Abstract: Synthetic peptides containing chemical modifications having anti-tumor properties are provided. Further provided are pharmaceutical compositions including the peptides and use thereof for treating proliferative and neoplastic diseases such as cancer.
Type:
Grant
Filed:
February 7, 2016
Date of Patent:
February 25, 2020
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: The invention provides efficient cyclization processes of hydroxyalkenoic acids and products produced therefrom. The following reactions are claimed: Formula (I), (II), (V) and (VI).
Type:
Application
Filed:
February 14, 2018
Publication date:
February 13, 2020
Applicant:
Yissum Research Development Company, of The Hebrew University of Jerusalem Ltd.
Abstract: Provided are objects constructed of compressed salt combinations including salt and at least one additive, wherein the at least one additive is selected to impart the object with resistance to water and humidity.
Type:
Application
Filed:
March 27, 2018
Publication date:
January 30, 2020
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Inventors:
Daniel MANDLER, Noa LAPIDOT, Andrea BUFFA, Gabriel DIKOVSKY, Lihi RIKANATI
Abstract: A method and system for providing Deep Packet Inspection (DPI) as a service to a computer network are provided herein. The contribution of embodiments of the present invention is two-folded. First, a possible framework of having DPI deployed as a service is detailed, including the necessary algorithms and required adaptations. Second, the superior performance of the suggested design is demonstrated via simulations. Since the focus is on the algorithmic aspects and network design, an SDN implementation of the suggested design is not provided herein. However, many aspects of such an SDN implementation follow closely the guidelines known in the art.
Type:
Grant
Filed:
June 23, 2015
Date of Patent:
January 21, 2020
Assignee:
Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.
Inventors:
David Hay, Yaron Koral, Yotam Harchol, Anat Brembler-Barr
Abstract: Provided is an antiangiogenic agent in the form of a vehicle, e.g., a nanoparticle associated (directly or indirectly) with at least one ocular angiogenesis growth factor aptamer, wherein said association labile to interaction between the aptamer and an ocular angiogenesis growth factor.
Type:
Application
Filed:
February 28, 2018
Publication date:
January 2, 2020
Applicants:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Bar Ilan University
Abstract: Provided is a novel photoinitiator in the form of a hybrid nanoparticle constructed of a semiconductor and metallic regions, and uses thereof.
Type:
Application
Filed:
August 27, 2019
Publication date:
December 26, 2019
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: Disclosed herein are genetically modified plants having altered biological activity of 3-?-hydroxysteroid dehydrogenase/isomerase (GAME25), or 2-oxoglutarate-dependent dioxygenase (GAME31), or a combination thereof, wherein the genetically modified plants have an altered content of at least one cholesterol derived compound selected from the group including a steroidal alkaloid or a glycosylated derivative thereof and an unsaturated or saturated steroidal saponin or a glycoside derivative thereof. Further disclosed herein are genetically modified plants having altered expression of a gene encoding a 3-?-hydroxysteroid dehydrogenase/isomerase (GAME25), or a 2-oxoglutarate-dependent dioxygenase (GAME31), or a combination thereof, wherein the genetically modified plant has an altered content of at least one cholesterol derived compound selected from the group including a steroidal alkaloid or a glycosylated derivative thereof and an unsaturated or saturated steroidal saponin or a glycoside derivative thereof.
Type:
Application
Filed:
February 8, 2018
Publication date:
December 5, 2019
Applicants:
YEDA RESEARCH AND DEVELOPMENT CO. LTD., Yissum Research Development Company, of The Hebrew University of Jerusalem Ltd.
Inventors:
Asaph AHARONI, Prashant SONAWANE, Pablo D. CARDENAS, BURDMAN Saul
Abstract: Disclosed are methods for treating, preventing and alleviating obesity, fatty liver syndrome, diabetes, one or more metabolic syndrome conditions or complications and/or cancer comprising administering an effective amount of ostreolysin, its functionally related variant, or an extract or mushroom extract comprising the same to subjects in need thereof.
Type:
Grant
Filed:
March 18, 2015
Date of Patent:
December 3, 2019
Assignee:
YISSUM RESEARCH DEVELOPMENT COMPANY OF of The Hebrew University of Jerusalem LTD.
Abstract: A method of promoting nerve growth or regeneration in a subject in need thereof, wherein the subject is not afflicted with a substantial connective tissue damage, is provided. The method comprises administering to the subject a therapeutically effective amount of full-length amelogenin, thereby promoting nerve growth or regeneration in the subject.
Type:
Grant
Filed:
September 29, 2016
Date of Patent:
November 19, 2019
Assignees:
Hadasit Medical Research Services and Development Ltd., Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Inventors:
Amir Haze, Anat Blumenfeld, Dan Deutsch
Abstract: A method and system for enhancing a speech signal is provided herein. The method may include the following steps: obtaining an original video, wherein the original video includes a sequence of original input images showing a face of at least one human speaker, and an original soundtrack synchronized with said sequence of images; and processing, using a computer processor, the original video, to yield an enhanced speech signal of said at least one human speaker, by detecting sounds that are acoustically unrelated to the speech of the at least one human speaker, based on visual data derived from the sequence of original input images.
Type:
Grant
Filed:
July 3, 2018
Date of Patent:
November 12, 2019
Assignee:
Yissum Research Development Company, of The Hebrew University of Jerusalem Ltd.
Abstract: The present invention provides compounds comprising fused tricyclic backbone structure and processes for their preparation. The invention further provides compounds and compositions useful in the treatment of pain and any type of disorder or symptom associated therewith.
Type:
Application
Filed:
June 17, 2019
Publication date:
October 31, 2019
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: The present invention provides a liquid coloring composition comprising of a coffee solution or coffee extract and an ink vehicle. The coloring composition is suitable for use as an ink in a non-impact printing device, including an ink jet type printer. The composition is composed of edible components. The invention further provides a process for applying a design to a food substrate, comprising of providing a non-impact printing device, wherein the ink cartridge or external container contains the coloring composition of the invention.
Type:
Grant
Filed:
October 8, 2014
Date of Patent:
October 29, 2019
Assignees:
Ripples Ltd., Yissum Research Development Company of the Hebrew University of Jerusalem
Inventors:
Eyal Eliav, Danny Lavie, Shlomo Magdassi
Abstract: Provided are methods for extraction of various agents, e.g. active agent, from a plant source, specifically with the use of extraction formulations which are based on micellar liquid systems.
Type:
Application
Filed:
September 28, 2017
Publication date:
October 17, 2019
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: The invention provides processes for the preparation of HU-910, which are scalable to industrial purposes, using safer reagents and having high yield and pure product and a crystalline structure of HU-910, which is a unique product thereof.
Type:
Application
Filed:
November 13, 2017
Publication date:
October 17, 2019
Applicant:
Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.
Inventors:
Jean-Michel ADAM, Pascal DOTT, Marcus HOHLER, Tanja BURGER, Orazio TAGLIENTE, Ernst MISCHLER
Abstract: Cyclic nitroxide compounds including, but not limited to, compounds having the general formula I: wherein the dashed line and R1-R8 are as defined herein, are disclosed herein for use in treating diseases and disorders of the respiratory tract and/or respiratory tract remodeling.
Type:
Grant
Filed:
March 24, 2016
Date of Patent:
October 15, 2019
Assignees:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Hadasit Medical Research Services and Development Ltd.
Inventors:
Sara Goldstein, Amram Samuni, Neville Berkman
Abstract: Provided is a novel photoinitiator in the form of a hybrid nanoparticle constructed of a semiconductor and metallic regions, and uses thereof.
Type:
Grant
Filed:
June 29, 2016
Date of Patent:
October 15, 2019
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: An integrated optical module is provided. The optical module includes multi optically-coupled channels, and enables the use thereof in an Artificial Neural Network (ANN). According to some embodiments the integrated optical module includes a multi-core optical fiber, wherein the cores are optically coupled.
Type:
Grant
Filed:
August 26, 2016
Date of Patent:
October 1, 2019
Assignees:
BAR-ILAN UNIVERSITY, Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Inventors:
Zeev Zalevsky, Michael London, Eyal Cohen, Amir Shemer, Dror Malka