Abstract: A method for fabricating a three-dimensional (3D) stacked integrated circuit. Pick-and-place strategies are used to stack the source wafers with device layers fabricated using standard two-dimensional (2D) semiconductor fabrication technologies. The source wafers may be stacked in either a sequential or parallel fashion. The stacking may be in a face-to-face, face-to-back, back-to-face or back-to-back fashion. The source wafers that are stacked in a face-to-back, back-to-face or back-to-back fashion may be connected using Through Silicon Vias (TSVs). Alternatively, source wafers that are stacked in a face-to-face fashion may be connected using Inter Layer Vias (ILVs).

Abstract: Compositions and methods are provided for detection of dynamic loci in a genome, where such loci may comprise structural variations as a result of DNA recombination; DNA duplication, insertions, deletions, transpositions, and epigenetic changes. The methods may utilize microfluidic platforms and functionalized polymer matrices to allow determination of mechanisms of cell-type-specific, programmed genomic heterogeneity. The method and compositions allow determination of mechanisms of cell-type-specific, programmed genomic heterogeneity.

Abstract: Systems and methods for manual gesture recognition to control prosthetic devices. Low encumbrance systems utilizing glove-based recognition to control prosthetic devices. Prosthetic control systems and methods are also provided utilizing elements for application on the user's fingernails.

Abstract: Certain embodiments are directed to methods and compositions for treating cancer, specifically colorectal cancer by administering an aldose reductase inhibitor and an immune checkpoint inhibitor to a subject in need thereof. Certain embodiments are directed to methods of treating a subject having cancer comprising, administering (i) a composition comprising an aldose reductase specific inhibitor and (ii) a composition comprising an immune checkpoint inhibitor to the subject having melanoma, head and neck, or colorectal cancer.

Abstract: A layered sheet polarizer including a multilayered structure having multiple transparent, low-absorption layers, the transparent, low-absorption layers including first layers having a relatively high index of refraction and second layers having a relatively low index of refraction, the first and second layers being arranged in an alternating manner within the structure so as to form resonator structures, and a dichroic layer positioned within the multilayered structure.

Abstract: Embodiments may provide improved techniques and devices for person identification that are discreet, offline, that can be trained in real-time and are physically small to provide the comfortable and convenient use in everyday situations. For example, in an embodiment, a system may comprise a wearable device comprising a visual display, an audio output device, and at least one sensor, a computer system comprising a processor, memory accessible by the processor, and computer program instructions stored in the memory and executable by the processor, receiving, from at least one sensor, data captured by the sensor, identifying a person based on the data captured by the sensor using a trained machine learning model, and indicating an identity of the person using at least one of the visual display and the audio output device. A person is also identified using fusion data recognition of sensor data fusion of at least two types of sensor data.

Abstract: Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R? is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.

Abstract: The present disclosure provides pharmaceutical compositions of niclosamide that may be administered either orally or by inhalation. These compositions may allow the achievement of a therapeutically effective dose of niclosamide to the lungs or the gastrointestinal tract. These compositions may be used to treat one or more diseases or disorders such as a viral infection or cancer.

Abstract: Provided herein are DNA aptamers targeting AXL receptor kinase. The DNA aptamers may comprise a thiophosphate backbone and be chemically modified. Further provided herein are methods of use thereof for the treatment of a disease or disorder, such as cancer.

Abstract: Apparatus and methods are described for ultrasound guided optoacoustic monitoring to provide diagnostic information for many clinical applications blood oxygenation in blood vessels and in tissues including for early diagnosis and management of circulatory shock (including that induced by hemorrhage). In certain embodiments provided herein, methods and apparatus for optoacoustics for measurement of blood oxygenation in the innominate vein are provided.

Abstract: Provided herein are engineered hMPV F proteins. In some aspects, the engineered F proteins exhibit enhanced conformational stability and/or antigenicity. Methods are also provided for use of the engineered F proteins as diagnostics, in screening platforms, and/or in vaccine compositions.

Abstract: The hiccup relieving apparatus includes a body with a first end having a mouthpiece, a second end having a restriction in the body between the first end and the second end. The restriction makes it difficult to draw fluid through the body to the user's mouth. The fluid can be air or the body can be immersed in water or other potable liquid in a container. The restriction requires an adult user, using the mouthpiece, to produce a threshold suction of for example water before water can flow from the water in the water container, through the body, through the mouthpiece, and to the user.

Abstract: A series of substituted 4,6-dihydrospiro[[1,2,3]triazolo[4,5-b]pyridine-7,3?-indoline]-2?,5(3H)-dione analogues, the use thereof and the preparation thereof.

Abstract: Various embodiments of the present technology provide for the ultra-high density heterogenous integration, enabled by nano-precise pick-and-place assembly. For example, some embodiments provide for the integration of modular assembly techniques with the use of prefabricated blocks (PFBs). These PFBs can be created on one or more sources wafers. Then using pick-and-place technologies, the PFBs can be selectively arranged on a destination wafer thereby allowing Nanoscale-aligned 3D Stacked Integrated Circuit (N3-SI) and the Microscale Modular Assembled ASIC (M2A2) to be efficiently created. Some embodiments include systems and techniques for the construction of construct semiconductor devices which are arbitrarily larger than the standard photolithography field size of 26×33 mm, using pick-and-place assembly.

Abstract: The present disclosure relates to calixpyrrole compounds and compositions thereof. The calixpyrrole compounds are chemical groups which are located in such a manner so as to be useful for the selective extraction of specific salts. Also provided herein are compositions and methods of use thereof.

Abstract: A biosensor device includes a porous substrate, where the substrate comprises semiconductor elements functionalized to conjugate with a particular analyte, the semiconductor elements are embedded within at least a portion of the substrate, and the substrate is to absorb fluid capable of carrying the particular analyte. The device further includes two or more electrodes attached to the substrate to correspond to the portion of the substrate, where the portion of the substrate further comprises Room-Temperature Ionic Liquid (RTIL).

Abstract: The present disclosure describes the use of immune modulators to promote nerve growth and regeneration, particularly in the context of nerve deficit stemming from trauma and disease. In particular, the disclosure provides for the use of CXCR4 antagonists, STAT3 activators, and an agent that increases levels of nitric oxide, either alone or in any combination of these drugs, in surgery performed to treat nerve deficit conditions, especially peripheral nerve deficit conditions caused by cut injury or tear injury, the method especially useful in bridging nerve gaps of 3 cm or longer.

Abstract: Devices, systems and methods to detect stress using kinematic data are disclosed herein. In certain embodiments a spatial attention mechanism is used to describe the contribution of each kinematic feature to the classification of normal/stressed movements. Some embodiments comprise determining if the kinematic data from a user belong to a class of sub-movements associated with known signatures found to highly correlate with when the user is experiencing motor degradation due to high psychological stress versus a normal class of movements where the user is unaffected by stress.

Abstract: A method for lithography includes preparing an indium-based precursor solution. The precursor solution is not limited to indium and may include other metals such as, but not limited to, zinc, tin, aluminum, or gallium, in addition to indium. Additionally, the precursor solution may include a nitrate, an acetate, a chloride, an acetylacetonate, an iodide, and other organic or inorganic groups. The method further includes spin-coating the precursor solution on a substrate at a predetermined rate to form a resist film with a predetermined thickness. The method further includes exposing the resist film to one of a low-energy electron beam and an extreme ultraviolet (EUV) beam to produce one or more chemical changes on the resist film to form a pattern. The resist is negative tone with the exposed regions remaining on the substrate and unexposed regions being removed from the substrate by the developer.

Abstract: The present invention provides methods and compositions for treating or preventing breast cancer with S-equol. The method and compositions are particularly suited to treating triple-negative breast cancer. The S-equol may be administered alone or in combination with one or more cytotoxic or immunotherapeutic compound or molecule.