Abstract: Provided is a peptide capable of binding to a receptor binding domain (RBD) in SARS-CoV-2. chemically synthesized easily, having extremely high solubility to ultra-pure water or a buffer solution and a high possibility of being put to practical use as a therapeutic drug for COVID-19.

Abstract: It was found that bacteria belonging to the genus Clostridium induce accumulation of regulatory T cells (Treg cells) in the colon. Moreover, the present inventors found that regulatory T cells (Treg cells) induced by from these bacteria suppressed proliferation of effector T-cells. From these findings, the present inventors found that the use of bacteria belonging to the genus Clostridium or a physiologically active substance derived therefrom made it possible to induce proliferation or accumulation of regulatory T cells (Treg cells), and further to suppress immune functions.

Abstract: Provided is a nanostmcture or a microstmcture comprising a plurality of cyclic molecules, each of which is provided with an opening, and a plurality of chain-like molecules, the nanostmcture or microstructure being such that each of the plurality of chain-like molecules is included in skewered fashion in some of the plurality of cyclic molecules, whereby a plurality of pseudo-polyrotaxanes and/or polyrotaxanes are formed, wherein some or all of the adjacent cyclic molecules in the nanostmcture or microstmcture crosslink with each other.

Abstract: An object of the present invention is to provide a therapeutic agent for arthrosis, which contains synovium-derived mesenchymal stem cells having a molecule essential for joint medical treatment, and a production method for the therapeutic agent for arthrosis. According to the present invention, there is provided a therapeutic agent for arthrosis, which contains synovium-derived mesenchymal stem cells having any one or more kinds of surface antigens of integrin ?1 or platelet-derived growth factor receptor ?.

Abstract: [Object] An object of the present invention is to provide a novel artificial slime-like polymer material capable of controlling flow characteristics without changing a chemical composition such as a main chain skeleton or a solvent constituting the polymer material. [Solution] It is found that a slime-like polymer material in which liquid-liquid phase separation is induced can be provided and fluidity of the polymer material can be controlled by adding a polymer that does not react with a polymer unit serving as a basic skeleton constituting the polymer material in addition to the polymer unit.

Abstract: The present invention provides a peptide having a fluoroalkyl group in the side chain. The present invention provides a peptide in which 2 or more amino acids are peptide-bonded in which at least one side chain of an amino acid residue constituting the peptide is represented by the following General Formula (1) [in the formula, Z1 is a divalent, trivalent, or tetravalent linking group other than an alkylene group; Rf is a C1-30 alkyl group substituted with at least two fluorine atoms, —SF5, or —SF4—CR101R102—CR103R104Cl (R101, R102, R103, and R104 are each independently a hydrogen atom, a fluorine atom, or a chlorine atom, and two or more of R101, R102, R103, and R104 are fluorine atoms); n3 is 1, 2, or 3, and the black circle indicates a bonding site].

Abstract: A control system for a vehicle (1) provided with a differential mechanism (3) that applies a torque difference to left and right wheels (5) and two electric motors (2) coupled to the differential mechanism (3), the control system including: two control units (11, 12) being connected to each other via high-speed communication means and each controlling one of the two electric motors (2); a first rotation speed sensor (26R) that detects a first rotation speed of a first electric motor (2R) of the two electric motors (2) and outputs the first rotation speed to the two control units (11, 12); a second rotation speed sensor (26L) that detects a second rotation speed of a second electric motor (2L) of the two electric motors (2) and outputs the second rotation speed to the two control units (11, 12); and a superordinate control unit (10) that calculates demanded torques of the two electric motors (2) based on vehicle information of the vehicle (1).

Abstract: An object is to provide a novel artificial slime-like polymer material having stability against an external solvent without changing the chemical composition of a main chain skeleton, a solvent, and the like constituting the polymer material and without impairing the viscosity and elasticity of the slime-like material. It has been found that by controlling the number of branches, terminal connectivity, and concentration of polymer units constituting the polymer material, it is possible to provide a slime-like polymer material that induces liquid-liquid phase separation and thereby control solubility in external solvents.

Abstract: Provided is a medium-molecular-weight compound conjugate capable of improving pharmacokinetic profile of a medium-molecular-weight compound, that is easy to obtain, safer to a biological body, and useful in vivo such as a nucleic acid aptamer, and a method of producing the same. The PMPC-medium-molecular-weight compound conjugate of the present invention is obtained by conjugating PMPC (poly-2-(methacryloyloxy)ethyl phosphoryicholine) to a medium-molecular-weight compound.

Abstract: An organic semiconductor element of the present invention includes: an organic semiconductor film formed from single crystal of an organic semiconductor, and a doped layer formed in a surface of the organic semiconductor film. A strain sensor of the present invention includes: the organic semiconductor element, a pair of electrodes which are electrically connected through the doped layer, and a substrate which is deformable, and which has the organic semiconductor element formed on one surface thereof. A vibration sensor of the present invention includes: the organic semiconductor element, a pair of electrodes which are electrically connected through the doped layer, and a substrate which has flexibility, and which is fixed at one end or both ends thereof, the substrate having the organic semiconductor element formed on the surface of the flexible portion of the substrate.

Abstract: Provided are an expression inhibitor of an inflammation promoting factor based on the discovery of a new factor influencing the expression amount/level of an inflammation promoting factor, and a development tool therefor. Provided are also a diagnostic agent and a diagnosis method for immune diseases, inflammatory diseases, painful conditions and similar. More specifically provided are: an expression inhibitor of an inflammation promoting factor containing at least one kind of inhibitor selected from the group consisting of RBMS2 expression inhibitor and RBMS2 function inhibitor; a screening method using as an indicator the expression or the function of RBMS2; an expression cassette useful for the method; as well as a diagnostic agent containing a product detection agent for RBMS2 gene expression and disease detection method using as an indicator RBMS2 gene expression amount/level.

Abstract: An object of the present invention is to provide a method for producing a hydrogel material having a ?m-scale porous structure in a simple manner.

Abstract: The vehicle control device (10) includes: an arithmetic unit (11) that calculates a target slip ratio (y) serving as a target value of a slip ratio (?) of the wheel (5); a limiting unit (12) that sets an upper limit value (ymax) of the target slip ratio (y), the upper limit value (ymax) being based on at least a vehicle velocity (V) of the vehicle (1), and limits the target slip ratio (y) calculated by the arithmetic unit (11) to a value equal to or less than the upper limit value (ymax); and a controlling unit (13) that controls driving torque of the vehicle (1) such that a wheel velocity that achieves the target slip ratio (y) limited by the limiting unit (12) is obtained.

Abstract: The present invention is intended to provide an adjuvant having high safety to living bodies and an action to sufficiently reinforce immune function, and a vaccine comprising the adjuvant. Specifically, the present invention relates to 34 novel adjuvant candidate compounds, which have been identified by screening 145 food additives and 51 injection additives, using, as indicators, an increase in the antibody titer against influenza virus and a protective effect against infection with influenza virus, and then selecting those having the function of increasing the antiviral antibody titer in blood and the protective effect against viral infection. In addition, the present invention also relates to a vaccine comprising these adjuvant candidate compounds.

Abstract: A fluorescent probe can be used to detect and visualize carboxypeptidase activity with high sensitivity. The fluorescent probe has, as a base nucleus, a fluorescent skeleton that functions in the visible light region, and makes carboxypeptidase activity detectable and visible, for example, within a cell or clinical specimen, with high sensitivity.

Abstract: To provide database generation techniques that can accurately and efficiently generate a database useable in text-based sound signal search. A sound signal database generation apparatus includes: a latent variable generation unit that generates, from a sound signal, a latent variable corresponding to the sound signal using a sound signal encoder; a data generation unit that generates a natural language representation corresponding to the sound signal from the latent variable and a condition concerning an index for a natural language representation using a natural language representation decoder; and a sound signal database generation unit that generates a record including the natural language representation corresponding to the sound signal and the sound signal from the natural language representation corresponding to the sound signal and the sound signal, and generates a sound signal database made up of the record.

Abstract: The present invention provides a transistor-based polyamine sensor with which it is possible to detect a polyamine easily and with high sensitivity. Specifically, the present invention provides a transistor-based polyamine sensor comprising a detection site, wherein an organic compound containing a carboxy group and a thiol group is immobilized on all or part of the surface of the detection site via the thiol group of the organic compound, a heavy metal ion is bound to the carboxy group of the organic compound, and a change in threshold voltage caused by bonding of the heavy metal ion to a polyamine is measured to detect the polyamine.

Abstract: A tunnel boring machine includes: a disc cutter including a cutter ring; and a member for use in measurement of a wear amount of the cutter ring with a three-dimensional shape measurement device, in which the member is provided at a part constant in relative position to the cutter ring.

Abstract: An object of the present invention is to provide an ever-better method for producing sinusoidal endothelial cells. The present invention provides a method for producing sinusoidal endothelial cells from sinusoidal endothelial progenitor cells, the method comprising the step of culturing the sinusoidal endothelial progenitor cells in a medium containing one or more substances selected from the interleukin 6 (IL-6) family, for example, oncostatin M (OSM), interleukin 6 (IL-6), or interleukin 11 (IL-11).

Abstract: The present invention is a method for producing a tetrafluorosulfanyl group-containing aryl compound, in which a thioaryl compound represented by General Formula (2) is subjected to a reaction by adding to an olefin compound represented by General Formula (3) in the presence of a radical initiator to synthesize a tetrafluorosulfanyl group-containing aryl compound represented by General Formula (1) [in the formula, A1 is an aryl group which may have a substituent, or a heteroaryl group which may have a substituent; and R1, R2, R3, and R4 are each independently a hydrogen atom, a fluorine atom, or a chlorine atom, and two or more of R1, R2, R3, and R4 are a fluorine atom].