Abstract: A method of culturing bacteria of the Bacilli class is disclosed. The method comprises: (a) adding the bacteria to a medium comprising pasteurized starch fibers of a legume of a leguminous plant, and (b) culturing the bacteria under conditions that promote generation of a biofilm of the bacteria on the starch fibers.
Type:
Application
Filed:
January 18, 2023
Publication date:
June 8, 2023
Applicants:
The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization, Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: The present invention provides microcapsules encapsulating hydrophilic or hydrophobic active agents in an inorganic shell, processes for their preparation and compositions comprising them.
Type:
Application
Filed:
November 22, 2018
Publication date:
June 8, 2023
Applicant:
Yissrm Research Developmet Company of The Hebrew University of Jerusalem Ltd.
Inventors:
Raed ABU-REZIQ, Charlie BATARSEH, Ahmad ZAROUR, Yafit SCHNELL, Amani ZOABI, Suzana NATOUR, Suheir OMAR, Esti WESS
Abstract: The present invention relates to a device for repair of a region within an ear via a natural orifice, the device comprising a body. The body comprises a first port for visibly identifying the region to be sealed, the region being inside the ear; and a second port through which a seal can be introduced into the ear through the device. The region comprises a perforation of a tympanic membrane of the ear and the device is a speculum. The present invention also relates to method for repairing a perforation in a tympanic membrane using the same device.
Type:
Application
Filed:
March 11, 2021
Publication date:
May 25, 2023
Applicants:
National University of Singapore, Hadasit Medical Research Services And Development Ltd, Yissum Research Development Company of the Hebrew University of Jerusalem Ltd
Abstract: The present disclosure provides, in part, a cell culture medium supplement comprising at least one plant protein homologue of a serum protein, a cell culture medium comprising a serum-free base medium and one or more plant based proteins, and methods of growing cells in vitro and of producing cultured meat using the cell culture medium.
Type:
Application
Filed:
January 20, 2021
Publication date:
March 23, 2023
Applicants:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Future Meat Technologies Ltd.
Inventors:
Yaakov Nahmias, Merav Cohen, Jonathan Caspi
Abstract: The present invention provides antimicrobial matrices comprising a water-insoluble polymer and a mixture comprising a plurality of synthetic peptides attached thereto via a linker, the peptides comprise cationic amino acid residues, hydrophobic amino acid residues, or combinations thereof, in random sequences. The invention further provides uses of the antimicrobial matrices for eliminating microorganisms, particularly pathogenic bacteria, from liquid or semi solid media including edible products or beverages.
Type:
Application
Filed:
February 9, 2021
Publication date:
March 9, 2023
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: The present disclosure provides, in part, a receptacle for filtering a liquid. The receptacle comprises a plurality of hollow fibers extending the length of the receptacle and at least one solid absorbent material occupying a space between the plurality of hollow fibers. Each hollow fiber comprises at least one opening and a lumen defined by the walls thereof, allowing the liquid to flow through. The hollow fiber walls have a porosity profile selective to passage of waste materials contained in the liquid from the lumen to the solid absorbent material(s), thereby filtering the liquid. Also provided is a system as well as a method for filtering and recycling a cell culture medium.
Type:
Application
Filed:
January 29, 2021
Publication date:
March 9, 2023
Applicants:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Future Meat Technologies Ltd.
Abstract: The present disclosure provides, in part, a cell culture medium comprising a serum-free medium and one or more fibroblast growth factor (FGF) activators, a kit comprising the cell culture medium and instructions for use, methods of growing cells in vitro and of producing a cultured meat using the cell culture medium, and a cultured meat so produced.
Type:
Application
Filed:
January 20, 2021
Publication date:
March 9, 2023
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Inventors:
Yaakov Nahmias, Muneef Ayyash, Laura Pasitka
Abstract: A composition for reducing the weight loss and/or preserving the natural gloss of post-harvest edible plant matter, and methods for applying the compositions to the surface of the plant matter. The compositions include an edible wax having a melting temperature below 70° C.; a hydrocolloid; a fatty acid; an emulsifier; and water, wherein the edible wax is present in a weight percent ranging from about 10% to about 25% of the total weight of the composition.
Type:
Application
Filed:
September 9, 2022
Publication date:
February 16, 2023
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Inventors:
Amos NUSSINOVITCH, Tal MARMUR, Yonatan ELKIND
Abstract: Isolated polypeptides of CD44 are provided. Accordingly, there is provided an isolated polypeptide consisting of an amino acid sequence selected from the group consisting of SEQ ID NOs: 1-3. Also provided is an isolated end-capping modified polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1-3, wherein the modified polypeptide comprises an anti-inflammatory activity. Also provided are compositions of matter, fusion proteins and pharmaceutical compositions and their use in the treatment of inflammatory disease.
Type:
Grant
Filed:
February 18, 2020
Date of Patent:
January 24, 2023
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Inventors:
David Naor, Lora Eshkar-Sebban, Keren-Or Amar, Shmuel Cohen
Abstract: The present invention relates to a method for forming a protective coating on a plant tissue following the consecutives steps of: (a) providing a plant having an external surface, wherein a portion of the external surface includes an exposed surface; (b) applying a first aqueous solution that contains a crosslinking agent to the external surface of the plant; and (c) applying to the external surface of the plant a second aqueous solution that contains a polysaccharide which is susceptible to crosslinking by the crosslinking agent, thereby forming a protective coating on the exposed surface of the plant. Further provided is a postharvest plant matter that includes a first segment covered by natural skin, and a second segment having an exposed surface that is coated by a protective coating that contains a polysaccharide with the first segment being essentially free of the protective coating.
Type:
Application
Filed:
July 15, 2020
Publication date:
November 24, 2022
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd
Abstract: Methods of treating a disease characterized by mRNA instability or nonsense-mediated decay of an mRNA of a disease-associated gene in a subject by administering a pharmaceutical composition comprising at least one agent that decreases FTO expression, function or both are provided. Kits and pharmaceutical compositions comprising an agent that decreases FTO expression, function or both and a read-through promoting agent are also provided, as are methods of determining suitability of a subject to be treated with an agent that decreases FTO expression, function or both.
Type:
Application
Filed:
September 23, 2020
Publication date:
October 27, 2022
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: Provided are methods for inhibiting binding of systemically administered drugs to a target in the skin by topically administering materials prior to or concomitantly with administration of the systemic drugs.
Type:
Application
Filed:
August 12, 2020
Publication date:
September 22, 2022
Applicants:
Hadasit Medical Research Services & Development Limited, Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: In a technique for inducing local electric field controlled magnetization, despite the absence of magnetic components, there is provided a novel heterostructure, a semiconductor device thereof, or an array of semiconductor devices. The heterostructure includes a semiconductor substrate carrying a plurality of layers forming at least one heterojunction and hosting a two-dimensional electron gas layer when one of the layer of the plurality of layers is bounded to an interacting layer being a chiral or a biological macromolecule assembly.
Type:
Grant
Filed:
April 7, 2019
Date of Patent:
September 6, 2022
Assignees:
Yeda Research and Development Co. Ltd., Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Inventors:
Yossef Paltiel, Ron Naaman, Karen Michaeli, Eilam Smolinsky
Abstract: The present invention relates to electrochemically initiated bioadhesive compositions comprising biocompatible polymers containing derivatives of diazonium, arylsulfonium, or diaryliodonium in general, and to their use in tissue fixation, in particular.
Type:
Grant
Filed:
January 14, 2015
Date of Patent:
June 14, 2022
Assignees:
Nanyang Technological University, Yissum Research Development Company of the Hebrew University of Jerusalem Ltd
Abstract: Provided is a compound including at least one carrier moiety associated with a plurality of CT imaging moieties, and with at least one enzyme interacting moiety as well as uses thereof in diagnosis.
Type:
Grant
Filed:
February 16, 2017
Date of Patent:
May 31, 2022
Assignee:
Yissum Research Development Company of the Hebrew
University of Jerusalem Ltd.
Inventors:
Galia Blum, Darya Tsivrkun, Hanmant Gaikwad
Abstract: The present invention is directed to a fatty acid amide of an amino acid, including a stereoisomer and a salt thereof for use in the treatment of a patient suffering from any type of addiction disorder, substance abuse disorder, including any condition and symptom associated therewith and including withdrawal syndrome and relapse addiction during and after a rehabilitation treatment of said patient.
Type:
Grant
Filed:
May 22, 2018
Date of Patent:
May 10, 2022
Assignee:
Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.
Inventors:
Raphael Mechoulam, Vincenzo Di Marzo, Fabiana Piscitelli, Aron H. Lichtman, Imad M. Damaj, Linda Parker, Rami Yaka
Abstract: The invention provides a process for the preparation of bismuth oxyhalide, comprising a precipitation of bismuth oxyhalide in an acidic aqueous medium in the presence of a reducing agent. Also provided are bismuth oxyhalide compounds doped with elemental bismuth Bi(0). The use of Bi(0)doped-bismuth oxyhalide as photocatalysts in water purification is also described.
Type:
Grant
Filed:
June 10, 2020
Date of Patent:
May 3, 2022
Assignee:
Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.