Abstract: It is an object of the present invention to provide a method of reliably chemogenetically controlling the activity of a protein, and to provide a protein used in the present method. Specifically, the present invention relates to a plurality of protein fragments, which recover the activity of the protein when the plurality of protein fragments assemble, and in which each of the plurality of protein fragments is tagged with a degradation domain (DD) sequence. In addition, the present invention also relates to a method of regulating the activity of a protein in a cell, comprising: a step of introducing into a cell, a fusion of a DD sequence, and each fragment of a protein that has been split into fragments, such that the fragments recover the activity of the protein when they assemble; and a step of introducing a DD sequence-specific stabilizing factor into the cell.

Abstract: An object is to prevent eavesdropping in quantum key distribution. A synchronization signal reception device receives a synchronization signal that is an optical signal for defining a timing at which a quantum signal is detected, and outputs a reference signal corresponding to the synchronization signal. A clock signal generation unit generates a clock signal in response to the reference signal. A photon detection device detects a photon of the quantum signal in response to the clock signal. A timing of the clock signal randomly changes within a predetermined range.

Abstract: A cell labeling molecule comprising a particle 101 having an identifiable property, an identification sequence 102 that is identifiable and corresponds to the property of the particle 101, a cleavable linker 103 that binds the particle 101 and the identification sequence 102, and a binding molecule 104 for binding to a cell, the binding molecule being bound to the identification sequence 102.

Abstract: An acquisition section (101) acquires an actual measurement value of a measured change in a specific environment of a data assimilation target. A computation section (102) uses a preliminary initial state and a preliminary value of an unknown parameter that are related to the data assimilation target to perform a numerical computation of a change in the specific environment of the data assimilation target. An update section (103) computes a value of an evaluation function representing errors between the actual measurement value and a value obtained from a result of the numerical computation and corresponding to the actual measurement value, finds an acquisition function from plural combinations of values of the initial state and the unknown parameter combined with the evaluation function value, and updates values of the initial state and the unknown parameter so as to minimize a value of the evaluation function based on a value of the acquisition function.

Abstract: A fusion protein of a molecule that recognizes cancer cells or the like and a mutant streptavidin, wherein the fusion protein is for use in the treatment or diagnosis of a cancer, is provided. In the fusion protein, a VHH antibody is bound, via a linker sequence, to the N-terminal side and/or C-terminal side of the amino acid sequence as set forth in SEQ ID NO: 1, provided that the C-terminal amino acid sequence consisting of Pro-Ser-Ala-Ala-Ser-His-His-His-His-His-His may be partially or entirely deleted.

Abstract: Provided is a digital assay method for determining the concentration of a substance in a solution, as a method available for making the operation of digital assay simpler and easier, the method comprising the step of: covering a chamber array region of a substrate with an adhesive tape comprising a base layer and an adhesive layer, followed by pressure-bonding the adhesive layer of the adhesive tape against the surface of the substrate, thereby discharging excess of a solution in the chamber array region outside the chamber array region and sealing each of the chambers containing the solution liquid-tight to function as reactors.

Abstract: To provide translation techniques for translating a natural language representation in one language into a natural language representation in another language using sound. With L1 and L2 being different languages from each other, a translation data generation apparatus includes: a latent variable generation unit that generates, from a natural language representation in the language L1, a latent variable corresponding to the natural language representation in the language L1 using a language L1 encoder; an index calculation unit that calculates an index for the natural language representation in the language L1 from the natural language representation in the language L1; and a natural language representation generation unit that generates a natural language representation in the language L2 corresponding to the natural language representation in the language L1 from the latent variable and the index for the natural language representation in the language L1 using a language L2 decoder.

Abstract: The present invention pertains to hepatocytes, liver progenitor cells, cholangiocytes, liver sinusoidal endothelial progenitor cells, liver sinusoidal endothelial cells, hepatic stellate progenitor cells, hepatic stellate cells, and liver cellular tissue models, as well as to methods for preparing these cells. The present invention also pertains to a cell fraction comprising liver progenitor cells, liver sinusoidal endothelial progenitor cells, or hepatic stellate progenitor cells. The present invention also pertains to a pharmaceutical composition or kit comprising the above-mentioned cells, a liver cellular tissue model, or a cell fraction.

Abstract: A first object of the present invention is to provide a method for producing a cyclic imide compound with high yield and high purity. A second object of the present invention is to provide a composition that can be used in the method for producing a cyclic imide compound with high yield and high purity. A third object of the present invention is to provide an intermediate compound that can be used in the method for producing a cyclic imide compound with high yield and high purity. The method for producing a cyclic imide compound according to the present invention includes reacting a compound represented by formula (1) below with at least one amine compound to obtain a compound represented by formula (2) below.

Abstract: The present invention provides an antibody for detecting mesothelioma and an antibody having high specificity to mesothelioma and high sensitivity thereto. The present invention also provides a method of diagnosis of mesothelioma by using the antibody, a reagent containing the antibody for use in diagnosis of mesothelioma, and a kit comprising the antibody for use in diagnosis of mesothelioma. Further, the present invention provides a marker for use in diagnosis of mesothelioma. Furthermore, the present invention provides a pharmaceutical composition containing the antibody according to the present invention or an antigen-binding fragment thereof for use in treatment of mesothelioma. An antibody that binds to a glycosylated HEG1 protein obtained from mesothelioma.

Abstract: It is an object of the present invention to provide a method of detecting an AAV (adeno-associated virus)-neutralizing antibody with high sensitivity, and tools used in this method (e.g. DNA, cells, etc.).

Abstract: A polar group-containing olefin copolymer comprising a structural unit (A) derived from at least one kind of monomer selected from the group consisting of ethylene and an olefin containing 3 to 20 carbon atoms, and at least one kind of structural unit (B) selected from the group consisting of a structural unit represented by the following general formula (I) and a structural unit selected from the following general formula (II): (reference numerals shown in the general formulae (I) and (II) are as described in the DESCRIPTION.

Abstract: A speech synthesis apparatus according to the present disclosure includes a memory and a processor coupled to the memory. The processor is configured to: obtain utterance information on subjects to be uttered, wherein the subjects to be uttered are texts contained in data on a book, obtain image information on images that are contained in the data on the book, obtain speech data corresponding to the subjects to be uttered; and generate, based on the obtained utterance information, the obtained image information, and the obtained speech data, a speech synthesis model for reading out a text associated with an image.

Abstract: A biomagnetic field measurement processing apparatus includes circuitry; and a memory storing computer-executable instructions that cause the circuitry to execute reconfiguring a current signal from a biomagnetic field signal; extracting a current component from the current signal; and based on the extracted current component, adding to each other at least two current waveforms among current waveforms of a plurality of inward currents that are current components directed toward a nerve axon from around the nerve axon, or adding to each other at least two current waveforms among current waveforms of a plurality of inward currents that are current components directed toward a muscle fiber from around the muscle fiber, and generating a current waveform to be displayed on a display device, according to the at least two current waveforms added to each other.

Abstract: An image extraction device, an image extraction system, an image extraction method, and an image extraction program are capable of extracting an appropriate reference image from a database by using a pathological image as a query. The image extraction device includes: an acquisition unit which acquires a pathological image; a first calculation unit which calculates a local feature amount of the pathological image; a second calculation unit which calculates a non-local feature amount based on a correlation with the local feature amount; a third calculation unit which calculates a degree of similarity between the non-local feature amount and a feature amount of each of a plurality of reference images stored in a database; and an extraction unit which extracts one or more reference images based on the degree of similarity.

Abstract: An energy harvesting device having an energy converting element that converts environmental energy into electric energy, an environmental sensor that is disposed in an identical environment as the energy converting element, and a power supply circuit that receives electricity from the energy converting element and outputs the electricity to an external load. The power supply circuit is configured to change an operation condition of, for example, a voltage converting circuit of the power supply circuit, in accordance with an output of the environmental sensor.

Abstract: It is an object of the present invention to provide an antibody that binds to CADM1 expressed on a cell, wherein the antibody alone is capable of inducing internalization of the antibody and the CADM1 into the cell. Specifically, the present invention relates to an antibody binding to CADM1 (Cell adhesion molecule 1), in which the antibody binds to CADM1 on the surface of a cell and induces internalization of the antibody and the CADM1 into the cell, or an antigen-binding fragment thereof.

Abstract: A biometric information display device includes circuitry, and a memory storing computer-executable instructions that cause the circuitry to display at least one biological signal waveform including a biological signal measured, and display a graphic representation representing a noise level included in the biological signal waveform at a location corresponding to a peak of the biological signal waveform.

Abstract: A biometric apparatus including an irradiation device configured to deliver radiation to a subject, a radiation detector configured to perform radiation imaging on a test site of the subject, and a magnetic detector configured to detect biomagnetism of the subject, the magnetic detector being placed between the radiation detector and the irradiation device.

Abstract: It was found that bacteria belonging to the genus Clostridium induce accumulation of regulatory T cells (Treg cells) in the colon. Moreover, the present inventors found that regulatory T cells (Treg cells) induced by from these bacteria suppressed proliferation of effector T-cells. From these findings, the present inventors found that the use of bacteria belonging to the genus Clostridium or a physiologically active substance derived therefrom made it possible to induce proliferation or accumulation of regulatory T cells (Treg cells), and further to suppress immune functions.