Patents Assigned to University of Tokyo
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Patent number: 11722074Abstract: A vibration-driven energy harvesting element includes: a pair of fixed electrode portions that have a plurality of fixed comb teeth and are arranged such that the plurality of fixed comb teeth face each other; and a movable electrode portion that is arranged between the pair of fixed electrode portions and has a pair of a plurality of movable comb teeth being inserted between the fixed comb teeth of the respective fixed electrode portions, wherein: the vibration-driven energy harvesting element has a three-terminal structure in which the fixed comb teeth and/or the movable comb teeth are electretized; a gap dimension of a clearance region between the fixed comb teeth and the movable comb teeth is smaller than 20 ?m; and an aspect ratio being a ratio of a dimension of the clearance region in a comb tooth height direction to the gap dimension of the clearance region, is 20 or more.Type: GrantFiled: November 15, 2019Date of Patent: August 8, 2023Assignees: The University of Tokyo, Saginomiya Seisakusho, Inc.Inventors: Hiroshi Toshiyoshi, Hiroaki Honma, Hiroyuki Mitsuya
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Publication number: 20230244918Abstract: A neural network device narrows down, from among respective time segments from when a spike is received to when a next spike is received, a candidate of a time segment including a firing timing of a spiking neuron, a membrane potential of the spiking neuron during a period from when a spike is received to when a next spike is received being represented by a monotonic function of time, a firing condition of the spiking neuron being represented by a comparison between the membrane potential and a threshold.Type: ApplicationFiled: April 19, 2021Publication date: August 3, 2023Applicants: NEC Corporation, The University of TokyoInventors: Yusuke SAKEMI, Kazuyuki AIHARA
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Publication number: 20230242682Abstract: A partial oxidative coupling catalyst has a structure in which a component represented by M2ZrO3 is supported on a support, where M represents an alkali metal.Type: ApplicationFiled: September 16, 2021Publication date: August 3, 2023Applicants: MITSUBISHI HEAVY INDUSTRIES, LTD., The University of TokyoInventors: Atsuhiro Yukumoto, Yukio Tanaka, Noriaki Senba, Kazuhiro Takanabe, Bhavin Siritanaratkul
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Publication number: 20230242554Abstract: It is an object of the present invention to provide a compound that has absorption in a near infrared region, has high efficiency of singlet oxygen generation (quantum yield), and also has high tumor toxicity when it is combined with an immunotoxin. According to the present invention, provided is a compound represented by the following formula (1) or a salt thereof: wherein L1 and L2 each independently represent a single bond, —O—, —CO—, an alkylene group containing 1 to 8 carbon atoms, a sugar chain, or a combination thereof; R1 and R2 each independently represent an alkyl group containing 1 to 8 carbon atoms, a carboxylic acid group, an amino group, a hydroxyl group, a thiol group, or a biotin residue; R3, R4, R5, R6, R7 and R8 each independently represent an alkyl group containing 1 to 8 carbon atoms, a phenyl group, a carboxylic acid group, an amino group, a hydroxyl group, a thiol group, or a biotin residue; and M represents Mg, Zn, Fe, P, Si, Cu, Sn, Al, Ti, Mo, or Ni.Type: ApplicationFiled: June 24, 2021Publication date: August 3, 2023Applicants: The University of Tokyo, PhotoQ3 Inc.Inventors: Akimitsu OKAMOTO, Wakako DEWA, Takao HAMAKUBO, Mikako HAMABE, Naoko TODA, Yukio SUDO
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Patent number: 11713926Abstract: Provided is a heat exchanger, including a plurality of heat exchange members arranged in a first direction so as to be spaced apart from each other. Each of the plurality of heat exchange members includes: a heat transfer pipe extending in a second direction intersecting with the first direction; and a heat transfer plate provided to the heat transfer pipe along the second direction. The heat transfer plate includes extending portions extending away from the heat transfer pipe in a third direction intersecting with each of the first direction and the second direction. The heat transfer plate is formed separately from the heat transfer pipe.Type: GrantFiled: March 21, 2022Date of Patent: August 1, 2023Assignees: Mitsubishi Electric Corporation, The University of TokyoInventors: Yuta Komiya, Shinya Higashiiue, Tsuyoshi Maeda, Ryota Akaiwa, Shigeyoshi Matsui, Akira Ishibashi, Eiji Hihara, Chaobin Dang, Jiyang Li
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Patent number: 11716033Abstract: A vibration-driven energy harvesting element that outputs an alternating current power from an output line, due to vibration from outside includes: an intermediate electrode that is not connected to the output line; a plurality of electret electrodes, each electret electrode being arranged to face the intermediate electrode and having an electret on at least a part of a surface of the electret electrode on a side facing the intermediate electrode; a holding unit that holds the intermediate electrode and the plurality of electret electrodes such that the intermediate electrode and the plurality of electret electrodes can vibrate with respect to each other; and a charge injector that injects a charge having characteristics opposite to a charge of the electrets formed in the surfaces of the plurality of electret electrodes, to the intermediate electrode.Type: GrantFiled: April 19, 2019Date of Patent: August 1, 2023Assignees: The University of Tokyo, Saginomiya Seisakusho, Inc.Inventors: Hiroshi Toshiyoshi, Hisayuki Ashizawa, Masahiro Morita
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Patent number: 11702645Abstract: The present invention aims to provide a modified Cas9 protein with relaxed restriction on target sequence while maintaining binding ability to guide RNA, and use thereof. A protein containing the amino acid sequence of SEQ ID NO: 1 in which the 1335-position arginine is mutated into alanine (R1335A), isoleucine (R1335I), methionine (R1335M), threonine (R1335T) or valine (R1335V), the 1111-position leucine is mutated into arginine (L1111R), the 1135-position aspartic acid is mutated into valine (D1135V), the 1218-position glycine is mutated into arginine (G1218R), the 1219-position glutamic acid is mutated into phenylalanine (E1219F), the 1322-position alanine is mutated into arginine (A1322R), and the 1337-position threonine is mutated into arginine (T1337R), and the like.Type: GrantFiled: June 24, 2022Date of Patent: July 18, 2023Assignee: The University of TokyoInventors: Osamu Nureki, Hiroshi Nishimasu, Hisato Hirano
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Publication number: 20230219273Abstract: An object of the present invention is to provide a method for producing a polymeric molded product, which does not undergo a considerable molecular weight reduction during melt-molding, even in a polymer may easily lose its molecular weight when it is in a melted state. The present invention provides a method for producing a polymeric molded product, which comprises melt-molding a polymer comprising lamellar crystals that are different in lamella thickness, in a temperature range where some of the lamellar crystals undergo melting and flowing, and the other balance lamellar crystals remain unmelted.Type: ApplicationFiled: June 2, 2021Publication date: July 13, 2023Applicants: Mitsubishi Gas Chemical Company, Inc., The University of TokyoInventors: Akira MAEHARA, Tadahisa IWATA, Taku OMURA, Taizo KABE
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Publication number: 20230220022Abstract: Disclosed are a novel therapeutic means effective and practical against cancer, and a novel substance useful as such a therapeutic means. Provided are novel peptides derived from a partial region of HMGN1, HMGN2, HMGN4 or HMGN5, and anti-cancer agents and anti-cancer effect enhancers containing the peptide as an active ingredient. The peptide of the present invention has an anti-tumor effect even independently, and exerts a remarkably excellent anti-tumor effect particularly when used in combination with an immune checkpoint regulator, or an anti-CD4 antibody or antigen-binding fragment thereof.Type: ApplicationFiled: January 3, 2023Publication date: July 13, 2023Applicants: The University of Tokyo, ONO PHARMACEUTICAL CO., LTD., TOKYO UNIVERSITY OF SCIENCE FOUNDATIONInventors: Kouji MATSUSHIMA, Satoshi UEHA, Shungo DESHIMARU, Chang-Yu CHEN, Shoji YOKOCHI, Yoshiro ISHIWATA, Shiro SHIBAYAMA
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Patent number: 11696840Abstract: A knee joint that is capable of widening a moveable range, and that has good energy efficiency and is small and lightweight is described. Also described is a knee joint that is of an active type, but comparatively inexpensive. A drive section moves a driven member. An elastic member is arranged between the driven member and a linear motion member. The linear motion member elastically moves in at least one direction, in accordance with movement of the driven member, by way of the elastic member. A crank mechanism can realize bending and extension of the knee joint by converting linear motion of the linear motion member to rotational motion.Type: GrantFiled: August 30, 2017Date of Patent: July 11, 2023Assignee: The University of TokyoInventors: Xiaojun Sun, Masayuki Inaba, Kei Okada, Yuki Asano
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Patent number: 11698428Abstract: An information processing apparatus according to an embodiment includes a processing circuit. The processing circuit acquires a measurement field corresponding to a spatial distribution of a predetermined physical quantity in a subject of measurement. The processing circuit calculates an unknown quantity in the subject of measurement based on a first equation between the measurement field and the unknown quantity having spatial dependence, and on the acquired measurement field. The first equation is one that is acquired based on a second equation expressing a dual field divergence of which can be expressed using the measurement field, by using the measurement field and the unknown quantity, and on the Helmholtz decomposition of the dual field.Type: GrantFiled: January 27, 2022Date of Patent: July 11, 2023Assignees: The University of Tokyo, CANON MEDICAL SYSTEMS CORPORATIONInventors: Takaaki Nara, Motofumi Fushimi, Naohiro Eda, Seiichi Shin, Hitoshi Yamagata, Koji Yano, Hiroyuki Fujita
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Publication number: 20230210987Abstract: The present invention is intended to provide an adjuvant having high safety to living bodies and an action to sufficiently reinforce immune function, and a vaccine comprising the adjuvant. Specifically, the present invention relates to 34 novel adjuvant candidate compounds, which have been identified by screening 145 food additives and 51 injection additives, using, as indicators, an increase in the antibody titer against influenza virus and a protective effect against infection with influenza virus, and then selecting those having the function of increasing the antiviral antibody titer in blood and the protective effect against viral infection. In addition, the present invention also relates to a vaccine comprising these adjuvant candidate compounds.Type: ApplicationFiled: March 10, 2023Publication date: July 6, 2023Applicant: The University of TokyoInventors: Yoshihiro KAWAOKA, Huapeng FENG, Tokiko WATANABE, Makoto YAMASHITA
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Publication number: 20230211539Abstract: An object of the present invention is to provide a method for producing a polymeric molded product, the method enabling expansion of a temperature range that can be used for partial melting. The present invention provides a method for producing a polymeric molded product, which comprises subjecting a crystalline polyhydroxyalkanoate to a heating treatment at a temperature equal to or higher than a glass transition temperature; and melt-molding a polyhydroxyalkanoate yielded by the heating treatment, which comprises lamellar crystals that are different in lamellar thickness, in a temperature range where some of the lamellar crystals undergo melting and flowing, and the other balance lamellar crystals remain unmelted.Type: ApplicationFiled: June 2, 2021Publication date: July 6, 2023Applicants: Mitsubishi Gas Chemical Company, Inc., The University of TokyoInventors: Akira MAEHARA, Tadahisa IWATA, Taku OMURA, Taizo KABE
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Publication number: 20230212306Abstract: The present invention provides a pharmaceutical composition comprising an antibody which binds specifically to human TLR7 or monkey TLR7 and does not bind to mouse TLR7 or rat TLR7, and has an activity of inhibiting a function of human TLR7 or monkey TLR7, and the like.Type: ApplicationFiled: December 27, 2022Publication date: July 6, 2023Applicants: Daiichi Sankyo Company, Limited, The University of TokyoInventors: Kensuke Miyake, Yusuke Murakami, Yuji Motoi, Atsuo Kanno, Toshiyuki Shimizu, Umeharu Ohto, Takaichi Shimozato, Atsushi Manno, Takashi Kagari, Jun Ishiguro, Kensuke Nakamura, Takashi Isobe
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Publication number: 20230212492Abstract: The present invention provides a culture method capable of maturing an organoid through long-term culture, and suitable for producing a conformational organ. The culture method of the present invention is a method for culturing an organoid and/or cells constituting an organ immobilized in a chamber with a culture fluid perfused, and the culture fluid is perfused in such a manner as to generate a turbulent flow in the chamber.Type: ApplicationFiled: June 7, 2021Publication date: July 6, 2023Applicants: National University Corporation Tokyo Medical and Dental University, Takeda Pharmaceutical Company LimitedInventors: Takanori TAKEBE, Norikazu SAIKI
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Patent number: 11692244Abstract: An alloy for biomedical use includes Zr as a main component, Nb the content of which is not less than 0.1% by weight and not greater than 25% by weight, Mo the content of which is not less than 0.1% by weight and not greater than 25% by weight, and Ta the content of which is not less than 0.1% by weight and not greater than 25% by weight. A tensile strength of the alloy is not less than 1000 MPa. A total content of Nb, Mo, and Ta in the alloy is not less than 2% by weight and not greater than 50% by weight. Mass susceptibility of the alloy is not greater than 1.50×10?6 cm3/g. A Young's modulus of the alloy is not greater than 100 GPa. Also disclosed is a medical product including the alloy and a method for producing the alloy.Type: GrantFiled: July 24, 2018Date of Patent: July 4, 2023Assignees: TOKUSEN KOGYO CO., LTD., National University Corporation Tokyo Medical and Dental UniversityInventors: Takao Hanawa, Yusuke Tsutsumi, Mitsutaka Sasakura
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Publication number: 20230192787Abstract: It has been revealed that, from a pre-onset stage of Alzheimer's disease, enhancement of phosphorylations of MARCKS and the like causes abnormal spine formation or the like, consequently developing the disease. It also has been revealed that the phosphorylations of MARCKS and the like are caused by PKC and the like, and further that b-raf is involved in phosphorylation of tau protein important for the progression of Alzheimer's disease. Thus, these proteins have been found to be target molecules useful in the diagnosis and treatment of Alzheimer's disease. In addition, it has also been revealed that, in a pre-onset stage of frontotemporal lobar degeneration, b-RAF phosphorylation enhancement causes a decrease in the number of spines and the like, consequently developing the disease. Thus, b-RAF has been found to be a target molecule useful in the diagnosis and treatment of frontotemporal lobar degeneration.Type: ApplicationFiled: February 23, 2023Publication date: June 22, 2023Applicant: National University Corporation Tokyo Medical and Dental UniversityInventor: Hitoshi OKAZAWA
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Publication number: 20230191096Abstract: A pharmaceutical composition may be used in administering oxygen to a subject. The pharmaceutical composition may contain a perfluorocarbon dissolving oxygen therein. Further, a pharmaceutical composition may be used in decreasing the blood carbon dioxide partial pressure of a subject, and the pharmaceutical composition may contain a perfluorocarbon. Such a composition may be suitable for administered oral administration, nasogastric administration, trans-fistula gastric administration, or administration into a large intestine.Type: ApplicationFiled: May 13, 2021Publication date: June 22, 2023Applicant: National University Corporation Tokyo Medical and Dental UniversityInventors: Takanori TAKEBE, Yosuke YONEYAMA, Ryo OKABE, Toyofumi YOSHIKAWA, Hiroshi DATE
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Patent number: 11674180Abstract: A method for determining a hyperexcitability in a subject comprising detecting a repeat expansion of TTTCA, TTTTA, or a complementary sequence thereof in a nucleic acid sample from the subject.Type: GrantFiled: February 12, 2019Date of Patent: June 13, 2023Assignee: The University of TokyoInventors: Shoji Tsuji, Hiroyuki Ishiura
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Publication number: 20230175949Abstract: An imaging flow cytometer includes: a flow channel in which an observation object flows and a length in a width direction is longer than a length in a height direction; an acoustic element configured to apply acoustic waves as standing waves to the flow channel; a light source that irradiates the flow channel with illumination light; an image sensor configured to image at least a line included in a cross section of the observation object crossing a flow line direction which is a direction in which the observation object flows in the flow channel by measuring or imaging the observation object passing through a position irradiated with the illumination light; and circuitry configured to generate an image in which the observation object is scanned in the flow line direction on the basis of a plurality of captured images acquired by the imaging unit imaging the line in a time series.Type: ApplicationFiled: September 10, 2021Publication date: June 8, 2023Applicant: The University of TokyoInventors: Sadao OTA, Masashi UGAWA