Patents Assigned to University of Jerusalem
  • CD247 as a biomarker for assessing the effect of chemotherapeutic and biological drugs
    Patent number: 10955415
    Abstract: The invention relates to methods, kits and compositions using CD247 as a biomarker for assessing the efficacy and selecting an appropriate therapy such as chemotherapeutic, biological therapy or combined therapy for treating a subject suffering from a pathologic disorder that leads to a chronic-inflammatory condition.
    Type: Grant
    Filed: September 27, 2012
    Date of Patent: March 23, 2021
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Michal Baniyash, Julia Kanterman, Moshe Sade-Feldman, Eliran Ish-Shalom
  • Antibodies specific to human T-cell immunoglobulin and ITIM domain (TIGIT)
    Patent number: 10946095
    Abstract: Monoclonal antibodies that recognize TIGIT and inhibit its suppressive activity on T-cells are provided as well as pharmaceutical compositions including them and methods for their use in cancer immunotherapy and in diagnosis and treatment of immune disorders.
    Type: Grant
    Filed: September 1, 2016
    Date of Patent: March 16, 2021
    Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., University of Rijeka Faculty of Medicine
    Inventors: Ofer Mandelboim, Noa S. Kaynan, Pinchas Tsukerman, Stipan Jonjic
  • Methods and devices for storage and release of hydrogen
    Patent number: 10944119
    Abstract: The invention relates to a process for generating hydrogen, comprising decomposing in a reaction vessel aqueous alkali formate in the presence of a transition metal-containing catalyst system dissolved in one or more organic solvent(s), characterized in that said organic solvent(s) comprise at least one solvent which is water-immiscible, thereby releasing hydrogen and forming bicarbonate in the aqueous phase, and separating the catalyst-containing organic solvent(s) from said bicarbonate. Also disclosed are apparatuses for carrying out hydrogen generation.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: March 9, 2021
    Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Energystoredge Ltd.
    Inventors: Yoel Sasson, Judith Toubiana, Ariel Givant, Sorel Rothschild
  • Method and apparatus for CO2 sequestration
    Patent number: 10920249
    Abstract: Processes, methods, and apparatus for carbon sequestration utilizing catalysis schemes configured to provide high concentrations of hydrated CO2 in proximity with a sequestration agent are provided. Reactants are combined with catalyst such that at least two regions of controlled catalytic activity form encompassing at least the interface between a sequestration agent and an aqueous solution containing dissolved CO2. Suitable reactants include various sequestration agents, catalyst, and carbon dioxide dissolved in an aqueous solution (seawater, for example). Possible products include bicarbonate and metal cations.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: February 16, 2021
    Assignees: California Institute of Technology, University of Southern California, Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Adam Vinay Subhas, William Max Berelson, Nick Everett Rollins, Jess Firey Adkins, Jonathan Erez
  • Process for removing pollutants from a flue gas
    Patent number: 10913030
    Abstract: A process for removing impurities from a flue gas, comprising treating the flue gas with a liquid absorbent comprising (i) a precursor of chlorine dioxide and (ii) an organic ionic liquid, and releasing a purified flue gas into the atmosphere. The process is useful for removing Hg, SO2 and NOx.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: February 9, 2021
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Zach Barnea, Yoel Sasson, Benny Bogoslavsky, Yaakov Mines
  • Kit for diagnosis, prognosis, and monitoring the immune status, of patients with chronic inflammatory diseases
    Patent number: 10914743
    Abstract: Provided are methods and kits, e.g.; for testing the immune status of patients with chronic inflammatory diseases by measuring the TCR zeta chain (CD247) expression levels, and in particular a method and a kit for testing the selective downregulation of TCR zeta chain expression in T cells, NK cells, or NKT cells. Zeta chain expression is measured using antibodies directed against the intracellular zeta chain region, and these levels are compared with the expression levels of other T cell receptor subunits and NK cell markers. Provided are methods for determining diabetes complications in a diabetic patient. Further provided are kits for diagnosis, prognosis, and monitoring of same.
    Type: Grant
    Filed: November 16, 2015
    Date of Patent: February 9, 2021
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Michal Baniyash, Ilan Vaknin
  • Characterization of plant behavior using transpiration rate and water uptake rate
    Patent number: 10897849
    Abstract: A system for characterizing a plant is disclosed. The system comprises: a plurality of sensors configured to sense a first parameter indicative of a transpiration rate from the whole plant and a second parameter indicative of a water uptake rate into the whole plant. The system also comprises a processor configured to receive signals from the sensors, to process the signals to calculate both the parameters, and to characterize the plant according to the calculated parameters. In some embodiments of the present invention the processor is configured for calculating at least one of the first parameter and the second parameters momentarily.
    Type: Grant
    Filed: April 28, 2015
    Date of Patent: January 26, 2021
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Menachem Moshelion, Rony Wallach, Ofer Halperin
  • Kit and discs for use in disc diffusion antibiotic sensitivity testing
    Patent number: 10889847
    Abstract: The present invention provides methods and kits for performing microbial sensitivity tests. Specifically, the invention relates to methods for identifying the susceptibility, tolerance or resistance of a microorganism to one or more antimicrobial agents, and the level of tolerance. The method comprises exposing the microorganism grown on a plate surface to one or more antimicrobial agents and to at least one growth promoting agent.
    Type: Grant
    Filed: October 18, 2016
    Date of Patent: January 12, 2021
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Natalie Balaban, Orit Gefen
  • COMPOSITIONS AND METHODS FOR DENTAL CARE
    Publication number: 20210000890
    Abstract: A composition comprising at least one sugar alcohol and a population of viable probiotic bacteria belonging to the class Bacilli is disclosed. The product is devoid of sugar or comprises no more than 5% of the amount of said sugar alcohol in the composition, the composition being formulated for oral delivery.
    Type: Application
    Filed: July 2, 2020
    Publication date: January 7, 2021
    Applicants: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization, Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Moshe SHEMESH, Doron STEINBERG
  • CHICKPEA PROTEIN CONCENTRATE
    Publication number: 20200390131
    Abstract: Provided are debittered chickpea based protein concentrates, methods of manufacturing thereof and food products comprising the protein concentrates.
    Type: Application
    Filed: July 9, 2017
    Publication date: December 17, 2020
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Ram REIFEN, Shimrit BAR-EL DADON, Martin SCHURING
  • Composition of matter comprising liposomes embedded in a polymeric matrix and methods of using same
    Patent number: 10842745
    Abstract: The present disclosure provides a composition of matter comprising liposomes encapsulating in their intraliposomal aqueous compartment at least one active agent, the liposomes having a diameter of at least 200 nm and being embedded in a water insoluble, water absorbed cross-linked polymeric matrix. In one embodiment, the composition of matter is held within an aqueous medium, preferably being in iso-osmotic equilibrium with the intraliposomal aqueous compartments of the liposomes.
    Type: Grant
    Filed: January 22, 2019
    Date of Patent: November 24, 2020
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Yechezkel Barenholz, Rivka Cohen
  • NANOPARTICLE COMPOSITIONS
    Publication number: 20200323777
    Abstract: Compositions comprising nanoparticles are described herein. At least a portion of the nanoparticles comprises a lipid and/or polymer which is water-insoluble, and an agent incorporated in the lipid and/or polymer. The nanoparticles are optionally associated with a surface of water-soluble particles which comprise a water-soluble compound. The polymer is optionally a polyanhydride. Further described herein are processes for preparing such compositions, comprising contacting a solution comprising the lipid and/or polymer dissolved in a non-aqueous solvent with an anti-solvent (in which the lipid and/or polymer and agent are insoluble) which is miscible with the non-aqueous solvent. Further described herein are uses of the compositions for nasal administration, and devices configured for nasal administration of the composition upon atomization.
    Type: Application
    Filed: July 20, 2018
    Publication date: October 15, 2020
    Applicants: Indiana University Research and Technology Corporation, Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Domb Abraham Jacob, Michael Kubek
  • Cross-linked resilin-containing materials
    Patent number: 10799616
    Abstract: Disclosed herein is a compositions-of-matter comprising a cross-linked polymer, the cross-linked polymer comprising a plurality of resilin polypeptide moieties, and at least one polymeric moiety covalently cross-linked to a plurality of the resilin polypeptide moieties via at least one cross-linking moiety, the cross-linking moiety being devoid of a biphenyl moiety. Further disclosed herein is a process for preparing the composition-of-matter, a composite material comprising the composition-of-matter and at least one additional polymeric substance bound to the cross-linked polymer, an article-of-manufacturing comprising the composition-of-matter and/or composite material, and a method of treating tissue damage or loss by implanting said article-of-manufacturing in a subject.
    Type: Grant
    Filed: November 5, 2014
    Date of Patent: October 13, 2020
    Assignees: CollPlant Ltd., Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Oded Shoseyov, Sigal Meirovitch, Shaul Lapidot, Amit Rivkin
  • METHOD TO REPRODUCE CIRCADIAN RHYTHMS ON A MICROFLUIDIC CHIP
    Publication number: 20200318077
    Abstract: Provided are in-vitro methods and devices for sustaining a synchronized circadian rhythm in cells of a cell culture by exposing the cells to a continuous flow of medium and to at least two stimuli provided in an oscillating manner with a periodicity of 24±4 hours, wherein a first stimulus and a second stimulus of said at least two stimuli are distinct, wherein said first stimulus is provided in a first time period and reaches a first peak in a first peak time period, and wherein a second stimulus is provided in a second time period and reaches a second peak in a second peak time period, and wherein an interval between end of time period of said first peak and beginning of said time period of said second peak is at least about 2 hours.
    Type: Application
    Filed: June 19, 2020
    Publication date: October 8, 2020
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventor: Yaakov NAHMIAS
  • Decoy oligonucleotides for the treatment of diseases
    Patent number: 10781445
    Abstract: An isolated oligonucleotide comprising ribonucleotides is disclosed. The oligonucleotide comprises a nucleic acid sequence which encodes at least one copy of a splicing-factor binding site. The oligonucleotide is no more than 150 bases and may be devoid of a sequence that allows hybridization thereof to cellular RNA under physiological conditions. The oligonucleotide inhibits overall cellular splicing activity of a specific splicing factor. Pharmaceutical compositions comprising the oligonucleotide and uses thereof are further disclosed.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: September 22, 2020
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventor: Rotem Karni
  • Methods of inducing metabolic maturation of human pluripotent stem cells— derived hepatocytes
    Patent number: 10772863
    Abstract: Provided are methods of increasing metabolic maturation of an immature hepatocyte, by contacting an immature hepatocyte which expresses alpha-fetoprotein (AFP) and albumin with an effective amount of a fatty acid or a small molecule selected from the group consisting of: an amphipathic carboxylic acid, Thiazolidinedione (TZD), WY-14643 (Pirinixic Acid), GW409544, GW6471, Leukotriene B4, GW 7647, Perfluorooctanesulfonic Acid, Perfluorooctanoic Acid, CP-775146, CP-865520, UNII-999KY5ZIGB, and Gemfibrozil. Also provided are isolated hepatocytes and uses thereof.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: September 15, 2020
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd
    Inventors: Yaakov Nahmias, Michal Zimerman, Gahl Levy, Yishai Avior
  • Method and system for enhancing a speech signal of a human speaker in a video using visual information
    Patent number: 10777215
    Abstract: A method and system for enhancing a speech signal is provided herein. The method may include the following steps: obtaining an original video, wherein the original video includes a sequence of original input images showing a face of at least one human speaker, and an original soundtrack synchronized with said sequence of images; and processing, using a computer processor, the original video, to yield an enhanced speech signal of said at least one human speaker, by detecting sounds that are acoustically unrelated to the speech of the at least one human speaker, based on visual data derived from the sequence of original input images.
    Type: Grant
    Filed: November 11, 2019
    Date of Patent: September 15, 2020
    Assignee: Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.
    Inventors: Shmuel Peleg, Asaph Shamir, Tavi Halperin, Aviv Gabbay, Ariel Ephrat
  • Hybrid nanopores and uses thereof for detection of analytes
    Patent number: 10760122
    Abstract: The invention relates to a hybrid structure comprising perforated solid substrate having at least one nanopore perforating therethrough, and devices and uses thereof.
    Type: Grant
    Filed: December 10, 2018
    Date of Patent: September 1, 2020
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Danny Porath, Oded Shoseyov, Yuval Nevo, Ke Liu, Dvir Marom Rotem
  • Particulate photoinitiators and uses thereof
    Patent number: 10761425
    Abstract: Provided is a novel class of solid water-dispersible powders, including a plurality of water-insoluble photoinitiators in nanoparticle forms for use in water-based ink formulations.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: September 1, 2020
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Shlomo Magdassi, Liraz Larush, Ido Cooperstein, Amol Ashok Pawar
  • Garlic plant named ‘NEVADA 19’
    Patent number: PP32517
    Abstract: A new and distinct variety of garlic plant, Allium sativum L., named ‘NEVADA 19’, particularly characterized by suitability for growing under climatic conditions such as prevailing in Nevada and California, regular bulb structure, good storage quality, white cover scale color, good clove peeling ability; and mid-season bulb harvest time.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: November 24, 2020
    Assignees: State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization, Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Rina Kamenetsky Goldstein, Einat Shemesh-Mayer, Haim D. Rabinowitch, Tomer Efraim Ben Michael, Chen Gershberg, Izhak Forer