Patents Assigned to University of Tokyo
  • Publication number: 20240050189
    Abstract: A biomagnetic field measurement device includes an irradiation unit configured to irradiate a subject with radiation; an imaging unit having a light-receiving surface for receiving radiation, the imaging unit being configured to image the subject based on the radiation from the irradiation unit; a marker part configured to absorb the radiation from the irradiation unit; and a processing circuit configured to output biological information based on third position information of the marker part and an imaged result of the subject by the imaging unit, the third position information of the marker part being calculated from first position information of the marker part, second position information of the irradiation unit, and a captured image of the marker part imaged by the imaging unit.
    Type: Application
    Filed: August 8, 2023
    Publication date: February 15, 2024
    Applicants: Ricoh Company, Ltd., National University Corporation Tokyo Medical and Dental University
    Inventors: Masahiro Takada, Shigenori Kawabata, Akira Kinoshita
  • Patent number: 11890145
    Abstract: An adhesion-preventing material having a high adhesion-preventing effect has been demanded. An adhesion-preventing material including a sterilized biocompatible sponge-like laminate, wherein the sponge-like laminate comprises a sponge-like first layer and a sponge-like second layer each of which is at least partially crosslinked with a curing agent and comprises a low-endotoxin alginic acid monovalent metal salt, the alginic acid monovalent metal salt in the first layer has a weight average molecular weight of 10,000 to 2,000,000, the alginic acid monovalent metal salt in the second layer has a weight average molecular weight of 1,000 to 1,000,000, the weight average molecular weights are measured by a GPC-MALS method after a decrosslinking treatment, and the weight average molecular weight of the alginic acid monovalent metal salt in the first layer is higher than that in the second layer.
    Type: Grant
    Filed: August 26, 2022
    Date of Patent: February 6, 2024
    Assignees: The University of Tokyo, Mochida Pharmaceutical Co., Ltd.
    Inventors: Taichi Ito, Seiichi Ohta, Norihiro Kokudo, Mitsuko Isaji, Satoshi Shimizu
  • Patent number: 11891443
    Abstract: The present invention provides an antibody recognizing a v9 fragment of the cell adhesion molecule CADM1.
    Type: Grant
    Filed: March 18, 2019
    Date of Patent: February 6, 2024
    Assignee: The University of Tokyo
    Inventors: Yoshinori Murakami, Takeshi Ito, Takao Hamakubo, Hiroko Iwanari
  • Publication number: 20240034440
    Abstract: Provided herein are compositions and methods for the induction and/or proliferation of CD8+ T-cells. The disclosure also provides methods of treatment of diseases that can be treated by the induction and/or proliferation of CD8+ T-cells.
    Type: Application
    Filed: March 10, 2023
    Publication date: February 1, 2024
    Applicants: Keio University, The University of Tokyo
    Inventors: Kenya Honda, Takeshi Tanoue, Masahira Hattori, Yutaka Kawakami
  • Publication number: 20240035007
    Abstract: The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems.
    Type: Application
    Filed: December 27, 2022
    Publication date: February 1, 2024
    Applicants: The Broad Institute, Inc., Massachusetts Institute of Technology, University of Tokyo, President and Fellows of Harvard College
    Inventors: Silvana KONERMANN, Alexandro TREVINO, Mark BRIGHAM, Fei RAN, Patrick HSU, Chie-yu LIN, Osamu NUREKI, Hiroshi NISHIMASU, Ryuichiro ISHITANI, Feng ZHANG
  • Publication number: 20240035006
    Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.
    Type: Application
    Filed: November 14, 2022
    Publication date: February 1, 2024
    Applicants: The Broad Institute, Inc., Massachusetts Institute of Technology, University of Tokyo, The United States of America, as Represented by the Secretary Dept of Health and Human Services
    Inventors: Takashi Yamano, Hiroshi Nishimasu, Bernd Zetsche, Ian Slaymaker, Yinqing Li, Iana Fedorova, Kira Makarova, Linyi Gao, Eugene Koonin, Feng Zhang, Osamu Nureki
  • Patent number: 11883410
    Abstract: This invention relates to a preventive and/or therapeutic agent for sarcopenia, comprising a prostaglandin D2 production inhibitor as an active ingredient.
    Type: Grant
    Filed: April 18, 2019
    Date of Patent: January 30, 2024
    Assignees: National University Corporation Tokyo University of Agriculture and Technolgy, Taiho Pharmaceutical Co., Ltd.
    Inventors: Masaki Inada, Daisuke Kajiwara
  • Publication number: 20240023862
    Abstract: A diagnostic support apparatus includes a computing unit that computes a decreasing rate of a current intensity of an inward current flowing into a nerve pathway, based on magnetic field data obtained by measuring a magnetic field generated by a subject.
    Type: Application
    Filed: January 11, 2022
    Publication date: January 25, 2024
    Applicants: Ricoh Company, Ltd., National University Corporation Tokyo Medical and Dental University
    Inventors: Nobuyori NAGAOKA, Taishi WATANABE, Shigenori KAWABATA
  • Publication number: 20240025901
    Abstract: A first object of the present invention is to provide a method for producing a cyclic imide compound with high yield and high purity. A second object of the present invention is to provide a composition that can be used in the method for producing a cyclic imide compound with high yield and high purity. A third object of the present invention is to provide an intermediate compound that can be used in the method for producing a cyclic imide compound with high yield and high purity. The method for producing a cyclic imide compound according to the present invention includes reacting a compound represented by formula (1) below with at least one amine compound to obtain a compound represented by formula (2) below.
    Type: Application
    Filed: July 13, 2023
    Publication date: January 25, 2024
    Applicants: FUJIFILM Corporation, The University of Tokyo
    Inventors: Hiroki SUGIURA, Yukio TANI, Tetsuya MATSUSHITA, Tetsuya WATANABE, Toshihiro OKAMOTO
  • Publication number: 20240024266
    Abstract: [Problem] To develop novel therapeutic agents for viral diseases such as coronavirus infections. [Solution] The present invention provides a therapeutic or prophylactic agent for viral diseases containing a compound with inhibitory activity against the function of Pin1 or a pharmaceutically acceptable salt thereof as an active ingredient.
    Type: Application
    Filed: November 16, 2021
    Publication date: January 25, 2024
    Applicants: Hiroshima University, Tokyo University of Pharmacy & Life Sciences, The University of Tokyo
    Inventors: Tomoichiro Asano, Takemasa Sakaguchi, Takeshi Yamamotoya, Yusuke Nakatsu, Hisanaka Ito, Takayoshi Okabe, Jeffrey Encinas
  • Publication number: 20240009224
    Abstract: The present invention provides a nucleic acid having excellent cell membrane permeability.
    Type: Application
    Filed: September 1, 2023
    Publication date: January 11, 2024
    Applicants: The University of Tokyo, AGC Inc.
    Inventors: Takashi OKAZOE, Kohsuke AIKAWA, Honoka WATANABE, Akimitsu OKAMOTO, Kunihiko MORIHIRO, Taiichi KAGEYAMA
  • Patent number: 11867610
    Abstract: Any one or both of an optical system with a structured lighting pattern and a structured detecting system having a plurality of regions with different optical characteristics are used. In addition, optical signals from an object to be observed through one or a small number of pixel detectors are detected while changing relative positions between the object to be observed and any one of the optical system and the detecting system, time series signal information of the optical signals are obtained, and an image associated with an object to be observed from the time series signal information is reconstructed.
    Type: Grant
    Filed: January 10, 2023
    Date of Patent: January 9, 2024
    Assignees: The University of Tokyo, Osaka University
    Inventors: Sadao Ota, Ryoichi Horisaki, Kazuki Hashimoto
  • Patent number: 11866497
    Abstract: The present invention provides an antibody to a fibrosis-related molecule and medical application thereof. The antibody of the present invention is an antibody that binds to CHL1 protein and an antibody that neutralizes the binding of the CHL1 protein to a fibroblast.
    Type: Grant
    Filed: August 11, 2021
    Date of Patent: January 9, 2024
    Assignee: The University of Tokyo
    Inventors: Yosuke Kurashima, Hiroshi Kiyono
  • Publication number: 20240000858
    Abstract: Species of human-derived bacteria belonging to the Clostridia class have been shown to induce accumulation of regulatory T cells (Treg cells) in the colon and suppress immune functions. Pharmaceutical compositions containing these bacteria can be used to prevent and treat immune-mediated diseases such as autoimmune diseases.
    Type: Application
    Filed: December 20, 2022
    Publication date: January 4, 2024
    Applicants: The University of Tokyo, School Corporation, Azabu Veterinary Medicine Educational Institution
    Inventors: Kenya Honda, Koji Atarashi, Takeshi Tanoue, Masahira Hattori, Hidetoshi Morita
  • Publication number: 20240000932
    Abstract: The present invention relates to a novel combination of (1) a substance that suppresses or inhibits the function of extracellular TCTP (translationally controlled tumor protein), especially released from tumor cells, and (2) a cancer immunotherapeutic agent for the treatment of cancer. Preferably, such a cancer immunotherapeutic agent is an immune checkpoint inhibitor. The substance that suppresses or inhibits the function of extracellular TCTP functions as an activator or enhancer of anti-tumor immune cells including T cells and natural killer (NK) cells and/or an antagonist of immunosuppressive cells, such as myeloid-derived suppressor cells (MDSCs), in the tumor immune microenvironment (TIME). The combination according to the present invention is useful for treating or preventing cancer. The combination according to the present invention is also useful for alleviating, reverting, or preventing immune suppression in the tumor immune microenvironment.
    Type: Application
    Filed: June 30, 2022
    Publication date: January 4, 2024
    Applicants: Boostimmune, Inc., The University of Tokyo
    Inventors: Gwanghee LEE, Jeonghyun RYOU, Jiwon HUH, Tadatsugu TANIGUCHI, Sho HANGAI, Hideyuki YANAI
  • Patent number: 11856927
    Abstract: The present invention has found that chimeric animals suffer from noticeable inflammation after birth, though neither immune response nor inflammation in the fetal period of these animals has been reported hitherto. This is an unexpected finding since chimeric animals in the fetal period were exclusively analyzed in prior studies and thus it is deemed that immunotolerance has been theoretically established therein. The present invention provides a composition for suppressing immune response or inflammation in the fetal period of a born chimeric animal.
    Type: Grant
    Filed: January 25, 2018
    Date of Patent: January 2, 2024
    Assignee: The University of Tokyo
    Inventors: Hiromitsu Nakauchi, Tomoyuki Yamaguchi, Sanae Hamanaka, Hideyuki Sato, Hideki Masaki, Naoaki Mizuno, Motoo Watanabe
  • Patent number: 11861889
    Abstract: An analysis device includes an analysis unit configured to receive scattered light, transmitted light, fluorescence, or electromagnetic waves from an observed object located in a light irradiation region light-irradiated from a light source and analyze the observed object on the basis of a signal extracted on the basis of a time axis of an electrical signal output from a light-receiving unit configured to convert the received light or electromagnetic waves into the electrical signal.
    Type: Grant
    Filed: November 29, 2022
    Date of Patent: January 2, 2024
    Assignees: The University of Tokyo, Osaka University
    Inventors: Sadao Ota, Issei Sato, Katsuhito Fujiu, Satoko Yamaguchi, Kayo Waki, Yoko Itahashi, Ryoichi Horisaki
  • Publication number: 20230417460
    Abstract: A refrigerant circuit includes a compressor that compresses refrigerant and an expansion mechanism that decompresses refrigerant. The refrigerant circuit configures a vapor compression refrigeration cycle in which the refrigerant circulates. The adsorbent adsorbs and desorbs the refrigerant circulating in a first unit. The refrigerant circuit includes a high-pressure region and a low-pressure region. The refrigeration cycle apparatus is operated under at least one of a first condition and a second condition. In the first condition, the refrigerant in the high-pressure region has a pressure lower than or equal to a critical pressure of the refrigerant, and the refrigerant in the high-pressure region has a temperature exceeding a critical temperature of the refrigerant.
    Type: Application
    Filed: June 27, 2023
    Publication date: December 28, 2023
    Applicants: DAIKIN INDUSTRIES, LTD., The University of Tokyo
    Inventors: Eiji KUMAKURA, Hirofumi DAIGUJI, Arun MAJUMDAR, Wei-Lun HSU, Jubair Ahmed SHAMIM
  • Publication number: 20230417459
    Abstract: A refrigeration cycle apparatus includes a refrigerant circuit and an adsorbent. The refrigerant circuit includes a compressor that compresses a refrigerant. The refrigerant circuit configures a vapor compression refrigeration cycle in which the refrigerant circulates. The adsorbent adsorbs and desorbs the refrigerant circulating in the refrigerant circuit. The adsorbent adsorbs and desorbs the refrigerant in accordance with a change in a pressure of the refrigerant circulating in the refrigerant circuit.
    Type: Application
    Filed: June 27, 2023
    Publication date: December 28, 2023
    Applicants: DAIKIN INDUSTRIES, LTD., The University of Tokyo
    Inventors: Eiji KUMAKURA, Ryuhei KAJI, Hiroki UEDA, Masaki TANAKA, Kosuke NISHIMURA, Kazuhiro FURUSHO, Yoshimasa KIKUCHI, Hirofumi DAIGUJI, Arun MAJUMDAR, Wei-Lun HSU, Jubair Ahmed SHAMIM
  • Patent number: 11854751
    Abstract: The present invention provides a light-transmitting electrode which has high electrical conductivity and high electron blocking performance. The present invention also provides a solar cell which is capable of achieving high energy conversion efficiency at low cost. The present invention provides a method for producing a light-transmitting electrode that has a light-transmitting substrate, a carbon nanotube film which is formed directly or indirectly on the light-transmitting substrate, and a metal oxide film which is formed directly on the carbon nanotube film. This production method includes vapor depositing the metal oxide film, which contains oxygen and a metal element belonging to the group 4, 5 or 6 of the periodic table, on one surface or both surfaces of the carbon nanotube film. The present invention provides a light-transmitting electrode which includes a light-transmitting substrate and a conductive carbon nanotube film that is formed directly or indirectly on the light-transmitting substrate.
    Type: Grant
    Filed: January 15, 2021
    Date of Patent: December 26, 2023
    Assignees: The University of Tokyo, Aalto University, Denso Corporation
    Inventors: Shigeo Maruyama, Yutaka Matsuo, Il Jeon, Kehang Cui, Esko I. Kauppinen, Albert G. Nasibulin