Abstract: Described herein are doppel-targeting molecules useful for inhibiting pathological angiogenesis and treating diseases and conditions associated with pathological angiogenesis, such as tumors, cancers, atherosclerosis, tuberculosis, asthma, pulmonary arterial hypertension (PAH), neoplasms and neoplasm-related conditions, and for detecting doppel expression in a subject. Related compositions and methods also are described.

Abstract: A method for detecting disease using a manometry includes obtaining pressure values from each of the plurality of pressure sensors during a pre-set time, obtaining a three-dimensional pressure distribution showing the changes in the pressure values according to location and time by using the time, the pressure values, and locations in which the pressure sensors are disposed within the arbitrary location section, and calculating the volume integral value of the interest location which is predetermined in accordance with the disease, in the three-dimensional pressure distribution.

Abstract: Provided are a microfluidic platform for cell culturing and a cell culturing method using the same. By applying a structure of a compartment which surrounds at least a portion of an annular reservoir and moving cells to be cultured to a site adjacent to a microchannel via rotation, a probability of observing cells that grew after culturing may increase and a probability of causing cells, particularly neurons, to grow so as to correspond to a signal transfer direction may increase.

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating liver diseases, containing a plasmalogen precursor, plasmalogen, or a plasmalogen analog as an effective component. More specifically, a plasmalogen precursor, or plasmalogen or a plasmalogen analog produced by metabolizing the plasmalogen precursor, can prevent or treat liver diseases such as hepatic steatosis, hepatitis, or liver cirrhosis, etc. by decreasing accumulation of neutral fats in the liver, repressing expressions of inflammatory cytokine genes, and increasing fatty acid oxidation capacity of peroxisome.

Abstract: There is provided a composition for prophylaxis or treatment of vascular or valvular calcification including a dipeptidylpeptidase-4 (DPP-4) inhibitor. The DPP-4 according to one exemplary embodiment of the present disclosure is expressed at an increased level when blood vessels and valves are calcified, and the calcification decreases remarkably upon administration of the DPP-4 inhibitor. Therefore, the DPP-4 inhibitor can be useful in treatment or prophylaxis of blood vessels or valves.

Abstract: A stator of a switched reluctance motor includes a stator core part, stator coiling parts, stator salient parts, and pairs of permanent magnets. The stator coiling parts protrude inwardly from the stator core part and have coils wound on an external side thereof. The stator salient parts protrude inwardly from the stator core part and are disposed between the stator coiling parts. Each pair of the permanent magnets is inserted into each of the stator coiling parts and magnetized in the same direction as a direction of a magnetic field generated by the excitation of the coils. This stator has an electromagnetic structure designed to prevent the reversal of a magnetic field generated by the excited coils. The output of the motor is enhanced by inserting the permanent magnets so as to be magnetized in the same direction as a direction of a magnetic field generated by the excited coils.

Abstract: The present invention relates to a water-soluble expression and a purification method of a human granulocyte colony-stimulating factor (hGCSF) recombinant protein having biological activities using an N-terminal tag, and provides a recombinant expression vector containing a solubility enhancing tag and a hGCSF gene. In addition, provided are: a recombinant microorganism transformed with the recombinant expression vector; a method for producing a hGCSF recombinant protein (rhGCSF); and a rhGCSF produced by the production method.

Abstract: A continuously variable valve lift device with improved lift amount change accuracy includes a rocker arm causing an engine valve to perform an opening/closing operation with a cam of a cam shaft, and an engine valve lift amount change mechanism. The mechanism has a control shaft which has an eccentric circular disc cam, a control arm which swings about the eccentric circular disc cam and having a cam contact portion in contact with a first cam and a first aim, second biasing means for biasing the cam contact portion against the first cam, a second cam portion of a free-form surface shape contacting with the second arm and the rocker arm, a cam member supported so as to be capable of turning around the shall main body, and a link arm with both ends supported so as to be capable of turning by the first arm and the second arm.

Abstract: Provided are a microfluidic platform for cell culturing and a cell culturing method using the same. By applying a structure of a compartment which surrounds at least a portion of an annular reservoir and moving cells to be cultured to a site adjacent to a microchannel via rotation, a probability of observing cells that grew after culturing may increase and a probability of causing cells, particularly neurons, to grow so as to correspond to a signal transfer direction may increase.

Abstract: Disclosed are a primer set and/or a probe capable of detecting specific nucleotide sequences of MTC and NTM, a kit for the detection of MTC and NTM, comprising the same, and a method for detecting MTC and NTM by duplex real-time PCR using the same. Useful in detecting genes characteristic of MTC and NTM, the primer sets and/or probes, detection kits, and detection methods can be applied as the clinical diagnosis of diseases caused by MTC and NTM, and therefore find applications in the medical fields including hospitals, research institutes, etc.

Abstract: Disclosed are primer sets specific for the IS6110 or 16S rRNA gene characteristic of MTC and for the 16S rRNA gene characteristic of NTM, kits for the detection of MTC and NTM, comprising the same, and methods for detecting MTC and NTM by duplex PCR using the same. Because the primers are exclusive to Mycobacterium tuberculosis and nontuberculous mycobacteria, the methods, which can employ an inexpensive typical PCR cycler, can be a clinical diagnostic means useful for the detection of both Mycobacterium tuberculosis and nontuberculous mycobacteria at the same time, with higher efficiency.

Abstract: Disclosed are primer sets specific for the IS6110 gene characteristic of MTC and for the 16S rRNA gene characteristic of NTM, kits for the detection of MTC and NTM, comprising the same, and methods for detecting MTC and NTM by duplex real-time PCR and melting profile analysis using the same. Because the primers are exclusive to Mycobacterium tuberculosis and nontuberculous mycobacteria, the methods can be a clinical diagnostic means useful for the detection of both Mycobacterium tuberculosis and nontuberculous mycobacteria at the same time, with higher efficiency.

Abstract: The present invention relates to an siRNA (small interfering RNA) having antiviral activity against nonpolio enteroviruses, and a pharmaceutical composition comprising same as an active ingredient for preventing and treating diseases caused by nonpolio enterovirus infection.