Patents Assigned to University of Toledo
  • Expandable Inter-Vertebral Cage and Method of Installing Same
    Publication number: 20160143747
    Abstract: An intervertebral cage includes a plurality of segments that are connected together by one or more members formed from a shape memory alloy material such that the segments are automatically moved from an initial orientation before implantation/insertion in an intervertebral space to an expanded orientation after implantation/insertion in the intervertebral space. Each of the plurality of segments may have a plurality of passageways or recesses formed therethrough, and wherein a wire formed from a shape memory alloy material extends through each of the plurality of passageways or recesses. The member may be formed from a shape memory alloy material that demonstrates shape memory effects and superelasticity properties, such as nitinol.
    Type: Application
    Filed: July 18, 2014
    Publication date: May 26, 2016
    Applicant: The University of Toledo
    Inventors: Anand K. Agarwal, Vijay K. Goel, Aakash Agarwal, David Dick
  • Catalysts and related processes for producing optically pure beta-lactones from aldehydes and compositions produced thereby
    Patent number: 9334266
    Abstract: Bi-functional cobalt-containing catalysts useful for making stereo specific compounds and compositions, along with methods of making, and uses thereof in the syntheses of optically pure ?-lactones from aldehydes and ketene are described. Precursors, intermediates, compositions, and particular features of the use if the compositions, such as high enantiomeric selectivity, high yield and low mole percent of catalyst useful are provided.
    Type: Grant
    Filed: June 7, 2010
    Date of Patent: May 10, 2016
    Assignee: The University of Toledo
    Inventor: Yun-Ming Lin
  • Polymeric Ionic Liquids, Methods of Making and Methods of Use Thereof
    Publication number: 20160114309
    Abstract: Polymeric ionic liquids, methods of making and methods of using the same are disclosed.
    Type: Application
    Filed: December 15, 2015
    Publication date: April 28, 2016
    Applicant: The University of Toledo
    Inventors: Jared L. Anderson, Fei Zhao, Yunjing Meng, Qichao Zhao
  • Aldose-Ketose Transformation for Separation and/or Chemical Conversion of C6 and C5 Sugars from Biomass Materials
    Publication number: 20160096857
    Abstract: Systems for converting aldose sugars to ketose sugars and separating and/or concentrating these sugars using differences in the sugars' abilities to bind to specific affinity ligands are described.
    Type: Application
    Filed: December 15, 2015
    Publication date: April 7, 2016
    Applicant: The University of Toledo
    Inventors: Sasidhar Varanasi, Patricia A. Relue, Bin Li
  • sGCalphal inhibiting compositions
    Patent number: 9301991
    Abstract: The present invention provides materials and methods useful to treat various sGC?1-expressing cancers. Materials include peptides which interfere with sGC?1's pro-survival functions, thereby resulting in apoptosis of sGC?1-expressing cells. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: April 5, 2016
    Assignee: The University of Toledo
    Inventors: Lirim Shemshedini, Shao-Yong Chen, Changmeng Cai, Chen-Lin Hsieh
  • Thermal energy conversion to electricity
    Patent number: 9297366
    Abstract: A system or methodology for converting thermal energy obtained from solar thermal, photovoltaic, geothermal or industrial waste heat into electrical power is disclosed. The energy efficient way of transferring two steams of liquid solutions containing different concentrations of ionic species is disclosed. The combination of thermal gradient in addition to concentration gradient to improve efficiency, reduce or avoid fouling is disclosed. This invention describes a method of efficient ion migration from concentrated stream to dilute stream thereby improving DC power generation process. The utilization of solar thermal energy from solar collector or concentrating photovoltaic (CPV) generator system or solar thermal power generation (CSP) system provides the additional driving force for ions transport from concentrated stream to dilute stream, apart from the concentration grading to generating power.
    Type: Grant
    Filed: September 3, 2013
    Date of Patent: March 29, 2016
    Assignees: SuGanit Systems Inc., The University of Toledo
    Inventors: Praveen Paripati, Rahul Patil, Gary Glenn Lipscomb, Mahabala Adiga
  • Treatment of cancers with A-8R peptide
    Patent number: 9295686
    Abstract: The present invention provides materials and methods useful to treat various sGC?1-expressing cancers. Materials include peptides which interfere with sGC?1's pro-survival functions, thereby resulting in apoptosis of sGC?1-expressing cells. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits.
    Type: Grant
    Filed: October 30, 2013
    Date of Patent: March 29, 2016
    Assignee: The University of Toledo
    Inventors: Lirim Shemshedini, Shao-Yong Chen, Changmeng Cai, Chen-Lin Hsieh
  • Ionically Crosslinked Polyelectrolytes as Underwater Adhesives as Controlled Release Vehicles
    Publication number: 20160074516
    Abstract: Underwater adhesive materials, methods of making the same, and methods of using the same are described.
    Type: Application
    Filed: March 5, 2015
    Publication date: March 17, 2016
    Applicant: The University of Toledo
    Inventors: Yakov Lapitsky, Yan Huang
  • Stabilized Spinal Fixation Device
    Publication number: 20160058478
    Abstract: A spinal fixation device includes a device body configured for implantation in a human body and a clamp that is formed from shape memory material and attached to the device body.
    Type: Application
    Filed: April 25, 2014
    Publication date: March 3, 2016
    Applicant: The University of Toledo
    Inventors: Anand K. Agarwal, Vijay K. Goel, John R. D'Onofrio, Nathaniel E. DuBois, Jared R. Pack, David J. Taylor
  • Polymeric ionic liquids, methods of making and methods of use thereof
    Patent number: 9249261
    Abstract: Polymeric ionic liquids, methods of making and methods of using the same are disclosed.
    Type: Grant
    Filed: August 10, 2009
    Date of Patent: February 2, 2016
    Assignee: The University of Toledo
    Inventors: Jared L. Anderson, Fei Zhao, Yunjing Meng, Qichao Zhao
  • Aldose-ketose transformation for separation and/or chemical conversion of C6 and C5 sugars from biomass materials
    Patent number: 9242222
    Abstract: Systems for converting aldose sugars to ketose sugars and separating and/or concentrating these sugars using differences in the sugars' abilities to bind to specific affinity ligands are described.
    Type: Grant
    Filed: April 19, 2011
    Date of Patent: January 26, 2016
    Assignee: The University of Toledo
    Inventors: Sasidhar Varanasi, Patricia Relue, Bin Li
  • Analogs of Peroxisome Proliferator Activated Receptor (PPAR) Agonists, and Methods of Using the Same
    Publication number: 20160016920
    Abstract: Analogs of PPAR5 and analogs of 20-OH-PGE2, which are PPAR5 agonists and 20-OH-PGE2 antagonists, respectively, and methods of using the same for inducing osteogenesis or chondrogenesis, are disclosed.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 21, 2016
    Applicant: The University of Toledo
    Inventors: Bruce E. Heck, Dong Hyun Kim, Paul Erhardt, Brian Kress
  • Ultrastable Silver Nanoparticles
    Publication number: 20160009736
    Abstract: Ultrastable silver nanoparticles, methods of making the same, and methods of using the same, are disclosed.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 14, 2016
    Applicant: The University of toledo
    Inventors: Terry BIGIONI, Anil DESIREDDY, Brian CONN
  • Methods and devices for detecting unsaturated compounds
    Patent number: 9228966
    Abstract: A method for detecting an unsaturated compound, the method comprising monitoring change in electrical properties of a substance that reacts or interacts with unsaturated compounds.
    Type: Grant
    Filed: November 24, 2010
    Date of Patent: January 5, 2016
    Assignee: The University of Toledo
    Inventors: Abdul-Majeed Azad, Desikan Sundararajan, Robert Howard Kinner
  • Na/K-ATPase-derived peptide Src inhibitors and ouabain antagonists and uses thereof
    Patent number: 9226952
    Abstract: A novel Src inhibitor that targets the Na/K-ATPase/Src receptor complex and antagonizes ouabain-induced protein kinase cascades and uses thereof are disclosed.
    Type: Grant
    Filed: March 3, 2014
    Date of Patent: January 5, 2016
    Assignee: The University of Toledo
    Inventors: Zi-Jian Xie, Zhichuan Li, Joseph I. Shapiro
  • Na/K-ATPase Ligand and Uses Thereof in Wound Healing
    Publication number: 20150342966
    Abstract: Methods and compositions for detecting, treating, characterizing, and diagnosing interstitial lung and/or fibrotic diseases are described.
    Type: Application
    Filed: July 6, 2015
    Publication date: December 3, 2015
    Applicant: The University of Toledo
    Inventors: Zi-Jian Xie, Joseph I. Shapiro
  • Methods for Standardized Sequencing of Nucleic Acids and Uses Thereof
    Publication number: 20150292001
    Abstract: Methods for standardized sequencing of nucleic acids and uses thereof are described. The identification of genetic information is becoming a key piece of information for the diagnosis and treatment of many diseases. In order to make such diagnostic tool readily available, it is desired that this identification be as efficient and as inexpensive as possible.
    Type: Application
    Filed: November 25, 2013
    Publication date: October 15, 2015
    Applicant: The University of Toledo
    Inventors: James C. Willey, Thomas Blomquist, Erin Crawford
  • Photovoltaic structures having a light scattering interface layer and methods of making the same
    Patent number: 9159851
    Abstract: Photovoltaic (PV) cell structures having an integral light scattering interface layer configured to diffuse or scatter light prior to entering a semiconductor material and methods of making the same are described.
    Type: Grant
    Filed: May 26, 2011
    Date of Patent: October 13, 2015
    Assignee: The University of Toledo
    Inventors: Xiangxin Liu, Alvin D. Compaan, Naba Raj Paudel
  • Na/K-ATPase Ligands, Ouabain Antagonists, Assays and Uses Thereof
    Publication number: 20150272923
    Abstract: The present disclosure relates to methods of inhibiting the ATPase activity of Na/K-ATPase without stimulating the receptor function, methods of blocking Na/K-ATPase interaction with Src, methods of inhibiting cell growth, and methods of abolishing ouabain-provoked signaling transduction in the heart of a subject, which includes providing an effective amount of at least one hydroxyl xanthone derivative.
    Type: Application
    Filed: June 11, 2015
    Publication date: October 1, 2015
    Applicant: The University of Toledo
    Inventors: Zi-Jian Xie, Joseph I. Shapiro, Shuyi Si, Zhongbing Zhang
  • Methods and devices for detecting unsaturated compounds
    Patent number: 9146226
    Abstract: A sensor for detecting the presence of unsaturated compounds, the sensor comprising: a semiconductor material doped with a metal halide in electrical connection with a monitoring device.
    Type: Grant
    Filed: May 29, 2012
    Date of Patent: September 29, 2015
    Assignee: The University of Toledo
    Inventors: Abdul-Majeed Azad, Desikan Sundararajan, Robert Howard Kinner