Abstract: A spatial distribution of cells or sub-cellular structures of a subject is quantified by receiving image data that includes a plurality of biomarkers and processing the image data to obtain a set of coordinates. Each coordinate denotes the location of a cell or sub-cellular structure represented by a biomarker or combination of biomarkers. The set of coordinates is processed into a two-dimensional symmetric matrix. Each element of the matrix indicates the frequency of a cell or sub-cellular structure represented by a first biomarker or combination of biomarkers being observed within an interaction distance of a cell or sub-cellular structure represented by a second biomarker or combination of biomarkers. A classifier assigns the subject to a group or category based on the matrix. A toxicity and/or efficacy of one or more interventions is assessed based on a comparison of the spatial distribution to one or more predetermined reference or control distributions.

Abstract: One embodiment of the invention provides an image processing method for use in fitting a deformable shape model to an acquired image. The deformable shape model specifies a set of target points whose motion is governed by the model. The method comprises, for each target point, generating a corresponding response image by: providing a feature detector to locate a given target point within the acquired image, wherein said feature detector includes a random forest comprising one or more decision trees; scanning a patch image across the acquired image to define multiple sampling locations with respect to the acquired image; for each sampling location of the patch image with respect to the acquired image, performing regression voting using the random forest to produce one or more votes for the location of the given target point within the acquired image; and accumulating the regression votes for all of the multiple sampling locations to generate said response image corresponding to the given target point.

Abstract: The present invention relates to methods of assessing whether a subject has or is likely to develop a neurodegenerative disease comprising determining whether the subject has a mutation in the C9orf72 gene wherein said mutation prevents or disrupts C9orf72 expression relative to expression in a reference from subjects without the mutation.

Abstract: A method for inhibiting cartilage degradation comprising administering to a subject a therapeutically effective amount of a polypeptide comprising or consisting of a Link_TSG6 polypeptide is disclosed.

Abstract: This invention relates to uses of graphene oxide, and in particular graphene oxide on a porous support, and a membrane comprising these materials. This invention also relates to methods of dehydration, which include vapour phase separation and pervaporation. Pervaporation is a method of separating mixtures of liquids using a membrane. Pervaporation consists of two basic steps: permeation of the permeate through the membrane and evaporation of the permeate from the other side of the membrane. Pervaporation is a mild which can be used to separate components which would not survive the comparatively harsh conditions needed for distillation (high temp, and/or low pressure).

Abstract: Disclosed herein are compositions comprising lopinavir alone or in combination with ritonavir for use as a medicament in the treatment of cancer or benign proliferative disorders (warts) or in the prevention of the development of cancer. Pharmaceutical compositions formulated for topical application comprising a therapeutically effective amount of lopinavir or a therapeutically effective amount lopinavir and ritonavir in a pharmaceutically acceptable vehicle are also provided. Also disclosed are methods of treating a patient having an HPV related dysplasia of the cervix comprising administering to said patient a therapeutically effective dose of the disclosed pharmaceutical compositions.

Abstract: The present invention provides a tissue repair scaffold comprising a secondary fiber bundle, the secondary fiber bundle comprising a plurality of primary fiber bundles, each primary fiber bundle comprising a plurality of fibers, wherein the fibers comprise a biocompatible polymer. In embodiments the biocompatible polymer is polycaprolactone (PCL) (also known as poly-?-caprolactone) and the average diameter of the fibers is less than 1 ?m. The scaffold is particularly adapted for tendon repair. In vivo mouse studies demonstrate that tendon repair can be achieved with normal ambulation returning after 24-48 hours. The scaffolds were easy to handle during surgery, being non-slippery and easy to suture in place.

Abstract: Some aspects of the invention include methods of treating a patient who has or is at risk of developing kidney disease, methods of selecting a suitable regimen for the prevention or treatment of kidney disease, and to methods of monitoring the effectiveness of a treatment regimen for the prevention or treatment of kidney disease. Other aspects of the invention include medical uses of a binding partner for an anti-IQCJ antibody, and methods of preventing or treating kidney disease in a subject using such binding partners. Still other aspects of the invention include devices for the extracorporeal treatment of a patient's blood.

Abstract: The present invention relates to amphiphilic peptides having antibacterial and/or antitumor activity, and to therapeutic and non-therapeutic compositions comprising these peptides. The peptides are of structural formula I or II shown below wherein A1, v, A2, w, A3, x, y, A4, z, R1, R2 and R3 are as defined in the application; or a salt thereof. The invention further relates to use of the peptides as antibacterial agents, or antitumor agents, including the medical use of the peptide in treating infection and/or cancer, as well as their use as preservatives and antibacterial agents in other products, including personal care products such as skin topical treatments, cleansers, mouth washes, toothpastes, shampoo, body lotions and creams etc.

Abstract: The present invention relates to an electron beam (eBeam) resist composition, particularly an (eBeam) resist composition for use in the fabrication of integrated circuits. Such resist compositions include an anti-scattering compound which minimises scattering and secondary electron generation, thus affording extremely high resolution lithography. Such high resolution lithography may be used directly upon silicon-based substrates to produce integrated circuits, or may alternatively be used to produce a lithographic mask (e.g. photomask) to facilitate high-resolution lithography.

Abstract: A method of producing graphene by the electrochemical insertion of alkylammonium cations in a solvent into graphite is disclosed.

Abstract: The present invention relates to peptides that are able to bind to anti-PLA2R antibodies. The peptides comprise the amino acid sequence K-X1-X2-X3-X4-X5-K-X6-X7-X8-X9-X10-X11-X12-X13-K (SEQ ID NO:2), in which both X1 and X13 may be cysteine residues. The peptides may have a length of up to 60 amino acid residues, or as little as 31 amino acid residues. The peptides are useful in the prevention or treatment of kidney disease, and methods of preventing or treating kidney disease by providing a therapeutically effective amount of a peptide to a subject, as well as devices for extra corporeal treatment of a patient's blood, are all provided. The invention also provides methods of determining levels of anti-PLA2R antibodies in a subject, and pharmaceutical compositions comprising a peptide and a pharmaceutically acceptable carrier.

Abstract: The present invention relates to a resist composition, especially for use in the production of electronic components via electron beam lithography. In addition to the usual base polymeric component (resist polymer), a secondary electron generator is included in resist compositions of the invention in order to promote secondary electron generation. This unique combination of components increases the exposure sensitivity of resists in a controlled fashion which facilitates the effective production of high-resolution patterned substrates (and consequential electronic components), but at much higher write speeds.

Abstract: Borylated compounds are disclosed, as well as their methods of preparation and their applications. The disclosed borylated compounds are highly stable, and have reduced band gap properties, thereby making them attractive candidates for incorporation into semiconducting materials for use in a variety of electronic, optical or electro-optical devices or components.

Abstract: A plasmonic structure (10) comprising a layer of metal (14) in which the metal is selected from: a Group 8 to Group 11 transition metal, aluminium, germanium, antimony or bismuth, and a barrier layer (16) formed from a 2-D material disposed on a surface of the layer of metal (14). The metal layer has a roughness that permits the propagation of running plasmons along the interface of the metal layer and the barrier layer.

Abstract: The present invention relates to a single cycle mixed refrigerant process for industrial cooling applications, for example, the liquefaction of natural gas. The present invention also relates to a refrigeration assembly configured to implement the processes defined herein and a mixed refrigerant composition usable in such processes.

Abstract: A method of selecting data, the method comprising, receiving data indicating a first requirement and identifying first records stored in a first database. The first records relate to first data subjects and the identification is based upon the first requirement. The first data subjects cannot be identified from the records of the first database. Second records are identified, the second records being stored in a second database and relating to the first data subjects. The first data subjects can be identified from the identified records of the second database. Each of the second records corresponds to a respective one of the first records, and the identification of the second records is based upon the first requirement.

Abstract: This application relates to graphene based heterostructures and methods of making graphene based heterostructures. The graphene heterostructures comprise: i) a first encapsulation layer; ii) a second encapsulation layer; and iii) a graphene layer. The heterostructures find application in electronic devices.

Abstract: The present invention relates to an improved method of providing photoreceptor function to a cell, for example for use in the treatment of retinal degeneration. The present invention also relates to compositions and kits, in particular for use in such methods.

Abstract: In a technique for quantifying the spatial distribution of cells or sub-cellular structures, image data representing a spatial map of biomarkers is processed to obtain a set of coordinates. Each of the coordinates in the set denotes the location of a cell or sub-cellular structure represented by a biomarker or combination of biomarkers. The set of coordinates is processed into a two-dimensional symmetric (2N?1)×(2N?1) or 2N×2N matrix. The resulting matrix may be used for various purposes, such as assigning subjects clinical characteristics, and/or forming and/or testing scientific hypotheses for interventions, for example. Also described herein is an apparatus for performing the described technique.