Patents Assigned to University of Toledo
  • Magnetic Ionic Liquids, Methods of Making and Uses Thereof as Solvents in the Extraction and Preservation of Nucleic Acids
    Publication number: 20190194643
    Abstract: Described herein are methods for making and using magnetic ionic liquid that have at least one cationic component and at least one anionic component, where at least one of the cationic components or the anionic components is a paramagnetic component. The magnetic ionic liquids are capable of manipulation by an external magnetic field.
    Type: Application
    Filed: March 7, 2019
    Publication date: June 27, 2019
    Applicant: The University of Toledo
    Inventors: Jared L. Anderson, Omprakash Nacham, Kevin D. Clark
  • Carbon Dioxide as a Directing Group for C-H Functionalization Reactions Involving Lewis Basic Amines, Alcohols, Thiols, and Phosphines for the Synthesis of Compounds
    Publication number: 20190185392
    Abstract: Methods of synthesizing compounds using CO2 as a directing group for C—H functionalization, and compounds made thereby, are described.
    Type: Application
    Filed: December 18, 2018
    Publication date: June 20, 2019
    Applicant: The University of Toledo
    Inventors: Michael C. Young, Mohit Kapoor
  • SUBSTITUTED ISOSELENAZOLONE ANTI-INFECTIVE, ANTI-INFLAMMATORY, ANTI-CANCER, CYTOPROTECTIVE, NEUROPROTECTIVE, AND ANTI-OXIDANT AGENTS
    Publication number: 20190161482
    Abstract: Compounds, compositions, and methods for the treatment of infections, inflammation, cancers, tinnitus, Meniere's disease, hearing loss, or bipolar disorder, or for providing cytoprotection against Clostridium difficile toxins, are disclosed.
    Type: Application
    Filed: June 21, 2017
    Publication date: May 30, 2019
    Applicant: The University of Toledo
    Inventors: Steven Sucheck, Sandeep Thanna, Donald Ronning, Alexander Landgraf
  • HYBRID MULTIFUNCTIONAL POSTERIOR INTERSPINOUS FUSION DEVICE
    Publication number: 20190150992
    Abstract: An interspinous stabilization device is provided that more evenly distributes loads throughout the adjacent vertebrae than known interspinous stabilization devices, and further can readily compensate for graft settling so as to maintain continued axial loading of the graft material.
    Type: Application
    Filed: January 28, 2019
    Publication date: May 23, 2019
    Applicant: The University of Toledo
    Inventors: Anand K. Agarwal, Vijay K. Goel, Aakash Agarwal
  • High-Yield Production of Fuels and Petro- and Oleo-Chemical Precursors from Vegetable Oils and Other Liquid Feedstocks in a Continuous-Flow Pyrolysis Reactor With or Without Catalysts
    Publication number: 20190144758
    Abstract: Systems, methods, and materials for pyrolyzing vegetable oil feedstocks to obtain high yields of various products are described.
    Type: Application
    Filed: January 15, 2019
    Publication date: May 16, 2019
    Applicant: The University of Toledo
    Inventors: Yaser Shirazi, Sridhar Viamajala, Sasidhar Varanasi
  • Reactive Oxygen Species-Sensitive Nitric Oxide Synthase Inhibitors for the Treatment of Ischemic Stroke
    Publication number: 20190144377
    Abstract: Disclosed are ROS-sensitive NOS inhibitors, as well as methods of making and using the same.
    Type: Application
    Filed: October 31, 2018
    Publication date: May 16, 2019
    Applicant: The University of Toledo
    Inventors: Kevin M. Nash, Isaac Schiefer, Zahoor Shah
  • Analogs of Proxisome Proliferator Activated Receptor (PPAR) Agonists and Methods of Using the Same
    Publication number: 20190147147
    Abstract: Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing osteogenesis and/or chondrogenesis, are disclosed.
    Type: Application
    Filed: January 14, 2019
    Publication date: May 16, 2019
    Applicant: The University of Toledo
    Inventors: Bruce E. Heck, Dong Hyun Kim, Paul W. Erhardt, Brian J. Kress
  • Magnetic ionic liquids, methods of making and uses thereof as solvents in the extraction and preservation of nucleic acids
    Patent number: 10280416
    Abstract: Described herein are methods for making and using magnetic ionic liquid that have at least one cationic component and at least one anionic component, where at least one of the cationic components or the anionic components is a paramagnetic component. The magnetic ionic liquids are capable of manipulation by an external magnetic field.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: May 7, 2019
    Assignee: The University of Toledo
    Inventors: Jared L. Anderson, Omprakash Nacham, Kevin D. Clark
  • Anti-Infective 2-Aminothiophenes
    Publication number: 20190119296
    Abstract: 2-Aminothiophene derivatives, uses of the same, and methods of making the same, are described.
    Type: Application
    Filed: April 21, 2017
    Publication date: April 25, 2019
    Applicant: The University of Toledo
    Inventors: Steven Sucheck, Jr., Sandeep Thanna, Richard Slayden
  • USE OF ACYL-HOMOSERINE LACTONE DERIVATIVES AS ANTI-THROMBOTIC AGENTS
    Publication number: 20190111023
    Abstract: Uses of acyl-homoserine lactone compounds are described. In particular, uses of acyl-homoserine lactone compounds as anti-thrombotic agents, to inhibit platelets from becoming hypersensitive, and/or to prevent thrombosis, are described.
    Type: Application
    Filed: December 12, 2018
    Publication date: April 18, 2019
    Applicant: The University of Toledo
    Inventors: Randall G. Worth, Glenn R. Westphal, Brenton R. Keeley, Leah M. Wuescher
  • Loading Platform For Three-Dimensional Tissue Engineered Scaffolds
    Publication number: 20190093063
    Abstract: A scaffold-stretching system includes at least one stretchable loading chamber configured to support a scaffold material and a supply of cells, such as human skin substitute cells, and is configured to allow for cultivation of a cellular three-dimensional scaffold; and a mechanical loading system is configured for application of cyclic and static uniaxial tensile mechanical loading on the cellular three-dimensional scaffold, and is configured to mimic the in vivo environment of musculoskeletal, cardiovascular, and other tissues that experience uniaxial strains.
    Type: Application
    Filed: March 3, 2017
    Publication date: March 28, 2019
    Applicant: The University of Toledo
    Inventors: Gayathri Subramanian, Mostafa Elsaadany, Eda Yildirim-Ayan
  • Targeting of Human Glucocorticoid Receptor Beta in Cancer
    Publication number: 20190085337
    Abstract: A peptide nucleic acid (PNA) referred to herein as Sweet-P, compositions comprising the methods of making the same, mid methods of using the same, are described.
    Type: Application
    Filed: March 7, 2017
    Publication date: March 21, 2019
    Applicant: The University of Toledo
    Inventors: Terry D. HINDS, JR., Lucien MCBETH
  • Xenoantigen-displaying anti-cancer vaccines and method of making
    Patent number: 10206988
    Abstract: Compositions, methods of making, and methods of using, xenoantigen-displaying anti-cancer vaccines are described.
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: February 19, 2019
    Assignee: The University Of Toledo
    Inventors: Steven J. Sucheck, Katherine A. Wall, Sourav Sarkar
  • Thin Molecules for the Treatment of Obesity and Type II Diabetes
    Publication number: 20190047952
    Abstract: Thin molecules, compounds producible by cleaving bilirubin at its methylene site in the center of the molecule, methods of making the same, and methods of using the same, are described.
    Type: Application
    Filed: February 27, 2017
    Publication date: February 14, 2019
    Applicant: The University of Toledo
    Inventors: Terry D. Hinds, Jr., David E. Stec, Christopher J. Trabbic
  • COMPOSITIONS USEFUL IN THERAPY OF AUTOPHAGY-RELATED PATHOLOGIES, AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20190040091
    Abstract: Lanthionine ketimine derivatives, and methods of making and using the same, are described. Included are lanthionine ketimine phosphonate (LK-P), lanthionine ketimine ester phosphonate (LKE-P) derivatives, as well as lanthionine ketimine derivatives having a tert-enamide moiety at the 2-position (NVP-LKE).
    Type: Application
    Filed: February 24, 2017
    Publication date: February 7, 2019
    Applicants: The University of Toledo, Washington State University
    Inventors: Kenneth Hensley, Travis Denton
  • Use of acyl-homoserine lactone derivatives as anti-thrombotic agents
    Patent number: 10195177
    Abstract: Uses of acyl-homoserine lactone compounds are described. In particular, uses of acyl-homoserine lactone compounds as anti-thrombotic agents, to inhibit platelets from becoming hypersensitive, and/or to prevent thrombosis, are described.
    Type: Grant
    Filed: September 27, 2016
    Date of Patent: February 5, 2019
    Assignee: The University of Toledo
    Inventors: Randall G. Worth, Glenn R. Westphal, Brenton R. Keeley, Leah M. Wuescher
  • High-yield production of fuels and petro- and oleo-chemical precursors from vegetable oils and other liquid feedstocks in a continuous-flow pyrolysis reactor with or without catalysts
    Patent number: 10190058
    Abstract: Systems, methods, and materials for pyrolyzing vegetable oil feedstocks to obtain high yields of various products are described.
    Type: Grant
    Filed: August 21, 2017
    Date of Patent: January 29, 2019
    Assignee: The University of Toledo
    Inventors: Yaser Shirazi, Sridhar Viamajala, Sasidhar Varanasi
  • Hybrid multifunctional posterior interspinous fusion device
    Patent number: 10188434
    Abstract: This invention relates to an improved structure for an interspinous stabilization device that more evenly distributes loads throughout the adjacent vertebrae than known interspinous stabilization devices, and further readily compensates for graft settling so as to maintain continued axial loading of the graft. More specifically, this invention relates to a medical device that helps in performing a spinal fusion procedure by holding the bone graft in place and stabilizing the facet screw by a plate that is attached to it. The invention also performs a dynamic function that compensates for settling of the bone graft over time. This dynamic function may, if desired, be enhanced by a movement-limiting mechanism that allows extension but not flexion such that the bone graft fusion remains in contact and fusion takes place.
    Type: Grant
    Filed: February 19, 2013
    Date of Patent: January 29, 2019
    Assignee: The University of Toledo
    Inventors: Anand K. Agarwal, Vijay K. Goel, Aakash Agarwal
  • Highly Selective Anti-Cancer Agents Targeting Non-Small Cell Lung Cancer and Other Forms of Cancer
    Publication number: 20190023671
    Abstract: Described herein are analogues of 2-methyl-3-(2-ethynylthiazol-4-yl)cyclopent-2-enol and the corresponding ketone 3-(2-ethynylthiazol-4-yl)-2-methylcyclopent-2-enone, the analogues having terminal alkyne groups at the 2-position of the thiazole ring. These drug-like molecules, referred to as CETZOLE compounds, are useful to treat non-small cell lung cancer and other forms of cancer. Methods of making and using the compounds, methods of treating various diseases, pharmaceutical compositions, and kits are also disclosed.
    Type: Application
    Filed: September 25, 2018
    Publication date: January 24, 2019
    Applicant: The University of Toledo
    Inventors: Viranga Tillekeratne, William Taylor, Sara Fedorka
  • Analogs of proxisome proliferator activated receptor (PPAR) agonists and methods of using the same
    Patent number: 10181018
    Abstract: Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing osteogenesis and/or chondrogenesis, are disclosed.
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: January 15, 2019
    Assignee: The University of Toledo
    Inventors: Bruce E. Heck, Dong Hyun Kim, Paul W. Erhardt, Brian J. Kress