Patents Assigned to University of Tsukuba
  • Publication number: 20200386684
    Abstract: A data creation method includes: an autofluorescence data generation step of placing a focus of light having a predetermined wavelength at one set of coordinates on a predetermined focal plane, irradiating a sample positioned at the set of coordinates with excitation light containing the light to obtain autofluorescence emitted from the sample, and generating autofluorescence data including intensity data and/or spectrum data of the autofluorescence; a reflected light data generation step of irradiating the set of coordinates on the predetermined focal plane with illumination light to obtain reflected light scattered by the sample, and generating intensity data of the reflected light; and a correspondence data creation step of creating correspondence data associating the autofluorescence data and the reflected light data on the set of coordinates on the predetermined focal plane.
    Type: Application
    Filed: December 22, 2017
    Publication date: December 10, 2020
    Applicant: University of Tsukuba
    Inventors: Nobuhiko NOMURA, Yutaka YAWATA, Tatsunori KIYOKAWA
  • Patent number: 10842585
    Abstract: A model of a body part, e.g., liver, of which the internal structure can be observed easily; and others. In a liver model according to the present invention, the liver parenchyma is formed in the form of a frame to make it possible to observe the portal, veins, a tumor and others in the inside of the frame 31a easily. In addition, the liver model can be handled easily by gripping a gripping part provided at the lower end surface of the inferior vena cava, and the tumor is integrated with the liver model by means of a joint part. The liver model can be manufactured from a model material using a 3D printer on the basis of three-dimensional shape data for model manufacturing purposes, which are produced using an information processing device.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: November 24, 2020
    Assignees: UNIVERSITY OF TSUKUBA, DAI NIPPON PRINTING CO., LTD.
    Inventors: Jun Mitani, Nobuhiro Ohkohchi, Yukio Oshiro, Kentaro Ko, Takuji Hayashi
  • Publication number: 20200309789
    Abstract: Biomarkers for detecting cognitive dysfunction diseases and methods for detecting cognitive dysfunction diseases using the biomarkers are provided. A method for detecting cognitive dysfunction diseases comprising measuring one or more biomarkers for detecting cognitive dysfunction diseases selected from the following (a), (b), and (c) in a biological sample simultaneously or separately: (a) a biomarker for detecting cognitive dysfunction diseases consisting of an intact protein of apolipoprotein A1 comprising the amino acid sequence represented by SEQ ID NO:1 or a partial peptide thereof; (b) a biomarker for detecting cognitive dysfunction diseases consisting of an intact protein of transthyretin comprising the amino acid sequence represented by SEQ ID NO:2 or a partial peptide thereof; and (c) a biomarker for detecting cognitive dysfunction diseases consisting of an intact protein of complement C3 comprising the amino acid sequence represented by SEQ ID NO:3 or a partial peptide thereof.
    Type: Application
    Filed: June 2, 2020
    Publication date: October 1, 2020
    Applicants: MCBI INC., UNIVERSITY OF TSUKUBA
    Inventors: Kazuhiko UCHIDA, Kohji MENO, Hideaki SUZUKI, Yoshinori NISHIMURA
  • Patent number: 10781108
    Abstract: A two-dimensional hydrogen boride-containing sheet of the present invention has a two-dimensional network that consists of (HB)n (n?4).
    Type: Grant
    Filed: October 18, 2017
    Date of Patent: September 22, 2020
    Assignees: University of Tsukuba, Tokyo Institute of Technology
    Inventors: Takahiro Kondo, Junji Nakamura, Hiroaki Nishino, Asahi Fujino, Tomohiro Fujimori, Hideo Hosono, Masahiro Miyauchi
  • Publication number: 20200290877
    Abstract: A carbon nanostructure producing method includes a growth step in which a plurality of catalyst particles in close contact with each other are separated in a flow of a carbon-containing gas so as to grow carbon nanotubes between the plurality of catalyst particles, and an elongation step in which the carbon nanotube is elongated by a wind pressure of the carbon-containing gas with at least one of the catalyst particles being retained.
    Type: Application
    Filed: June 29, 2018
    Publication date: September 17, 2020
    Applicants: SUMITOMO ELECTRIC INDUSTRIES, LTD., UNIVERSITY OF TSUKUBA
    Inventors: Takeshi HIKATA, Soichiro OKUBO, Ryusuke NAKAI, Jun-ichi FUJITA
  • Patent number: 10777330
    Abstract: A MgF2 system fluoride sintered body for a radiation moderator having a compact polycrystalline structure excellent in radiation moderation performance, especially neutron moderation performance, contains CaF2 of 90% by weight at the maximum and has a relative density of 95.2% or more.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: September 15, 2020
    Assignees: TECHNO EYE CORPORATION, DAICO MFG CO., LTD., UNIVERSITY OF TSUKUBA
    Inventors: Hiroaki Kumada, Tetsuyuki Nakamura, Takeshi Ikeda, Takuji Shigeoka
  • Patent number: 10745710
    Abstract: The present invention relates to a plant having an improved sugar content in fruit compared with its wild type plant, which has a mutant cyclin F-box gene comprising a nucleotide mutation that causes a non-conservative amino acid substitution in the cyclin F-box protein. The present invention also relates to a parthenocarpic plant having a mutant cyclin F-box gene comprising a nucleotide mutation that causes a non-conservative amino acid substitution in the cyclin F-box protein.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: August 18, 2020
    Assignee: UNIVERSITY OF TSUKUBA
    Inventors: Hiroshi Ezura, Tohru Ariizumi, Jun-ichiro Masuda, Yoshihiro Okabe
  • Patent number: 10702442
    Abstract: Provided is a walking aid device capable of easily offering walking training by aiding the oscillation of the user's pelvis. The walking aid device comprises a drive part which supports each of at least two or more locations of the user's lumbar region, and applies external force independently to each of the supported locations; a gait recognition unit which recognizes the user's gait; and a control unit which sets the user's ideal walking motion pattern based on a recognition result of the gait recognition unit, and controls the external force applied by the drive part to each of the locations of the lumbar region so that the user's pelvis position within the lumbar region will oscillate to match the walking motion pattern.
    Type: Grant
    Filed: May 19, 2016
    Date of Patent: July 7, 2020
    Assignees: CYBERDYNE INC., UNIVERSITY OF TSUKUBA
    Inventors: Yoshiyuki Sankai, Masahiro Takama, Tomoyoshi Kawabata, Hiromasa Hara, Ryotaro Sabe, Martin Peris Martorell
  • Publication number: 20200200767
    Abstract: This invention provides a method for detecting cognitive disfunction diseases including mild cognitive impairment and Alzheimer's disease using a protein and a peptide of the protein different in the presence level in subjects having a normal cognitive function and patients suffering from cognitive disfunction diseases and a biomarker for detecting cognitive disfunction diseases including mild cognitive impairment and Alzheimer's disease containing the protein and the peptide.
    Type: Application
    Filed: July 13, 2017
    Publication date: June 25, 2020
    Applicants: University of Tsukuba
    Inventors: Kazuhiko UCHIDA, Kohji MENO, Hideaki SUZUKI
  • Publication number: 20200173990
    Abstract: This invention provides a method for diagnosis of rheumatoid arthritis of a subject, a method for assisting diagnosis of rheumatoid arthritis, and a method for monitoring disease activity of rheumatoid arthritis and/or therapeutic effects of an agent for rheumatoid arthritis, comprising detecting citrullination of an arginine residue of the inter-?-trypsin inhibitor heavy chain (ITIH) 4 in a biological sample obtained from the subject. This invention also provides a citrullinated protein derived from the protein having the amino acid sequence as shown in SEQ ID NO: 1 or 5 by modification of arginine 438 into citrulline or a fragment thereof, an antibody binding to such citrullinated protein, and an agent for diagnosis of rheumatoid arthritis comprising such antibody.
    Type: Application
    Filed: July 2, 2018
    Publication date: June 4, 2020
    Applicant: University of Tsukuba
    Inventors: Isao Matsumoto, Takayuki Sumida, Hoshimi Kawaguchi
  • Patent number: 10647956
    Abstract: The purpose of the present invention is to provide a method for isolating, removing and analyzing cells. Provided is a method for isolating, removing and analyzing cells by filtering a liquid specimen containing cells through a porous polyimide film, and subjecting the cells captured by the film which did not pass through the porous polyimide film, or the cells in the liquid specimen which did pass through the porous polyimide film, to an examination of one or more cell properties selected from a group consisting of cell number or type, internal or external cell structure, type or amount of cell surface antigen, type or amount of material secreted from cells, cell adhesion, and cell survival rate.
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: May 12, 2020
    Assignees: UBE INDUSTRIES, LTD., UNIVERSITY OF TSUKUBA
    Inventors: Akiyoshi Fukamizu, Jun-Dal Kim, Masahiko Hagihara, Yukinori Wada
  • Patent number: 10589141
    Abstract: The present invention is intended to provide an active exercise apparatus for lower limbs that allows a user to perform on a floor lower limb active exercise highly effective in preventing thrombosis.
    Type: Grant
    Filed: February 22, 2017
    Date of Patent: March 17, 2020
    Assignees: UNIVERSITY OF TSUKUBA, NEMOTO SEISAKUSHO CO. LTD.
    Inventors: Yukiyo Shimizu, Masashi Yamazaki, Hiroshi Kamada, Kenta Tanaka, Toshiji Mizukoshi, Tsutomu Mizukoshi
  • Publication number: 20200069684
    Abstract: The present invention provides a therapeutic agent and others for various tumors including angioimmunoblastic T-cell lymphoma (AITL), which is an orphan disease. The present invention relates to a therapeutic agent and others for tumors identified by phosphorylation of a proto-oncogene protein belonging to the VAV family, which comprises dasatinib or a prodrug thereof or a pharmacologically acceptable salt thereof or a hydrate or solvate thereof as an active ingredient.
    Type: Application
    Filed: April 24, 2019
    Publication date: March 5, 2020
    Applicant: University of Tsukuba
    Inventors: Shigeru CHIBA, Mamiko YANAGIMOTO
  • Publication number: 20200060993
    Abstract: The present invention relates to a carotenoid-containing composition for use in exercise therapy for improving cognitive function, particularly exercise therapy for hippocampal neurogenesis.
    Type: Application
    Filed: October 28, 2019
    Publication date: February 27, 2020
    Applicants: ASTAREAL CO., LTD., UNIVERSITY OF TSUKUBA
    Inventors: Hideaki SOYA, Jangsoo YOOK
  • Patent number: 10558028
    Abstract: A super-resolution microscope includes an illuminator and a detector. The illuminator irradiates illumination beams of different wavelengths through an objective lens onto a sample while causing at least a portion of the illumination beams to overlap spatially and temporally. The detector detects a signal beam generated by the sample as a result of irradiation of the sample with the illumination beams. The illumination beams include a first illumination beam that induces a first nonlinear optical process with respect to the sample and a second illumination beam that induces a second nonlinear optical process that suppresses the first nonlinear optical process. The nonlinear susceptibility of the second nonlinear optical process is greater than the nonlinear susceptibility of the first nonlinear optical process.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: February 11, 2020
    Assignees: OLYMPUS CORPORATION, UNIVERSITY OF TSUKUBA
    Inventors: Yoshinori Iketaki, Hideaki Kanou
  • Publication number: 20200037923
    Abstract: The purpose of the present invention is to enable, even in an endoscopic operation, an operation upon a specific operation site while monitoring the overall surgical site, such as an organ. An artificial magnetic field is generated such that a surgical site of a patient is positioned within a generated three-dimensional artificial magnetic field space. A plurality of magnetic sensors are respectively mounted in a plurality of predetermined locations of the surgical site of the patient. Data of a 3-D image of the surgical site and position information of the mounting locations of the magnetic sensors with respect to the surgical site are stored in a storage unit as position information of the mounting locations with respect to the 3-D image of the surgical site.
    Type: Application
    Filed: July 20, 2017
    Publication date: February 6, 2020
    Applicant: University of Tsukuba
    Inventors: Jian LU, Ryutaro MAEDA, Lan ZHANG, Hiroshi HIROSHIMA, Nobuhiro OHKOHCHI, Masanao KURATA, Youichi OKUDA
  • Publication number: 20200040077
    Abstract: The present invention aims to provide: an immunostimulant useful for maintaining, enhancing or suppressing an immune function associated with CD300a activation signaling, or an immunomodulator as an immunosuppressant useful for suppressing the immune function; use of a CD300a gene-deficient mouse for pathology analysis and the like; an anti-CD300a antibody; and the like.
    Type: Application
    Filed: October 17, 2019
    Publication date: February 6, 2020
    Applicant: UNIVERSITY OF TSUKUBA
    Inventors: Akira Shibuya, Chigusa Oda, Satoko Tahara, Tsukasa Nabekura, Udayanga Sanath Kankanam Gamage, Haruka Miki, Syuichi Iino
  • Patent number: 10525015
    Abstract: The present invention relates to a nalfurafine-containing percutaneous absorption patch having a support, a drug layer and a control layer which are laminated successively, wherein the drug layer contains at least one kind of a drug selected from the group consisting of nalfurafine and a salt thereof, and capable of maintaining a given level of drug skin permeation amount without permeation of an excess amount of the drug through the skin in a short time even when applied to the skin in which the horny cell layer and the like are damaged and the skin barrier is insufficient.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: January 7, 2020
    Assignee: UNIVERSITY OF TSUKUBA
    Inventors: Hiroshi Nagase, Makiko Tada, Megumi Yashima, Takeshi Saiki
  • Patent number: 10517495
    Abstract: An electrocardiogram analyzer includes a first acquiring section that acquires a body surface electrocardiogram of a subject, a second acquiring section that acquires an intracardiac electrocardiogram of a ventricle of a heart of the subject, and an analyzing section that performs a frequency analysis on the intracardiac electrocardiogram and includes a range setting section that sets an analysis time range of the frequency analysis in the intracardiac electrocardiogram based on a unit waveform of the body surface electrocardiogram, and a calculating section that, in the analysis time range, performs the frequency analysis on the intracardiac electrocardiogram, and that calculates an index value indicating a ratio of local abnormal ventricular activities in the intracardiac electrocardiogram.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: December 31, 2019
    Assignees: UNIVERSITY OF TSUKUBA, NIHON KOHDEN CORPORATION
    Inventors: Akihiko Nogami, Koji Takizawa
  • Patent number: 10519233
    Abstract: The present invention aims to provide: an immunostimulant useful for maintaining, enhancing or suppressing an immune function associated with CD300a activation signaling, or an immunomodulator as an immunosuppressant useful for suppressing the immune function; use of a CD300a gene-deficient mouse for pathology analysis and the like; an anti-CD300a antibody; and the like.
    Type: Grant
    Filed: November 7, 2012
    Date of Patent: December 31, 2019
    Assignee: UNIVERSITY OF TSUKUBA
    Inventors: Akira Shibuya, Chigusa Oda, Satoko Tahara, Tsukasa Nabekura, Udayanga Sanath Kankanam Gamage, Haruka Miki, Syuichi Iino