Patents Assigned to University of Tsukuba
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Publication number: 20250147498Abstract: An information processing method, an information processing system, and a recording medium are provided.Type: ApplicationFiled: January 10, 2025Publication date: May 8, 2025Applicants: Tokyo Electron Limited, University of TsukubaInventors: Jun TAMURA, Tsuyoshi MORIYA, Yuki KATAOKA, Akira IMAKURA, Tetsuya SAKURAI, Yasunori FUTAMURA, Xiucai YE
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Patent number: 12265026Abstract: A phase gradient calculation unit calculates a phase gradient on a plane intersecting an irradiation direction of light corresponding to an optical coherence tomography signal indicating a state of a sample for each of sample points arranged on the plane. A bulk phase error calculation unit integrates, for each of plurality of paths from an origin that is a sample point where a bulk phase error is determined to a destination that is a sample point where the bulk phase error is not determined, the phase gradient for each of the sample points along each of the plurality of corresponding paths to calculate a path specific phase error at the destination, and combines the path specific phase errors among the plurality of corresponding paths to determine the bulk phase error at the destination.Type: GrantFiled: November 13, 2020Date of Patent: April 1, 2025Assignee: University of TsukubaInventors: Yoshiaki Yasuno, Daisuke Oida, Kensuke Oikawa
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Publication number: 20250057628Abstract: A medical imaging device according to the present invention includes an illumination unit 11 that spot-illuminates a center of operative field of a surgical patient, an operative field camera unit 12 that images a center of irradiation range by the illumination unit 11, a housing 13 that covers the illumination unit 11 and the operative field camera unit 12, and a pair of display units 14 and 14 that are visible from both sides of the surgical patient.Type: ApplicationFiled: December 15, 2022Publication date: February 20, 2025Applicants: University of Tsukuba, Yamada Shadowless Lamp Co., Ltd.Inventors: Tatuya Oda, Kazuaki Yamazaki, Toshihiro Suzuki, Hiroyuki Urashima
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Patent number: 12178939Abstract: A medical instrument in which an inorganic salt solid such as apatite into which a peptide hormone or the like is embedded is placed so that a metal or the like is coated therewith, in which the inorganic salt solid is provided by controlled delay co-precipitation or the like in an unstable supersaturated calcium phosphate solution, and the medical instrument is exposed to ionizing radiation at a dose sufficient for sterilization.Type: GrantFiled: January 30, 2020Date of Patent: December 31, 2024Assignees: Cell-Medicine, Inc., National Institute of Advanced Industrial Science and Technology, University of Tsukuba, Nihon Parkerizing Co., Ltd.Inventors: Tadao Ohno, Mayu Yasunaga, Atsuo Ito, Yu Sogo, Fumiko Kobayashi
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Publication number: 20240395547Abstract: This semiconductor apparatus has a base film and a semiconductor film formed on the base film, wherein the base film comprises a polyimide obtained by condensation polymerization of an aromatic diamine and an aromatic tetracarboxylic acid anhydride and has a tensile elasticity in the machine direction of 7 GPa or more, and the semiconductor film is polycrystalline and comprises crystal particles having an average particle size of 1 ?m or more.Type: ApplicationFiled: July 26, 2022Publication date: November 28, 2024Applicants: University of Tsukuba, TOYOBO CO., LTD.Inventors: Kaoru TOKO, Muneatsu NAKAMURA, Satoshi MAEDA
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Patent number: 12060562Abstract: An expression system is provided, including a first nucleic acid fragment containing a long intergenic region (LIR) derived from geminivirus, a small intergenic region (SIR) derived from geminivirus, and an expression cassette of a target protein linked between the LIR and the SIR and a second nucleic acid fragment containing an expression cassette of a Rep/RepA protein derived from geminivirus, in which the expression cassette of the target protein includes a promoter, a nucleic acid fragment encoding the target protein, and two or more linked terminators in this order.Type: GrantFiled: March 6, 2018Date of Patent: August 13, 2024Assignee: University of TsukubaInventors: Kenji Miura, Hiroshi Ezura, Ken Hoshikawa
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Publication number: 20240180485Abstract: The present invention provides a method for inducing a hibernation-like state and an apparatus therefor. According to the present invention, provided is a method for decreasing a theoretical setpoint temperature of body temperature and a feedback gain of heat generation in a subject or a method for inducing a hibernation-like state in a subject, the method being a chemical and/or physical method including providing an excitatory stimulus to a pyroglutamylated RFamide peptide (QRFP)-producing neuron. According to the present invention, an apparatus used to practice this method is also provided.Type: ApplicationFiled: March 30, 2022Publication date: June 6, 2024Applicants: University of Tsukuba, RIKENInventors: Takeshi SAKURAI, Genshiro SUNAGAWA
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Patent number: 11944579Abstract: A biological activity detection apparatus includes: a drive unit that actively or passively drives in conjunction with a limb motion of a subject; a periarticular detection unit that detects a periarticular physical quantity around a joint in association with the limb motion of the subject based on an output signal from the drive unit; a biological signal detection unit located at a body surface site of the subject with reference to the joint and includes an electrode group for detecting a biological signal of the subject, wherein an activity status of a musculoskeletal system and/or a transmission status of a peripheral nervous system around the joint are converted into quantitative musculoskeletal system data and/or nervous system data on the basis of the physical quantity acquired from the periarticular detection unit and a myogenic potential signal and a neural transmission signal which are acquired from the biological signal processing unit.Type: GrantFiled: August 24, 2017Date of Patent: April 2, 2024Assignees: CYBERDYNE Inc., University of TsukubaInventor: Yoshiyuki Sankai
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Patent number: 11934558Abstract: A distributed data integration device includes an acquisition unit configured to acquire, for a piece of analysis target data, an anchor data intermediate representation and an analysis target intermediate representation, the anchor data intermediate representation being an intermediate representation obtained by converting anchor data by a first function, the anchor data being data commonly used in integration of a plurality of the pieces of analysis target data that are distributed, the analysis target intermediate representation being an intermediate representation obtained by converting the analysis target data by the first function, an anchor data conversion unit configured to convert, for the piece of analysis target data, a plurality of the anchor data intermediate representations by a second function, a calculation unit configured to calculate, for the piece of analysis target data, the second function that minimizes a difference between the plurality of the anchor data intermediate representations, aType: GrantFiled: December 18, 2019Date of Patent: March 19, 2024Assignee: University of TsukubaInventors: Akira Imakura, Tetsuya Sakurai
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Publication number: 20240029434Abstract: A non-transitory computer-readable recording medium has stored therein a program that causes a computer to execute a process, the process including acquiring movie data including a plurality of consecutive frames calculating first likelihood of a class of the movie data by inputting the acquired movie data to a trained model, calculating an optical flow indicating movement of an area included in the movie data, based on the movie data generating occluded movie data by setting an occluded area in each of the frames included in the movie data, based on the optical flow, calculating second likelihood of a class of the occluded movie data by inputting the occluded movie data to the model identifying an area that affects identification of the class among areas in the movie data, based on the first likelihood and the second likelihood and displaying the identified area that affects identification of the class.Type: ApplicationFiled: July 19, 2022Publication date: January 25, 2024Applicants: FUJITSU LIMITED, University of TsukubaInventors: Tomoki UCHIYAMA, Naoya SOGI, Koichiro NIINUMA, Kazuhiro FUKUI
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Publication number: 20240000829Abstract: An objective of the present invention is to provide a self-assembled polymer micelle-type ornithine donor, which has high bioavailability, low toxicity, and high therapeutic effectiveness, even when provided by oral administration. Another objective of the present invention is to provide a self-assembled polymer micelle-type ornithine donor which is effective in preventing or treating hepatic disorders. In order to achieve the above objectives, an acyl group is introduced into the primary amino group in the side chain of an ornithine unit in the poly(ornithine) segment of poly(ethylene glycol)-b-poly(ornithine), which spontaneously forms polymer micelles without polyion complex formation.Type: ApplicationFiled: November 9, 2021Publication date: January 4, 2024Applicant: University of TsukubaInventors: Yukio NAGASAKI, Yaroslav LEE, Long Binh VONG, Yuta KODA, Yuanyuan DING
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Publication number: 20230364303Abstract: [Object] Provided is a method of producing a nerve fascicle including efficiently extending axons of neural cells. [Solution] Neural cells are cultivated in the presence of feeder cells including at least one type of cells selected from the group consisting of vascular component cells, perivascular cells, and oligodendrocytes.Type: ApplicationFiled: September 17, 2021Publication date: November 16, 2023Applicant: University of TsukubaInventors: Hiroshi ISHIKAWA, Aiki MARUSHIMA, Yuji MATSUMARU, Masao KODA, Akira MATSUMURA, Hiroki BUKAWA, Akihiro OHYAMA, Junko TOYOMURA, Miho WATANABE, Tetsuya ABE, Shohei TAKAOKA, Yosuke SHIBAO, Hideaki MATSUMURA
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Patent number: 11787037Abstract: [Problem] Learning of object operation skills robust against variation of conditions is implemented. [Solution] A behavior estimation apparatus 100 includes a collection unit 200 configured to collect skill data obtained when a slave robot is operated under a plurality of different conditions by using a bilateral system capable of operating the slave robot via a master robot through bidirectional control between the master robot and the slave robot. The behavior estimation apparatus 100 further includes a behavior estimation device 300 configured to estimate a command value for causing the slave robot 520 to automatically behave, based on the skill data collected by the collection unit 200 and a response output from the slave robot 520.Type: GrantFiled: March 20, 2019Date of Patent: October 17, 2023Assignee: University of TsukubaInventor: Sho Sakaino
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Publication number: 20230316700Abstract: An information processing apparatus acquires an image; generates a shielding image in which a part of an area included in an area of the acquired image has been shielded; calculates, by inputting the image to a first model that has been trained, first likelihood of the target object included in the image; calculates, by inputting the shielding image to a second model that calculates an approximation value of likelihood of the target object included in the image when the image is input, second likelihood corresponding to the approximation value of the likelihood of the target object included in the shielding image; specifies, based on the first likelihood and the second likelihood, an area that affects discrimination of the class and that is included in the area of the image; and displays the specified area that affects discrimination of the class.Type: ApplicationFiled: March 31, 2022Publication date: October 5, 2023Applicants: FUJITSU LIMITED, University of TsukubaInventors: Naoya SOGI, Tomoki UCHIYAMA, Kazuhiro FUKUI, Koichiro NIINUMA
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Patent number: 11774447Abstract: This invention provides a method for diagnosis of rheumatoid arthritis of a subject, a method for assisting diagnosis of rheumatoid arthritis, and a method for monitoring disease activity of rheumatoid arthritis and/or therapeutic effects of an agent for rheumatoid arthritis, comprising detecting citrullination of an arginine residue of the inter-?-trypsin inhibitor heavy chain (ITIH) 4 in a biological sample obtained from the subject. This invention also provides a citrullinated protein derived from the protein having the amino acid sequence as shown in SEQ ID NO: 1 or 5 by modification of arginine 438 into citrulline or a fragment thereof, an antibody binding to such citrullinated protein, and an agent for diagnosis of rheumatoid arthritis comprising such antibody.Type: GrantFiled: July 2, 2018Date of Patent: October 3, 2023Assignee: University of TsukubaInventors: Isao Matsumoto, Takayuki Sumida, Hoshimi Kawaguchi
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Patent number: 11746316Abstract: Proposed are a three-dimensional structuring method of cells and a three-dimensional structuring system of cells capable of efficiently bonding multiple cell clusters in a three-dimensional direction, pursuant to their growth, while ensuring safety. A plurality of fibers, in which one end of each of the fibers is held by a flat plate, are inserted together with the flat plate into a flow path through which a culture solution is supplied, a plurality of cell clusters are placed in the flow path upon causing the cell clusters to run with a liquid flow of the culture solution, and each of the cell clusters is cultured by being stacked on an outer surface of each of the fibers with the flat plate as a growth origin.Type: GrantFiled: June 9, 2017Date of Patent: September 5, 2023Assignees: CYBERDYNE Inc., University of TsukubaInventor: Yoshiyuki Sankai
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Patent number: 11672721Abstract: A motion assisting apparatus includes a multijoint structure having links in series rotatably connected in a relative manner, the links being integrally deformed in a bendable manner, a linear member inserted through each of the links, wherein one end is fixed to the link in front and another end is elongated via the link in rear, a sliding/holding part which fixes an elongated portion of the linear member, and slidably guides the rear link in a connecting direction between each of the links, a drive unit which drives the rear link to slide toward the sliding/holding part and causes the multijoint structure, through which the linear member has been inserted, to engage in an extending or flexing motion, and a control unit which drive-controls the drive unit so that a sliding direction, a sliding speed and a sliding position of the rear link will become an intended state.Type: GrantFiled: March 21, 2017Date of Patent: June 13, 2023Assignees: CYBERDYNE, INC., University of TsukubaInventor: Yoshiyuki Sankai
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Patent number: 11673867Abstract: The present invention aims to provide a novel low-molecular-weight compound showing an orexin receptor agonist activity and expected to be useful as a prophylactic or therapeutic agent for narcolepsy and the like. The present invention provides a compound represented by the formula (I): wherein each symbol is as described in the description, or a pharmaceutically acceptable acid addition salt thereof, which has an orexin receptor agonist activity, and an orexin receptor agonist containing the compound or a pharmaceutically acceptable acid addition salt thereof.Type: GrantFiled: December 11, 2018Date of Patent: June 13, 2023Assignees: University of Tsukuba, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Hiroshi Nagase, Tsuyoshi Saitoh, Masashi Yanagisawa, Yoko Irukayama
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Publication number: 20230169627Abstract: A model learning unit determines a model parameter for calculating an estimated value for each of a plurality of training sets, each including a measurement signal and at least one type of predetermined characteristic value indicating characteristics of the measurement signal as a target value, to minimize a difference between the estimated value calculated for the measurement signal using a predetermined mathematical model and the target value is minimized, determines characteristic value sets, each being a set of a plurality of types of characteristic values indicating characteristics of the measurement signal including the target value, with which, for each target value, the target value is common to a plurality of characteristic value sets, and generates, for each of the characteristic value sets, each of the plurality of training sets including the target value and a measurement signal having characteristics indicated by the plurality of types of characteristic values.Type: ApplicationFiled: April 6, 2021Publication date: June 1, 2023Applicant: University of TsukubaInventors: Yoshiaki YASUNO, Thitiya SEESAN
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Patent number: 11654035Abstract: A gait disorder support apparatus and gait disorder support method capable of detecting an onset sign of a gait disorder associated with motor symptoms in advance and performing motion assist are proposed. The onset sign of the gait disorder associated with the motor symptoms of a wearer is detected based on the correlation between a gait cycle and a reduction ratio of the gait cycle as compared to immediately preceding gait; and when the onset sign of the gait disorder is detected, a drive unit is controlled so that the drive unit applies assist power to a knee joint of the wearer; and on the other hand, when the onset sign of the gait disorder is not detected, the drive unit is controlled so that driving torque by the drive unit does not hinder the wearer's gait motion.Type: GrantFiled: March 17, 2017Date of Patent: May 23, 2023Assignees: CYBERDYNE Inc., University of TsukubaInventor: Yoshiyuki Sankai