Patents Assigned to University of Tsukuba
  • Patent number: 11774447
    Abstract: This invention provides a method for diagnosis of rheumatoid arthritis of a subject, a method for assisting diagnosis of rheumatoid arthritis, and a method for monitoring disease activity of rheumatoid arthritis and/or therapeutic effects of an agent for rheumatoid arthritis, comprising detecting citrullination of an arginine residue of the inter-?-trypsin inhibitor heavy chain (ITIH) 4 in a biological sample obtained from the subject. This invention also provides a citrullinated protein derived from the protein having the amino acid sequence as shown in SEQ ID NO: 1 or 5 by modification of arginine 438 into citrulline or a fragment thereof, an antibody binding to such citrullinated protein, and an agent for diagnosis of rheumatoid arthritis comprising such antibody.
    Type: Grant
    Filed: July 2, 2018
    Date of Patent: October 3, 2023
    Assignee: University of Tsukuba
    Inventors: Isao Matsumoto, Takayuki Sumida, Hoshimi Kawaguchi
  • Patent number: 11759104
    Abstract: In a scanning imaging apparatus of some aspect examples, a scanner applies an optical scan to a sample to acquire data. A scan controller controls the scanner to sequentially apply, to the sample, pattern scans according to a two-dimensional pattern including cycles. A movement unit relatively moves a scan area corresponding to the two-dimensional pattern and the sample. A movement controller controls the movement unit such that cycles in first and second scans of the pattern scans cross each other. An image constructing unit constructs an image based on data acquired under controls performed by the scan controller and the movement controller. The scan controller and the movement controller perform controls of the scanner and the movement unit respectively such that first and second cycles in a pattern scan cross each other at least at one point.
    Type: Grant
    Filed: September 7, 2020
    Date of Patent: September 19, 2023
    Assignees: UNIVERSITY OF TSUKUBA, TOPCON CORPORATION
    Inventors: Yoshiaki Yasuno, Shuichi Makita, Tatsuo Yamaguchi, Toshihiro Mino
  • Patent number: 11746316
    Abstract: Proposed are a three-dimensional structuring method of cells and a three-dimensional structuring system of cells capable of efficiently bonding multiple cell clusters in a three-dimensional direction, pursuant to their growth, while ensuring safety. A plurality of fibers, in which one end of each of the fibers is held by a flat plate, are inserted together with the flat plate into a flow path through which a culture solution is supplied, a plurality of cell clusters are placed in the flow path upon causing the cell clusters to run with a liquid flow of the culture solution, and each of the cell clusters is cultured by being stacked on an outer surface of each of the fibers with the flat plate as a growth origin.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: September 5, 2023
    Assignees: CYBERDYNE Inc., University of Tsukuba
    Inventor: Yoshiyuki Sankai
  • Publication number: 20230272123
    Abstract: A paramylon-based resin having a weight-average molecular weight of paramylon in a range of 70000 to 140000, and formed by substituting hydrogen atoms of hydroxy groups of a paramylon with a long-chain component being a linear saturated aliphatic acyl group having 14 or more carbon atoms and a short-chain component being an acyl group (acetyl group or/and propionyl group) having 2 or 3 carbon atoms, wherein a degree of substitution with the long-chain component (DSLo) and a degree of substitution with the short-chain component (DSSh) satisfy the following conditional expressions (1) and (2), Izod impact strength is 5.0 kJ/m2 or more, and an MFR (melt flow rate at 210° C. and under a load of 5 kg) is 2 g/10 min or more. To provide a paramylon-based resin excellent in mechanical characteristics and thermoplasticity. 2.2?DSLo+DSSh?2.
    Type: Application
    Filed: April 20, 2023
    Publication date: August 31, 2023
    Applicants: NEC CORPORATION, UNIVERSITY OF TSUKUBA
    Inventors: Midori SHIMURA, Shukichi Tanaka, Toshie Miyamoto, Masatoshi Iji
  • Patent number: 11697679
    Abstract: In order to develop tools and methods useful in a variety of applications, including the research and development of medical treatments which involve the modification of collagen protein and use of the same, the present invention provides a modified collagen protein expressed in a transformed cell and capable of forming collagen fibers outside of the cell, wherein the transformation is performed by introducing, into the cell, polynucleotides coding the modified collagen protein.
    Type: Grant
    Filed: November 14, 2018
    Date of Patent: July 11, 2023
    Assignee: UNIVERSITY OF TSUKUBA
    Inventors: Yoshihiro Miwa, Junko Kijima
  • Patent number: 11685655
    Abstract: A carbon nanostructure producing method includes a growth step in which a plurality of catalyst particles in close contact with each other are separated in a flow of a carbon-containing gas so as to grow carbon nanotubes between the plurality of catalyst particles, and an elongation step in which the carbon nanotube is elongated by a wind pressure of the carbon-containing gas with at least one of the catalyst particles being retained.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: June 27, 2023
    Assignees: SUMITOMO ELECTRIC INDUSTRIES, LTD., UNIVERSITY OF TSUKUBA
    Inventors: Takeshi Hikata, Soichiro Okubo, Ryusuke Nakai, Jun-ichi Fujita
  • Patent number: 11678916
    Abstract: Problem to be Solved A traverse that is percutaneously provided and a surgical instrument for percutaneously providing the transverse are provided. Solution A rod 10 is placed in each of two rod openings 113, 123 and a transverse bar 130 is inserted in two bar holes 111, 121. Set screws 140, 150 are screwed in screw holes 114, 124. The set screws 140, 150 press the transverse bar 130, thereby restraining the transverse bar 130 in the longitudinal direction. Since portions of the bar holes 111, 121 adjoin the rod openings 113, 123, the pressed transverse bar 130 contacts the rods 10 and pushes the rods 10 against the rod openings 113, 123. A protrusion 127 engages with the rods 10 to restrain hooks 110, 120 in the longitudinal direction and circumferential direction of the rods 10.
    Type: Grant
    Filed: December 17, 2020
    Date of Patent: June 20, 2023
    Assignees: ASRO MEDICAL, UNIVERSITY OF TSUKUBA
    Inventors: Tetsuya Abe, Masataka Sakane, Taira Takato
  • Patent number: 11673867
    Abstract: The present invention aims to provide a novel low-molecular-weight compound showing an orexin receptor agonist activity and expected to be useful as a prophylactic or therapeutic agent for narcolepsy and the like. The present invention provides a compound represented by the formula (I): wherein each symbol is as described in the description, or a pharmaceutically acceptable acid addition salt thereof, which has an orexin receptor agonist activity, and an orexin receptor agonist containing the compound or a pharmaceutically acceptable acid addition salt thereof.
    Type: Grant
    Filed: December 11, 2018
    Date of Patent: June 13, 2023
    Assignees: University of Tsukuba, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Hiroshi Nagase, Tsuyoshi Saitoh, Masashi Yanagisawa, Yoko Irukayama
  • Patent number: 11672721
    Abstract: A motion assisting apparatus includes a multijoint structure having links in series rotatably connected in a relative manner, the links being integrally deformed in a bendable manner, a linear member inserted through each of the links, wherein one end is fixed to the link in front and another end is elongated via the link in rear, a sliding/holding part which fixes an elongated portion of the linear member, and slidably guides the rear link in a connecting direction between each of the links, a drive unit which drives the rear link to slide toward the sliding/holding part and causes the multijoint structure, through which the linear member has been inserted, to engage in an extending or flexing motion, and a control unit which drive-controls the drive unit so that a sliding direction, a sliding speed and a sliding position of the rear link will become an intended state.
    Type: Grant
    Filed: March 21, 2017
    Date of Patent: June 13, 2023
    Assignees: CYBERDYNE, INC., University of Tsukuba
    Inventor: Yoshiyuki Sankai
  • Patent number: 11673806
    Abstract: A carbon nanotube composite assembled wire is a carbon nanotube composite assembled wire including a plurality of carbon nanotube composites, each of the plurality of carbon nanotube composites including one carbon nanotube and an amorphous carbon-containing layer that coats the carbon nanotube, the carbon nanotube having a D/G ratio of 0.1 or less, the D/G ratio being a ratio of a peak intensity of a D band to a peak intensity of a G band in Raman spectroscopic analysis with a wavelength of 532 nm, each of the plurality of carbon nanotube composites being fibrous and having a diameter of 0.1 ?m or more and 50 ?m or less, the plurality of carbon nanotube composites being oriented in a longitudinal direction of the carbon nanotube composite assembled wire.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: June 13, 2023
    Assignees: SUMITOMO ELECTRIC INDUSTRIES, LTD., UNIVERSITY OF TSUKUBA
    Inventors: Toshihiko Fujimori, Takeshi Hikata, Soichiro Okubo, Jun-ichi Fujita
  • Publication number: 20230174681
    Abstract: A paramylon-based resin excellent in mechanical characteristics and thermoplasticity is provided. The present embodiment provides a paramylon-based resin in which hydrogen atoms of hydroxy groups of paramylon are substituted by linear saturated aliphatic acyl group having 14 or more carbon atoms as a long chain component and/or acyl group having 2 or 3 carbon atoms (acetyl group or/and propionyl group) as a short chain component, wherein the paramylon has a weight average molecular weight in the range of more than 140000 to 220000 and a molecular weight distribution (weight average molecular weight/number average molecular weight) of 6.5 or less, a protein content of the paramylon is 0.22% by mass to 5.0% by mass, and a degree of substitution (DSLo) by the long chain component and a degree of substitution (DSSh) by the short chain component satisfy the following expressions (S1), (L1) and (T1); 1.7?DSSh?2.8 (S1), 0?DSLo?0.4 (L1), 2.1?DSLo+DSSh?2.8 (T1).
    Type: Application
    Filed: May 7, 2021
    Publication date: June 8, 2023
    Applicants: NEC CORPORATION, UNIVERSITY OF TSUKUBA
    Inventors: Midori SHIMURA, Shukichi TANAKA, Masatoshi IJI
  • Publication number: 20230169627
    Abstract: A model learning unit determines a model parameter for calculating an estimated value for each of a plurality of training sets, each including a measurement signal and at least one type of predetermined characteristic value indicating characteristics of the measurement signal as a target value, to minimize a difference between the estimated value calculated for the measurement signal using a predetermined mathematical model and the target value is minimized, determines characteristic value sets, each being a set of a plurality of types of characteristic values indicating characteristics of the measurement signal including the target value, with which, for each target value, the target value is common to a plurality of characteristic value sets, and generates, for each of the characteristic value sets, each of the plurality of training sets including the target value and a measurement signal having characteristics indicated by the plurality of types of characteristic values.
    Type: Application
    Filed: April 6, 2021
    Publication date: June 1, 2023
    Applicant: University of Tsukuba
    Inventors: Yoshiaki YASUNO, Thitiya SEESAN
  • Patent number: 11654035
    Abstract: A gait disorder support apparatus and gait disorder support method capable of detecting an onset sign of a gait disorder associated with motor symptoms in advance and performing motion assist are proposed. The onset sign of the gait disorder associated with the motor symptoms of a wearer is detected based on the correlation between a gait cycle and a reduction ratio of the gait cycle as compared to immediately preceding gait; and when the onset sign of the gait disorder is detected, a drive unit is controlled so that the drive unit applies assist power to a knee joint of the wearer; and on the other hand, when the onset sign of the gait disorder is not detected, the drive unit is controlled so that driving torque by the drive unit does not hinder the wearer's gait motion.
    Type: Grant
    Filed: March 17, 2017
    Date of Patent: May 23, 2023
    Assignees: CYBERDYNE Inc., University of Tsukuba
    Inventor: Yoshiyuki Sankai
  • Publication number: 20230113829
    Abstract: The invention provides an HIF-1 activator for treatment, prevention, alleviation, improvement or recovery from diseases or symptoms associated with reduced HIF-1 activity, as well as a pharmaceutical composition, cosmetic and food composition comprising the activator. Provided is an HIF-1 activator comprising olive leaf extract. Also provided is an HIF-1 activator which is for maintaining the undifferentiated state of stem cells via HIF-1 activation and/or improving dysdifferentiation of stem cells.
    Type: Application
    Filed: October 4, 2022
    Publication date: April 13, 2023
    Applicants: NUTRITION ACT. CO.,LTD., UNIVERSITY OF TSUKUBA
    Inventors: HIROKO ISODA, SHINJI KONDO, FARHANA FERDOUSI, MASAHITO ISHIKAWA, YOUKO WATANABE, KEN YAMAUCHI, MIKI YOKOZAWA
  • Publication number: 20230106845
    Abstract: A trained model generation program causes a computer to implement a learning execution function of inputting first input image data representing a first input image generated by a first reconstruction method using compressed sensing and second input image data representing a second input image generated by a second reconstruction method different from the first reconstruction method to a machine learning device to execute machine learning, the second reconstruction method being an analytical reconstruction method, and causing the machine learning device to generate a trained model, and a trained model acquisition function of acquiring trained model data indicating the trained model. Then, input image data representing an input image is input to the trained model to generate a reconstructed image with improved image quality.
    Type: Application
    Filed: February 24, 2021
    Publication date: April 6, 2023
    Applicant: University of Tsukuba
    Inventors: Hiroyuki KUDO, Kazuki MORI
  • Publication number: 20230094530
    Abstract: A diagnostic imaging support device includes: a learning unit that calculates a feature quantity about each of infectiousness condition and non-infectiousness condition for determining a condition in a determination image of an anterior eye through machine learning on the basis of a learning image of an anterior eye and information about a condition in the learning image.
    Type: Application
    Filed: February 12, 2021
    Publication date: March 30, 2023
    Applicants: NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM, UNIVERSITY OF TSUKUBA
    Inventors: Kensaku MORI, Masahiro ODA, Tetsuro OSHIKA, Yuta UENO, Takefumi YAMAGUCHI, Hideki FUKUOKA
  • Patent number: 11607126
    Abstract: A biopotential can be measured with high accuracy without the electrodes coming into direct contact with the skin and without being affected by any motion artifact. The present invention comprises a first lead which detects a biopotential containing noise components, a second lead which is electrically isolated from the first lead and detects noise components, and a differential amplifier circuit which is input with a first signal output from the first lead and a second signal output from the second lead, and which amplifies and outputs a difference between the first signal and the second signal, wherein a value of an input impedance on the second signal side of the differential amplifier circuit is set so that the noise components detected from the second lead will have a frequency that is higher than a frequency spectrum of the biopotential.
    Type: Grant
    Filed: June 1, 2015
    Date of Patent: March 21, 2023
    Assignees: University of Tsukuba, CYBERDYNE Inc.
    Inventors: Yoshiyuki Sankai, Alexsandr Igorevitch Ianov
  • Patent number: 11600251
    Abstract: A musicality information provision method includes acquiring first performance data from a performance of a given composition, calculating, with respect to a combination of a plurality of parameters indicating musicality, which are included in the first performance data, respective distances between the first performance data and a plurality of sets of second performance data that are acquired from performances of the given composition and that are compared with the first performance data, and outputting determination information for determining the musicality of the first performance data, the determination information including information indicating the distances.
    Type: Grant
    Filed: October 23, 2020
    Date of Patent: March 7, 2023
    Assignees: UNIVERSITY OF TSUKUBA, OSAKA UNIVERSITY, ROLAND CORPORATION
    Inventors: Shinichi Yamagiwa, Yoshinobu Kawahara, Hidemasa Togai, Yoshiyasu Kitagawa, Ikuo Tanaka, Tomoko Nakai
  • Patent number: 11583820
    Abstract: A hydrogen generator includes a reaction vessel, a water supply, a temperature adjustor, and a controller. The reaction vessel houses a hydrogen generating material having hydrogen generating ability. The hydrogen generating material includes a two-dimensional hydrogen boride sheet having a two-dimensional network and containing multiple negatively charged boron atoms. The controller is configured to execute a hydrogen generating mode to generate hydrogen from the hydrogen generating material and a regenerating mode to recover the hydrogen generating ability of the hydrogen generating material. The controller controls the temperature adjustor to heat the hydrogen generating material at a first predetermined temperature during the hydrogen generating mode. The controller controls the temperature adjustor to adjust the temperature of the hydrogen generating material to a second predetermined temperature and controls the water supply to supply water during the regenerating mode.
    Type: Grant
    Filed: September 29, 2021
    Date of Patent: February 21, 2023
    Assignees: DENSO CORPORATION, University of Tsukuba, TOKYO INSTITUTE OF TECHNOLOGY
    Inventors: Yasuyuki Hikita, Hiroaki Yoto, Takahiro Kondo, Shin-ichi Ito
  • Publication number: 20230040622
    Abstract: There is provided a mutant KLF protein that can induce reprogramming of a somatic cell at a higher efficiency than a KLF protein having a natural amino acid sequence. There is also provided a method for efficiently producing an iPS cell by using the mutant KLF protein. There is provided a mutant KLF protein having an amino acid substitution, or a peptide fragment thereof containing the amino acid substitution.
    Type: Application
    Filed: December 16, 2020
    Publication date: February 9, 2023
    Applicants: RIKEN, UNIVERSITY OF TSUKUBA
    Inventors: Yohei HAYASHI, Evgeniia BORISOVA, Koji HISATAKE, Ken NISHIMURA, Fumiaki YUMOTO