Patents Assigned to University of Tsukuba
  • Publication number: 20250147498
    Abstract: An information processing method, an information processing system, and a recording medium are provided.
    Type: Application
    Filed: January 10, 2025
    Publication date: May 8, 2025
    Applicants: Tokyo Electron Limited, University of Tsukuba
    Inventors: Jun TAMURA, Tsuyoshi MORIYA, Yuki KATAOKA, Akira IMAKURA, Tetsuya SAKURAI, Yasunori FUTAMURA, Xiucai YE
  • Patent number: 12265026
    Abstract: A phase gradient calculation unit calculates a phase gradient on a plane intersecting an irradiation direction of light corresponding to an optical coherence tomography signal indicating a state of a sample for each of sample points arranged on the plane. A bulk phase error calculation unit integrates, for each of plurality of paths from an origin that is a sample point where a bulk phase error is determined to a destination that is a sample point where the bulk phase error is not determined, the phase gradient for each of the sample points along each of the plurality of corresponding paths to calculate a path specific phase error at the destination, and combines the path specific phase errors among the plurality of corresponding paths to determine the bulk phase error at the destination.
    Type: Grant
    Filed: November 13, 2020
    Date of Patent: April 1, 2025
    Assignee: University of Tsukuba
    Inventors: Yoshiaki Yasuno, Daisuke Oida, Kensuke Oikawa
  • Publication number: 20250057628
    Abstract: A medical imaging device according to the present invention includes an illumination unit 11 that spot-illuminates a center of operative field of a surgical patient, an operative field camera unit 12 that images a center of irradiation range by the illumination unit 11, a housing 13 that covers the illumination unit 11 and the operative field camera unit 12, and a pair of display units 14 and 14 that are visible from both sides of the surgical patient.
    Type: Application
    Filed: December 15, 2022
    Publication date: February 20, 2025
    Applicants: University of Tsukuba, Yamada Shadowless Lamp Co., Ltd.
    Inventors: Tatuya Oda, Kazuaki Yamazaki, Toshihiro Suzuki, Hiroyuki Urashima
  • Patent number: 12178939
    Abstract: A medical instrument in which an inorganic salt solid such as apatite into which a peptide hormone or the like is embedded is placed so that a metal or the like is coated therewith, in which the inorganic salt solid is provided by controlled delay co-precipitation or the like in an unstable supersaturated calcium phosphate solution, and the medical instrument is exposed to ionizing radiation at a dose sufficient for sterilization.
    Type: Grant
    Filed: January 30, 2020
    Date of Patent: December 31, 2024
    Assignees: Cell-Medicine, Inc., National Institute of Advanced Industrial Science and Technology, University of Tsukuba, Nihon Parkerizing Co., Ltd.
    Inventors: Tadao Ohno, Mayu Yasunaga, Atsuo Ito, Yu Sogo, Fumiko Kobayashi
  • Publication number: 20240395547
    Abstract: This semiconductor apparatus has a base film and a semiconductor film formed on the base film, wherein the base film comprises a polyimide obtained by condensation polymerization of an aromatic diamine and an aromatic tetracarboxylic acid anhydride and has a tensile elasticity in the machine direction of 7 GPa or more, and the semiconductor film is polycrystalline and comprises crystal particles having an average particle size of 1 ?m or more.
    Type: Application
    Filed: July 26, 2022
    Publication date: November 28, 2024
    Applicants: University of Tsukuba, TOYOBO CO., LTD.
    Inventors: Kaoru TOKO, Muneatsu NAKAMURA, Satoshi MAEDA
  • Patent number: 12060562
    Abstract: An expression system is provided, including a first nucleic acid fragment containing a long intergenic region (LIR) derived from geminivirus, a small intergenic region (SIR) derived from geminivirus, and an expression cassette of a target protein linked between the LIR and the SIR and a second nucleic acid fragment containing an expression cassette of a Rep/RepA protein derived from geminivirus, in which the expression cassette of the target protein includes a promoter, a nucleic acid fragment encoding the target protein, and two or more linked terminators in this order.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: August 13, 2024
    Assignee: University of Tsukuba
    Inventors: Kenji Miura, Hiroshi Ezura, Ken Hoshikawa
  • Publication number: 20240180485
    Abstract: The present invention provides a method for inducing a hibernation-like state and an apparatus therefor. According to the present invention, provided is a method for decreasing a theoretical setpoint temperature of body temperature and a feedback gain of heat generation in a subject or a method for inducing a hibernation-like state in a subject, the method being a chemical and/or physical method including providing an excitatory stimulus to a pyroglutamylated RFamide peptide (QRFP)-producing neuron. According to the present invention, an apparatus used to practice this method is also provided.
    Type: Application
    Filed: March 30, 2022
    Publication date: June 6, 2024
    Applicants: University of Tsukuba, RIKEN
    Inventors: Takeshi SAKURAI, Genshiro SUNAGAWA
  • Patent number: 11944579
    Abstract: A biological activity detection apparatus includes: a drive unit that actively or passively drives in conjunction with a limb motion of a subject; a periarticular detection unit that detects a periarticular physical quantity around a joint in association with the limb motion of the subject based on an output signal from the drive unit; a biological signal detection unit located at a body surface site of the subject with reference to the joint and includes an electrode group for detecting a biological signal of the subject, wherein an activity status of a musculoskeletal system and/or a transmission status of a peripheral nervous system around the joint are converted into quantitative musculoskeletal system data and/or nervous system data on the basis of the physical quantity acquired from the periarticular detection unit and a myogenic potential signal and a neural transmission signal which are acquired from the biological signal processing unit.
    Type: Grant
    Filed: August 24, 2017
    Date of Patent: April 2, 2024
    Assignees: CYBERDYNE Inc., University of Tsukuba
    Inventor: Yoshiyuki Sankai
  • Patent number: 11934558
    Abstract: A distributed data integration device includes an acquisition unit configured to acquire, for a piece of analysis target data, an anchor data intermediate representation and an analysis target intermediate representation, the anchor data intermediate representation being an intermediate representation obtained by converting anchor data by a first function, the anchor data being data commonly used in integration of a plurality of the pieces of analysis target data that are distributed, the analysis target intermediate representation being an intermediate representation obtained by converting the analysis target data by the first function, an anchor data conversion unit configured to convert, for the piece of analysis target data, a plurality of the anchor data intermediate representations by a second function, a calculation unit configured to calculate, for the piece of analysis target data, the second function that minimizes a difference between the plurality of the anchor data intermediate representations, a
    Type: Grant
    Filed: December 18, 2019
    Date of Patent: March 19, 2024
    Assignee: University of Tsukuba
    Inventors: Akira Imakura, Tetsuya Sakurai
  • Publication number: 20240029434
    Abstract: A non-transitory computer-readable recording medium has stored therein a program that causes a computer to execute a process, the process including acquiring movie data including a plurality of consecutive frames calculating first likelihood of a class of the movie data by inputting the acquired movie data to a trained model, calculating an optical flow indicating movement of an area included in the movie data, based on the movie data generating occluded movie data by setting an occluded area in each of the frames included in the movie data, based on the optical flow, calculating second likelihood of a class of the occluded movie data by inputting the occluded movie data to the model identifying an area that affects identification of the class among areas in the movie data, based on the first likelihood and the second likelihood and displaying the identified area that affects identification of the class.
    Type: Application
    Filed: July 19, 2022
    Publication date: January 25, 2024
    Applicants: FUJITSU LIMITED, University of Tsukuba
    Inventors: Tomoki UCHIYAMA, Naoya SOGI, Koichiro NIINUMA, Kazuhiro FUKUI
  • Publication number: 20240000829
    Abstract: An objective of the present invention is to provide a self-assembled polymer micelle-type ornithine donor, which has high bioavailability, low toxicity, and high therapeutic effectiveness, even when provided by oral administration. Another objective of the present invention is to provide a self-assembled polymer micelle-type ornithine donor which is effective in preventing or treating hepatic disorders. In order to achieve the above objectives, an acyl group is introduced into the primary amino group in the side chain of an ornithine unit in the poly(ornithine) segment of poly(ethylene glycol)-b-poly(ornithine), which spontaneously forms polymer micelles without polyion complex formation.
    Type: Application
    Filed: November 9, 2021
    Publication date: January 4, 2024
    Applicant: University of Tsukuba
    Inventors: Yukio NAGASAKI, Yaroslav LEE, Long Binh VONG, Yuta KODA, Yuanyuan DING
  • Publication number: 20230364303
    Abstract: [Object] Provided is a method of producing a nerve fascicle including efficiently extending axons of neural cells. [Solution] Neural cells are cultivated in the presence of feeder cells including at least one type of cells selected from the group consisting of vascular component cells, perivascular cells, and oligodendrocytes.
    Type: Application
    Filed: September 17, 2021
    Publication date: November 16, 2023
    Applicant: University of Tsukuba
    Inventors: Hiroshi ISHIKAWA, Aiki MARUSHIMA, Yuji MATSUMARU, Masao KODA, Akira MATSUMURA, Hiroki BUKAWA, Akihiro OHYAMA, Junko TOYOMURA, Miho WATANABE, Tetsuya ABE, Shohei TAKAOKA, Yosuke SHIBAO, Hideaki MATSUMURA
  • Patent number: 11787037
    Abstract: [Problem] Learning of object operation skills robust against variation of conditions is implemented. [Solution] A behavior estimation apparatus 100 includes a collection unit 200 configured to collect skill data obtained when a slave robot is operated under a plurality of different conditions by using a bilateral system capable of operating the slave robot via a master robot through bidirectional control between the master robot and the slave robot. The behavior estimation apparatus 100 further includes a behavior estimation device 300 configured to estimate a command value for causing the slave robot 520 to automatically behave, based on the skill data collected by the collection unit 200 and a response output from the slave robot 520.
    Type: Grant
    Filed: March 20, 2019
    Date of Patent: October 17, 2023
    Assignee: University of Tsukuba
    Inventor: Sho Sakaino
  • Publication number: 20230316700
    Abstract: An information processing apparatus acquires an image; generates a shielding image in which a part of an area included in an area of the acquired image has been shielded; calculates, by inputting the image to a first model that has been trained, first likelihood of the target object included in the image; calculates, by inputting the shielding image to a second model that calculates an approximation value of likelihood of the target object included in the image when the image is input, second likelihood corresponding to the approximation value of the likelihood of the target object included in the shielding image; specifies, based on the first likelihood and the second likelihood, an area that affects discrimination of the class and that is included in the area of the image; and displays the specified area that affects discrimination of the class.
    Type: Application
    Filed: March 31, 2022
    Publication date: October 5, 2023
    Applicants: FUJITSU LIMITED, University of Tsukuba
    Inventors: Naoya SOGI, Tomoki UCHIYAMA, Kazuhiro FUKUI, Koichiro NIINUMA
  • Patent number: 11774447
    Abstract: This invention provides a method for diagnosis of rheumatoid arthritis of a subject, a method for assisting diagnosis of rheumatoid arthritis, and a method for monitoring disease activity of rheumatoid arthritis and/or therapeutic effects of an agent for rheumatoid arthritis, comprising detecting citrullination of an arginine residue of the inter-?-trypsin inhibitor heavy chain (ITIH) 4 in a biological sample obtained from the subject. This invention also provides a citrullinated protein derived from the protein having the amino acid sequence as shown in SEQ ID NO: 1 or 5 by modification of arginine 438 into citrulline or a fragment thereof, an antibody binding to such citrullinated protein, and an agent for diagnosis of rheumatoid arthritis comprising such antibody.
    Type: Grant
    Filed: July 2, 2018
    Date of Patent: October 3, 2023
    Assignee: University of Tsukuba
    Inventors: Isao Matsumoto, Takayuki Sumida, Hoshimi Kawaguchi
  • Patent number: 11746316
    Abstract: Proposed are a three-dimensional structuring method of cells and a three-dimensional structuring system of cells capable of efficiently bonding multiple cell clusters in a three-dimensional direction, pursuant to their growth, while ensuring safety. A plurality of fibers, in which one end of each of the fibers is held by a flat plate, are inserted together with the flat plate into a flow path through which a culture solution is supplied, a plurality of cell clusters are placed in the flow path upon causing the cell clusters to run with a liquid flow of the culture solution, and each of the cell clusters is cultured by being stacked on an outer surface of each of the fibers with the flat plate as a growth origin.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: September 5, 2023
    Assignees: CYBERDYNE Inc., University of Tsukuba
    Inventor: Yoshiyuki Sankai
  • Patent number: 11672721
    Abstract: A motion assisting apparatus includes a multijoint structure having links in series rotatably connected in a relative manner, the links being integrally deformed in a bendable manner, a linear member inserted through each of the links, wherein one end is fixed to the link in front and another end is elongated via the link in rear, a sliding/holding part which fixes an elongated portion of the linear member, and slidably guides the rear link in a connecting direction between each of the links, a drive unit which drives the rear link to slide toward the sliding/holding part and causes the multijoint structure, through which the linear member has been inserted, to engage in an extending or flexing motion, and a control unit which drive-controls the drive unit so that a sliding direction, a sliding speed and a sliding position of the rear link will become an intended state.
    Type: Grant
    Filed: March 21, 2017
    Date of Patent: June 13, 2023
    Assignees: CYBERDYNE, INC., University of Tsukuba
    Inventor: Yoshiyuki Sankai
  • Patent number: 11673867
    Abstract: The present invention aims to provide a novel low-molecular-weight compound showing an orexin receptor agonist activity and expected to be useful as a prophylactic or therapeutic agent for narcolepsy and the like. The present invention provides a compound represented by the formula (I): wherein each symbol is as described in the description, or a pharmaceutically acceptable acid addition salt thereof, which has an orexin receptor agonist activity, and an orexin receptor agonist containing the compound or a pharmaceutically acceptable acid addition salt thereof.
    Type: Grant
    Filed: December 11, 2018
    Date of Patent: June 13, 2023
    Assignees: University of Tsukuba, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Hiroshi Nagase, Tsuyoshi Saitoh, Masashi Yanagisawa, Yoko Irukayama
  • Publication number: 20230169627
    Abstract: A model learning unit determines a model parameter for calculating an estimated value for each of a plurality of training sets, each including a measurement signal and at least one type of predetermined characteristic value indicating characteristics of the measurement signal as a target value, to minimize a difference between the estimated value calculated for the measurement signal using a predetermined mathematical model and the target value is minimized, determines characteristic value sets, each being a set of a plurality of types of characteristic values indicating characteristics of the measurement signal including the target value, with which, for each target value, the target value is common to a plurality of characteristic value sets, and generates, for each of the characteristic value sets, each of the plurality of training sets including the target value and a measurement signal having characteristics indicated by the plurality of types of characteristic values.
    Type: Application
    Filed: April 6, 2021
    Publication date: June 1, 2023
    Applicant: University of Tsukuba
    Inventors: Yoshiaki YASUNO, Thitiya SEESAN
  • Patent number: 11654035
    Abstract: A gait disorder support apparatus and gait disorder support method capable of detecting an onset sign of a gait disorder associated with motor symptoms in advance and performing motion assist are proposed. The onset sign of the gait disorder associated with the motor symptoms of a wearer is detected based on the correlation between a gait cycle and a reduction ratio of the gait cycle as compared to immediately preceding gait; and when the onset sign of the gait disorder is detected, a drive unit is controlled so that the drive unit applies assist power to a knee joint of the wearer; and on the other hand, when the onset sign of the gait disorder is not detected, the drive unit is controlled so that driving torque by the drive unit does not hinder the wearer's gait motion.
    Type: Grant
    Filed: March 17, 2017
    Date of Patent: May 23, 2023
    Assignees: CYBERDYNE Inc., University of Tsukuba
    Inventor: Yoshiyuki Sankai