Abstract: An isolated polynucleotide encoding a fusion protein which comprises a catalytically inactive CRISPR associated 9 (dCas9) protein linked to a TET protein is disclosed. Use thereof and of the fusion protein itself is also disclosed.
Type:
Application
Filed:
June 2, 2017
Publication date:
April 4, 2019
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: Compositions that include certain phenyl substituted cyclohexenyl compounds are administered to a subject in a method for treating obesity or an associated disease or disorder or in a method of reducing food consumption or body weight.
Type:
Grant
Filed:
November 22, 2017
Date of Patent:
March 26, 2019
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: A polarized light source configured for use in display device and backlight unit is described. The polarized light source comprising: at least one optically active structure comprising a plurality of nanorods configured to emit light of one or more wavelengths in response to exciting pumping field, said plurality of nanorods comprising nanorods aligned with a predetermined alignment axis so as to produce a desired polarization direction of the emitted light; and a light directing assembly comprising one or more optical elements in optical path of light emitted from the light emitting structure, said light directing assembly being configured to enhance output of the emitted light from the emitting structure while substantially maintaining the polarization of the emitted light passing therethrough. Preferably, layers associated with the polarized light source are aligned with parallel principal axes.
Type:
Grant
Filed:
June 25, 2018
Date of Patent:
March 19, 2019
Assignees:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Qlight Nanotech Ltd.
Abstract: A method of treating a lipid-related disorder in a subject in need thereof is disclosed. The method comprises administering to the subject a therapeutically effective amount of a polynucleotide agent which is substantially complementary to a nucleotide sequence of human miR-132, thereby treating the lipid related disorder in the subject.
Type:
Application
Filed:
November 19, 2018
Publication date:
March 14, 2019
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Inventors:
Hermona SOREQ, Geula HANIN, David S. GREENBERG
Abstract: The present invention relates to the use of pomegranate oil and fractions thereof for preventing and treating neurodegenerative diseases. Particularly, the present invention relates to emulsions of the pomegranate oil or fractions thereof for the prevention and treatment of brain diseases, including Creutzfeldt-Jacob disease (CJD) and multiple sclerosis (MS).
Type:
Application
Filed:
November 8, 2018
Publication date:
March 7, 2019
Applicants:
Hadasit Medical Research Services and Development Ltd., Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: The invention provides mesoporous nanoparticles loaded within its pores with at least one loaded pharmaceutically active agent and at least one capping pharmaceutically active agent chemically coordinated with at least one ligand being boronic acid or derivative thereof on the surface of said pores; compositions comprising such mesoporous nanoparticles and uses thereof.
Type:
Application
Filed:
March 2, 2017
Publication date:
February 28, 2019
Applicant:
Yissum Research Development Company, of The Hebrew University of Jerusalem Ltd.
Abstract: Provided is a composition for oral administration which includes a lipophilic active substance and a phospholipid, providing a prolonged therapeutic effect.
Type:
Application
Filed:
December 6, 2016
Publication date:
February 21, 2019
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: Provided is a compound including at least one carrier moiety associated with a plurality of CT imaging moieties, and with at least one enzyme interacting moiety as well as uses thereof in diagnosis.
Type:
Application
Filed:
February 16, 2017
Publication date:
February 21, 2019
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Inventors:
Galia BLUM, Darya TSIVRKUN, Hanmant GAIKWAD
Abstract: A method and a system for generating adaptive fast forward of egocentric videos are provided here. The method may include the following steps: obtaining a video footage containing a sequence of image frames captured by a non-stationary capturing device; estimating a moving direction of the non-stationary capturing device for a plurality of frames in the sequence of image frames; and generating a shortened video footage having fewer frames than said video footage, by sampling the sequence of image frames, wherein the sampling is carried out by selecting specific image frames and that minimize an overall cost associated with a deviation from a specific direction related to the moving direction, calculated for each of said plurality of image frames.
Type:
Grant
Filed:
June 5, 2017
Date of Patent:
February 19, 2019
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: Provided are methods for disrupting biofilms and/or preventing the formation of biofilms. Further provided are random-sequence peptide mixtures for use in disrupting bacterial biofilms. The random-sequence peptides include hydrophobic and/or cationic amino acids, and the ratio of the total hydrophobic and cationic amino acids in the mixture is predefined.
Type:
Application
Filed:
February 2, 2017
Publication date:
February 7, 2019
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: A method for searchable symmetric encryption. The method includes: accessing a computerized database that comprises keyword lists, each of the keyword lists comprising memory addresses of electronic documents that all contain a respective keyword; binning the memory addresses by performing balanced allocation of the memory addresses into ordered bins, such that at least some of the ordered bins each contains memory addresses of electronic documents that contain different keywords; encrypting each of the memory addresses with an encryption key that is derived from the keyword of the respective memory address; and storing the ordered bins at consecutive locations in a non-transient computer-readable memory, wherein the consecutive locations preserve the order of the ordered bins.
Type:
Application
Filed:
January 19, 2017
Publication date:
January 24, 2019
Applicants:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Yeda Research and Development Co. Ltd.
Inventors:
Gil SEGEV, Ido SHAHAF, Gilad ASHAROV, Moni NAOR
Abstract: Provided are tomato plants having fruit with red and yellow segments that appear across the fruit from the internal seed area to the most external layer of the epidermis. The present invention discloses that this phenotype, designated Arlecchino, is linked to insertion mutation within the Phytoene synthase 1 (Psy1) gene.
Type:
Application
Filed:
July 5, 2016
Publication date:
January 24, 2019
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: The invention relates to a hybrid structure including perforated solid substrate having at least one nanopore perforating therethrough, and devices and uses thereof.
Type:
Grant
Filed:
February 6, 2014
Date of Patent:
January 15, 2019
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Inventors:
Danny Porath, Oded Shoseyov, Yuval Nevo, Ke Liu, Dvir Marom Rotem
Abstract: The present invention provides liposomes comprising a lipid bilayer and a polymer-conjugated lipid, wherein said polymer-conjugated lipid is incorporated into said lipid bilayer. The present invention also provides methods of producing the liposomes as well as a method of delivering a nucleic acid to a subject comprising the step of administering said nucleic acid encapsulated in a mixed liposome, a method for performing diagnostic imaging in a subject, comprising the step of administering a diagnostic agent encapsulated in a mixed liposome, and methods for treating, inhibiting, or suppressing a pathological condition in a subject comprising administering to said subject a mixed liposome.
Type:
Grant
Filed:
May 10, 2012
Date of Patent:
January 15, 2019
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: A method of treating a lipid-related disorder in a subject in need thereof is disclosed. The method comprises administering to the subject a therapeutically effective amount of a polynucleotide agent which is substantially complementary to a nucleotide sequence of human miR-132, thereby treating the lipid related disorder in the subject.
Type:
Grant
Filed:
September 21, 2015
Date of Patent:
January 8, 2019
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Inventors:
Hermona Soreq, Geula Hanin, David S. Greenberg
Abstract: A method and system for enhancing a speech signal is provided herein. The method may include the following steps: obtaining an original video, wherein the original video includes a sequence of original input images showing a face of at least one human speaker, and an original soundtrack synchronized with said sequence of images; and processing, using a computer processor, the original video, to yield an enhanced speech signal of said at least one human speaker, by detecting sounds that are acoustically unrelated to the speech of the at least one human speaker, based on visual data derived from the sequence of original input images.
Type:
Application
Filed:
July 3, 2018
Publication date:
January 3, 2019
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: The compounds D9-tetrahydrocannabinol (THC), cannabidiol (CBD) and capsaicin are useful for prevention, treatment, or both, of hepatic encephalopathy. The compounds capsaicin, 2-arachidonoylglycerol (2-AG), HU-308 and cannabidiol are useful for prevention, treatment, or both, of liver cirrhosis.
Type:
Grant
Filed:
June 16, 2011
Date of Patent:
January 1, 2019
Assignees:
Yissum Research Development Company of the Hebrew University of Jerusalem, Hadasit Medical Research Services & Development Ltd., Aristotle University of Thessaloniki
Inventors:
Elliot Berry, Yosefa Avraham, Raphael Mechoulam, Yaron Ilan, Yossi Dagon, Iddo Magen, Nicholas Grigoriadis, Theofilos Poutachidis