Patents Assigned to University of Toledo
  • Minimally Invasive Collapsible Cage
    Publication number: 20170128228
    Abstract: An articulating fusible support cage comprises a first support member having a first and second end and a second support member having a first and second end. A first end cap is pivotally connected to the first and second support members at the first ends. The first end cap supports a jackscrew for rotation. A second end cap is pivotally connected to the first and second support members at the second ends opposite the first ends. The second end cap has a threaded sleeve configured to engage a portion of the jackscrew. Rotation of the jackscrew into the threaded sleeve causes the first and second support members to extend outwardly from a collapsed condition to a deployed condition.
    Type: Application
    Filed: December 9, 2016
    Publication date: May 11, 2017
    Applicant: The University of Toledo
    Inventors: Vijay K. Goel, Aaron Matyas
  • Compositions and Methods of Treatment of Cancers
    Publication number: 20170114097
    Abstract: Described herein are compositions and methods useful to treat cancers. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits.
    Type: Application
    Filed: December 9, 2016
    Publication date: April 27, 2017
    Applicant: The University of Toledo
    Inventors: Lirim Shemshedini, Shao-Yong Chen, Changmeng Cai, Chen-Lin Hsieh
  • Antibacterial Surfactant/Microgel Formulations, Methods of Making and Methods of Using the Same
    Publication number: 20170099838
    Abstract: Formulations having, as active agents, at least one quaternized polymeric microgel and at least one nonionic surfactant, methods of making, and methods of using are described.
    Type: Application
    Filed: December 19, 2016
    Publication date: April 13, 2017
    Applicant: The University of Toledo
    Inventors: Yakov Lapitsky, Youngwoo Seo, Kristopher Richardson
  • System for Simultaneous Isomerization and Fermentation of Sugars
    Publication number: 20170101613
    Abstract: Methods and systems for the isomerization and fermentation of xylose and hexose sugars using an immobilized enzyme system capable of sustaining two different pH microenvironments in a single vessel are disclosed. Bilayer particles are dispersed in a mixture comprising an ionic borate source and xylose. The bilayer particles have a first region with a first enzymatic activity comprising xylose isomerase and a pH of 6 or above, and a second region having a second enzymatic activity at an acidic pH.
    Type: Application
    Filed: December 22, 2016
    Publication date: April 13, 2017
    Applicant: The University of Toledo
    Inventors: Sasidhar Varanasi, Kripa Rao, Patricia Ann Relue, Dawei Yuan
  • Microalgae Harvesting Using Stimuli-Sensitive Hydrogels
    Publication number: 20170088811
    Abstract: A harvesting device and methods of harvesting (i.e., dewatering) algae are described. The harvesting device and methods involve the use of stimuli-sensitive hydrogels.
    Type: Application
    Filed: September 13, 2016
    Publication date: March 30, 2017
    Applicant: The University of Toledo
    Inventors: Agasteswar Vadlamani, Xiaofei Zhao, Sridhar Viamajala, Sasidhar Varanasi
  • Xenoantigen-Displaying Anti-Cancer Vaccines and Method of Making
    Publication number: 20170072037
    Abstract: Compositions, methods of making, and methods of using, xenoantigen-displaying anti-cancer vaccines are described.
    Type: Application
    Filed: November 28, 2016
    Publication date: March 16, 2017
    Applicant: The University of Toledo
    Inventors: Steven J. Sucheck, Katherine A. Wall, Sourav Sarkar
  • Biodegradable Magnesium Alloys and Composites
    Publication number: 20170072103
    Abstract: Biodegradable, magnesium alloys and composites, articles produced therefrom, methods of making the same, and methods of using the same are described.
    Type: Application
    Filed: May 5, 2015
    Publication date: March 16, 2017
    Applicant: The University of Toledo
    Inventors: Sarit B. Bhaduri, Huan Zhou
  • Amine-terminated aptamer functionalized surface plasmon resonanace sensors, methods of making and methods of using same
    Patent number: 9562266
    Abstract: Sensors for target entities having functionalized thereon, at least one amine-terminated aptamer specific to the target entity, and methods of making and using the same are described.
    Type: Grant
    Filed: January 14, 2013
    Date of Patent: February 7, 2017
    Assignee: The University of Toledo
    Inventors: Brent D. Cameron, Dong-Shik Kim, Rui Zheng, Byung-Wook Park
  • Methods for production of fatty acid alkanolamides (FAAAs) from microalgae biomass
    Patent number: 9562210
    Abstract: Provided herein are methods for fatty acid alkanolamide (FAAA) synthesis and isolation from lipid-containing algal biomass, and the products of such methods.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: February 7, 2017
    Assignee: The University of Toledo
    Inventors: Kana Yamamoto, Sridhar Viamajala, Sasidhar Varanasi, Ajith Yapa Mudiyanselage, Pramod Prasad Poudel
  • Catalysts and Related Processes For Producing Optically Pure Beta-Lactones From Aldehydes and Compositions Produced Thereby
    Publication number: 20170021343
    Abstract: Bi-functional cobalt-containing catalysts useful for making stereospecific compounds and compositions, along with methods of making, and uses thereof in the syntheses of optically pure ?-lactones from aldehydes and ketene are described. Precursors, intermediates, compositions, and particular features of the use if the compositions, such as high enantiomeric selectivity, high yield and low mole percent of catalyst useful are provided.
    Type: Application
    Filed: April 15, 2016
    Publication date: January 26, 2017
    Applicant: The University of Toledo
    Inventor: Yun-Ming Lin
  • Compositions and methods of treatment of cancers
    Patent number: 9546196
    Abstract: Described herein are compositions and methods useful to treat cancers. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: January 17, 2017
    Assignee: The University of Toledo
    Inventors: Lirim Shemshedini, Shao-Yong Chen, Changmeng Cai, Chen-Lin Hsieh
  • Enhancement of Lignocellulose Saccharification Via A Low Temperature Ionic Liquid Pre-Treatment Scheme
    Publication number: 20170009265
    Abstract: A method for pretreating lignocellulosic biomass having a lignin component, a hemicellulose component, and a cellulose component, for conversion to sugar is disclosed. Also disclosed is the pretreated lignocellulosic biomass resulting from the method.
    Type: Application
    Filed: February 16, 2015
    Publication date: January 12, 2017
    Applicant: The University of Toledo
    Inventors: Constance A. Schall, Samira Vasheghani Farahani
  • Amorphous polyester from bio-based bis-furan assembly
    Patent number: 9527952
    Abstract: Polymers, including Polyesters and Polycarbonates comprising residue of bis-furan diol, which is produced from renewable furfural feedstock and methods of making and using of those polyesters and polycarbonates are described. The method includes reacting a bis-furan diol with a dicarboxylic acid in the presence of a carbodiimide to produce the bis-furan containing polymers. In certain embodiments, the dicarboxylic acid is succinic acid; the bis-furan diol is the 5,5?-(propane-2,2-diyl)bis(furan-2,5-diyl) dimethanol and the carbodiimide is of N,N-diisopropylcarbodiimide.
    Type: Grant
    Filed: February 13, 2015
    Date of Patent: December 27, 2016
    Assignee: The University of Toledo
    Inventors: Steven Sucheck, Vishwanath Gaitonde, Maria Coleman
  • System for simultaneous isomerization and fermentation of sugars
    Patent number: 9528104
    Abstract: Methods and systems for the isomerization and fermentation of xylose and hexose sugars using an immobilized enzyme system capable of sustaining two different pH microenvironments in a single vessel are disclosed. Bilayer particles are dispersed in a mixture comprising an ionic borate source and xylose. The bilayer particles have a first region with a first enzymatic activity comprising xylose isomerase and a pH of 6 or above, and a second region having a second enzymatic activity at an acidic pH.
    Type: Grant
    Filed: July 31, 2013
    Date of Patent: December 27, 2016
    Assignee: The University of Toledo
    Inventors: Sasidhar Varanasi, Kripa Rao, Patricia Ann Relue, Dawei Yuan
  • Materials and methods for quality-controlled two-color RT-QPCR diagnostic testing of formalin fixed embedded and/or fresh-frozen samples
    Patent number: 9528161
    Abstract: Described herein are materials, methods, and kits enabling accurate and reproducible two-color reverse-transcription real-time quantitative PCR (RT-qPCR) for quality-controlled molecular diagnostic testing of samples that may contain degraded RNA. In certain aspects described herein are materials, methods, and kits for use in the molecular diagnostic testing of lung cancer in FFPE samples and/or fresh-frozen samples. Also described herein are materials and methods to control for inter-experimental variation occurring during two-color RT-qPCR amplification arising from variation in fluorescence specific activity, use of different thermocyclers, and inter-laboratory differences.
    Type: Grant
    Filed: February 11, 2015
    Date of Patent: December 27, 2016
    Assignee: The University of Toledo
    Inventors: James C. Willey, Jiyoun Yeo, Erin Crawford
  • Peptide Nanotubes for Slow Release of Drugs at Peripheral Nerve Injury
    Publication number: 20160361255
    Abstract: Described herein are materials and methods useful for the treatment of neurodegenerative disorders in a subject. Materials described herein include polysaccharide digestive products resulting from the enzymatic hydrolysis of low acyl gellan gum.
    Type: Application
    Filed: June 9, 2016
    Publication date: December 15, 2016
    Applicant: The University of Toledo
    Inventors: Joshua Park, Dong Shik Kim, Nicholas Chiaia
  • Iron Pyrite Nanocrystal Film As A Copper-Free Back Contact For Polycrystalline CdTe Thin Film Solar Cells
    Publication number: 20160351736
    Abstract: The invention discloses nanocrystalline (NC) FeS2 thin films as the back contact for CdTe solar cells. In one example, the FeS2 NC layer is prepared from a solution directly on the CdTe surface using spin-casting and chemical treatment at ambient temperature and pressure, without a thermal treatment step. Solar cells prepared by applying the NC FeS2 back contact onto CdTe yield efficiencies of about 95% to 100% that of standard Cu/Au back contact devices. In another example, FeS2 is interposed between Cu and Au to form a Cu/FeS2 NC/Au back contact configuration yielding an efficiency improvement of 5 to 9 percent higher than standard Cu/Au devices.
    Type: Application
    Filed: February 10, 2015
    Publication date: December 1, 2016
    Applicant: The University of Toledo
    Inventors: Khagendra Bhandari, Randy J. Ellingson, Rajendra R. Khanal
  • Aptamers for detection and measurement of analytes
    Patent number: 9494582
    Abstract: Sensors for target entities having functionalized thereon, at least one aptamer specific to the target entity, and methods of making and using the same are described for use in glycated protein monitoring and/or biomarkers.
    Type: Grant
    Filed: July 31, 2014
    Date of Patent: November 15, 2016
    Assignee: The University of Toledo
    Inventors: Brent D. Cameron, Dong-Shik Kim
  • Na/K-ATPase ligand and uses thereof in wound healing
    Patent number: 9492463
    Abstract: Methods and compositions for detecting, treating, characterizing, and diagnosing interstitial lung and/or fibrotic diseases are described.
    Type: Grant
    Filed: July 6, 2015
    Date of Patent: November 15, 2016
    Assignee: The University of Toledo
    Inventors: Zi-Jian Xie, Joseph I. Shapiro
  • Integrated Magneto-Optic Modulator/Compensator System, Methods of Making, and Methods of Using the Same
    Publication number: 20160324452
    Abstract: Described herein is an integrated Faraday modulator and Faraday compensator (IFMC) system. Further described are methods of making an IFMC system, methods of customizing an IFMC system for a specific application, and methods of optimizing an IFMC system for a specific application. Further described is a robust 3D Finite Element Model (FEM) for designing and optimizing an IFMC system. Further described are optical instruments comprising an integrated Faraday modulator and Faraday compensator requiring only one optical crystal.
    Type: Application
    Filed: July 19, 2016
    Publication date: November 10, 2016
    Applicant: The University of Toledo
    Inventors: Brent D. Cameron, Brandon W. Clarke