Patents Assigned to University of Tokyo
  • Publication number: 20230352184
    Abstract: Provided is a health support apparatus including an acquisition unit that acquires first data about a target user which is data about health and does not change or changes by less than a predetermined amount in a predetermined period and second data about the target user which is data about health and changes by more than or equal to the predetermined amount in the predetermined period, a determination unit that determines a future state parameter of the target user based on the first data and the second data, a generation unit that generates an image showing a future state of an appearance or an image showing a future state of an organ of the target user using the future state parameter of the target user determined in the determination unit, and an output unit that outputs the image generated in the generation unit.
    Type: Application
    Filed: July 2, 2021
    Publication date: November 2, 2023
    Applicant: The University of Tokyo
    Inventors: Akiko Kishi, Masahiro Nakamura, Thomas Svensson
  • Publication number: 20230340504
    Abstract: A transformant obtained by introducing a DNA of (a1), (a2), or (a3) below, and (b) an alcohol dehydrogenase gene, into a bacterium of the genus Hydrogenophilus, can efficiently produce isobutanol utilizing carbon dioxide as a sole carbon source. (a1) DNA which consists of a base sequence of SEQ ID NO: 1; (a2) DNA which consists of a base sequence having 90% or more identity with SEQ ID NO: 1, the DNA encoding a polypeptide having 2-keto-acid decarboxylase activity; (a3) DNA which hybridizes with a DNA consisting of a base sequence complementary to SEQ ID NO: 1 under stringent conditions, and which encodes a polypeptide having 2-keto-acid decarboxylase activity.
    Type: Application
    Filed: May 11, 2023
    Publication date: October 26, 2023
    Applicants: Utilization of Carbon Dioxide Institute Co., Ltd., The University of Tokyo
    Inventors: Hideaki Yukawa, Naoto Ohtani, Masaharu Ishii
  • Publication number: 20230340503
    Abstract: A transformant obtained by introducing a DNA of (a1), (a2), or (a3) below, and (b) an alcohol dehydrogenase gene, into a bacterium of the genus Hydrogenophilus, can efficiently produce isobutanol utilizing carbon dioxide as a sole carbon source. (a1) DNA which consists of a base sequence of SEQ ID NO: 1; (a2) DNA which consists of a base sequence having 90% or more identity with SEQ ID NO: 1, the DNA encoding a polypeptide having 2-keto-acid decarboxylase activity; (a3) DNA which hybridizes with a DNA consisting of a base sequence complementary to SEQ ID NO: 1 under stringent conditions, and which encodes a polypeptide having 2-keto-acid decarboxylase activity.
    Type: Application
    Filed: May 11, 2023
    Publication date: October 26, 2023
    Applicants: Utilization of Carbon Dioxide Institute Co., Ltd., The University of Tokyo
    Inventors: Hideaki Yukawa, Naoto Ohtani, Masaharu Ishii
  • Patent number: 11788948
    Abstract: The present disclosure provides methods and systems for ghost cytometry (GC), which may be used to produce an image of an object without using a spatially resolving detector. This may be used to perform image-free ultrafast fluorescence “imaging” cytometry, based on, for example, a single pixel detector. Spatial information obtained from the motion of cells relative to a patterned optical structure may be compressively converted into signals that arrive sequentially at a single pixel detector. Combinatorial use of the temporal waveform with the intensity distribution of the random or pseudo-random pattern may permit computational reconstruction of cell morphology. Machine learning methods may be applied directly to the compressed waveforms without image reconstruction to enable efficient image-free morphology-based cytometry.
    Type: Grant
    Filed: December 8, 2020
    Date of Patent: October 17, 2023
    Assignees: ThinkCyte, Inc., University of Tokyo, Osaka University
    Inventors: Sadao Ota, Ryoichi Horisaki, Yoko Kawamura, Masashi Ugawa, Issei Sato
  • Patent number: 11784729
    Abstract: There is provided a calibration device including: a calibration signal supply unit configured to supply, as a calibration input signal, a multitone signal having tones at a plurality of frequency bands to a converter configured to multiply an input signal by each of a plurality of signal patterns and limit a band to obtain each of a plurality of bandpass signals, and reconstruct an output signal in accordance with the input signal from the plurality of bandpass signals; a calibration bandpass signal acquisition unit configured to acquire a plurality of calibration bandpass signals obtained by the converter in response to the multitone signal; and a calibration processing unit configured to calibrate a parameter for the reconstruction in the converter based on the plurality of calibration bandpass signals.
    Type: Grant
    Filed: June 5, 2022
    Date of Patent: October 10, 2023
    Assignees: ADVANTEST CORPORATION, The University of Tokyo
    Inventors: Koji Asami, Tetsuya Iizuka, Zolboo Byambadorj
  • Patent number: 11785845
    Abstract: An object of the present invention is to provide a composition capable of manufacturing an organic thin film transistor having excellent carrier mobility even under low temperature conditions. The composition of the present invention contains a compound represented by Formula (1) and an alcohol represented by Formula (S1).
    Type: Grant
    Filed: October 18, 2021
    Date of Patent: October 10, 2023
    Assignees: FUJIFILM Corporation, The University of Tokyo
    Inventors: Koki Nakamura, Hiroki Sugiura, Yukio Tani, Tetsuya Matsushita, Tetsuya Watanabe, Junichi Takeya, Toshihiro Okamoto
  • Publication number: 20230312689
    Abstract: It is an object of the present invention to provide antibodies against coronavirus (SARS-CoV-2). It is also an object of the present invention to provide a pharmaceutical composition against coronavirus infection using the antibody. According to the present invention, an antibody or antigen-binding fragment thereof that binds to the receptor-binding domain present in the spike protein of coronavirus and is capable of neutralizing the coronavirus, and a pharmaceutical composition for the prevention or treatment of coronavirus infection containing the antibody or antigen-binding fragment, are provided.
    Type: Application
    Filed: July 9, 2021
    Publication date: October 5, 2023
    Applicants: NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY, The University of Tokyo
    Inventors: Shuzo MATSUSHITA, Yu KAKU, Takeo KUWATA, Yoshihiro KAWAOKA, Masaki IMAI, Seiya YAMAYOSHI
  • Patent number: 11773376
    Abstract: The present invention relates to providing artificial tendon or ligament tissue having sufficient strength. More specifically, artificial tendon or ligament tissue having sufficient strength is provided by embedding collagen-secreting cells in a gel having strength capable of resisting a tensile load and by culturing the cells while applying a tensile load to the gel to produce artificial tendon or ligament tissue. Cells that steadily express the Mkx gene can be used as the collagen-secreting cells. A fibrin gel containing aprotinin can be used as the gel.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: October 3, 2023
    Assignee: National University Corporation Tokyo Medical and Dental University
    Inventors: Hiroshi Asahara, Kensuke Kataoka, Tomoki Chiba
  • Publication number: 20230301909
    Abstract: The present invention addresses the problem of providing a pregnancy-induced hypertension syndrome therapy composition having controlled placental permeability. Provided are nicotinamide-encapsulating micelles having a particle diameter of 25-100 nm. Controlling the particle diameter of the nicotinamide-encapsulating micelles enables control of placental permeability so as to make it possible to accumulate nicotinamide-encapsulating micelles in a placental while suppressing transfer to a fetus. Administering the nicotinamide-encapsulating micelles brings about a superior effect of reducing blood pressure during a pregnancy-induced hypertension syndrome.
    Type: Application
    Filed: October 8, 2021
    Publication date: September 28, 2023
    Applicants: The University of Tokyo, ASKA Pharmaceutical Co., Ltd.
    Inventors: Horacio Cabral, Takuya Miyazaki, Pengwen Chen, Naoya Kawashima
  • Publication number: 20230293782
    Abstract: A material for preventing adhesion having a high adhesion preventing effect has been desired. Provided is a sheet-like material for preventing adhesion which contains alginate, at least a portion of which is crosslinked with a curing agent, the material for preventing adhesion satisfying (1) and (2) when a dissolution test is performed in which a sample cut into a substantial circle having a diameter of 8 mm is left to stand, via a mesh, on agar of a petri dish to which a physiological saline solution is added substantially to a top surface of the agar, the petri dish is shaken at an amplitude of 25 mm and 40 shakes/min., and the weight of the sample is measured at least one arbitrary point in time. (1) The time required for the weight of the sample to be less than 0.01 g is 5-36 hours from a start of the test, and (2) the time required for the weight of the sample to reach the maximum weight is 10 hours or less from the start of the test.
    Type: Application
    Filed: July 30, 2021
    Publication date: September 21, 2023
    Applicants: Mochida Pharmaceutical Co., Ltd., The University of Tokyo
    Inventors: Taichi ITO, Seiichi OHTA, Kiyoshi HASEGAWA, Mitsuko ISAJI, Daichi TANAKA
  • Publication number: 20230295628
    Abstract: Developed and provided is: a nucleic acid agent that is efficiently delivered to the central nervous system, to which drug delivery is inhibited by the blood brain barrier mechanism, and that provides an antisense effect to a target transcription product at the delivery site; and a composition containing such a nucleic acid agent. Provided is a double-stranded nucleic acid complex consisting of a first nucleic acid strand and a second nucleic acid strand that are annealed to each other; wherein the first nucleic acid strand hybridizes with part of a target transcription product and has an antisense effect on the target transcription product; and wherein the second nucleic acid strand includes a base sequence complementary to the first nucleic acid strand and is conjugated to a phosphatidylethanolamine or an analog thereof.
    Type: Application
    Filed: February 2, 2023
    Publication date: September 21, 2023
    Applicants: National University Corporation Tokyo Medical and Dental University, Takeda Pharmaceutical Company Limited
    Inventors: Takanori Yokota, Tetsuya Nagata, Hideki Furukawa, Yasuo Nakagawa, Takatoshi Yogo, Ryosuke Tokunoh, Shigekazu Sasaki, Kosuke Hidaka, Tomohiro Seki, Kenichi Miyata, Akio Uchida
  • Publication number: 20230294278
    Abstract: Provided is a robot system comprising: a robot mechanism provided with fingers for grasping a workpiece; a detection unit that detects a grasping state of the workpiece by the fingers; a recognition unit that recognizes the number of workpieces being grasped by the fingers on the basis of a detection result from the detection unit; and a control unit that, after causing the robot mechanism to perform a motion of grasping the workpieces from a placing area where a plurality of workpieces are placed, if the number of the workpieces recognized by the recognition unit is different from a specified number specified in advance, controls the motion of the robot mechanism such that the number of the grasped workpieces is equal to the specified number. At least one of the fingers is flexible. The control unit controls the motion of the robot mechanism such that, in a state in which workpieces are being grasped by the fingers, the position of at least one of the fingers is changed.
    Type: Application
    Filed: August 17, 2021
    Publication date: September 21, 2023
    Applicants: OMRON Corporation, The University of Tokyo
    Inventors: Matthew Ishige, Takuya Umedachi, Yoshihisa Ijiri
  • Patent number: 11761837
    Abstract: A multi-axial tactile sensor for detecting forces in directions of three axes and a moment about at least one axis includes at least four sensor elements including at least three shearing force detecting elements having beam structures provided with a first resistive layer and a second resistive layer at specific portions, and at least one pressing force detecting element having a beam structure provided with a third resistive layer and a fourth resistive layer at specific portions, the beam structures of the four sensor elements being arranged on a sensor substrate so that their respective longitudinal directions are radially arranged, and the moment about at least one axis is detected based on outputs of two or more sensor elements being arranged at positions of rotational symmetry around the center of the radial arrangement of the plurality of sensor elements.
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: September 19, 2023
    Assignee: The University of Tokyo
    Inventors: Isao Shimoyama, Akihito Nakai
  • Publication number: 20230284951
    Abstract: The present invention is designed such that, even when inward currents cannot be calculated properly, it is possible to generate current waveforms that can appropriately evaluate the action of a target body tissue by calculating currents that are equivalent to inward currents. A biomagnetic field measurement system includes circuitry and a memory storing executable instructions which, when executed by the circuitry, cause the circuitry to: based on current components extracted from current signals calculated from a biomagnetic field signal, add up current waveforms of current components along a conduction pathway of an action current in a body tissue that is targeted for evaluation, and generate a current waveform for evaluating an intra-cellular current flowing in the conduction pathway, locations of the current components of the added current waveforms being predetermined set distances apart on the conduction pathway, in front of and behind a location of interest on the conduction pathway.
    Type: Application
    Filed: March 6, 2023
    Publication date: September 14, 2023
    Applicants: Ricoh Company, Ltd., National University Corporation Tokyo Medical and Dental University
    Inventors: Koki Ishida, Taishi Watanabe, Shigenori Kawabata, Yuta Tanaka
  • Publication number: 20230287373
    Abstract: The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRJSPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CR.ISPR-Cas enzyme systems. In particular the present invention comprehends engineered new guide architectures and enzymes to be used in optimized Staphylococcus aureus CRISPR-Cas enzyme systems.
    Type: Application
    Filed: January 26, 2023
    Publication date: September 14, 2023
    Applicants: The Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows of Harvard College, University of Tokyo
    Inventors: Feng ZHANG, Winston YAN, Osamu NUREKI, Kaijie ZHENG, Le CONG, Hiroshi NISHIMASU, Fei RAN, Yinqing LI
  • Publication number: 20230276703
    Abstract: Provided is a compound capable of forming through a printing process an organic semiconductor exhibiting high charge mobility. The compound according to the present disclosure is represented by Formula (1) below. In Formula (1), X1 and X2 are the same or different and each represent —O—, —NR1—, or —PR2-. Y1 and Y2 are the same or different and each represent an oxygen atom or a sulfur atom. Z1 to Z8 are the same or different and each represent ?N— or ?CR3—. The R1, R2, and R3 are the same or different and each represent a hydrogen atom or an organic group. n represents an integer of 0 or greater.
    Type: Application
    Filed: September 1, 2021
    Publication date: August 31, 2023
    Applicants: The University of Tokyo, DAICEL CORPORATION
    Inventors: Toshihiro OKAMOTO, Tadanori KUROSAWA, Craig Peiqi YU, Junichi TAKEYA, Akito YAMAMOTO, Daiji IKEDA
  • Patent number: 11739303
    Abstract: Modified influenza virus neuraminidases are described herein that have stabilized NA tetramers which may improve vaccine production efficiency, thus improving the yield of vaccine viruses.
    Type: Grant
    Filed: January 22, 2021
    Date of Patent: August 29, 2023
    Assignees: Wisconsin Alumni Research Foundation (WARF), The University of Tokyo
    Inventors: Yoshihiro Kawaoka, Yuri Furusawa, Seiya Yamayoshi
  • Patent number: 11740459
    Abstract: Provided is a head-mounted display that enables viewing of a stereoscopic image without visual fatigue caused by vergence-accommodation conflict. A head-mounted display includes a display device to display images for the left eye and the right eye on a screen, virtual image forming optical systems for the left eye and the right eye, respectively disposed with respect to images for the left eye and the right eye on the screen, and wide-focus lenses for the left eye and the right eye having a negative focal length with a range, and respectively disposed with respect to the virtual image forming optical systems for the left eye and the right eye so as to overlap optical axis directions of the virtual image forming optical systems for the left eye and the right eye. By respectively displaying virtual images of images, a permissible range of vergence and accommodation is expanded.
    Type: Grant
    Filed: July 22, 2019
    Date of Patent: August 29, 2023
    Assignees: National University Corporation Tokyo University of Agriculture and Technology, ITOH OPTICAL INDUSTRIAL CO., LTD.
    Inventors: Yasuhiro Takaki, Yasushi Miyajima
  • Publication number: 20230264169
    Abstract: An adsorbent and a granulated substance for which reduction in adsorption performance in low humidity environments is suppressed are provided. The adsorbent includes: a porous body mainly composed of silicon dioxide, including a plurality of fine pores, and having a specific surface area of not less than 1 m2/g and not more than 10 m2/g; one of an acid and a base with which inside of the fine pores of the porous body is impregnated to neutralize a target gas to generate a salt; and a hydrophilic fiber held in the porous body.
    Type: Application
    Filed: September 2, 2021
    Publication date: August 24, 2023
    Applicants: DAIKIN INDUSTRIES, LTD., The University of Tokyo
    Inventors: Mayu NISHIMURA, Takuya MATSUOKA, Ichiro SAKATA, Bunshi FUGETSU, Takayuki UEKI
  • Publication number: 20230255038
    Abstract: Provided is a semiconductor device and a method of manufacturing the semiconductor device that is capable of improving the connection reliability between an electronic element and a substrate in a semiconductor device in which the electronic element is fixed to the substrate. The semiconductor device includes: a substrate 10 provided with wirings and wiring connection parts 12 connected to the wirings; electronic elements 20, 30, 40, and 50 electrically connected to the wiring connection parts 12 and fixed to the substrate; and a resin film 60 laminated on one surface of the substrate 10, conforming to the shapes of the electronic elements 20, 30, 40, and 50, and covering the electronic elements 20, 30, 40, and 50.
    Type: Application
    Filed: October 8, 2021
    Publication date: August 10, 2023
    Applicants: The University of Tokyo, PI-CRYSTAL INC., ORGANO-CIRCUIT INC.
    Inventors: Junichi Takeya, Kazuyoshi Watanabe, Han Nozawa, Yuichi Ono