Patents Assigned to University of Toledo
  • Optic Ultrasound Training Simulator
    Publication number: 20190325786
    Abstract: Ocular ultrasound models, and ocular ultrasound training simulators using the same, along with methods of making and using the same, are described.
    Type: Application
    Filed: April 16, 2019
    Publication date: October 24, 2019
    Applicant: The University of Toledo
    Inventors: Kelley Stanko, Yixing Chen, Daniel Brainard
  • Potent phthalate inhibitors of aspartate N-acetyltransferase and selective aspartate pathway inhibitors
    Patent number: 10449168
    Abstract: Phthalate derivatives that are aspartate-P-semialdehyde dehydrogenase (ASADH) inhibitor compounds, aspartate N-acetyltransferase (ANAT) inhibitor compounds, or both, are described, as well as methods of making the same, and methods of using the same.
    Type: Grant
    Filed: August 29, 2016
    Date of Patent: October 22, 2019
    Assignee: The University of Toledo
    Inventors: Ronald E. Viola, Bharani Thangavelu, Vinay Mutthamsetty, Qinzhe Wang, Pravin Bhansali
  • Sn Whisker Growth Mitigation Using NiO Sublayers
    Publication number: 20190314937
    Abstract: Semiconductor layers useable for minimizing or preventing the growth of metal whiskers, as well as devices and methods utilizing the same and kits for making the same, are described.
    Type: Application
    Filed: April 11, 2019
    Publication date: October 17, 2019
    Applicant: The University of Toledo
    Inventors: Vamsi Borra, Daniel G. Georgiev, Srikanth Itapu
  • Compositions and Methods for Reverse Automated Nucleic Acid Synthesis
    Publication number: 20190315794
    Abstract: Methods for reverse automated nucleic acid synthesis, and 5?-H-phosphonates suitable for use in the same, as well as methods for making 5?-H-phosphonates, are described.
    Type: Application
    Filed: April 15, 2019
    Publication date: October 17, 2019
    Applicant: The University of Toledo
    Inventors: Matthew Ellis, Amanda Bryant-Friedrich
  • FUROXANS AS THERAPIES FOR NEURODEGENERATIVE DISORDERS
    Publication number: 20190308959
    Abstract: Furoxan compounds, compositions comprising the same, and methods of making and using the same, are described.
    Type: Application
    Filed: November 14, 2017
    Publication date: October 10, 2019
    Applicant: The University of Toledo
    Inventors: Isaac Schiefer, Zahoor Shah
  • Protocol for preconcentration and quantification of microcystins using LC-MS
    Patent number: 10436794
    Abstract: Methods for detecting and quantifying one or more microcystin compounds in a sample are described. The methods may include a preconcentration step, and generally utilize an LC-MS or LC-MS/MS analysis with an Orbitrap Fusion mass spectrometer. The methods provide excellent recoveries and limits of quantification of microcystins.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: October 8, 2019
    Assignee: The University of Toledo
    Inventors: Dragan Isailovic, Dilrukshika Palagama, Raymond West
  • Biodegradable magnesium alloys and composites
    Patent number: 10426869
    Abstract: Biodegradable, magnesium alloys and composites, articles produced therefrom, methods of making the same, and methods of using the same are described.
    Type: Grant
    Filed: May 5, 2015
    Date of Patent: October 1, 2019
    Assignee: The University of Toledo
    Inventors: Sarit B. Bhaduri, Huan Zhou
  • Nitinol organ positioner to prevent damage to healthy tissue during radiation oncology treatments
    Patent number: 10426976
    Abstract: Devices, systems, and methods for repositioning organs, such as the rectum, during radiation therapy treatments, are described.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: October 1, 2019
    Assignee: The University of Toledo
    Inventors: E. Ishmael Parsai, Mohammad Elahinia
  • Highly selective anti-cancer agents targeting non-small cell lung cancer and other forms of cancer
    Patent number: 10392354
    Abstract: Described herein are analogs of 2-methyl-3-(2-ethynylthiazol-4-yl)cyclopent-2-enol and the corresponding ketone 3-(2-ethynylthiazol-4-yl)-2-methylcyclopent-2-enone, the analogs having terminal alkyne groups at the 2-position of the thiazole ring. These drug-like molecules, referred to as CETZOLE compounds, are useful to treat non-small cell lung cancer and other forms of cancer. Methods of making and using the compounds, methods of treating various diseases, pharmaceutical compositions, and kits are also disclosed.
    Type: Grant
    Filed: September 25, 2018
    Date of Patent: August 27, 2019
    Assignee: The University of Toledo
    Inventors: Viranga Tillekeratne, William Taylor, Sara Fedorka
  • Method for modifying surfaces for better osseointegration
    Patent number: 10369253
    Abstract: In one aspect, there is provided a method for preparing a biocompatible coated substrate. The method generally includes: depositing nucleation amorphous calcium phosphate sites on at least a portion of an outer surface of a substrate by: exposing at least the portion of the outer surface to a mixture having a favorable Ca/P molar ratio, and irradiating with microwave energy; and, stabilizing the deposited nucleation amorphous calcium phosphate sites on the portion of the outer surface. In another aspect, there is provided herein a method for preparing a biocompatible coated substrate.
    Type: Grant
    Filed: October 31, 2012
    Date of Patent: August 6, 2019
    Assignee: The University of Toledo
    Inventors: Sarit B. Bhaduri, Vijay K. Goel, Huan Zhou
  • Functionally Graded All-Graphene Based Free-Standing Materials, Methods of Making and Uses Thereof
    Publication number: 20190233292
    Abstract: Functionally graded graphene materials, methods of making and uses thereof are described.
    Type: Application
    Filed: January 29, 2019
    Publication date: August 1, 2019
    Applicant: The University of Toledo
    Inventors: Syed Reza Rizvi, Sheikh Rasel, Omkar Bhatkar, David Smith
  • SYNTHETIC LIPOPEPTIDE VACCINES AND IMMUNOTHERAPEUTICS
    Publication number: 20190231860
    Abstract: Single molecules useful in vaccine compositions, and methods of making and using the same, are described.
    Type: Application
    Filed: September 26, 2017
    Publication date: August 1, 2019
    Applicant: The University of Toledo
    Inventors: Abhishek R. Vartak, Steven J. Sucheck, Katherine Ann Wall, Anthony Quinn, Marcia F. Mcinerney
  • Bilevel Equalizer for Battery Cell Charge Management
    Publication number: 20190222034
    Abstract: An equalizer circuit provides both passive and active charge transfer between cells in a battery pack to improve charge and discharge efficiency. The equalizer circuit is a bilevel circuit that uses both resistive equalizers and switching equalizers to balance cell charge. The cells may be grouped into size limited sections which are balanced by resistive equalizers. The sections are balanced by switching equalizers to promote increased pack discharge capacity.
    Type: Application
    Filed: January 27, 2017
    Publication date: July 18, 2019
    Applicant: The University of Toledo
    Inventor: Thomas A. Stuart
  • Methods for high yield production of furans from biomass sugars at mild operating conditions
    Patent number: 10351886
    Abstract: Facile methods for high-yield furfural and HMF production from biomass sugars are described. The methods generally involve converting the biomass sugars in high yield to their ketose isomers, resulting in furan production under low temperature and pressure conditions with efficient recycling of the process streams.
    Type: Grant
    Filed: November 27, 2017
    Date of Patent: July 16, 2019
    Assignee: The University of Toledo
    Inventors: Siamak Alipour, Bin Li, Sasidhar Varanasi, Patricia Relue, Sridhar Viamajala
  • Bone graft material mixing and delivery device
    Patent number: 10349994
    Abstract: Described herein are bone graft material (BGM) delivery devices having a tray configured to provide a mixing and/or holding area for BGM to substantially prevent BGM from inadvertently being delivered to an unacceptable surgical site.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: July 16, 2019
    Assignee: The University of Toledo
    Inventors: Hossein Elgafy, Anand K. Agarwal, Vijay K. Goel, Narjes Momeni Shahraki, Amey V. Kelkar
  • Proxisome proliferator activated receptor (PPAR) compounds and methods of using the same
    Patent number: 10351541
    Abstract: Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing osteogenesis and/or chondrogenesis, are disclosed.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: July 16, 2019
    Assignee: The University of Toledo
    Inventors: Bruce E. Heck, Dong Hyun Kim, Paul Erhardt, Brian Kress
  • Iron pyrite nanocrystal film as a copper-free back contact for polycrystalline CdTe thin film solar cells
    Patent number: 10355148
    Abstract: The invention discloses nanocrystalline (NC) FeS2 thin films as the back contact for CdTe solar cells. In one example, the FeS2 NC layer is prepared from a solution directly on the CdTe surface using spin-casting and chemical treatment at ambient temperature and pressure, without a thermal treatment step. Solar cells prepared by applying the NC FeS2 back contact onto CdTe yield efficiencies of about 95% to 100% that of standard Cu/Au back contact devices. In another example, FeS2 is interposed between Cu and Au to form a Cu/FeS2 NC/Au back contact configuration yielding an efficiency improvement of 5 to 9 percent higher than standard Cu/Au devices.
    Type: Grant
    Filed: February 10, 2015
    Date of Patent: July 16, 2019
    Assignee: The University of Toledo
    Inventors: Khagendra Bhandari, Randy J. Ellingson, Rajendra R. Khanal
  • Composite Micro-Sensor for Detecting Free Radicals
    Publication number: 20190212286
    Abstract: A sensor and method for detecting free radicals in a sample includes providing an electrode at least partially coated with: an inner coating of a first material capable of catalyzing rapid electron transfer; and, an outer coating at least partially coating the inner coating. The outer coating can be a second material comprised of a cerium oxide/graphene composite.
    Type: Application
    Filed: January 8, 2019
    Publication date: July 11, 2019
    Applicant: The University of Toledo
    Inventors: Dong-Shik Kim, Surachet Duanghathaipornsuk
  • Bioactive Glass/Polymer Composite Filament, and Methods of Making
    Publication number: 20190210273
    Abstract: Bioactive glass compositions, composites of the bioactive glass compositions with polymers, and 3D printable filaments made from the same, along with methods of making and using the same, are described. In some embodiments, the compositions, composites, and filaments have antibacterial activity.
    Type: Application
    Filed: January 7, 2019
    Publication date: July 11, 2019
    Applicant: The University of Toledo
    Inventors: Aisling Coughlan, Emily Krull
  • Injectable, biodegradable bone cements and methods of making and using same
    Patent number: 10342893
    Abstract: Compositions of, methods of making, and methods of using alkaline earth phosphate bone cements are disclosed. A bone cement composition includes a powder comprising a basic source of calcium, magnesium, or strontium, a setting solution comprising H3PO4 and a buffer, and a biocompatible polymer that is incorporated into the setting solution. The powder is mixed with the setting solution to form a bone cement paste that either (a) sets into a hardened mass, or (b) is irradiated with electromagnetic radiation to form dry powders, the dry powders then being mixed with a second setting solution to form a radiation-assisted bone cement paste that sets into a hardened mass.
    Type: Grant
    Filed: January 31, 2013
    Date of Patent: July 9, 2019
    Assignee: The University of Toledo
    Inventors: Sarit B. Bhaduri, Huan Zhou, Anand K. Agarwal, Vijay K. Goel