Abstract: Described herein is an isolated antibody or antigen-binding fragment including a heavy chain variable region including three heavy chain complementary determining regions (HCDRs), wherein the sequence of HCDR1 is GYRLSELS (SEQ ID NO: 1), the sequence of HCDR2 is ISGWDGNT (SEQ ID NO: 2), and the sequence of HCDR3 is ARASGYNY (SEQ ID NO: 3), wherein the isolated antibody or antigen-binding fragment specifically binds human HSP90, specifically HSP90 beta. Also included are detection and therapeutic methods using the isolated antibodies or antigen-binding fragments.

Abstract: Hybrid organic/inorganic coating compositions of nanometer thickness are described, where the organic layer is a clay-containing layer comprising a clay and a hydrophilic polymer and the inorganic layer is a metal-containing layer comprising a metal with a refractive index greater than 1.5, where the coating compositions allow for the generation and tenability of iridescent color through control of the coat thickness.

Abstract: A core-shell microneedle system and a method of manufacturing the microneedle system provides a pulsatile drug delivery system which is programmed to release drugs/vaccines at predictable times using biodegradable polymers and with controllable dosages. This microneedle system can be fully embedded into the skin and then release drugs/vaccines as sharp bursts in a timely manner, similar to multiple bolus injections.

Abstract: Aspects of the subject disclosure may include, for example, accessing adaptive streaming information for a multimedia content segment, determining available access bandwidths for a plurality of video tracks and a plurality of audio tracks identified by the adaptive streaming information, selecting one of a plurality of candidate track pairings identified by the adaptive streaming information based on the available access bandwidths, obtaining video content of the multimedia content segment via a video track of the selected track pairing, and obtaining audio content of the multimedia content segment via an audio track of the selected track pairing. Other embodiments are disclosed.

Abstract: In an embodiment, a hydrogen monitoring system comprises a plurality of sensing elements that individually comprise a working electrode, a counter electrode, an insulating layer located in between the working electrode and the counter electrode, a catalyst located on an end of both the working electrode and the counter electrode, an electrolyte located on the end of the sensing elements on both the working electrode and the counter electrode, between the working electrode and the counter electrode, and in contact with the catalyst, and an electrical circuit located on an opposite end of the sensing element that connects the working electrode and the counter electrode.

Abstract: Disclosed herein are analogues of itraconazole that are both angiogenesis and hedgehog signaling pathway inhibitors, formulations thereof, including liposome formulations thereof. The compounds are expected to be useful in the treatment of cell proliferation disorders such as cancer, particularly cancers that are dependent upon the hedgehog signaling pathway such as basal cell carcinoma and medulloblastoma.

Abstract: Porous, electrically conductive ceramic foams incorporating continuous self-assembled graphene networks are described. The disclosed approach uses interfacial trapping to spontaneously exfoliate and assemble pristine graphite, not graphite oxide, in a ceramic sol-gel. The composite foams display electrical conductivity and joule heating, with anticipated applications as, for example, catalyst supports, thermoelectrics, and porous electrodes.

Abstract: Methods and systems for damage assessment and restoration. One system includes an electronic processor configured to receive weather data for an area of interest. The electronic processor is also configured to determine a first damage prediction for the area of interest using a damage prediction model developed with machine learning using training data, the training data including historical weather data for the area of interest and associated damage. The electronic processor is also configured to determine a restoration time estimate based on the first damage prediction for the area of interest based on different resource allocations. The electronic processor is also configured to transmit a damage assessment report for display on a user device, where the damage assessment report includes the restoration time estimate.

Abstract: A delivery vehicle which comprises a nucleic acid construct, wherein the nucleic acid construct comprises (i) an enhancer which specifically drives gene expression in cells of the entorhinal cortex (ii) a promoter; and (iii) a therapeutic gene, wherein said enhancer, promoter and therapeutic gene are operatively linked, said enhancer and therapeutic gene are heterologous, and said delivery vehicle is suitable for delivery of the nucleic acid construct to the brain of a mammal.

Abstract: The present disclosure provides advantageous graphene/graphite stabilized composites (e.g., graphene/graphite stabilized emulsion-templated foam composites), and improved methods for fabricating such graphene/graphite stabilized composites. More particularly, the present disclosure provides improved methods for fabricating pristine, graphene/graphite/polymer composite foams derived from emulsions stabilized by graphene/graphite kinetic trapping. In exemplary embodiments, the present disclosure provides that, instead of viewing the insolubility of pristine graphene/graphite as an obstacle to be overcome, it is utilized as a means to create or fabricate water/oil emulsions, with graphene/graphite stabilizing the spheres formed. These emulsions are then the frameworks used to make foam composites that have shown bulk conductivities up to about 2 S/m, as well as compressive moduli up to about 100 MPa and breaking strengths of over 1200 psi, with densities as low as about 0.25 g/cm3.

Abstract: The present disclosure relates to tungsten bronze thin films and method of making the same. Specifically, the present disclosure relates to a thin, homogeneous, highly conducting cubic tungsten bronze film with densely packed micron size particles and the process of making the film.

Abstract: A method, system, and non-transitory computer readable medium describing an autoencoder that creates a reduced feature space from healthy power electronics devices for training. Devices under test are then encoded and compared to the encoded features of the healthy devices to determine health of the other devices. Contextual information is used to build multiple models that compare power electronics devices from similarly operated vehicles with one another.

Abstract: The present disclosure includes systems and methods for capture a whole slide image of a sample. In exemplary embodiments, a camera is configured to capture a digital image of a sample. The system captures a bright field image of the sample, and captures a digital image of the sample illuminated from a first incident angle at a first wavelength and a second incident angle at a second wavelength. The system can determine whether the sample is defocused based on the transitional shift between a first wavelength channel and a second wavelength channel of the captured digital image. The system can determine the defocus distance based on the transitional shift and autofocus using the defocus distance such the bright field image is in focus.

Abstract: A wearable 3D augmented reality display and method, which may include 3D integral imaging optics.

Abstract: A system and method that determines whether a heat exchanger within a complex networked system is fouling is provided. The system and method includes training classifiers indicative of a plurality of fouling conditions associated with the heat exchanger and testing the classifiers with optimal sensor data from optimal sensors to determine whether the fouling is being experienced by the heat exchanger.

Abstract: Described herein are methods of identifying immunologically protective neo-epitopes from the cancer tissue DNA of cancer patients using biophysical principles as well as bioinformatics techniques. The identification of immunologically protective neo-epitopes provides pharmaceutical compositions with a limited number of tumor-specific peptides suitable for personalized genomics-driven immunotherapy of human cancer. Specifically disclosed herein is a method of using the conformational stability of an epitope in an MHC protein-binding groove to predict immunogenicity of peptides in a putative neo-peptide set from a tumor from a cancer patient. Pharmaceutical compositions and methods of administration are also included.

Abstract: Systems/methods for continuous operation of fixed bed reactors using gaseous fuels for the purpose of power generation through integration with a combined cycle power plant are provided. The fixed bed reactors are assumed to operate in a semi-batch mode composed of reactor modules that are integrated into module trains that comprise the chemical-looping combustion island of the power plant. The scheduling of each reactor train is cast as an optimization problem that maximizes thermodynamic efficiency subject to constraints imposed to each reactor and the entire island. When the chemical-looping reactors are arranged cyclically, each feeding to or being fed from another reactor, in an operating scheme that mimics simulated moving bed reactors, the thermodynamic efficiency of the reactor island can be improved. Allowing the reversal of module order in the cyclically arranged reactor modules further improves the overall thermodynamic efficiency (to 84.

Abstract: Disclosed herein are isolated compositions including at least 2 of mutant peptides selected from the group consisting of SEQ ID NOS: 1-149, or polypeptides comprising the mutant peptides; wherein the composition comprises mutant peptides encoded by 2 or more genes. Also disclosed are methods for personalized treatment of breast cancer involving creating a peptide array of mutant peptides comprising the mutations in protein-encoding regions of the high-frequency cancer genes or the exome in a subject and screening the peptide array with a biological sample from the subject to detect antibodies in the biological sample that bind to the array, to detect antigenic targets for therapy in treating the subject.

Abstract: Systems and methods of testing the health of vehicular power devices are disclosed herein. A method may include producing operating points as a function of cycling current (Ids) and voltage drain to source (Vds) when a subject device is conducting current. The method may further include determining a mean of moving distribution to adapt a center of the moving distribution contrasted with a plurality of known healthy devices. The method may also include indicating an imminent fault in the subject device based upon a discontinuity among operating points above a threshold.

Abstract: A processing system including at least one processor may obtain a selection of a desired perceptual quality for a video and selects a first video chunk from among a first plurality of video chunks, wherein the first plurality of video chunks is associated with a first time block of the video, wherein the selecting is based upon a manifest file of the video, wherein each video chunk of the first plurality of video chunks is associated with a respective perceptual quality and a respective encoding bitrate, wherein the first video chunk is part of a subset of the first plurality of video chunks for which the respective perceptual quality matches the desired perceptual quality within a predefined threshold tolerance, and wherein the respective encoding bitrate of the first video chunk is lower than a highest encoding bitrate associated with the subset of the first plurality of video chunks. The processing system may obtain the first video chunk from a server and store the first video chunk in a buffer.