Patents Assigned to University of Tokyo
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Patent number: 11662148Abstract: In a heat exchanger, each of a plurality of heat exchange members includes: a flat pipe; and a heat transfer plate integrated with the flat pipe along a longitudinal direction of the flat pipe. A width direction of each of the flat pipes intersects with a direction in which the plurality of heat exchange members are arranged side by side. Each of the heat transfer plates includes an extending portion extending outward in the width direction of each of the flat pipes from at least one of one end of a corresponding one of the flat pipes in the width direction and another end of the corresponding one of the flat pipes in the width direction. Each of the flat pipes has one or more flat pipe bent portions, each forming a groove extending along the longitudinal direction of the flat pipes.Type: GrantFiled: August 3, 2017Date of Patent: May 30, 2023Assignees: Mitsubishi Electric Corporation, The University of TokyoInventors: Akira Ishibashi, Tsuyoshi Maeda, Shinya Higashiiue, Daisuke Ito, Shin Nakamura, Ryota Akaiwa, Akira Yatsuyanagi, Ryuichi Nagata, Eiji Hihara, Chaobin Dang, Jiyang Li
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Patent number: 11658309Abstract: A fuel cell is an ammonia fuel cell using an ammonia-containing fuel. A catalyst used for an anode of the fuel cell is a ruthenium complex having two first ligands and one second ligand, and the first ligand is pyridine or a condensed cyclic pyridine compound with or without a substituent, and the second ligand is 2,2?-bipyridyl-6,6?-dicarboxylic acid with or without a substituent on a pyridine ring.Type: GrantFiled: March 2, 2020Date of Patent: May 23, 2023Assignees: THE UNIVERSITY OF TOKYO, NISSAN CHEMICAL CORPORATIONInventors: Yoshiaki Nishibayashi, Kazunari Nakajima, Hiroki Toda, Shoichi Kondo, Takamasa Kikuchi
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Patent number: 11655269Abstract: To provide novel compounds that are promising as prodrug-type anticancer agents, a compound represented by general formula (I) or a salt thereof is provided.Type: GrantFiled: March 4, 2019Date of Patent: May 23, 2023Assignee: THE UNIVERSITY OF TOKYOInventors: Yasuteru Urano, Mako Kamiya, Kento Hayashi
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Patent number: 11655046Abstract: A safety management system to prevent unauthorized use, accident, resale, theft, and so forth of a flying object. The safety management system includes changing, at a motor controller, a power feeding amount to each drive unit based on an instruction from a main control unit, an authentication information storage unit which records registered identification information for performing operator authentication, an authentication accepting unit which accepts an input of input identification information, an operator authentication unit which performs operator authentication of an operator of the flying object based on the input identification information and the registered identification information, and a safety managing unit connected between a power source of the flying object and the motor controller of the flying object. The safety managing unit includes a switch which controls electrical connection between the motor controller and the power source based on the result of the operator authentication.Type: GrantFiled: April 21, 2016Date of Patent: May 23, 2023Assignees: The University of Tokyo, Blue Innovation Co., Ltd.Inventors: Shinji Suzuki, Takeshi Tsuchiya, Masayuki Kumada
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Publication number: 20230149558Abstract: It is an object of the present invention to provide a conjugate of a duocarmycin derivative and a biotin-modified dimer, which is useful for pretargeting methods. According to the present invention, a compound represented by the following formula (1) or formula (2) is provided: wherein R1 and R2 each independently represent a hydrogen atom, a lower alkyl group, or a lower alkoxycarbonyl group; one of R3, R4, and R5 represents —O-L7-(Xaa)m-L6-N3, and the remaining two each independently represent a hydrogen atom, a lower alkyl group, or a lower alkoxycarbonyl group; X represents a reactive group; L6 and L7 each independently represent a divalent linking group; Xaa represents an amino acid residue; m represents an integer of 2 to 10; and Me represents a methyl group.Type: ApplicationFiled: April 23, 2021Publication date: May 18, 2023Applicants: The University of Tokyo, SAVID THERAPEUTICS INC., TOHOKU UNIVERSITYInventors: Motomu KANAI, Kenzo YAMATSUGU, Toshifumi TATSUMI, Tatsuhiko KODAMA, Akira SUGIYAMA, Masanobu TSUKAGOSHI, Hidetoshi TOKUYAMA, Juri SAKATA
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Publication number: 20230148933Abstract: An electric signal transmission device including an electrode 11, disposed to be opposed to an electrogenic cell, and for sending and receiving electric signals to and from the electrogenic cell via the electrode 11.Type: ApplicationFiled: April 1, 2021Publication date: May 18, 2023Applicant: The University of TokyoInventor: Masataka WATANABE
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Publication number: 20230151141Abstract: Provided is a dopant with which a conductor material having high electrical conductivity can be formed. The present disclosure relates to a dopant containing a radical cation represented by Formula (1) and a counter anion. In Formula (1), R1 to R3 may be the same or different, and each denotes a monovalent aromatic group or a group represented by Formula (r). at least one of R1 to R3 is a group represented by Formula (r), and n indicates the valence of the radical cation and is equal to the quantity (n) of nitrogen atoms in the formula. In Formula (r), Ar1, Ar2, and Ar3 may be the same or different, and each denotes a divalent aromatic group, and Ar4, Ar5, Ar6, and Ar7 may be the same or different, and each denotes a monovalent aromatic group optionally having a substituent represented by Formula (sb) below. Furthermore, m and n may be the same or different, and each represents an integer of 0 or greater.Type: ApplicationFiled: April 15, 2021Publication date: May 18, 2023Applicants: THE UNIVERSITY OF TOKYO, DAICEL CORPORATIONInventors: Toshihiro OKAMOTO, Tadanori KUROSAWA, Junichi TAKEYA, Daiji IKEDA, Takeshi YOKOO, Yasuyuki AKAI
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Patent number: 11650988Abstract: The database management system (DBMS) receives a first instruction specifying anonymization rule information corresponding to a column of the relation table, among anonymization rule information that is present for each column included in the relation table and shows a plurality of generalization rules. The DBMS reads the column from the relation table in response to the first instruction, and generates a temporary result obtained by generalizing each attribute value of the column based on any of a plurality of generalization rules. The DBMS generates an aggregate result obtained by aggregating the temporary result. The DBMS generates an anonymization method including generalization information indicating a correspondence relationship of each attribute value of the column and any of the plurality of generalization rules when the aggregate result satisfies a disclosure rule. The DBMS generates anonymization information as a result of processing the relation table based on the first anonymization method.Type: GrantFiled: September 23, 2020Date of Patent: May 16, 2023Assignees: HITACHI, LTD., THE UNIVERSITY OF TOKYOInventors: Yuya Isoda, Kazuhiko Mogi, Norifuml Nishikawa, Kazuo Goda, Yuto Hayamizu, Masaru Kitsuregawa
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Patent number: 11649311Abstract: There is provided a method for introducing a temperature-sensitive probe comprising a copolymer, which comprises a thermoresponsive unit and a fluorescent unit, into a cell, and the method using the copolymer further comprising a cationic unit as the temperature-sensitive probe, and the method comprising the step of mixing the copolymer with the cell in a solvent. The copolymer can be preferably used as a fluorescence temperature sensor which measures intracellular temperature since the copolymer has a cationic group and thus enters into a cell without using a special method.Type: GrantFiled: December 13, 2018Date of Patent: May 16, 2023Assignees: KIRIN HOLDINGS KABUSHIKI KAISHA, THE UNIVERSITY OF TOKYOInventors: Toshikazu Tsuji, Kumiko Ikado, Seiichi Uchiyama, Kyoko Kawamoto
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Publication number: 20230146664Abstract: Engineered FnCas9 variants are provided that have an enhanced kinetic activity and a broader PAM recognition. The protein engineering methodology introduced specific mutations that stabilized interaction between Cas9 enzyme and target DNA. The enhanced kinetic activity increases NHEJ-mediated editing, owing to more efficient DSB generation potential than WT FnCas9, and the broadened PAM specificity increases the target range of FnCas9 variants. Thus, the scope and accessibility of CRISPR-Cas9 system targets are widened, along with generating robust and highly specific engineered FnCas9 variants.Type: ApplicationFiled: October 25, 2022Publication date: May 11, 2023Applicants: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH, DEPARTMENT OF BIOLOGICAL SCIENCES, GRADUATE SCHOOL OF SCIENCE, THE UNIVERSITY OF TOKYOInventors: Debojyoti CHAKRABORTY, Souvik MAITI, Osamu NUREKI, Hiroshi NISHIMASU, Sundaram ACHARYA, Seichi HIRANO, Hirano Hisato
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Publication number: 20230147800Abstract: An object is to provide a shape measurement system and a shape measurement method that allow deriving a three-dimensional shape of a linear object to be measured over a long distance and with high resolution.Type: ApplicationFiled: June 3, 2021Publication date: May 11, 2023Applicants: NIPPON TELEGRAPH AND TELEPHONE CORPORATION, THE UNIVERSITY OF TOKYOInventors: Nobutomo HANZAWA, Kazuhide NAKAJIMA, Takashi MATSUI, Hideaki MURAYAMA, Ryota WADA, Makito KOBAYASHI
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Publication number: 20230148041Abstract: A small transistor type sensor capable of detecting a specific compound such as oxytocin is provided. The transistor type sensor includes a detection electrode that detects a compound by capturing the compound, and a field effect transistor that has a gate electrode connected to the detection electrode, wherein a surface of the detection electrode is provided with a film of a molecularly imprinted polymer having a space to which the compound is allowed to bond.Type: ApplicationFiled: October 13, 2022Publication date: May 11, 2023Applicants: THE UNIVERSITY OF TOKYO, JNC CORPORATIONInventors: Tsuyoshi MINAMI, Qi ZHOU, Yusuke YAMANASHI, Katsumasa NAKAHARA, Hirokazu NAGAOKA
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Publication number: 20230143744Abstract: The present invention is to provide a novel adsorbent which is low in cost, has versatility and has high adsorption ability. Specifically, the present invention is to provide an adsorbent containing a metal salt of a cyanometallic acid obtained by a reaction of a salt of a cyanometallic acid and a compound containing a metal element, wherein the reaction is carried out using the compound containing a metal element in an amount of less than 100 mol % of the theoretical amount relative to 1 mol of the salt of a cyanometallic acid, a method of producing the same, and a method for removing harmful ions from water using such an adsorbent.Type: ApplicationFiled: January 20, 2021Publication date: May 11, 2023Applicant: THE UNIVERSITY OF TOKYOInventors: Kazuyuki ISHII, Kyoko ENOMOTO
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Publication number: 20230144658Abstract: A monitoring system according to one aspect of the present disclosure includes: a sensor to measure physical quantities at one or a plurality of measurement points of a structural body; processing circuitry configured to acquire measured values from the measurer; a memory to store the measured values acquired from the measurer; and a data storage that, when one or some of the measured values stored in the memory satisfy a predetermined trigger condition, and as a result, it is determined that the structural body has received impact, records a group of data of the measured values which are within a certain time range and include the measured value based on which it is determined that the trigger condition is satisfied.Type: ApplicationFiled: January 13, 2023Publication date: May 11, 2023Applicants: KAWASAKI JUKOGYO KABUSHIKI KAISHA, The University of TokyoInventors: Takuya ISHIDA, Hiroshi MAMIZU, Yuji IKEDA, Shu MINAKUCHI
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Publication number: 20230148264Abstract: An object of the present invention is to provide an information processing apparatus capable of more easily evaluating a depression state. The present invention is an information processing apparatus including: means for inputting voice data uttered by a subject; means for acquiring time-series data of sound pressure in the input voice data; and means for obtaining a Sound Pressure Change acceleration index that is an index based on a force toward a center and a force away from the center of the acquired time-series data of the sound pressure.Type: ApplicationFiled: March 16, 2021Publication date: May 11, 2023Applicants: PST INC., THE UNIVERSITY OF TOKYOInventors: Yasuhiro OMIYA, Shuji SHINOHARA
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Publication number: 20230145009Abstract: A configuration of the present disclosure specifies a signal point of a specific component and a background point, based on time series two-dimensional spectroscopic image data of a gas; calculates a correlation coefficient between a time series detection signal at the signal point and a time series detection signal at the background point; and generates a time series detection signal of the specific component, based on a corrected time series detection signal obtained by subtracting a product of the correlation coefficient and the time series detection signal at the background point from the time series detection signal at the signal point.Type: ApplicationFiled: February 26, 2021Publication date: May 11, 2023Applicant: THE UNIVERSITY OF TOKYOInventors: Yohei KOBAYASHI, Shuntaro TANI, Hiroharu TAMARU
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Publication number: 20230145308Abstract: An adhesion-preventing material having a high adhesion-preventing effect has been demanded. An adhesion-preventing material including a sterilized biocompatible sponge-like laminate, wherein the sponge-like laminate comprises a sponge-like first layer and a sponge-like second layer each of which is at least partially crosslinked with a curing agent and comprises a low-endotoxin alginic acid monovalent metal salt, the alginic acid monovalent metal salt in the first layer has a weight average molecular weight of 10,000 to 2,000,000, the alginic acid monovalent metal salt in the second layer has a weight average molecular weight of 1,000 to 1,000,000, the weight average molecular weights are measured by a GPC-MALS method after a decrosslinking treatment, and the weight average molecular weight of the alginic acid monovalent metal salt in the first layer is higher than that in the second layer.Type: ApplicationFiled: August 26, 2022Publication date: May 11, 2023Applicants: Mochida Pharmaceutical Co., Ltd., The University of TokyoInventors: Taichi ITO, Seiichi OHTA, Norihiro KOKUDO, Mitsuko ISAJI, Satoshi SHIMIZU
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Patent number: 11646562Abstract: A current interrupting device includes a current limiting element on a power supply path from a predetermined power supply to a load device. The current limiting element is configured to exhibit a current limiting action when current flowing in the power supply path exceeds a first current threshold value. The current interrupting device further includes a current diversion path switch, and a controller programmed to control on and off of the current diversion path switch. The controller is programmed to switch a current diversion path switch on from an off state when it is detected that current flowing in the current limiting element is limited to a second current threshold value after the current flowing in the current limiting element has exceeded the first current threshold value, and switch the switch off again after a predetermined switched-on holding time has elapsed since the switch has been switched on.Type: GrantFiled: September 15, 2020Date of Patent: May 9, 2023Assignees: National University Corporation Saitama University, Tokyo Institute of Technology, The University of TokyoInventors: Yuki Inada, Yasushi Yamano, Mitsuaki Maeyama, Shungo Zen, Wataru Ohnishi
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Patent number: 11643649Abstract: The present disclosure provides a method for screening cells, the method including a step of preparing a plurality of cells which are tagged with a first barcode nucleic acid associated with a test target and treated with the test target, a step of sorting the plurality of cells based on cellular phenotype using an imaging cell sorter, and a step of identifying the test target used to treat each cell using the first barcode nucleic acid as an indicator.Type: GrantFiled: January 12, 2021Date of Patent: May 9, 2023Assignees: ThinkCyte, Inc., The University of Tokyo, RIKENInventors: Asako Tsubouchi, Sadao Ota, Fumiko Kawasaki
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Patent number: 11645859Abstract: An analysis device configured to analyze a correlation between feature values in a cell in response to a stimulus includes: a cell-image acquiring unit configured to acquire a plurality of cell images in which the cell that is stimulated is captured; a feature value calculating unit configured to calculate a feature value for constituent elements that form the cell, based on the plurality of cell images acquired by the cell-image acquiring unit; a correlation calculating unit configured to use the feature value calculated by the feature value calculating unit and to calculate correlations between the constituent elements; a correlation selecting unit configured to select a first correlation from the correlations calculated by the correlation calculating unit; and an image selecting unit configured to select a first cell image from the plurality of cell images that are captured, based on the first correlation that is selected.Type: GrantFiled: June 30, 2016Date of Patent: May 9, 2023Assignees: NIKON CORPORATION, THE UNIVERSITY OF TOKYOInventors: Takuro Saigo, Shinichi Furuta, Shunsuke Takei, Masafumi Yamashita, Shoko Yamasaki, Masayuki Murata, Fumi Kano, Yoshiyuki Noguchi