Abstract: The described invention is directed toward pharmaceutical compositions and methods of using 6-mercaptopurine ribosides and analogues thereof for the treatment of cancer and other hyperproliferative diseases. The described compounds can be converted into telomere substrates in vivo and can be recognized by telomerase for incorporation into telomeres of telomerase active cells, leading to induction of cell death of the telomerase active cells.

Abstract: The present invention provides methods and compositions for modulating molecular markers, and hence treating or preventing breast cancer (e.g., triple-negative breast cancer) and melanoma with a pharmaceutically effective amount of S-equol or a pharmaceutical composition comprising S-equol. The S-equol may be administered alone or in combination with one or more cytotoxic or immunotherapeutic compound or molecule.

Abstract: Methods described herein are directed to solving the problem of safely evaluating organs or tissues in a living subject and assessing and monitoring these living systems. In certain aspects the brain of a living subject is evaluated. The methods described herein integrate behavioral measurements and other non-invasive information gathering (e.g., imaging, EEG, etc.) or minimally invasive information gathering (e.g., biological fluid sampling) with cellular imaging, and biomimetic models to safely evaluate a subject. In vitro models are established that can be manipulated and monitored on the cellular level.

Abstract: A quad-polymer composition includes monomers of (a) acrylonitrile, (a) vinylimidazole, (c) methyl acrylate and (d) either acrylic acid or itaconic acid. Such quad-polymer compositions may be used to form fibers (such as by melt spinning) that may then be annealed, stabilized, and/or carbonized to produce carbon fibers. The quad-polymer composition may be used for supercapacitors, lithium battery electrodes once carbonized, and as synthesized, it may be used for wound healing fibers, fabrics, coatings, and films, and anti-bacterial/anti-microbial fibers, fabrics, coatings and films. The carbon fibers formed from the quad-polymer composition may be used for the fiber composites for automobile, aerospace structures, marine structures, military equipment/parts, sporting goods, robotics, furniture, and electronic parts.

Abstract: The present invention provides methods and compositions for treating or preventing melanoma with S-equol. The S-equol may be administered alone or in combination with one or more cytotoxic or immunotherapeutic compound or molecule.

Abstract: A high-throughput screening system is provided for optimizing the conditioning of patient-specific mesenchymal stem cells using a combinatorial set of biochemical factors, pharmacological inhibitors, and biomechanical forces. Also provided are generalized conditions for performing such conditioning. Cells made by these methods are also provided, in addition to cells having a mixed endothelial cell/pericyte phenotype. These cells produce angiogenic growth factors and induce vascularization following implantation.

Abstract: The present disclosure is directed to antibodies binding to PD-L2 and methods of using such antibodies to treat cancers, such as those that express or overexpress PD-L2.

Abstract: Actuators (artificial muscles) comprising twisted polymer fibers generate tensile actuation when powered thermally. In some embodiments, the thermally-powered polymer fiber tensile actuator can be incorporated into an article, such as a textile or garment.

Abstract: A magnetic tunnel junction device is disclosed comprising a first device layer comprising a material having a magnetic moment; a second device layer comprising a material having a magnetic moment, e.g., wherein the magnetic moment of the material of the second device layer is different from that of the material of the first device layer; and a barrier layer, e.g., tunnel barrier, having a first interface to the first device layer comprising predominantly of a scandium nitride (ScN) material and having a second interface to the second device layer comprising predominantly of a scandium nitride (ScN) material.

Abstract: Described herein are compositions, kits, and methods for potent delivery to a cell of a subject. The cell can be of a particular cell type, such as a basal cell, a ciliated cell, or a secretory cell. In some cases, the cell can be a lung cell of a particular cell type. Also described herein are pharmaceutical compositions comprising a therapeutic or prophylactic agent assembled with a lipid composition. The lipid composition can comprise an ionizable cationic lipid, a phospholipid, and a selective organ targeting lipid. Further described herein are high-potency dosage forms of a therapeutic or prophylactic agent formulated with a lipid composition.

Abstract: The present invention provides compositions comprising aligned fibers of electrospun PNIPAAm and poly (?-caprolactone) (PCL) (denoted PNIPAAm/PCL fibers). The PNIPAAm/PCL compositions enable enhanced growth and detachment of intact anisotropic cell sheets. The compositions do not require chemical modification or resource-intensive techniques, thus saving time and expense, and have the potential to generate tissue-specific, aligned cell sheets for transplant studies.

Abstract: Embodiments of the present disclosure pertain to methods of monitoring an environment for the presence of a solvent by: (i) exposing the environment to a luminescent compound, where the relative luminescence emission intensity of the luminescent compound changes upon interaction with the solvent; and (ii) monitoring a change in the relative luminescence emission intensity of the luminescent compound, where the absence of the change indicates the absence of the solvent from the environment, and where the presence of the change indicates the presence of the solvent in the environment. The luminescent compounds include a phosphorous atom with one or more carboxyl groups, where the carboxyl groups are coordinated with one or more metallic ions (e.g., lanthanide ions and yttrium ions). The present disclosure also pertains to sensors for monitoring an environment for the presence of a solvent, where the sensors include one or more of the aforementioned luminescent compounds.

Abstract: A computer-implemented method, system and computer program product for compressing video. A set of video frames is partitioned into two subsets of different types of frames, a first type and a second type. The first type of frames of videos is compressed to generate a first representation by a first stage encoder. The first representation is then decoded to reconstruct the first type of frames using a first stage decoder. The second type of frames of video is compressed to generate a second representation that only contains soft edge information by a second stage encoder. A generative model corresponding to a second stage decoder is then trained using the first representation and the reconstructed first type of frames by using a discriminator employed by a machine learning system. After training the generative model, it generates reconstructed first and second types of frames using the soft edge information.

Abstract: A novel high torque density double stator permanent magnet electric machine is provided. An outer stator is provided which has complex teeth and optionally can have windings every tooth or every other tooth. A rotor is provided having a plurality of magnet receivers, each with a complex topology. Magnets are provided in the rotor which are tangentially magnetized with alternating polarities and a complex topology to increase torque density. An inner stator is provided having a plurality of teeth with complex topologies. Windings are provided around every tooth or every other tooth, alternatively. Air-gaps are provided between the outer stator and the rotor and between the rotor and inner stator. The air-gap between the inner stator and the rotor is smaller than the air-gap between the outer stator and the rotor. A lower current density in certain windings improves thermal response without comprising average torque.

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

Abstract: Methods and compositions for estimating one or more downhole qualities of a drilling apparatus by obtaining axial acceleration data. The axial acceleration data may be acquired by measuring an axial acceleration of a bottom hole assembly. The axial acceleration may then be used to estimate one or more of a downward weight on a drill bit of the drilling apparatus or a rate of penetration of the drill bit.

Abstract: Described herein are compositions, techniques, methods, and systems for sequestering carbon, for producing oil, for improved oil recovery, and for storing hydrogen by way of injecting aqueous mixtures into subterranean reservoirs. The aqueous mixtures include one or more carboxylates, which can represent a form of carbon dioxide and/or a form of hydrogen. The aqueous mixtures including carboxylates may also or alternatively be useful for increasing a viscosity of a fluid within the reservoir or modifying the wettability of rock within the reservoir to improve the availability and production of hydrocarbons contained within pores of the rock.

Abstract: A method of measuring spectral emissivity of materials is provided. The method comprises placing material in a controlled chamber and exposing the material to an energy source to heat the material. At least one multi-wavelength pyrometer measures the spectral emissivity of the material produced by heating by the energy source, wherein the multi-wavelength pyrometer is positioned at a distal end of a tube extending from the chamber, wherein the tube provides a sacrificial surface for vapor condensation to prevent the vapor condensation from obscuring a view port used by the pyrometer.

Abstract: Described herein are therapeutic pH responsive compositions useful for the treatment of cancer. The compositions involve combining a STING activating polymer micelle, such as PC7A, with a non-peptide STING agonist, such as cGAMP. Methods of administering these compositions in the treatment of cancer are also disclosed. These methods include administration of the pharmaceutical compositions by intratumoral injection in the treatment of solid tumors.