Abstract: Described herein are doppel-targeting molecules useful for inhibiting pathological angiogenesis and treating diseases and conditions associated with pathological angiogenesis, such as tumors, cancers, atherosclerosis, tuberculosis, asthma, pulmonary arterial hypertension (PAH), neoplasms and neoplasm-related conditions, and for detecting doppel expression in a subject. Related compositions and methods also are described.

Abstract: The inventive concept relates to an endoscopic procedure simulator module and an endoscopic procedure simulator using the same. The endoscopic procedure simulator module according to the inventive concept includes a lesion indicating part having a discharge hole formed therein, through which a fluid is discharged to present a bleeding state, a module body to which the lesion indicating part is coupled, the module body having a fluid channel and a spacing space formed therein, in which the fluid to be discharged through the discharge hole flows through the fluid channel and the spacing space is separated from the fluid channel, and a diaphragm provided in the spacing space of the module body so as to be expandable, in which the diaphragm is expanded by a separate fluid injected into the spacing space and closes the discharge hole of the lesion indicating part.

Abstract: The present disclosure relates to a catheter delivery device having an improved mechanism for inserting a catheter into a blood vessel of a patient. The catheter delivery device includes at least: a body including a delivery path of a catheter; a pair of feeders having grippers located on the delivery path of the body and are configured to grip and release the catheter; and a rotator configured to rotate the catheter gripped by the feeders. The feeders move from a grip position where the grippers grip the catheter to a forward position where the grippers advance in a state of gripping the catheter, from the forward position to a grip release position where the grippers release the catheter, from the grip release position to a backward position where the grippers retract in a state of releasing a grip on the catheter, and from the backward position to the grip position.

Abstract: The present disclosure relates to a catheter and a surgical medical device. The catheter includes at least: a first elastic member positioned at an end portion of the catheter, a second elastic member connected with the first elastic member, the second elastic member being curved with a first radius of curvature to protrude toward a first direction; a first wire connected with a first surface of the first elastic member, and configured to pull the catheter to bend the catheter in the first direction; a second wire connected with a second surface of the first elastic member, which is opposite to the first surface, and configured to pull the catheter to bend the catheter in a second direction; and a tube containing the first elastic member, the second elastic member, the first wire, and the second wire.

Abstract: A method for manufacturing an implant for implantation into a human body, includes preparing a mold having an inner space part so as to have an inner shape corresponding to a defective portion in a human body; injecting silicone foam into the space part of the mold; curing the silicone foam while applying pressure to same; and removing the mold.

Abstract: Provided is an apparatus for manufacturing a surgical guide that guides a cutting line formed to surround a tumor of an organ, the apparatus including: an organ modeling unit configured to model a 3-dimensional (3D) image of the organ, based on an image of a patient captured by an external imaging apparatus; a cutting line determining unit configured to determine, in the 3D image of the organ, the cutting line to correspond to a location of the tumor and an entry angle of a surgical instrument to the cutting line; and a guide manufacturing unit configured to manufacture a surgical guide that guides the surgical instrument to the cutting line in a slanting manner corresponding to the entry angle, based on the 3D image of the organ.

Abstract: The present disclosure relates to a tool for a closed reduction of a fracture. The tool includes at least: a winding portion having a winding shape; a support extending from the winding portion in a normal direction relative to a plane of the winding shape; and a handle extending from the support in the normal direction, and configured to be gripped.

Abstract: The present disclosure relates to a system and a method for estimating an acute cerebral infarction onset time. The method according to the present disclosure includes at least: receiving a first image and a second image of a first patient whose acute cerebral infarction onset time is not identified; extracting an infarction area image from the second image; aligning the second image with the first image; defining an infarction area in the first image, based on a result of the alignment of the second image with the first image; extracting feature information of the first patient, from the infarction area in the first image; comparing the extracted feature information with reference data; and calculating an amount of time that has elapsed since the acute cerebral infarction onset time, based on a result of the comparison of the extracted feature information with reference data.

Abstract: The present invention relates to a customized surgical guide device and a customized surgical guide generating method and program. A customized surgical guide generating method comprises the steps of: acquiring body surface data and treatment area data from medical image data by a computer; a first shape data generating step, wherein the first shape data is data which corresponds to the shape of the body part cover; a target point setting step of setting one or more target points; setting individual first points on the body surface accessible to the target point with a medical tool; setting a guide tube length on the basis of a distance from the first point to the target point; and generating final shape data in which one or more guide tubes are combined to the first shape data by applying the guide tube length to the first point.

Abstract: The present invention relates to a nucleic acids extraction method using a solid subject, and it can isolate nucleic acids with large amounts and high purity at a low cost and simpler than conventional methods of extracting nucleic acids by forming a complex of a nucleic acids sample and an imidoesters compound in the subject, and particularly, the thin film device used for extracting nucleic acids has improved hydrophilicity compared to the conventional silicon substrate, so that nucleic acids can be extracted more efficiently.

Abstract: Provided are a device for driving a robot joint using a wire, an endoscope robot device including the same, and a medical robot device including the same. The device for driving a robot joint includes at least: a base; a first link coupled with the base, and configured to be rotatable relative to the base; a second link coupled with the first link, and configured to be rotatable relative to the first link; a plurality of wires positioned opposite each other, and configured to generate motions of the first and second links; and a wire drive device configured to drive the plurality of wires. Each of the plurality of wires is fixed, via the second link, on one of the base and the first link. Positions where the plurality of wires are fixed are asymmetrical to each other and have different heights to each other.

Abstract: Provided is a peptide for targeting colorectal cancer, a composition for diagnosing radioresponsiveness-dependent prognosis of colorectal cancer using the peptide, and a drug delivery use of the peptide, wherein a functional peptide capable of targeting cancer has been discovered so as to implement personalized diagnosis and treatment for individual patients having cancer, in consideration of problems occurring during treatment in which treatment cases of respective patients differ due to different therapeutic responses resulting from genetic differences in the individual patients.

Abstract: Disclosed are a device, a method, and a program for training memory using brain stimulation. The method includes at least: displaying a first problem on a task display portion of a screen; receiving a first response corresponding to the first problem; and evaluating a memory state of a user based on the first response. The first problem includes one or more output images to be displayed at a specific location within the task display portion, and the first response includes a result of comparing a previous first problem that was displayed before N times (N is a natural number) of executing the method, with the displayed first problem.

Abstract: The present invention relates to a pharmaceutical composition containing TNP (N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine) or a pharmaceutically acceptable salt thereof as an active ingredient for suppressing appetite. Particularly, TNP or a pharmaceutically acceptable salt thereof can be effectively used as an active ingredient of a pharmaceutical composition or a nutraceutical food for suppressing appetite since it is confirmed that food intake is reduced and weight gain is inhibited in mice when the central nervous system of mice is treated with TNP.

Abstract: The present invention relates to a high-sensitivity liquid field-effect sensor for colon cancer, applicable to a sample such as blood or stool. The sensor according to one aspect enables ultra-high precision/low-concentration detection of colon cancer biomarkers, thereby having an effect of enabling early diagnosis of colon cancer even with a very small amount of a sample.

Abstract: A composition and a method for improving sensitivity and specificity of detection of nucleic acids, use dCas9 and gRNA, which binds to a target nucleic acid sequence, in amplification of nucleic acids including DNAs, RNAs, and the like increases efficiency in amplification of nucleic acids and thereby can ultimately improve sensitivity and specificity of a target diagnosis on the basis of a functional difference between Cas9 and dCas9.

Abstract: The present invention relates to a biomarker composition for diagnosing radiation-resistant cancer comprising LRP-1 as an active ingredient and a method of diagnosing radiation-resistant cancer using the same, and identifies LRP-1 which a binding partner protein to which specific peptide sequences specifically targeting radiation-resistant colon cancer tissues are actually bound, and based on this, suggests the possibility of radiation therapy resistance factor for cancer.

Abstract: A word semantic embedding apparatus includes: a data storing unit to store a lexical semantic network including word dictionary data and word semantic data; a word list generating unit to extract vocabularies having a predetermined part of speech from the stored word dictionary data and generate a list of words to be learned; a processing data generating unit to bring the generated list of words to be learned and the word semantic data of a word to be learned included in the list of words to be learned from the data storing unit and process the data suitable for word embedding learning to generate processing data; and a word embedding learning unit to learn the word to be learned through the word embedding learning using a learning model formed of an input/output layer and a projection layer with the generated processing data to generate a word vector.

Abstract: Disclosed is a composition for proliferation, differentiation promotion, and senescence inhibition of stem cells, including a JAK1 inhibitor as an active ingredient, wherein JAK1 inhibitor-treated stem cells or JAK1 knockout stem cells have an activity for decreasing senescence and increasing the survival rate of the stem cells, thereby being usable in a composition for proliferation, differentiation promotion, and senescence inhibition of stem cells.

Abstract: Described herein are doppel-targeting molecules useful for inhibiting pathological angiogenesis and treating diseases and conditions associated with pathological angiogenesis, such as tumors, cancers, atherosclerosis, tuberculosis, asthma, pulmonary arterial hypertension (PAH), neoplasms and neoplasm-related conditions, and for detecting doppel expression in a subject. Related compositions and methods also are described.