Abstract: 5-hydroxytryptophan (5-HTP), a precursor of serotonin, is produced in a microbial host cell. A modified bacterial phenylalanine 4-hydroxylase (P4H) catalyzes the tryptophan 5-hydroxylation reaction. Optionally the host cell includes a cofactor regeneration mechanism, allowing continuous production of 5-HTP without supplementation of exogenous cofactors.
Type:
Application
Filed:
June 14, 2018
Publication date:
October 4, 2018
Applicant:
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
Abstract: A pecan tree distinguished by the following unique combination of characteristics: Large nut size, good kernel quality, moderately early harvest date, and excellent resistance to the scab fungus (Fusicladosporium effusum).
Type:
Application
Filed:
March 21, 2017
Publication date:
September 27, 2018
Applicant:
University of Georgia Research Foundation, Inc.
Abstract: Disclosed are various embodiments for a berry impact recording device. The berry impact recording device comprises a shell. Within the shell are at least a sensor and an integrated circuit. The sensor may be configured to detect an acceleration of the berry impact recording device. The integrated circuit may be configured to record the acceleration of the berry impact recording device and a timestamp corresponding to the acceleration.
Type:
Grant
Filed:
November 6, 2017
Date of Patent:
September 25, 2018
Assignee:
University of Georgia Research Foundation, Inc.
Abstract: This invention provides methods and compositions for using Listeria monocytogenes as an adjuvant for enhancing immune responses in a subject.
Type:
Grant
Filed:
July 27, 2016
Date of Patent:
September 4, 2018
Assignees:
ADVAXIS, INC., UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC., THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Inventors:
John Rothman, Anu Wallecha, Reshma Singh, Donald A. Harn, Jr., Yvonne Paterson
Abstract: The present disclosure includes methods and compositions for reducing turf thatch and/or preventing turf thatch buildup. The compositions include isolated fungal laccase enzymes, such as laccase enzymes from white rot fungi. Methods of reducing and/or preventing turf thatch buildup include applying compositions including isolated fungal laccase enzymes to turfgrass.
Type:
Grant
Filed:
December 23, 2014
Date of Patent:
August 21, 2018
Assignee:
University of Georgia Research Foundation, Inc.
Inventors:
Qingguo Huang, Sudeep S. Sidhu, Paul L. Raymer, Robert N. Carrow
Abstract: The present invention relates to the differentiation of human pluripotent cells, including human pluripotent stems cells to produce a self-renewing multipotent neural crest cell population in a single step method without the requirement of isolation of intermediate cells and without appreciable contamination (in certain preferred instances, virtually none) with Pax6+ neural progenitor cells in the population of p75+ Hnk1+ Ap2+ multipotent neural crest-like cells. The multipotent neural crest cell population obtained can be clonally amplified and maintained for >25 passages (>100 days) while retaining the capacity to differentiate into peripheral neurons, smooth muscle cells and mesenchymal precursor cells.
Type:
Grant
Filed:
January 19, 2016
Date of Patent:
August 21, 2018
Assignee:
University of Georgia Research Foundation, Inc.
Abstract: The present disclosure provides photosynthetic electrochemical cells including photosynthetic compounds and methods of generating an electrical current using the photosynthetic electrochemical cells.
Type:
Grant
Filed:
September 6, 2016
Date of Patent:
August 21, 2018
Assignee:
University of Georgia Research Foundation, Inc.
Abstract: Provided herein are methods for producing an ortho-hydroxylated phenylpropanoid. In one embodiment the method includes culturing a microbe that includes HpaBC activity in the presence of a phenylpropanoid substrate. Also provided are genetically engineered microbes engineered to have greater levels of HpaB and/or HpaC than a control microbe.
Type:
Grant
Filed:
June 10, 2014
Date of Patent:
July 31, 2018
Assignee:
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
Abstract: The subject matter disclosed herein relates to compositions that contain a protein cage and a therapeutic agent, such as a photosensitizer. The protein cage is a protein that binds metal ion. The composition can further contain a cell recognition moiety. The methods disclosed are for permeabilizing the endothelial lining of a cancerous tissue or for treating a cancerous tissue to cause therapeutic injury resulting in the reduction of at least one of the surface area, the depth, and the amount of the tissue affected by the cancerous condition, in a subject.
Type:
Grant
Filed:
May 11, 2015
Date of Patent:
July 17, 2018
Assignee:
University of Georgia Research Foundation, Inc.
Abstract: 5-hydroxytryptophan (5-HTP), a precursor of serotonin, is produced in a microbial host cell. A modified bacterial phenylalanine 4-hydroxylase (P4H) catalyzes the tryptophan 5-hydroxylation reaction. Optionally the host cell includes a cofactor regeneration mechanism, allowing continuous production of 5-HTP without supplementation of exogenous cofactors.
Type:
Grant
Filed:
May 14, 2015
Date of Patent:
July 17, 2018
Assignee:
University of Georgia Research Foundation, Inc.
Abstract: Embodiments of the present disclosure, in one aspect, relate to structures having a polymer composition covalently bonded to the surface of the structure, methods of attaching the polymer to the surface of the structure, methods of decreasing the amount of microorganisms formed on a structure, materials, methods of attaching materials, and the like.
Type:
Grant
Filed:
August 8, 2017
Date of Patent:
July 3, 2018
Assignee:
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
Abstract: Described is a targeted molecular scaffold for construction of a metabolic inhibitor loaded with cancer-cell specific activity and anti-tumor immunity. Incorporation of a mitochondria targeting moiety such as triphenylphosphonium cation through a biodegradable linker in allowed for mitochondria targeting of certain metabolic inhibitors like dichloroacetic acid (DCA).
Type:
Grant
Filed:
July 1, 2014
Date of Patent:
June 26, 2018
Assignee:
University of Georgia Research Foundation Inc.
Abstract: The present invention relates to novel strains of avian reovirus that were isolated from clinical cases of viral arthritis/tenosynovitis in chickens in the southeast United States. The invention is directed to these novel group 1 and group 2 avian reoviruses, diagnostic assays using antibodies and/or nucleotide- or amino acid-specific components of such viruses, such as the S1 gene encoding the sigma C protein, and to vaccines that protect chickens from disease caused by such viruses.
Type:
Grant
Filed:
July 29, 2016
Date of Patent:
May 15, 2018
Assignee:
University of Georgia Research Foundation, Inc.
Abstract: Various examples are provided for jamming avoidance response (JAR), and photonic implementations thereof. In one example, a method includes generating optical pulses that correspond to raising envelope of a beat signal associated with an interference signal and a reference signal; generating optical spikes that correspond to positive zero crossing points of the reference signal; providing a phase output that indicates whether the beat signal is leading or lagging the reference signal, the phase output based at least in part upon the optical spikes; and determining an adjustment to the reference frequency based at least in part upon the optical pulses and the phase output. In another example, a JAR system includes a photonic P-unit to generate the optical pulses; a photonic ELL/T-unit to generate the optical spikes; a photonic TS unit to provide the phase output; and a logic unit to determine the adjustment to the reference frequency.
Type:
Grant
Filed:
October 27, 2016
Date of Patent:
April 24, 2018
Assignee:
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
Abstract: This invention relates to methods of using a Listeria vaccine vector to induce a Th1 immune response in subjects having persistent Th2 immune response profiles.
Type:
Grant
Filed:
October 7, 2015
Date of Patent:
April 17, 2018
Assignees:
The Trustees of the University of Pennsylvania, University of Georgia Research Foundation, Inc.
Inventors:
Donald A. Harn, Jr., Yvonne Paterson, Lisa McEwen
Abstract: The present disclosure describes methods and compositions for reducing and/or preventing soil water repellency. Embodiments of methods of reducing soil water repellency (SWR) of the present disclosure include applying to an area of groundcover a composition including an effective amount of at least one isolated enzyme capable of degrading or altering organic matter associated with SWR, where the SWR of the area of groundcover is reduced after treatment with the enzyme composition.
Type:
Grant
Filed:
May 29, 2013
Date of Patent:
April 17, 2018
Assignee:
University of Georgia Research Foundation, Inc.
Inventors:
Qingguo Huang, Robert N. Carrow, Paul L. Raymer
Abstract: The present invention provides chemical and chemo-enzymatic methods for the synthesis of a wide array of complex asymmetric multi-antennary glycans.
Type:
Grant
Filed:
March 23, 2012
Date of Patent:
April 10, 2018
Assignee:
University of Georgia Research Foundation, Inc.
Abstract: A pecan tree distinguished by the following unique combination of characteristics: Consistent and acceptable fruit production, small fruit clusters, moderately early nut maturity, large nut producing mammoth kernels with excellent color and no speckling, and high resistance to scab fungus.
Type:
Grant
Filed:
July 5, 2016
Date of Patent:
May 29, 2018
Assignee:
University of Georgia Research Foundation, Inc.
Abstract: A pecan tree distinguished by the following unique combination of characteristics: Consistent and acceptable fruit production, small fruit cluster, early nut maturity, large nut producing mammoth kernels with excellent color, and high resistance to scab fungus.
Type:
Grant
Filed:
July 5, 2016
Date of Patent:
June 26, 2018
Assignee:
University of Georgia Research Foundation, Inc.