Patents Assigned to University of Tsukuba
  • Publication number: 20210078955
    Abstract: The present invention aims to provide a novel low-molecular-weight compound showing an orexin receptor agonist activity and expected to be useful as a prophylactic or therapeutic agent for narcolepsy and the like. The present invention provides a compound represented by the formula (I): wherein each symbol is as described in the description, or a pharmaceutically acceptable acid addition salt thereof, which has an orexin receptor agonist activity, and an orexin receptor agonist containing the compound or a pharmaceutically acceptable acid addition salt thereof.
    Type: Application
    Filed: December 11, 2018
    Publication date: March 18, 2021
    Applicants: University of Tsukuba, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Hiroshi NAGASE, Tsuyoshi SAITOH, Masashi YANAGISAWA, Yoko IRUKAYAMA
  • Publication number: 20210031358
    Abstract: [Problem] Learning of object operation skills robust against variation of conditions is implemented. [Solution] A behavior estimation apparatus 100 includes a collection unit 200 configured to collect skill data obtained when a slave robot is operated under a plurality of different conditions by using a bilateral system capable of operating the slave robot via a master robot through bidirectional control between the master robot and the slave robot. The behavior estimation apparatus 100 further includes a behavior estimation device 300 configured to estimate a command value for causing the slave robot 520 to automatically behave, based on the skill data collected by the collection unit 200 and a response output from the slave robot 520.
    Type: Application
    Filed: March 20, 2019
    Publication date: February 4, 2021
    Applicant: University of Tsukuba
    Inventor: Sho SAKAINO
  • Publication number: 20200386684
    Abstract: A data creation method includes: an autofluorescence data generation step of placing a focus of light having a predetermined wavelength at one set of coordinates on a predetermined focal plane, irradiating a sample positioned at the set of coordinates with excitation light containing the light to obtain autofluorescence emitted from the sample, and generating autofluorescence data including intensity data and/or spectrum data of the autofluorescence; a reflected light data generation step of irradiating the set of coordinates on the predetermined focal plane with illumination light to obtain reflected light scattered by the sample, and generating intensity data of the reflected light; and a correspondence data creation step of creating correspondence data associating the autofluorescence data and the reflected light data on the set of coordinates on the predetermined focal plane.
    Type: Application
    Filed: December 22, 2017
    Publication date: December 10, 2020
    Applicant: University of Tsukuba
    Inventors: Nobuhiko NOMURA, Yutaka YAWATA, Tatsunori KIYOKAWA
  • Patent number: 10781108
    Abstract: A two-dimensional hydrogen boride-containing sheet of the present invention has a two-dimensional network that consists of (HB)n (n?4).
    Type: Grant
    Filed: October 18, 2017
    Date of Patent: September 22, 2020
    Assignees: University of Tsukuba, Tokyo Institute of Technology
    Inventors: Takahiro Kondo, Junji Nakamura, Hiroaki Nishino, Asahi Fujino, Tomohiro Fujimori, Hideo Hosono, Masahiro Miyauchi
  • Publication number: 20200200767
    Abstract: This invention provides a method for detecting cognitive disfunction diseases including mild cognitive impairment and Alzheimer's disease using a protein and a peptide of the protein different in the presence level in subjects having a normal cognitive function and patients suffering from cognitive disfunction diseases and a biomarker for detecting cognitive disfunction diseases including mild cognitive impairment and Alzheimer's disease containing the protein and the peptide.
    Type: Application
    Filed: July 13, 2017
    Publication date: June 25, 2020
    Applicants: University of Tsukuba
    Inventors: Kazuhiko UCHIDA, Kohji MENO, Hideaki SUZUKI
  • Publication number: 20200173990
    Abstract: This invention provides a method for diagnosis of rheumatoid arthritis of a subject, a method for assisting diagnosis of rheumatoid arthritis, and a method for monitoring disease activity of rheumatoid arthritis and/or therapeutic effects of an agent for rheumatoid arthritis, comprising detecting citrullination of an arginine residue of the inter-?-trypsin inhibitor heavy chain (ITIH) 4 in a biological sample obtained from the subject. This invention also provides a citrullinated protein derived from the protein having the amino acid sequence as shown in SEQ ID NO: 1 or 5 by modification of arginine 438 into citrulline or a fragment thereof, an antibody binding to such citrullinated protein, and an agent for diagnosis of rheumatoid arthritis comprising such antibody.
    Type: Application
    Filed: July 2, 2018
    Publication date: June 4, 2020
    Applicant: University of Tsukuba
    Inventors: Isao Matsumoto, Takayuki Sumida, Hoshimi Kawaguchi
  • Publication number: 20200069684
    Abstract: The present invention provides a therapeutic agent and others for various tumors including angioimmunoblastic T-cell lymphoma (AITL), which is an orphan disease. The present invention relates to a therapeutic agent and others for tumors identified by phosphorylation of a proto-oncogene protein belonging to the VAV family, which comprises dasatinib or a prodrug thereof or a pharmacologically acceptable salt thereof or a hydrate or solvate thereof as an active ingredient.
    Type: Application
    Filed: April 24, 2019
    Publication date: March 5, 2020
    Applicant: University of Tsukuba
    Inventors: Shigeru CHIBA, Mamiko YANAGIMOTO
  • Publication number: 20200037923
    Abstract: The purpose of the present invention is to enable, even in an endoscopic operation, an operation upon a specific operation site while monitoring the overall surgical site, such as an organ. An artificial magnetic field is generated such that a surgical site of a patient is positioned within a generated three-dimensional artificial magnetic field space. A plurality of magnetic sensors are respectively mounted in a plurality of predetermined locations of the surgical site of the patient. Data of a 3-D image of the surgical site and position information of the mounting locations of the magnetic sensors with respect to the surgical site are stored in a storage unit as position information of the mounting locations with respect to the 3-D image of the surgical site.
    Type: Application
    Filed: July 20, 2017
    Publication date: February 6, 2020
    Applicant: University of Tsukuba
    Inventors: Jian LU, Ryutaro MAEDA, Lan ZHANG, Hiroshi HIROSHIMA, Nobuhiro OHKOHCHI, Masanao KURATA, Youichi OKUDA
  • Patent number: 10519507
    Abstract: A method for detecting T-cell lymphoma characterized in that gene mutations of at least one base selected from a group comprising base numbers 50, 331, 334, and 482 or gene mutations of base numbers 49 to 51 in the base sequence of an RHOA gene collected from a subject are analyzed, and the analysis results and T-cell lymphoma are associated with each other.
    Type: Grant
    Filed: May 1, 2014
    Date of Patent: December 31, 2019
    Assignee: University of Tsukuba
    Inventors: Shigeru Chiba, Mamiko Yanagimoto, Seishi Ogawa
  • Patent number: 10485874
    Abstract: Hyaluronic acid modified with sphingosine-1-phosphate, and a medicine comprising the hyaluronic acid as an active ingredient, wherein the medicine can alleviate hepatic disorder caused by hypoxia/reoxygenation by protecting the liver sinusoidal endothelial cells, and the medicine can prevent and/or treat liver failure due to liver transplantation, hepatectomy, or other surgeries associated with liver ischemia/reperfusion.
    Type: Grant
    Filed: March 5, 2015
    Date of Patent: November 26, 2019
    Assignees: Kewpie Corporation, University of Tsukuba
    Inventors: Hideyoshi Harashima, Mamoru Hyodo, Naoyuki Toriyabe, Nobuhiro Ohkohchi, Takafumi Tamura, Naoki Sano
  • Publication number: 20190315628
    Abstract: A two-dimensional hydrogen boride-containing sheet of the present invention has a two-dimensional network that consists of (HB)n (n?4).
    Type: Application
    Filed: October 18, 2017
    Publication date: October 17, 2019
    Applicants: University of Tsukuba, Tokyo Institute of Technology
    Inventors: Takahiro Kondo, Junji Nakamura, Hiroaki Nishino, Asahi Fujino, Tomohiro Fujimori, Hideo Hosono, Masahiro Miyauchi
  • Publication number: 20190175093
    Abstract: A swallowing action measurement device includes a holder, a sound detector and a posture detector. The holder is fitted to a neck region of a person being measured from behind. The sound detector is held in the holder in contact with the outer side surface of the neck region close to the epiglottis, and detects sound associated with at least a swallowing action of the person being measured and outputs a measured sound signal. The posture detector detects a posture of the person being measured.
    Type: Application
    Filed: February 15, 2019
    Publication date: June 13, 2019
    Applicant: University of Tsukuba
    Inventor: Kenji SUZUKI
  • Publication number: 20190015559
    Abstract: Provided is a gel material for ophthalmic treatment useful as a synthetic vitreous body which is a novel intraocular tamponade material having a low swelling pressure, an appropriate elastic force, and no toxicity to ocular tissues, specifically, to retinas, and which is capable of stably maintaining a long-term stable tamponade effect. A gel material for ophthalmic treatment including a hydrogel in which a gel precursor cluster crosslinks to form a three-dimensional network. The gel precursor cluster has a structure with crosslinked monomer units or crosslinked polymer units present at concentrations less than a critical gelation concentration, and the gel precursor cluster has a relationship of G?<G? where G? represents a storage elastic modulus and G? represents a loss elastic modulus. The hydrogel has a polymer content of 50 g/L or less, a storage elastic modulus G? of 1 to 10,000 Pa at a frequency of 1 Hz, and a fractal dimension of 1.5 to 2.5.
    Type: Application
    Filed: December 21, 2016
    Publication date: January 17, 2019
    Applicants: The University of Tokyo, University of Tsukuba
    Inventors: Takamasa SAKAI, Yuichi TEI, Fumiki OKAMOTO, Sujin HOSHI
  • Publication number: 20180207467
    Abstract: The present invention is intended to provide an active exercise apparatus for lower limbs that allows a user to perform on a floor lower limb active exercise highly effective in preventing thrombosis.
    Type: Application
    Filed: February 22, 2017
    Publication date: July 26, 2018
    Applicants: University of Tsukuba, Nemoto Seisakusho Co. Ltd.
    Inventors: Yukiyo SHIMIZU, Masashi YAMAZAKI, Hiroshi KAMADA, Kenta TANAKA, Toshiji MIZUKOSHI, Tsutomu MIZUKOSHI
  • Patent number: 9963460
    Abstract: A morphinan derivative represented by the following formula (I), a tautomer or a stereoisomer of the compound, or a pharmaceutically acceptable salt thereof, or a solvate thereof, and a medicament, an analgesic and an antipruritic drug including the same as an active ingredient: wherein R is selected from hydrogen and C1-6 alkyl, and n represents an integer of 0 to 2.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: May 8, 2018
    Assignees: University of Tsukuba, Nippon Chemiphar Co., Ltd.
    Inventors: Hiroshi Nagase, Naoshi Yamamoto
  • Patent number: 9815787
    Abstract: The present invention aims to provide a novel low-molecular-weight compound having an orexin agonist activity, which is expected to be useful as a superior agent for the treatment or prophylaxis of narcolepsy. The present invention provides a compound showing superior orexin agonist activity which is represented by the formula (I) wherein each symbol is as defined in the DESCRIPTION, and a pharmaceutically acceptable acid addition salt thereof, as well as an orexin agonist containing the compound or a pharmaceutically acceptable acid addition salt thereof.
    Type: Grant
    Filed: December 12, 2014
    Date of Patent: November 14, 2017
    Assignee: University of Tsukuba
    Inventors: Hiroshi Nagase, Takashi Nagahara
  • Patent number: 9782518
    Abstract: A method for producing an implant material by: (A): setting a porous ceramic material having substantially unidirectionally arrayed pores at any depth position inside a container, (B): filling the container with a cell-containing liquid containing at least bone marrow blood and/or peripheral blood, and (C): applying, on the container, a centrifugal force in the direction along the axis of the container.
    Type: Grant
    Filed: November 10, 2011
    Date of Patent: October 10, 2017
    Assignees: KURARAY CO., LTD., University of Tsukuba
    Inventors: Yuji Hotta, Masataka Sakane
  • Patent number: 9758846
    Abstract: Provided is a super elastic alloy for biological use having a high biocompatibility, good processability and super elasticity, said super elastic alloy being a super elastic zirconium alloy for biological use comprising 27-54 mol % inclusive of titanium, 5-9 mol % inclusive of niobium which is a ? phase-stabilizing element capable of stabilizing the ? phase of zirconium, and 1-4 mol % inclusive in total of tin and/or aluminum which are ? phase-suppressing elements capable of suppressing the ? phase of zirconium, with the balance consisting of zirconium and inevitable impurities.
    Type: Grant
    Filed: August 28, 2012
    Date of Patent: September 12, 2017
    Assignee: University of Tsukuba
    Inventors: Shuichi Miyazaki, Heeyoung Kim, Yosuke Sato
  • Patent number: 9717687
    Abstract: [Problem] To provide: a lipid membrane structure which has such a particle diameter that the lipid membrane structure can be sterilized by filtration, contains a lipid that is bound to a peptide composed of multiple arginine residues as a constituent lipid, and includes a bacterial cell component having dispersibility in a non-polar solvent; and a method for producing a lipid membrane structure which has such a particle diameter that the lipid membrane structure can be sterilized by filtration and includes a substance of interest having dispersibility in a non-polar solvent. [Solution] A lipid membrane structure which has such a particle diameter that the lipid membrane structure can be sterilized by filtration, contains a lipid that is bound to a peptide composed of multiple arginine residues as a constituent lipid, and includes a bacterial cell component having dispersibility in a non-polar solvent.
    Type: Grant
    Filed: August 27, 2013
    Date of Patent: August 1, 2017
    Assignees: National University Corporation Hokkaido University, Japan BCG Laboratory, University of Tsukuba
    Inventors: Hideyoshi Harashima, Takashi Nakamura, Masafumi Fukiage, Megumi Higuchi, Hideyuki Akaza, Jun Miyazaki, Akihiro Nakaya
  • Publication number: 20170188830
    Abstract: A biopotential can be measured with high accuracy without the electrodes coming into direct contact with the skin and without being affected by any motion artifact. The present invention comprises a first lead which detects a biopotential containing noise components, a second lead which is electrically isolated from the first lead and detects noise components, and a differential amplifier circuit which is input with a first signal output from the first lead and a second signal output from the second lead, and which amplifies and outputs a difference between the first signal and the second signal, wherein a value of an input impedance on the second signal side of the differential amplifier circuit is set so that the noise components detected from the second lead will have a frequency that is higher than a frequency spectrum of the biopotential.
    Type: Application
    Filed: June 1, 2015
    Publication date: July 6, 2017
    Applicants: University of Tsukuba, CYBERDYNE Inc.
    Inventors: Yoshiyuki SANKAI, Alexsandr Igorevitch IANOV