow to remove entrained gas includes providing a liquid flow that includes an initial level of entrained gas, delivering the liquid flow to a permeate device, wherein the permeate device includes (i) at least one non-porous, gas permeable element configured for direct contact with the flow; and (ii) at least one element fabricated at least in part from a porous material configured so as to permit gas flow therethrough, and applying a negative pressure to the permeate device to draw entrained gas from the flow within an operative portion of the permeate device.

Abstract: The present disclosure provides advantageous sheet stabilized emulsion based inks, and improved methods for fabricating and using such inks. More particularly, the present disclosure provides improved methods for fabricating conductive inks derived from water-in-oil emulsions stabilized by sheets exfoliated from layered materials (e.g., substantially pristine and non-oxidized graphite or hexagonal boron nitride), and related methods of use. A layered material (e.g., substantially pristine and non-oxidized graphite or hexagonal boron nitride) can be exfoliated into individual sheets, and these sheets can be utilized to stabilize water-in-oil emulsions. In certain embodiments, by utilizing long chain alkanes (e.g., hexadecane), one can advantageously fabricate emulsions with high viscosity and stability. In this form, the emulsions can be used as inks, thereby advantageously providing an inexpensive route to printing electrically conducting and/or insulating lines and shapes.