Abstract: A mitochondria targeted gold nanoparticle (T-3-BP-AuNP) decorated with 3-bromopyruvate (3-BP) and delocalized lipophilic triphenylphosphonium (TPP) cations to target the mitochondrial membrane potential (??m) was developed for delivery of 3-BP to cancer cell mitochondria by taking advantage of higher ??m in cancer cell compared to normal cells. This construct showed remarkable anticancer activity in prostate cancer cells compared to non-targeted construct NT-3-BP-AuNP and free 3-BP. Anticancer activity of T-3-BP-AuNP was further enhanced upon laser irradiation by exciting the surface plasmon resonance band of AuNP and thereby utilizing a combination of 3-BP chemotherapeutic and AuNP photothermal effects. T-3-BP-AuNPs showed markedly enhanced ability to alter cancer cell metabolism by inhibiting glycolysis and demolishing mitochondrial oxidative phosphorylation in prostate cancer cells.
Type:
Grant
Filed:
March 13, 2015
Date of Patent:
September 3, 2019
Assignee:
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
Abstract: A new Hibiscus plant named ‘RutHib2’ is characterized by a combination of good form, medium vigor, purple foliage, magenta flowers with a red eye, and good tolerance to Alternaria, Cercospora, and Phytophthora pathogens.
Type:
Application
Filed:
February 26, 2018
Publication date:
August 29, 2019
Applicant:
University of Georgia Research Foundation, Inc.
Abstract: A new Hibiscus plant named ‘RutHib1’ is characterized by a combination of good form, medium vigor, predominately purple foliage, white flowers with a red eye, and good tolerance to Alternaria, Cercospora, and Phytophthora pathogens.
Type:
Application
Filed:
February 26, 2018
Publication date:
August 29, 2019
Applicant:
University of Georgia Research Foundation, Inc.
Abstract: A new crapemyrtle plant has deep, uniform purple foliage and stems; a true pink flower color; an intermediate upright growth habit; and powdery mildew and Cercospera resistance.
Type:
Application
Filed:
February 5, 2019
Publication date:
August 8, 2019
Applicant:
University of Georgia Research Foundation, Inc.
Abstract: A new crapemyrtle plant has deep, uniform purple foliage and stems; a light lavender to white flower color; an intermediate upright growth habit; and powdery mildew and Cercospera resistance.
Type:
Application
Filed:
February 5, 2019
Publication date:
August 8, 2019
Applicant:
University of Georgia Research Foundation, Inc.
Abstract: A new crapemyrtle plant has deep, uniform purple foliage and stems; a deep raspberry pink/red flower color; an intermediate upright growth habit; and powdery mildew and Cercospera resistance.
Type:
Application
Filed:
February 5, 2019
Publication date:
August 8, 2019
Applicant:
University of Georgia Research Foundation, Inc.
Abstract: The carbohydrate processing enzyme PNGase F was catalytically inactivated through mutation. Additional mutations yielded a catalytically inactive carbohydrate-binding protein with lectin-like properties including high affinity and specificity N-linked glycans, O-linked glycans, or both.
Type:
Grant
Filed:
April 17, 2015
Date of Patent:
July 23, 2019
Assignees:
University of Georgia Research Foundation, Inc., Glycosensors and Diagnostics, LLC
Inventors:
Kausar N. Samli, Robert J. Woods, Loretta Yang
Abstract: Compositions, devices, grafts and methods for reducing or preventing anti-neointima following cardiovascular injuries and interventions are disclosed. The compositions, devices, and grafts typically include an effective amount of a CTP synthase 1 inhibitor to reduce proliferation of vascular smooth muscle cells, without substantial reducing the proliferation of endothelial cells. Methods of reducing neointima formation, accelerating re-endothelialization, and reducing restenosis in a subject using the compositions, devices, and grafts are also disclosed.
Type:
Grant
Filed:
November 16, 2015
Date of Patent:
June 25, 2019
Assignee:
University of Georgia Research Foundation, Inc.
Abstract: Attenuated isolates of the Arkansas serotype of infectious bronchitis virus (IBV), including the IBV isolate ArkGA p60 deposited at the ATCC under Patent Designation PTA-123783, and compositions thereof are presented. Methods for administering the isolates or compositions as vaccines to the prevent virulent IBV infection in birds of the order Galliformes are also presented.
Type:
Grant
Filed:
January 26, 2018
Date of Patent:
June 25, 2019
Assignee:
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
Abstract: The present invention includes the Paramyxovirus Parainfluenza Virus 5 (PIV5) as an oncolytic agent for treating various cancers, including, but not limited to breast cancer, lung cancer and melanoma. PIV5 oncolytic agents include both wild type PIV5 and various recombinant PIV5 constructs. Recombinant PIV5 constructs may include PIV5 lacking the conserved C-terminus of the V protein (PIV5V?C), PIV5 with mutations in the N-terminus of the V/P protein (PIV5CPI?), and PIV5 expressing MDA-7/IL-24 (rPIV5-MDA7), rPIV5-V/P-CPI?, rPIV5-CPI+, rPIV5-Rev, rPIV5-RL, rPIV5-P-S157A, rPIV5-P-S308A, rPIV5-L-A1981D, rPIV5-F-5443P, rPIV5-MDA7, rPIV5?SH-CPI?, or rPIV5?SH-Rev. Also included are methods of making and using such oncolytic agents and compositions including such oncolytic agents.
Type:
Grant
Filed:
June 30, 2017
Date of Patent:
June 25, 2019
Assignee:
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
Abstract: Host cells are metabolically engineered to consume glucose and glycerol simultaneously, and to divert glucose from catabolic to anabolic pathways without adversely affecting glucose uptake.
Type:
Application
Filed:
May 5, 2017
Publication date:
June 6, 2019
Applicant:
University of Georgia Research Foundation, Inc.
Inventors:
Yajun YAN, Yifei WU, Xinxiao SUN, Yuheng LIN
Abstract: Disclosed are compositions, articles, and method for enhancing exercise performance in a subject. The method involves contacting the oral cavity of the subject with a composition comprising a sweet and caloric food product for a period sufficient to cause a cephalic phase response in the subject.
Type:
Grant
Filed:
December 16, 2016
Date of Patent:
June 4, 2019
Assignee:
University of Georgia Research Foundation, Inc.
Abstract: Systems and methods for estimating time-dependent voltages that are induced in electrophysiological monitoring systems by magnetic field gradients generated during a magnetic resonance imaging (“MRI”) scan are provided. The gradient-induced voltages are subsequently removed from signals acquired with the electrophysiological monitoring system during an MRI scan. As an example, the electrophysiological monitoring system can include an electrocardiography (“ECG”) system, an electroencephalography (“EEG”) system, an electromyography (“EMG”) system, a voltage device tracking (“VDT”) system, and so on. The gradient-induced voltages are estimated using a two-step procedure in which a learning algorithm is used to determine fitting parameters to be used in a model of the gradient-induced voltages. The fitting parameters are then used together with the model to extract the gradient-induced voltages from signals acquired during an MRI scan. The gradient-induced voltages can then be removed from the acquired signals.
Type:
Grant
Filed:
July 10, 2015
Date of Patent:
June 4, 2019
Assignees:
BRIGHAM AND WOMEN'S HOSPTIAL, INC., UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
Inventors:
Wei Wang, HuaLei Zhang, Ehud J. Schmidt, Tsz Ho Tse
Abstract: Convenient methods of preparing aza-dibenzocyclooctynes are disclosed herein. Aza-dibenzocyclooctynes attached to a surface are also disclosed herein. Aza-dibenzocyclooctynes can be reacted with azides to form heterocyclic compounds. Such reactions can be useful in a wide variety of applications including, for example, labeling surfaces.
Type:
Grant
Filed:
December 16, 2016
Date of Patent:
July 30, 2019
Assignee:
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
Inventors:
Vladimir V. Popik, Alexander Kuzmin, Andrei Polukhtine
Abstract: A new variety of Citrus ichangensis x C. maxima plant named ‘Tift2-16’ produces fruit with a reduced number of seeds, making it valuable as a backyard fruit tree. Also, it is a desirable tree for landscaping.
Type:
Grant
Filed:
October 3, 2017
Date of Patent:
August 20, 2019
Assignee:
University of Georgia Research Foundation, Inc.
Abstract: A new variety of Citrus reticulata plant named ‘Tift3-46’ produces fruit with a reduced number of seeds, making it valuable as a backyard fruit tree. Also, it is a desirable tree for landscaping.
Type:
Grant
Filed:
October 3, 2017
Date of Patent:
August 20, 2019
Assignee:
University of Georgia Research Foundation, Inc.
Abstract: A new Hibiscus plant named ‘RutHib1’ is characterized by a combination of good form, medium vigor, predominately purple foliage, white flowers with a red eye, and good tolerance to Alternaria, Cercospora, and Phytophthora pathogens.
Type:
Grant
Filed:
February 26, 2018
Date of Patent:
August 20, 2019
Assignee:
University of Georgia Research Foundation, Inc.
Abstract: A new Hibiscus plant named ‘RutHib2’ is characterized by a combination of good form, medium vigor, purple foliage, magenta flowers with a red eye, and good tolerance to Alternaria, Cercospora, and Phytophthora pathogens.
Type:
Grant
Filed:
February 26, 2018
Date of Patent:
August 27, 2019
Assignee:
University of Georgia Research Foundation, Inc.