Patents Assigned to University of Tsukuba
  • Publication number: 20240197964
    Abstract: Provided is a gel material for ophthalmic treatment useful as a synthetic vitreous body which is a novel intraocular tamponade material having a low swelling pressure, an appropriate elastic force, and no toxicity to ocular tissues, specifically, to retinas, and which is capable of stably maintaining a long-term stable tamponade effect. A gel material for ophthalmic treatment including a hydrogel in which a gel precursor cluster crosslinks to form a three-dimensional network. The gel precursor cluster has a structure with crosslinked monomer units or crosslinked polymer units present at concentrations less than a critical gelation concentration, and the gel precursor cluster has a relationship of G?<G? where G? represents a storage elastic modulus and G? represents a loss elastic modulus. The hydrogel has a polymer content of 50 g/L or less, a storage elastic modulus G? of 1 to 10,000 Pa at a frequency of 1 Hz, and a fractal dimension of 1.5 to 2.5.
    Type: Application
    Filed: March 5, 2024
    Publication date: June 20, 2024
    Applicants: THE UNIVERSITY OF TOKYO, UNIVERSITY OF TSUKUBA
    Inventors: Takamasa SAKAI, Yuichi TEI, Fumiki OKAMOTO, Sujin HOSHI
  • Publication number: 20240180485
    Abstract: The present invention provides a method for inducing a hibernation-like state and an apparatus therefor. According to the present invention, provided is a method for decreasing a theoretical setpoint temperature of body temperature and a feedback gain of heat generation in a subject or a method for inducing a hibernation-like state in a subject, the method being a chemical and/or physical method including providing an excitatory stimulus to a pyroglutamylated RFamide peptide (QRFP)-producing neuron. According to the present invention, an apparatus used to practice this method is also provided.
    Type: Application
    Filed: March 30, 2022
    Publication date: June 6, 2024
    Applicants: University of Tsukuba, RIKEN
    Inventors: Takeshi SAKURAI, Genshiro SUNAGAWA
  • Patent number: 11980751
    Abstract: A first drive unit, in a state where a top end of a tubular joint is interposed into a chest of a target person and is located at a lower heart part, pushes a diaphragm out from the top end of the tubular joint while pressing a gas into the diaphragm, and simultaneously causes the diaphragm to start flexing to cover and wrap the lower heart part, and then stops pressing the gas into the diaphragm at a time point where compression balloons are positioned at atriums and ventricles of a heart, respectively; and second drive units support a pumping function of the heart by alternately repeating an ejecting operation to fill each of the compression balloons with a fluid and cause each compression balloon to expand and an absorbing operation to cause each compression balloon to discharge the fluid and contract.
    Type: Grant
    Filed: August 30, 2019
    Date of Patent: May 14, 2024
    Assignees: CYBERDYNE INC., UNIVERSITY OF TSUKUBA
    Inventor: Yoshiyuki Sankai
  • Patent number: 11944579
    Abstract: A biological activity detection apparatus includes: a drive unit that actively or passively drives in conjunction with a limb motion of a subject; a periarticular detection unit that detects a periarticular physical quantity around a joint in association with the limb motion of the subject based on an output signal from the drive unit; a biological signal detection unit located at a body surface site of the subject with reference to the joint and includes an electrode group for detecting a biological signal of the subject, wherein an activity status of a musculoskeletal system and/or a transmission status of a peripheral nervous system around the joint are converted into quantitative musculoskeletal system data and/or nervous system data on the basis of the physical quantity acquired from the periarticular detection unit and a myogenic potential signal and a neural transmission signal which are acquired from the biological signal processing unit.
    Type: Grant
    Filed: August 24, 2017
    Date of Patent: April 2, 2024
    Assignees: CYBERDYNE Inc., University of Tsukuba
    Inventor: Yoshiyuki Sankai
  • Publication number: 20240099631
    Abstract: This apparatus (1) comprises at least one intravascular device (10), (20) that is disposed in a blood vessel of an organism and that is equipped with at least one electrode (11), (12), (21), (22) for detecting or stimulating the activity of nerve tissue positioned outside the blood vessel nearby, the electrodes (11), (12), (21), (22) being provided on a wire member.
    Type: Application
    Filed: January 17, 2022
    Publication date: March 28, 2024
    Applicants: E.P.MEDICAL INC., UNIVERSITY OF TSUKUBA
    Inventor: Yuji MATSUMARU
  • Patent number: 11939219
    Abstract: The carbon nanotube assembled wire includes a plurality of carbon nanotubes oriented at a degree of orientation of 0.9 or more and 1 or less.
    Type: Grant
    Filed: December 26, 2019
    Date of Patent: March 26, 2024
    Assignees: SUMITOMO ELECTRIC INDUSTRIES, LTD., UNIVERSITY OF TSUKUBA
    Inventors: Toshihiko Fujimori, Takeshi Hikata, Soichiro Okubo, Jun-ichi Fujita
  • Patent number: 11934558
    Abstract: A distributed data integration device includes an acquisition unit configured to acquire, for a piece of analysis target data, an anchor data intermediate representation and an analysis target intermediate representation, the anchor data intermediate representation being an intermediate representation obtained by converting anchor data by a first function, the anchor data being data commonly used in integration of a plurality of the pieces of analysis target data that are distributed, the analysis target intermediate representation being an intermediate representation obtained by converting the analysis target data by the first function, an anchor data conversion unit configured to convert, for the piece of analysis target data, a plurality of the anchor data intermediate representations by a second function, a calculation unit configured to calculate, for the piece of analysis target data, the second function that minimizes a difference between the plurality of the anchor data intermediate representations, a
    Type: Grant
    Filed: December 18, 2019
    Date of Patent: March 19, 2024
    Assignee: University of Tsukuba
    Inventors: Akira Imakura, Tetsuya Sakurai
  • Publication number: 20240088394
    Abstract: A secondary battery of the present disclosure includes a positive electrode, an electrolyte layer, a negative electrode current collector, and metallic lithium as a negative electrode active material that is deposited between the electrolyte layer and the negative electrode current collector by charging, an intermediate layer is present between the electrolyte layer and the negative electrode current collector, and the intermediate layer contains hydrogen boride.
    Type: Application
    Filed: September 6, 2023
    Publication date: March 14, 2024
    Applicants: TOYOTA JIDOSHA KABUSHIKI KAISHA, UNIVERSITY OF TSUKUBA
    Inventors: Ximeng LI, Takahiro Kondo
  • Patent number: 11925437
    Abstract: A photoacoustic imaging apparatus comprises: a light emitting unit emitting pulsed light with a wavelength absorbed inside a subject; a thin, flexible film applied to a skin surface of the subject to make the pulsed light transmit it and reflects the light on its outer surface at the same time; a multi-directional light emitting unit emitting a plurality of visible light beams from multi-directions to the outer surface of the thin film; a micro-vibration detection unit detects, on the basis of diffraction and/or interference of a plurality of reflected light obtained from the outer surface of the thin film, a state of causing micro-vibrations of the thin film as the photoacoustic waves generated from the light absorber collide against an inner backside of the thin film; and a shape image transformation unit that produces the images of a shape of the light absorber as detected by the micro-vibration detection unit.
    Type: Grant
    Filed: July 24, 2019
    Date of Patent: March 12, 2024
    Assignee: CYBERDYNE INC., UNIVERSITY OF TSUKUBA
    Inventor: Yoshiyuki Sankai
  • Publication number: 20240029434
    Abstract: A non-transitory computer-readable recording medium has stored therein a program that causes a computer to execute a process, the process including acquiring movie data including a plurality of consecutive frames calculating first likelihood of a class of the movie data by inputting the acquired movie data to a trained model, calculating an optical flow indicating movement of an area included in the movie data, based on the movie data generating occluded movie data by setting an occluded area in each of the frames included in the movie data, based on the optical flow, calculating second likelihood of a class of the occluded movie data by inputting the occluded movie data to the model identifying an area that affects identification of the class among areas in the movie data, based on the first likelihood and the second likelihood and displaying the identified area that affects identification of the class.
    Type: Application
    Filed: July 19, 2022
    Publication date: January 25, 2024
    Applicants: FUJITSU LIMITED, University of Tsukuba
    Inventors: Tomoki UCHIYAMA, Naoya SOGI, Koichiro NIINUMA, Kazuhiro FUKUI
  • Patent number: 11876542
    Abstract: A compression apparatus performs processing of registering a symbol, which is input, in a predetermined entry among a plurality of entries in a case where the symbol is not registered in a first table having the plurality of entries and outputting the symbol and index data indicating non-compression, processing of outputting index data indicating compression and positional information indicating a position of the entry having the symbol registered therein and having a size smaller than a size of the symbol in a case where the symbol has been registered in the table, and processing of changing the size of the positional information depending on usage conditions of the plurality of entries.
    Type: Grant
    Filed: April 28, 2020
    Date of Patent: January 16, 2024
    Assignee: UNIVERSITY OF TSUKUBA
    Inventors: Shinichi Yamagiwa, Koichi Marumo, Eisaku Hayakawa
  • Patent number: 11866330
    Abstract: A method for manufacturing a carbon nanotube includes: a mist generating step of generating a mist including a catalyst particle and a liquid carbon source; and a growing step of growing a carbon nanotube from the catalyst particle by heating the mist.
    Type: Grant
    Filed: February 18, 2020
    Date of Patent: January 9, 2024
    Assignees: SUMITOMO ELECTRIC INDUSTRIES, LTD., UNIVERSITY OF TSUKUBA
    Inventors: Takeshi Hikata, Toshihiko Fujimori, Soichiro Okubo, Jun Otsuka, Jun-ichi Fujita
  • Publication number: 20240000829
    Abstract: An objective of the present invention is to provide a self-assembled polymer micelle-type ornithine donor, which has high bioavailability, low toxicity, and high therapeutic effectiveness, even when provided by oral administration. Another objective of the present invention is to provide a self-assembled polymer micelle-type ornithine donor which is effective in preventing or treating hepatic disorders. In order to achieve the above objectives, an acyl group is introduced into the primary amino group in the side chain of an ornithine unit in the poly(ornithine) segment of poly(ethylene glycol)-b-poly(ornithine), which spontaneously forms polymer micelles without polyion complex formation.
    Type: Application
    Filed: November 9, 2021
    Publication date: January 4, 2024
    Applicant: University of Tsukuba
    Inventors: Yukio NAGASAKI, Yaroslav LEE, Long Binh VONG, Yuta KODA, Yuanyuan DING
  • Publication number: 20240003913
    Abstract: Biomarkers for detecting cognitive dysfunction diseases and methods for detecting cognitive dysfunction diseases using the biomarkers are provided. A method for detecting cognitive dysfunction diseases comprising measuring one or more biomarkers for detecting cognitive dysfunction diseases selected from the following (a), (b), and (c) in a biological sample simultaneously or separately: (a) a biomarker for detecting cognitive dysfunction diseases consisting of an intact protein of apolipoprotein A1 comprising the amino acid sequence represented by SEQ ID NO:1 or a partial peptide thereof; (b) a biomarker for detecting cognitive dysfunction diseases consisting of an intact protein of transthyretin comprising the amino acid sequence represented by SEQ ID NO:2 or a partial peptide thereof; and (c) a biomarker for detecting cognitive dysfunction diseases consisting of an intact protein of complement C3 comprising the amino acid sequence represented by SEQ ID NO:3 or a partial peptide thereof.
    Type: Application
    Filed: July 12, 2023
    Publication date: January 4, 2024
    Applicants: MCBI INC., UNIVERSITY OF TSUKUBA
    Inventors: Kazuhiko UCHIDA, Kohji MENO, Hideaki SUZUKI, Yoshinori NISHIMURA
  • Publication number: 20230403143
    Abstract: A secure computation system comprising secure computation server apparatuses, each of which comprises: a discriminant share generation part that computes discriminant shares configured so that an index relating to an input corresponds to a specific value from shares representing the index relating to the input and possible combinations of index shares of an array; a combination configuration part that configures a combination of shares of an element in the array and the discriminant shares for all possible combinations of indices of the array; a shuffle part that shuffles the combinations; a reconstruction part that reconstructs the discriminant shares in the shuffled combinations; and a selection part that selects shares of an element in the array in the combinations where the reconstructed value is the specific value.
    Type: Application
    Filed: November 20, 2020
    Publication date: December 14, 2023
    Applicants: NEC CORPORATION, UNIVERSITY OF TSUKUBA
    Inventors: Hikaru TSUCHIDA, Takashi NISHIDE
  • Publication number: 20230364303
    Abstract: [Object] Provided is a method of producing a nerve fascicle including efficiently extending axons of neural cells. [Solution] Neural cells are cultivated in the presence of feeder cells including at least one type of cells selected from the group consisting of vascular component cells, perivascular cells, and oligodendrocytes.
    Type: Application
    Filed: September 17, 2021
    Publication date: November 16, 2023
    Applicant: University of Tsukuba
    Inventors: Hiroshi ISHIKAWA, Aiki MARUSHIMA, Yuji MATSUMARU, Masao KODA, Akira MATSUMURA, Hiroki BUKAWA, Akihiro OHYAMA, Junko TOYOMURA, Miho WATANABE, Tetsuya ABE, Shohei TAKAOKA, Yosuke SHIBAO, Hideaki MATSUMURA
  • Publication number: 20230346125
    Abstract: A rocking device includes: a seat which supports a body of a user; a motor which rotates a rotation shaft in a first rotation direction and in a second rotation direction that is a rotation direction opposite to the first rotation direction, and thereby supplies motive power for rocking the seat via a gear attached to the rotation shaft; and a controller which controls rocking of the seat via the motor. The seat is configured to make a first motion of moving in a first movement direction, in accordance with rotation of the rotation shaft in the first rotation direction, and make a second motion of moving in a second movement direction, in accordance with rotation of the rotation shaft in the second rotation direction. The controller is configured to control rocking of the seat such that a prescribed stopped period is provided between the first motion and second motion.
    Type: Application
    Filed: April 13, 2023
    Publication date: November 2, 2023
    Applicants: TOYOTA BOSHOKU KABUSHIKI KAISHA, UNIVERSITY OF TSUKUBA
    Inventors: Yasuhiro KATO, Akio SHIMIZU, Takahiro HARITA, Takashi ABE
  • Patent number: 11787037
    Abstract: [Problem] Learning of object operation skills robust against variation of conditions is implemented. [Solution] A behavior estimation apparatus 100 includes a collection unit 200 configured to collect skill data obtained when a slave robot is operated under a plurality of different conditions by using a bilateral system capable of operating the slave robot via a master robot through bidirectional control between the master robot and the slave robot. The behavior estimation apparatus 100 further includes a behavior estimation device 300 configured to estimate a command value for causing the slave robot 520 to automatically behave, based on the skill data collected by the collection unit 200 and a response output from the slave robot 520.
    Type: Grant
    Filed: March 20, 2019
    Date of Patent: October 17, 2023
    Assignee: University of Tsukuba
    Inventor: Sho Sakaino
  • Publication number: 20230316700
    Abstract: An information processing apparatus acquires an image; generates a shielding image in which a part of an area included in an area of the acquired image has been shielded; calculates, by inputting the image to a first model that has been trained, first likelihood of the target object included in the image; calculates, by inputting the shielding image to a second model that calculates an approximation value of likelihood of the target object included in the image when the image is input, second likelihood corresponding to the approximation value of the likelihood of the target object included in the shielding image; specifies, based on the first likelihood and the second likelihood, an area that affects discrimination of the class and that is included in the area of the image; and displays the specified area that affects discrimination of the class.
    Type: Application
    Filed: March 31, 2022
    Publication date: October 5, 2023
    Applicants: FUJITSU LIMITED, University of Tsukuba
    Inventors: Naoya SOGI, Tomoki UCHIYAMA, Kazuhiro FUKUI, Koichiro NIINUMA
  • Patent number: 11774447
    Abstract: This invention provides a method for diagnosis of rheumatoid arthritis of a subject, a method for assisting diagnosis of rheumatoid arthritis, and a method for monitoring disease activity of rheumatoid arthritis and/or therapeutic effects of an agent for rheumatoid arthritis, comprising detecting citrullination of an arginine residue of the inter-?-trypsin inhibitor heavy chain (ITIH) 4 in a biological sample obtained from the subject. This invention also provides a citrullinated protein derived from the protein having the amino acid sequence as shown in SEQ ID NO: 1 or 5 by modification of arginine 438 into citrulline or a fragment thereof, an antibody binding to such citrullinated protein, and an agent for diagnosis of rheumatoid arthritis comprising such antibody.
    Type: Grant
    Filed: July 2, 2018
    Date of Patent: October 3, 2023
    Assignee: University of Tsukuba
    Inventors: Isao Matsumoto, Takayuki Sumida, Hoshimi Kawaguchi