Patents Assigned to University of Toledo
  • PROCESS TO PRODUCE HIGH-STRENGTH AND CORROSION RESISTANT ALLOY FOR PATIENT-SPECIFIC BIORESORBABLE BONE FIXATION IMPLANTS AND HARDWARE
    Publication number: 20190001027
    Abstract: A Quaternary Mg—Zn—Ca-based alloy and a heat treatment process for producing bioresorbable bone fixation implants are described thereof. The mechanical and biocorrosion properties of the fabricated Mg-based alloy were improved by combining careful selection of the alloy's chemical composition and subsequent post-shaping process (heat treatments). Heat treatment process is more privileged especially after fabricating the part into its final shape such as in additive manufacturing (3D-printing) and powder metallurgy. In this way, it is possible to produce biocompatible, strong and less corrosive patient-specific bone fixation hardware. Also, such heat-treated Mg—Zn—Ca-based parts can be further coated with various types of biocompatible ceramic coatings for slower and more tailored biocorrosion rates.
    Type: Application
    Filed: December 21, 2016
    Publication date: January 3, 2019
    Applicants: The University of Toledo, Ohio State University
    Inventors: Hamdy IBRAHIM, Mohammad ELAHINIA, Howard David DEAN
  • Injectable, Biodegradable Bone Cements And Methods Of Making And Using Same
    Publication number: 20180369445
    Abstract: Compositions of, methods of making, and methods of using alkaline earth phosphate bone cements are disclosed.
    Type: Application
    Filed: August 30, 2018
    Publication date: December 27, 2018
    Applicant: The University of Toledo
    Inventors: Sarit B. Bhaduri, Huan Zhou, Anand K. Agarwal, Vijay K. Goel
  • Active Flow Control For Ducted Fans And Fan-In-Wing Configurations
    Publication number: 20180346108
    Abstract: Systems, methods, lift fans, and aircraft involving active flow control of a ducted fan or fan-in-wing configuration are described.
    Type: Application
    Filed: May 16, 2017
    Publication date: December 6, 2018
    Applicant: The University of Toledo
    Inventors: Chunhua Sheng, Qiuying Zhao
  • Methods and devices for detection and measurement of analytes
    Patent number: 10145844
    Abstract: Sensors for target entities having functionalized thereon, at least one aptamer specific to the target entity, and methods of making and using the same are described for use in glycated protein monitoring and/or biomarkers.
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: December 4, 2018
    Assignee: The University of Toledo
    Inventors: Brent D. Cameron, Dong-Shik Kim
  • TREATMENT OF RAYNAUD`S PHENOMENON BY INHIBITION OF TRANSIENT RECEPTOR POTENTIAL MELASTATIN-8 (TRPM-8)
    Publication number: 20180338907
    Abstract: Described herein are compositions for, and methods of treating, Raynaud's phenomenon. The compositions comprise a TRPM-8 antagonist formulated in a topical formulation in an amount effective to treat Raynaud's phenomenon.
    Type: Application
    Filed: September 7, 2016
    Publication date: November 29, 2018
    Applicant: The University of Toledo
    Inventors: Bashar Kahaleh, Nezam Altorok, Sai HS. Boddu, Vivek Nagaraja
  • PURIFICATION OF A SOLUBLE AND ACTIVE FORM OF ASPARTATE N-ACETYLTRANSFERASE
    Publication number: 20180340156
    Abstract: Fusion proteins that include N-acetylaspartate synthetase (ANAT) and at least one solubilizing partner, such as glutathione 5-transferase (GST), thioredoxin (TRX), or maltose binding protein (MBP), are described. Also described are methods of making the fusion proteins, methods of solubilizing the fusion proteins, methods of purifying the fusion proteins, and methods of using the fusion proteins.
    Type: Application
    Filed: September 8, 2016
    Publication date: November 29, 2018
    Applicant: The University of Toledo
    Inventors: Ronald E. Viola, Qinzhe Wang, Mojun Zhao, Gwenn Parungao
  • Highly selective anti-cancer agents targeting non-small cell lung cancer and other forms of cancer
    Patent number: 10138216
    Abstract: Described herein are analogues of 2-methyl-3-(2-ethynylthiazol-4-yl)cyclopent-2-enol and the corresponding ketone 3-(2-ethynylthiazol-4-yl)-2-methylcyclopent-2-enone, the analogues having terminal alkyne groups at the 2-position of the thiazole ring. These drug-like molecules, referred to as CETZOLE compounds, are useful to treat non-small cell lung cancer and other forms of cancer. Methods of making and using the compounds, methods of treating various diseases, pharmaceutical compositions, and kits are also disclosed.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: November 27, 2018
    Assignee: The University of Toledo
    Inventors: Viranga Tillekeratne, William Taylor, Sara Fedorka
  • Protocol for Preconcentration and Quantification of Microcystins Using LC-MS
    Publication number: 20180321237
    Abstract: Methods for detecting and quantifying one or more microcystin compounds in a sample are described. The methods may include a preconcentration step, and generally utilize an LC-MS or LC-MS/MS analysis with an Orbitrap Fusion mass spectrometer or a QqQ mass spectrometer. The methods provide excellent recoveries and limits of quantification of microcystins.
    Type: Application
    Filed: July 12, 2018
    Publication date: November 8, 2018
    Applicant: The University of Toledo
    Inventors: Dragan Isailovic, Dilrukshika Palagama, David Baliu-Rodriguez, Bruce S. Levison, David J. Kennedy, Steven T. Haller, Kenneth Hensley
  • Amorphous polyester from bio-based bis-furan assembly
    Patent number: 10100145
    Abstract: Polymers, including polyesters and polycarbonates comprising residue of bis-furan diol, which is produced from renewable furfural feedstock, and methods of making and using those polyesters and polycarbonates are described. The method includes reacting a bis-furan diol with a dicarboxylic acid in the presence of a carbodiimide to produce the bis-furan containing polymers. In certain embodiments, the dicarboxylic acid is succinic acid, the bis-furan diol is the 5,5?-(propane-2,2-diyl)bis(furan-2,5-diyl) dimethanol, and the carbodiimide is of N,N-diisopropylcarbodiimide.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: October 16, 2018
    Assignee: The University of Toledo
    Inventors: Steven Sucheck, Vishwanath Gaitonde, Maria Coleman
  • Bifunctional Bioactive Antibacterial Coatings, and Process for Coating Implant Surfaces Therewith
    Publication number: 20180289858
    Abstract: Bifunctional coatings and implants coated with the same are described, as well as methods and compositions for making the same.
    Type: Application
    Filed: April 6, 2018
    Publication date: October 11, 2018
    Applicant: The University of Toledo
    Inventors: Sarit B. Bhaduri, Vijay K. Goel, Yufu Ren, Prabaha Sikder
  • USE OF ACYL-HOMOSERINE LACTONE DERIVATIVES AS ANTI-THROMBOTIC AGENTS
    Publication number: 20180280345
    Abstract: Uses of acyl-homoserine lactone compounds are described. In particular, uses of acyl-homoserine lactone compounds as anti-thrombotic agents, to inhibit platelets from becoming hypersensitive, and/or to prevent thrombosis, are described.
    Type: Application
    Filed: September 27, 2016
    Publication date: October 4, 2018
    Applicant: The University of Toledo
    Inventors: Randall G. Worth, Glenn R. Westphal, Brenton R. Keeley, Leah M. Wuescher
  • Cross metathesis approach to C11-C13 fatty-chain amino esters from oleic acid derivatives
    Patent number: 10087137
    Abstract: A concise method of producing nylon 11, 12, or 13 precursors from oleic acid or an ester of oleic acid is described. The method involves cross-metathesis reactions as the key C—C bond formation step. Subsequent steps are provided to convert the metathesis product to the corresponding nylon precursors. Also provided are the products of the method.
    Type: Grant
    Filed: June 22, 2015
    Date of Patent: October 2, 2018
    Assignee: The University of Toledo
    Inventors: Kana Yamamoto, Sridhar Viamajala, Sasidhar Varanasi, Kim Nguyen, Godwin Abel, Ajith Yapa Mudiyanselage
  • A BIOSENSOR DEVICE TO DETECT TARGET ANALYTES IN SITU, IN VIVO, AND/OR IN REAL TIME, AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20180271423
    Abstract: A biosensor device for the real-time detection of a target analyte includes a receptor component operatively connected to a transducer component which is adapted to interpret and transmit a detectable signal. The receptor component includes a sensing element capable of detecting and binding to at least one target analyte, and a self-assembled monolayer (SAM) layer. The SAM layer is positioned between and in contact with the sensing element and an electrode such that the sensing element, in the presence of the target analyte, causes a detectable signal capable of being transmitted to the electrode. The SAM layer may include an anti-fouling agent. The transducer component includes an electrode (or set of electrodes that includes a working electrode) and microprocessor configured to screen noise and to pick up a detectable signal, such as impedance change at a very low frequency range.
    Type: Application
    Filed: October 6, 2016
    Publication date: September 27, 2018
    Applicant: The University of Toledo
    Inventors: Anand K. Agarwal, Vijay K. Goel, Dong-Shik Kim, Boren Lin
  • Microalgae harvesting using stimuli-sensitive hydrogels
    Patent number: 10077422
    Abstract: A harvesting device and methods of harvesting (i.e., dewatering) algae are described. The harvesting device and methods involve the use of stimuli-sensitive hydrogels.
    Type: Grant
    Filed: September 13, 2016
    Date of Patent: September 18, 2018
    Assignee: The University of Toledo
    Inventors: Agasteswar Vadlamani, Xiaofei Zhao, Sridhar Viamajala, Sasidhar Varanasi
  • Minimally Invasive Thrombectomy
    Publication number: 20180256177
    Abstract: A minimally invasive blood clot capturing invention made of nitinol The nitinol is shaped into a plurality of fingers to form a frame for a basket and funnel to capture and remove blood clots. The basket and funnel being delivered to the blood clot by a catheter. The basket and funnel are capable of being collapsed within a catheter, capable of being deployed into a blood vessel, and capable of being retracted into the catheter for removal from the blood vessel.
    Type: Application
    Filed: March 13, 2018
    Publication date: September 13, 2018
    Applicant: The University of Toledo
    Inventors: Christopher J. Cooper, Mohammad H. Elahinia, Rajesh Gupta, Hamdy Ibrahim
  • POTENT PHTHALATE INHIBITORS OF ASPARTATE N-ACETYLTRANSFERASE AND SELECTIVE ASPARTATE PATHWAY INHIBITORS
    Publication number: 20180250252
    Abstract: Phthalate derivatives that are aspartate-P-semialdehyde dehydrogenase (ASADH) inhibitor compounds, aspartate N-acetyltransferase (ANAT) inhibitor compounds, or both, are described, as well as methods of making the same, and methods of using the same.
    Type: Application
    Filed: August 29, 2016
    Publication date: September 6, 2018
    Applicant: The University of Toledo
    Inventors: Ronald E. Viola, Bharani Thangavelu, Vinay Mutthamsetty, Qinzhe Wang, Pravin Bhansali
  • Injectable, biodegradable bone cements and methods of making and using same
    Patent number: 10064972
    Abstract: Compositions of, methods of making, and methods of using alkaline earth phosphate bone cements are disclosed. A bone cement composition includes a powder comprising a basic source of calcium, magnesium, or strontium, a setting solution comprising H3PO4 and a buffer, and a biocompatible polymer that is incorporated into the setting solution. The powder is mixed with the setting solution to form a bone cement paste that either (a) sets into a hardened mass, or (b) is irradiated with electromagnetic radiation to form dry powders, the dry powders then being mixed with a second setting solution to form a radiation-assisted bone cement paste that sets into a hardened mass.
    Type: Grant
    Filed: January 31, 2013
    Date of Patent: September 4, 2018
    Assignee: The University of Toledo
    Inventors: Sarit B. Bhaduri, Huan Zhou, Anand K. Agarwal, Vijay K. Goel
  • Back contact layer for photovoltaic cells
    Patent number: 10043922
    Abstract: A photovoltaic cell structure is disclosed that includes a back contact layer that includes single wall carbon nanotube elements. The single wall carbon nanotube (SWNT) back contact is in electrical communication with an adjacent semiconductor layer and provides a buffer characteristic that impedes elemental metal migration from the back contact into the semiconductor active layers. In one embodiment, the SWNT back contact includes a semiconductor characteristic and a buffer characteristic. In another embodiment, the SWNT back contact further includes a metallic characteristic.
    Type: Grant
    Filed: August 13, 2013
    Date of Patent: August 7, 2018
    Assignee: The University Of Toledo
    Inventors: Michael J. Heben, Adam B. Phillips, Rajendra R. Khanal, Victor V. Plotnikov, Alvin D. Compaan
  • Inexpensive, Earth-Abundant, Tunable Hole Transport Material For CdTe Solar Cells
    Publication number: 20180219166
    Abstract: Hole transport layers, electron transport layers, layer stacks, and optoelectronic devices involving perovskite materials and materials used as precursors, and methods of making the same, are described.
    Type: Application
    Filed: January 26, 2018
    Publication date: August 2, 2018
    Applicant: The University of Toledo
    Inventors: Randall J. Ellingson, Khagendra P. Bhandari, Michael Heben, Suneth Watthage, Zhaoning Song
  • METHODS FOR STANDARDIZED SEQUENCING OF NUCLEIC ACIDS AND USES THEREOF
    Publication number: 20180216163
    Abstract: Methods for controlling for non-systematic error in an amplification-based next generation sequencing (NGS) library preparation are described, which method includes using an internal amplification control (IAC) sharing identical priming sites to a native nucleic acid target template of interest in a NGS library preparation.
    Type: Application
    Filed: March 1, 2018
    Publication date: August 2, 2018
    Applicant: The University of Toledo
    Inventors: James C. Willey, Thomas Blomquist, Erin Crawford