Patents Assigned to University of Tokyo
  • Structure for joining column and beam frame and shear wall
    Patent number: 11702836
    Abstract: In between a shear wall of a reinforced concrete structure disposed in a column and beam frame of a reinforced concrete structure and the frame, transmission capability of a shear force between is enhanced from a stage which a relative deformation occurs among between the frame and the shear wall. Plate is disposed between an inner peripheral surface of a frame and an outer peripheral surface of a shear wall, integrated with any one of the frame and the shear wall, and continuous in a longitudinal direction and in a height direction of the shear wall and penetrate the plate in a thickness direction. The anchors are dispersedly in the longitudinal direction and in the height direction of the shear wall.
    Type: Grant
    Filed: April 28, 2022
    Date of Patent: July 18, 2023
    Assignees: THE UNIVERSITY OF TOKYO, SANKO TECHONO CO., LTD., KSE NETWORK CO., LTD., OHMOTO GUMI CO., LTD., SSD CORPORATION, MARUKAWA ASSOCIATES ARCHITECTS AND ENGINEERS
    Inventors: Hitoshi Shiohara, Masaomi Teshigawara, Yoshio Inoue, Takashi Sato, Yasue Yagisawa, Kenji Yokota, Syunichiro Shishido, Koji Oka, Masaki Yamaguchi
  • HMGN PARTIAL PEPTIDE AND CANCER THERAPY USING THE SAME
    Publication number: 20230220022
    Abstract: Disclosed are a novel therapeutic means effective and practical against cancer, and a novel substance useful as such a therapeutic means. Provided are novel peptides derived from a partial region of HMGN1, HMGN2, HMGN4 or HMGN5, and anti-cancer agents and anti-cancer effect enhancers containing the peptide as an active ingredient. The peptide of the present invention has an anti-tumor effect even independently, and exerts a remarkably excellent anti-tumor effect particularly when used in combination with an immune checkpoint regulator, or an anti-CD4 antibody or antigen-binding fragment thereof.
    Type: Application
    Filed: January 3, 2023
    Publication date: July 13, 2023
    Applicants: The University of Tokyo, ONO PHARMACEUTICAL CO., LTD., TOKYO UNIVERSITY OF SCIENCE FOUNDATION
    Inventors: Kouji MATSUSHIMA, Satoshi UEHA, Shungo DESHIMARU, Chang-Yu CHEN, Shoji YOKOCHI, Yoshiro ISHIWATA, Shiro SHIBAYAMA
  • METHOD FOR PRODUCING POLYMERIC MOLDED PRODUCT
    Publication number: 20230219273
    Abstract: An object of the present invention is to provide a method for producing a polymeric molded product, which does not undergo a considerable molecular weight reduction during melt-molding, even in a polymer may easily lose its molecular weight when it is in a melted state. The present invention provides a method for producing a polymeric molded product, which comprises melt-molding a polymer comprising lamellar crystals that are different in lamella thickness, in a temperature range where some of the lamellar crystals undergo melting and flowing, and the other balance lamellar crystals remain unmelted.
    Type: Application
    Filed: June 2, 2021
    Publication date: July 13, 2023
    Applicants: Mitsubishi Gas Chemical Company, Inc., The University of Tokyo
    Inventors: Akira MAEHARA, Tadahisa IWATA, Taku OMURA, Taizo KABE
  • Genus bacterium transformant
    Patent number: 11697817
    Abstract: A transformant obtained by introducing a DNA of (a1), (a2), or (a3) below, and (b) an alcohol dehydrogenase gene, into a bacterium of the genus Hydrogenophilus, can efficiently produce isobutanol utilizing carbon dioxide as a sole carbon source. (a1) DNA which consists of a base sequence of SEQ ID NO: 1; (a2) DNA which consists of a base sequence having 90% or more identity with SEQ ID NO: 1, the DNA encoding a polypeptide having 2-keto-acid decarboxylase activity; (a3) DNA which hybridizes with a DNA consisting of a base sequence complementary to SEQ ID NO: 1 under stringent conditions, and which encodes a polypeptide having 2-keto-acid decarboxylase activity.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: July 11, 2023
    Assignees: UTILIZATION OF CARBON DIOXIDE INSTITUTE CO., LTD., THE UNIVERSITY OF TOKYO
    Inventors: Hideaki Yukawa, Naoto Ohtani, Masaharu Ishii
  • Knee joint
    Patent number: 11696840
    Abstract: A knee joint that is capable of widening a moveable range, and that has good energy efficiency and is small and lightweight is described. Also described is a knee joint that is of an active type, but comparatively inexpensive. A drive section moves a driven member. An elastic member is arranged between the driven member and a linear motion member. The linear motion member elastically moves in at least one direction, in accordance with movement of the driven member, by way of the elastic member. A crank mechanism can realize bending and extension of the knee joint by converting linear motion of the linear motion member to rotational motion.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: July 11, 2023
    Assignee: The University of Tokyo
    Inventors: Xiaojun Sun, Masayuki Inaba, Kei Okada, Yuki Asano
  • Information processing apparatus and information processing method
    Patent number: 11698428
    Abstract: An information processing apparatus according to an embodiment includes a processing circuit. The processing circuit acquires a measurement field corresponding to a spatial distribution of a predetermined physical quantity in a subject of measurement. The processing circuit calculates an unknown quantity in the subject of measurement based on a first equation between the measurement field and the unknown quantity having spatial dependence, and on the acquired measurement field. The first equation is one that is acquired based on a second equation expressing a dual field divergence of which can be expressed using the measurement field, by using the measurement field and the unknown quantity, and on the Helmholtz decomposition of the dual field.
    Type: Grant
    Filed: January 27, 2022
    Date of Patent: July 11, 2023
    Assignees: The University of Tokyo, CANON MEDICAL SYSTEMS CORPORATION
    Inventors: Takaaki Nara, Motofumi Fushimi, Naohiro Eda, Seiichi Shin, Hitoshi Yamagata, Koji Yano, Hiroyuki Fujita
  • Method for producing copolymer of allyl monomer having polar group
    Patent number: 11697698
    Abstract: The present invention pertains to a method for producing a copolymer of ethylene and an allyl monomer having a polar group represented by general formula (1), or a copolymer of ethylene, an allyl monomer having a polar group represented by general formula (1), and other monomers, wherein the copolymer is produced in the presence of a boron compound having a boron-hydrogen bond or a boron-carbon bond (for example, a compound represented by general formula (2)) by using a metal complex represented by general formula (C1) as a polymerization catalyst (the symbols in the formulas are as described in the description). According to the present invention, a copolymer of ethylene and an allyl monomer can be efficiently produced with high catalytic activity, wherein the copolymer has a polar group and can be used in various applications.
    Type: Grant
    Filed: March 7, 2019
    Date of Patent: July 11, 2023
    Assignees: THE UNIVERSITY OF TOKYO, SHOWA DENKO K.K., JAPAN POLYETHYLENE CORPORATION
    Inventors: Kyoko Nozaki, Shingo Ito, Junichi Kuroda, Yoshikuni Okumura, Shinya Hayashi, Minoru Kobayashi, Yuichiro Yasukawa
  • ADJUVANT AND VACCINE CONTAINING ADJUVANT
    Publication number: 20230210987
    Abstract: The present invention is intended to provide an adjuvant having high safety to living bodies and an action to sufficiently reinforce immune function, and a vaccine comprising the adjuvant. Specifically, the present invention relates to 34 novel adjuvant candidate compounds, which have been identified by screening 145 food additives and 51 injection additives, using, as indicators, an increase in the antibody titer against influenza virus and a protective effect against infection with influenza virus, and then selecting those having the function of increasing the antiviral antibody titer in blood and the protective effect against viral infection. In addition, the present invention also relates to a vaccine comprising these adjuvant candidate compounds.
    Type: Application
    Filed: March 10, 2023
    Publication date: July 6, 2023
    Applicant: The University of Tokyo
    Inventors: Yoshihiro KAWAOKA, Huapeng FENG, Tokiko WATANABE, Makoto YAMASHITA
  • METHOD FOR PRODUCING POLYMERIC MOLDED PRODUCT COMPRISING PRETREATMENT BY HEATING
    Publication number: 20230211539
    Abstract: An object of the present invention is to provide a method for producing a polymeric molded product, the method enabling expansion of a temperature range that can be used for partial melting. The present invention provides a method for producing a polymeric molded product, which comprises subjecting a crystalline polyhydroxyalkanoate to a heating treatment at a temperature equal to or higher than a glass transition temperature; and melt-molding a polyhydroxyalkanoate yielded by the heating treatment, which comprises lamellar crystals that are different in lamellar thickness, in a temperature range where some of the lamellar crystals undergo melting and flowing, and the other balance lamellar crystals remain unmelted.
    Type: Application
    Filed: June 2, 2021
    Publication date: July 6, 2023
    Applicants: Mitsubishi Gas Chemical Company, Inc., The University of Tokyo
    Inventors: Akira MAEHARA, Tadahisa IWATA, Taku OMURA, Taizo KABE
  • ANTI-HUMAN TLR7 ANTIBODY
    Publication number: 20230212306
    Abstract: The present invention provides a pharmaceutical composition comprising an antibody which binds specifically to human TLR7 or monkey TLR7 and does not bind to mouse TLR7 or rat TLR7, and has an activity of inhibiting a function of human TLR7 or monkey TLR7, and the like.
    Type: Application
    Filed: December 27, 2022
    Publication date: July 6, 2023
    Applicants: Daiichi Sankyo Company, Limited, The University of Tokyo
    Inventors: Kensuke Miyake, Yusuke Murakami, Yuji Motoi, Atsuo Kanno, Toshiyuki Shimizu, Umeharu Ohto, Takaichi Shimozato, Atsushi Manno, Takashi Kagari, Jun Ishiguro, Kensuke Nakamura, Takashi Isobe
  • Thermoelectric conversion element and thermoelectric conversion device
    Patent number: 11683985
    Abstract: A thermoelectric conversion element is made of a material with a band structure having Weyl points in the vicinity of Fermi energy. The thermoelectric conversion element has a thermoelectric mechanism for generating electromotive force by the anomalous Nernst effect. A thermoelectric conversion device includes a substrate; and a power generator provided on the substrate and including a plurality of thermoelectric conversion elements. Each of the plurality of thermoelectric conversion elements has a shape extending in one direction, and is made of a material identical to that of the above-mentioned thermoelectric conversion element. The plurality of thermoelectric conversion elements is arranged in parallel to one another in a direction perpendicular to the one direction and electrically connected in series to one another in a serpentine shape.
    Type: Grant
    Filed: July 3, 2018
    Date of Patent: June 20, 2023
    Assignee: THE UNIVERSITY OF TOKYO
    Inventors: Satoru Nakatsuji, Akito Sakai
  • Method and kit for determining hyperexcitability in subject
    Patent number: 11674180
    Abstract: A method for determining a hyperexcitability in a subject comprising detecting a repeat expansion of TTTCA, TTTTA, or a complementary sequence thereof in a nucleic acid sample from the subject.
    Type: Grant
    Filed: February 12, 2019
    Date of Patent: June 13, 2023
    Assignee: The University of Tokyo
    Inventors: Shoji Tsuji, Hiroyuki Ishiura
  • THERMOPLASTIC POLYMER COMPOSITION COMPRISING POLYROTAXANE
    Publication number: 20230174767
    Abstract: A composition includes a thermoplastic polymer and a polyrotaxane. The polyrotaxane includes a plurality of cyclic molecules and a chain polymer passing through the plurality of the cyclic molecules in a skewering manner, at least a part of the hydroxyl groups of the plurality of cyclic molecules being substituted with a hydrophobic group. A group that enhances miscibility of the polyrotaxane to the thermoplastic polymeris bound to at least a part of the hydrophobic groups of each of the plurality of cyclic molecules.
    Type: Application
    Filed: August 28, 2020
    Publication date: June 8, 2023
    Applicants: The Texas A&M University System, The University of Tokyo
    Inventors: Hung-Jue Sue, Chia-Ying Tsai, Glendimar S. Molero, Kohzo Ito, Koichi Mayumi, Shuntaro Uenuma, Shota Ando
  • ELECTRODE ACTIVE MATERIAL, ELECTRODE, AND SECONDARY BATTERY
    Publication number: 20230178735
    Abstract: An electrode active material has a high energy density, high output, and a superior cycle property with little decrease in capacity even after repeated charge and discharge. An electrode and a secondary battery can include the electrode active material. An electrode active material which contains a compound having a dithiadiazine group, and is used as an active material of a secondary battery that repeats charge and discharge by a battery electrode reaction, and electrode containing the electrode active material and a conductive material. In addition, a secondary battery wherein the electrode active material is contained in any one of a reaction starting material, a product, and an intermediate product of at least a discharge reaction of the battery electrode reaction.
    Type: Application
    Filed: March 15, 2021
    Publication date: June 8, 2023
    Applicant: THE UNIVERSITY OF TOKYO
    Inventors: Masaharu SATO, Hiroshi NISHIHARA, Ying WANG
  • IMAGING FLOW CYTOMETER
    Publication number: 20230175949
    Abstract: An imaging flow cytometer includes: a flow channel in which an observation object flows and a length in a width direction is longer than a length in a height direction; an acoustic element configured to apply acoustic waves as standing waves to the flow channel; a light source that irradiates the flow channel with illumination light; an image sensor configured to image at least a line included in a cross section of the observation object crossing a flow line direction which is a direction in which the observation object flows in the flow channel by measuring or imaging the observation object passing through a position irradiated with the illumination light; and circuitry configured to generate an image in which the observation object is scanned in the flow line direction on the basis of a plurality of captured images acquired by the imaging unit imaging the line in a time series.
    Type: Application
    Filed: September 10, 2021
    Publication date: June 8, 2023
    Applicant: The University of Tokyo
    Inventors: Sadao OTA, Masashi UGAWA
  • INDUCTION OF PROLIFEROUS PANCREATIC ISLET PRECURSOR CELL-LIKE CELLS BY TRANSIENT EXPRESSION OF MYCL AND INDUCTION OF DIFFERENTIATION INTO INSULIN-POSITIVE CELLS
    Publication number: 20230173020
    Abstract: Establishment of pancreatic islet-like insulin producing cells by inducing differentiation of ES/iPS cells has been reported. However, no technique has been developed so far for producing functional pancreatic islet insulin-positive cells in a large amount. In addition, there are concerns regarding rejection responses, accidental immune responses, etc. The present invention provides pancreatic islet-like cells having Mycl gene introduced thereinto and a method that comprises inducing proliferation of pancreatic islet-like cells by transient expression of Mycl gene and then inducing degradation thereof into insulin producing cells.
    Type: Application
    Filed: December 10, 2020
    Publication date: June 8, 2023
    Applicant: THE UNIVERSITY OF TOKYO
    Inventors: YASUHIRO YAMADA, MICHITADA HIRANO
  • Negative electrode for secondary battery, secondary battery, and manufacturing methods thereof
    Patent number: 11670756
    Abstract: To provide a negative electrode for a secondary battery and a secondary battery having a large energy density and a capacity less likely to reduce even after repeated charging and discharging, and manufacturing methods thereof. The above-described problem is solved by a negative electrode for a secondary battery (3) comprising a negative electrode active material layer (3?) including at least a silicon-based active material and a binder, and a negative electrode current collector (14) having a structural form in which the silicon-based active material has an amorphous region including lithium and island-shaped lithium carbonate is distributed in the amorphous region.
    Type: Grant
    Filed: October 31, 2018
    Date of Patent: June 6, 2023
    Assignee: THE UNIVERSITY OF TOKYO
    Inventors: Hiroshi Nishihara, Mariko Miyachi, Masaharu Sato
  • Foot sole pressure measurement instrument, information provision device, and information provision method
    Patent number: 11666244
    Abstract: A foot sole pressure measurement instrument includes a measurement unit which is installed on a foot sole part of a subject and measures a pressure applied to the foot sole part of the subject, and an output unit configured to output data of the measured pressure.
    Type: Grant
    Filed: August 13, 2018
    Date of Patent: June 6, 2023
    Assignees: NIPPON TELEGRAPH AND TELEPHONE CORPORATION, THE UNIVERSITY OF TOKYO
    Inventors: Shingo Tsukada, Hiroshi Nakashima, Nahoko Kasai, Hideo Hatta
  • CONDUCTOR MATERIAL
    Publication number: 20230170107
    Abstract: Provided is a conductor material having high conductivity. The conductor material according to an embodiment of the present disclosure has a configuration in which a conjugated polymeric compound having an electron donating group containing a heteroatom in a side chain is doped with a dopant containing an anion selected from a nitrogen anion, a boron anion, a phosphorus anion and an antimony anion, and a counter cation. The anion is preferably an anion represented by Formula (1) below: where R1 and R2 are identical or different, and each represent an electron withdrawing group; and R1 and R2 may be bonded to each other to form a ring with an adjacent nitrogen atom.
    Type: Application
    Filed: April 27, 2021
    Publication date: June 1, 2023
    Applicants: THE UNIVERSITY OF TOKYO, DAICEL CORPORATION
    Inventors: Toshihiro OKAMOTO, Tadanori KUROSAWA, Yu YAMASHITA, Junichi TAKEYA, Daiji IKEDA, Takeshi YOKOO, Yasuyuki AKAI
  • Power supply circuit and vibration-driven energy harvester
    Patent number: 11664749
    Abstract: A power supply circuit that outputs an electric power input from a vibration-driven energy harvesting element to an external load includes a rectifying circuit that rectifies an alternating current power input from the vibration-driven energy harvesting element; a first capacitor that accumulates a power output from the rectifying circuit; a chopper circuit that has a switching element controlling a chopper timing and has an input terminal connected to the first capacitor; and a control signal generation unit that supplies a control signal to the switching element, wherein: the control signal generation unit generates the control signal without referring to a voltage of the first capacitor.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: May 30, 2023
    Assignees: The University of Tokyo, Saginomiya Seisakusho, Inc.
    Inventors: Hiroshi Toshiyoshi, Hisayuki Ashizawa, Masahiro Morita