Patents Assigned to University of Georgia Research Foundation, Inc.
  • Alkynes and methods of reacting alkynes with 1,3-dipole-functional compounds
    Patent number: 9932297
    Abstract: 1,3-Dipole-functional compounds (e.g., azide functional compounds) can be reacted with certain alkynes in a cyclization reaction to form heterocyclic compounds. Useful alkynes (e.g., strained, cyclic alkynes) and methods of making such alkynes are also disclosed. The reaction of 1,3-dipole-functional compounds with alkynes can be used for a wide variety of applications including the immobilization of biomolecules on a substrate.
    Type: Grant
    Filed: July 24, 2017
    Date of Patent: April 3, 2018
    Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    Inventors: Geert-Jan Boons, Jun Guo, Xinghai Ning, Margaretha Wolfert
  • Measuring, categorizing, and/or mitigating malware distribution paths
    Patent number: 9930065
    Abstract: Systems and methods for event path traceback may utilize a processor and a path traceback and categorization (ATC) module in communication with the processor. The processor may be configured to perform processing associated with receiving network traffic from a network. The ATC module may be configured to perform processing associated with identifying an event within the network traffic, tracing a sequence of network transactions related to the event, and outputting an annotated event path (AMP) including data about the event and the sequence of network transactions related to the event. Performing processing associated with tracing the sequence of network transactions may comprise reconstructing a sequence of transactions within the network traffic that led to the event while filtering out unrelated traffic within the network traffic.
    Type: Grant
    Filed: March 25, 2015
    Date of Patent: March 27, 2018
    Assignees: University of Georgia Research Foundation, Inc., Dambala, Inc.
    Inventors: Terry Lee Nelms, Roberto Perdisci
  • Glycan-specific analytical tools
    Patent number: 9926612
    Abstract: Provided are lectenz molecules, which are mutated carbohydrate processing enzymes that are catalytically inactive and that have had their substrate affinity increased by at least 1.2 fold. Further provided are methods for making and methods of using such lectenz. Additional mutated proteins following the lectenz approach are further provided.
    Type: Grant
    Filed: December 10, 2009
    Date of Patent: March 27, 2018
    Assignees: University of Georgia Research Foundation, Inc., Glycosensors and Diagnostics, LLC
    Inventors: Robert J. Woods, Loretta Yang
  • MITOCHONDRIA-TARGETING PLATINUM(IV) PRODRUG
    Publication number: 20180066004
    Abstract: Pt(IV) compounds include a mitochondria targeting moiety. One example of a Pt(IV) compound having a mitochondria targeting moiety is a Pt(IV) cisplatin-based compound. Upon reduction, the mitochondrial targeting moieties are released resulting in a Pt(II) therapeutic agent. Pt(IV) compounds including a mitochondria targeting moiety can be included in nanoparticles. The compounds or nanoparticles can be used to treat, for example, cancer.
    Type: Application
    Filed: April 8, 2015
    Publication date: March 8, 2018
    Applicant: University of Georgia Research Foundation, Inc.
    Inventors: Shanta Dhar, Rakesh Pathak, Sean Marrache
  • Therapeutic compositions and methods for treating infections
    Patent number: 9907822
    Abstract: This disclosure describes, in one aspect, a composition that includes a transgenic pathogen that expresses a heterologous pathogen associated molecular pattern (PAMP). In some embodiments, the pathogen may be attenuated. In some embodiments, the pathogen can include T. cruzi. In another aspect, this disclosure describes a method of treating an infection in a subject. Generally, the method includes administering to the subject, in an amount effective to treat the infection, a pathogen genetically modified to express a pathogen-associated molecular pattern (PAMP) not natively expressed by the pathogen.
    Type: Grant
    Filed: January 17, 2014
    Date of Patent: March 6, 2018
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Rick Tarleton, Samarchith Kurup
  • 2'-FLUORO-6'-METHYLENE CARBOCYCLIC NUCLEOSIDES AND METHODS OF TREATING VIRAL INFECTIONS
    Publication number: 20180063059
    Abstract: The present invention relates to 2?-Fluoro-6?-methylene carbocyclic nucleosides, pharmaceutical compositions containing these nucleosides and their use in the treatment or prophylaxis of a number of viral infections and secondary disease states and conditions thereof, especially including Hepatitis B virus (HBV) and secondary disease states and conditions thereof (cirrhosis and liver cancer), Heptatitis C virus (HCV), Herpes Simplex virus I and II (HSV-1 and HSV-2), cytomegalovirus (CMV), Varicella-Zoster Virus (VZV) and Epstein Barr virus (EBV) and secondary cancers which occur thereof (lymphoma, nasopharyngeal cancer, including drug resistant (especially including lamivudine and/or adefovir resistant) and other mutant forms of these viruses, especially HBV.
    Type: Application
    Filed: May 31, 2017
    Publication date: March 1, 2018
    Applicant: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    Inventors: Chung K. Chu, Jianing Wang
  • Apoptosis-targeting nanoparticles
    Patent number: 9901616
    Abstract: Nanoparticles include a core and one or more targeting moieties, as well as one or more contrast agents or one or more therapeutic agents. The contrast agents or therapeutic agents may be contained or embedded within the core. If the nanoparticle includes therapeutic agents, the agents are preferably released from the core at a desired rate. The core may be biodegradable and may release the agents as the core is degraded or eroded. The targeting moieties preferably extend outwardly from the core so that they are available for interaction with cellular components, which interactions will target the nanoparticles to the appropriate cells, such as apoptotic cells; organelles, such as mitochondria; or the like. The targeting moieties may be tethered to the core or components that interact with the core.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: February 27, 2018
    Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    Inventors: Shanta Dhar, Sean Marrache
  • PIV5-Based Amplifying Virus-Like Particles
    Publication number: 20180044644
    Abstract: Compositions, methods of use and methods of manufacture are provided for PIV5-based amplifying VLP (AVLP) that can deliver an expressible heterologous nucleotide sequence in target cells without producing progeny, and which demonstrate useful safety and therapeutic efficacy in multiple animal and human health applications, such as vaccination, gene therapy and cancer therapy.
    Type: Application
    Filed: April 28, 2016
    Publication date: February 15, 2018
    Applicant: University of Georgia Research Foundation, Inc.
    Inventor: Biao He
  • Photochemical cross-linkable polymers, methods of making photochemical cross-linkable polymers, methods of using photochemical cross-linkable polymers, and methods of making articles containing photochemical cross-linkable polymers
    Patent number: 9879117
    Abstract: Structures having a polymer composition covalently bonded to the surface of the structure, methods of attaching the polymer to the surface of the structure, methods of decreasing the amount of microorganisms formed on a structure, and the like, are disclosed.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: January 30, 2018
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Jason J. Locklin, Vikram Dhende
  • Devices and methods for separating particles
    Patent number: 9873126
    Abstract: Embodiments of the present disclosure provide for devices, methods for separating particles, and the like.
    Type: Grant
    Filed: October 11, 2016
    Date of Patent: January 23, 2018
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Leidong Mao, Taotao Zhu, Mark A. Eiteman
  • Pecan tree named 'Tanner'
    Publication number: 20180014440
    Abstract: A pecan tree distinguished by the following unique combination of characteristics: Consistent and acceptable fruit production, small fruit cluster, early nut maturity, large nut producing mammoth kernels with excellent color, and high resistance to scab fungus.
    Type: Application
    Filed: July 5, 2016
    Publication date: January 11, 2018
    Applicant: University of Georgia Research Foundation, Inc.
    Inventor: Darrell Sparks
  • 2? Fluoronucleosides
    Patent number: 9861652
    Abstract: 2?-Fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formulae: wherein Base is a purine or pyrimidine base; R1 is OH, H, OR3, N3, CN, halogen, CF3, lower alkyl, amino, loweralkylamino, di(lower)alkylamino, or alkoxy; R2 is H, phosphate, or a stabilized phosphate prodrug; acyl, or other pharmaceutically acceptable leaving benzyl, a lipid, an amino acid, peptide, or cholesterol; and R3 is acyl, alkyl, phosphate, or other pharmaceutically acceptable leaving group; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: November 6, 2015
    Date of Patent: January 9, 2018
    Assignees: Emory University, The University of Georgia Research Foundation, Inc.
    Inventors: Raymond F. Schinazi, Dennis C. Liotta, Chung K. Chu, J. Jeffrey McAtee, Junxing Shi, Yongseok Choi, Kyeong Lee, Joon H. Hong
  • SYSTEM AND METHOD FOR FOWL VACCINATION
    Publication number: 20170360540
    Abstract: A method, apparatus and system for delivery of live or attenuated viral and bacterial vaccines to fowl are described.
    Type: Application
    Filed: December 21, 2015
    Publication date: December 21, 2017
    Applicant: The University of Georgia Research Foundation, Inc .
    Inventors: Mark W Jackwood, Brian Jordan
  • Methods to identify soybean aphid resistant quantitative trait loci in soybean and compositions thereof
    Patent number: 9844196
    Abstract: The present invention is in the field of plant breeding and aphid resistance. More specifically, the invention includes a method for breeding soybean plants containing quantitative trait loci that are associated with resistance to aphids, Aphis glycines. The invention further includes method for monitoring the introgression quantitative trait loci (QTL) conferring aphid resistance into elite germplasm in a breeding program.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: December 19, 2017
    Assignees: Monsanto Technology LLC, University of Georgia, Research Foundation, Inc.
    Inventors: Vergel Concibido, James Narvel, Jennifer Yates, Henry Roger Boerma
  • Photochemical cross-linkable polymers, methods of making photochemical cross-linkable polymers, methods of using photochemical cross-linkable polymers, and methods of making articles containing photochemical cross-linkable polymers
    Patent number: 9839213
    Abstract: Embodiments of the present disclosure, in one aspect, relate to polymer compositions, methods of making polymer compositions, structures having the polymer composition covalently bonded to the surface of the structure, methods of attaching the polymer to the surface of the structure, methods of decreasing the amount of microorganisms formed on a structure, materials, methods of attaching materials, and the like.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: December 12, 2017
    Assignee: THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    Inventor: Jason J. Locklin
  • Computerized tomography detection of microbial damage of plant tissues
    Patent number: 9816948
    Abstract: The present disclosure encompasses embodiments of X-ray computed tomography-based methods for the detection of onion quality factors. Such methods are advantageous in detecting internal damage to onion bulbs due to bacterial and fungal rots and mechanical damage while also providing for the overall assessment of onion bulb quality and market value. Because CT images provide cross-sectional reconstructions of the subject under study, CT scans of onion bulbs can be used not only to detect damage from disease, but also cuts and bruises that increase an onion bulb's susceptibility to disease, and the presence of shoots or seed stems and overall shape of the bulbs.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: November 14, 2017
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Mark A. Haidekker, Richard Speir
  • Attenuation of infectious bronchitis virus variant GA-13
    Patent number: 9790474
    Abstract: The present invention provides the isolation and characterization of a new infectious bronchitis virus (IBV) variant, the IBV GA-13 variant, and the production of attenuated isolates thereof, including, but not limited to, the attenuated IBV GA13 isolate 103505 Kd E86, and the use of such IBV isolates in materials and methods for combating infectious bronchitis virus in poultry and reducing the economic impact that infectious bronchitis disease has on poultry production.
    Type: Grant
    Filed: July 24, 2015
    Date of Patent: October 17, 2017
    Assignee: University of Georgia Research Foundation, Inc.
    Inventor: Holly S. Sellers
  • Rabbiteye blueberry plant named ‘T-1101’
    Patent number: PP28623
    Abstract: The new variety ‘T-1101’ ripens around late May in southern Georgia and mid June in middle Georgia. The fruit of the new variety ‘T-1101’ are very large, firm, have good flavor and scar. The new variety ‘T-1101’ is vigorous with an estimated chilling requirement of about 400 to 450 hours at or below approximately 7° C. The asexually reproduced variety is reliably propagated vegetatively.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: November 14, 2017
    Assignee: University of Georgia Research Foundation, Inc.
    Inventor: D. Scott NeSmith
  • Rabbiteye blueberry plant named ‘T-460’
    Patent number: PP28624
    Abstract: The new variety ‘T-460’ ripens around mid June in southern Georgia and early July in middle Georgia. The fruit of the new variety ‘T-460’ are large, with good scar and very good color. The new variety ‘T-460’ is moderately vigorous with an estimated chilling requirement of about 500 to 550 hours at or below approximately 7° C. The asexually reproduced variety is reliably propagated vegetatively.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: November 14, 2017
    Assignee: University of Georgia Research Foundation, Inc.
    Inventor: D. Scott NeSmith
  • Dwarf hybrid blueberry plant named ‘TO-1319’
    Patent number: PP28665
    Abstract: The new variety ‘TO-1319’ has fruit that ripens around late May in southern Georgia and mid-late June in middle Georgia. The fruit of the new variety ‘TO-1319’ are light-blue, medium size, and firm, with a mild flavor. The new variety ‘TO-1319’ is vigorous with an estimated chilling requirement of about 400 to 500 hours at or below approximately 45° C.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: November 21, 2017
    Assignee: University of Georgia Research Foundation, Inc.
    Inventor: D. Scott NeSmith