Patents Assigned to UNIVERSITY OF ULSAN
  • Publication number: 20210371515
    Abstract: Provided are a genetically modified immunocyte expressing a chimeric antigen receptor (CAR) comprising an antigen binding domain specifically binding to cancer cells and/or expressing TRAIL, a composition for preventing or treating cancer, the composition comprising the immunocytes, a cell therapeutic agent, a method of providing information for cancer diagnosis, and a method of preparing the genetically modified immunocyte.
    Type: Application
    Filed: March 10, 2020
    Publication date: December 2, 2021
    Applicants: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY, THE ASAN FOUNDATION, UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
    Inventors: Mihue JANG, Eunsung JUN, Anna JU
  • Patent number: 11185666
    Abstract: A catheter delivery device having an improved mechanism for inserting a catheter into a blood vessel of a patient. The catheter delivery device includes at least: a body including a delivery path of a catheter; a pair of feeders having grippers located on the delivery path of the body and are configured to grip and release the catheter; and a rotator configured to rotate the catheter gripped by the feeders. The feeders move from a grip position where the grippers grip the catheter to a forward position where the grippers advance in a state of gripping the catheter, from the forward position to a grip release position where the grippers release the catheter, from the grip release position to a backward position where the grippers retract in a state of releasing a grip on the catheter, and from the backward position to the grip position.
    Type: Grant
    Filed: August 2, 2019
    Date of Patent: November 30, 2021
    Assignees: THE ASAN FOUNDATION, UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
    Inventors: Jae Soon Choi, Young Jin Moon, Gi Byoung Nam, Young Hak Kim, Zhenkai Hu, Ho Yul Lee
  • Patent number: 11154362
    Abstract: The present invention relates to a customized surgical guide device and a customized surgical guide generating method and program. A customized surgical guide generating method comprises the steps of: acquiring body surface data and treatment area data from medical image data by a computer; a first shape data generating step, wherein the first shape data is data which corresponds to the shape of the body part cover; a target point setting step of setting one or more target points; setting individual first points on the body surface accessible to the target point with a medical tool; setting a guide tube length on the basis of a distance from the first point to the target point; and generating final shape data in which one or more guide tubes are combined to the first shape data by applying the guide tube length to the first point.
    Type: Grant
    Filed: May 16, 2019
    Date of Patent: October 26, 2021
    Assignees: THE ASAN FOUNDATION, UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
    Inventors: Namkug Kim, Guk Bae Kim, Beom Seok Ko, Sang Wook Lee, Sei Hyun Ahn, Byung Ho Son, Jong Won Lee
  • Publication number: 20210256689
    Abstract: A medical image learning method of a medical image process apparatus includes preparing a plurality of body X-ray images for learning as an input of a learning data set, preparing internal diagnostic indicator information corresponding to each of the plurality of body X-ray images for learning as a label of the learning data set, and learning an artificial neural network model using the learning data set. The internal diagnostic indicator information includes information on a cardiovascular border. The information on the cardiovascular border includes information on at least one of an aortic knob, a pulmonary conus, a left atrial appendage, an upper right cardiac border, a lower right cardiac border, a lower left cardiac border, a descending aorta, a carina, an upper end point of a diaphragm, a right pulmonary artery, a posterior cardiac border, and an anterior spinal border.
    Type: Application
    Filed: January 25, 2021
    Publication date: August 19, 2021
    Applicants: THE ASAN FOUNDATION, UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
    Inventors: Dong Hyun YANG, June Goo LEE, Gaeun LEE
  • Patent number: 11083385
    Abstract: The present invention relates to an apparatus for measuring blood circulation disorders, and a method therefor. The apparatus for measuring blood circulation disorders using a pulse wave transit time includes a measurement unit configured to measure a pulse wave and an electrocardiogram of a subject to be measured, a detection unit configured to detect time information of a peak value point of the electrocardiogram and a peak value point and a foot value point of the pulse wave, an operation unit configured to calculate an average pulse wave transit time using the time information of the peak value point of the electrocardiogram and the peak value point and the foot value point of the pulse wave and calculate a blood circulation disorder determination index using the average pulse wave transit time, and a diagnosis unit configured to diagnose a blood circulation disorder using the blood circulation disorder determination index.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: August 10, 2021
    Assignee: UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
    Inventors: Chae Hun Leem, Young Boum Lee, Moo Yong Rhee
  • Publication number: 20210241481
    Abstract: A method for determining the size of a bicuspid annulus of bicuspid, including acquiring an image of the heart including the left ventricle and the aorta; generating a first plane, which includes a line that passes through two base points in the bicuspid of the image of the heart; and generating multiple second planes, which are obtained per each rotation, while rotating the first plane multiple times by a predetermined angle about the line that passes through the two base points; measuring the cross-sectional area of each of at least one of the left ventricle and the aorta, which are formed on the first plane and the multiple second planes; selecting a plane for measuring the size of a bicuspid annulus among the first plane and the multiple second planes based on the measured cross-sectional area; and measuring the size of the bicuspid annulus based on the selected plane.
    Type: Application
    Filed: April 22, 2019
    Publication date: August 5, 2021
    Applicants: THE ASAN FOUNDATION, UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
    Inventors: Dong Hyun YANG, June Goo LEE, Hyun Jung KOO, Jung-Min AHN
  • Patent number: 11052263
    Abstract: The present invention relates to a body insertable device having an outer body being bent; and an inner body positioned inside the outer body, having an accommodation space in which the resource soured is accommodated, and being capable of rotating inside the outer body, wherein a radiation emission direction is continuously adjusted by rotation of the inner body.
    Type: Grant
    Filed: June 19, 2017
    Date of Patent: July 6, 2021
    Assignees: NATIONAL CANCER CENTER, KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES, THE ASAN FOUNDATION, UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
    Inventors: Young Kyung Lim, Jung Won Kwak, Dae Yong Kim, Yeon Joo Kim, Joo Young Kim, Soon Ki Min, Young Dae Jung, Ho Jin Jeong, Sang Hyoun Choi, Ui Jung Hwang
  • Patent number: 11049241
    Abstract: Disclosed is a method for the quantification of pulmonary vessels by lobe, the method including extracting, at extraction unit, pulmonary vessels based on a medical image, locating, at analysis unit, voxels of pulmonary vessels with respect to the surface of a lobe, and quantifying, at calculation unit, the extracted pulmonary vessels.
    Type: Grant
    Filed: June 4, 2019
    Date of Patent: June 29, 2021
    Assignees: Coreline Soft Co., Ltd., The Asan Foundation, UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
    Inventors: Donghoon Yu, Hyungi Seo, Joon Beom Seo, Nam Kug Kim
  • Patent number: 11039392
    Abstract: The present description relates to a frequency-based wake-up device and a sensor communication device using such the same. The present invention comprises: a RF signal to voltage converter for receiving a wireless signal including a first signal and a second signal and converting the frequency of the preamble to voltage to generate a driving voltage and provide the same; a decoder activated by the driving voltage and extracts ID information of the sensor communication device by decoding the second signal; and a signal processor that is activated by the driving voltage and compares the extracted ID information of the sensor communication device by the decoder with pre-stored ID information of a pre-determined sensor communication device and notifies of reception of a wake-up signal when the extracted ID information and the pre-stored ID information are the same.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: June 15, 2021
    Assignee: UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
    Inventors: Hoon Oh, Trang Tien Nguyen
  • Publication number: 20210169439
    Abstract: An esophageal stethoscope is disclosed. The esophageal stethoscope includes a cuff, a tube, one end of which is disposed in the interior of the cuff, and extending to a side that is opposite to the one end thereof, a mount member mounted on an opposite end of the tube, and a microphone disposed in the interior of the mount member, the tube includes at least one hole configured to allow sound waves that passes through the cuff to be provided into the tube, and the microphone absorbs cardiac sound and converts the cardiac sound to a cardiac sound electric signal, and is electrically connected to an external device to deliver the cardiac sound electric signal to the external device.
    Type: Application
    Filed: February 23, 2021
    Publication date: June 10, 2021
    Applicants: THE ASAN FOUNDATION, UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
    Inventors: Sung Hoon KIM, Young Jin MOON
  • Patent number: 11026633
    Abstract: A motion artifact detecting method using wavelet transform which is capable of removing the problem caused by a radio noise and a motion artifact generated during the measurement of a PPG signal which is one of bio-signals, the method including: measuring a PPG signal; generating a signal obtained by removing a radio noise from the measured PPG signal; setting a reference signal from the signal from which the radio noise is removed; selecting a base signal based on the set reference signal; performing wavelet transform using the base signal; and detecting and removing a motion artifact using the wavelet-transformed value.
    Type: Grant
    Filed: December 30, 2015
    Date of Patent: June 8, 2021
    Assignee: UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
    Inventors: Sungoh Kwon, Da Hee Ban
  • Patent number: 11026620
    Abstract: The present disclosure relates to a system and a method for estimating an acute cerebral infarction onset time. The method according to the present disclosure includes at least: receiving a first image and a second image of a first patient whose acute cerebral infarction onset time is not identified; extracting an infarction area image from the second image; aligning the second image with the first image; defining an infarction area in the first image, based on a result of the alignment of the second image with the first image; extracting feature information of the first patient, from the infarction area in the first image; comparing the extracted feature information with reference data; and calculating an amount of time that has elapsed since the acute cerebral infarction onset time, based on a result of the comparison of the extracted feature information with reference data.
    Type: Grant
    Filed: May 20, 2019
    Date of Patent: June 8, 2021
    Assignees: THE ASAN FOUNDATION, UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
    Inventors: Namkug Kim, Hyun Na Lee, Sung Won Ham, Dong Wha Kang
  • Publication number: 20210144976
    Abstract: The present invention relates to a Pde6b-deficient animal model of retinal degeneration produced by engineered endonucleases, and a method for producing the same. In the animal model of retinal degeneration according to the present invention, only a specific target gene can be removed using engineered endonucleases, so that mutagenesis can be stably achieved. In addition, it is possible to produce a congenital animal model through genetic manipulation at the embryonic stage rather than through acquired factors, which allows for production of an animal model that uniformly exhibits symptoms of the disease in question without being influenced by other factors.
    Type: Application
    Filed: November 15, 2019
    Publication date: May 20, 2021
    Applicants: UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION, THE ASAN FOUNDATION
    Inventors: Joo Yong LEE, In Jeoung BAEK, Young Hoon SUNG
  • Publication number: 20210137486
    Abstract: An information acquisition method using heart and lung sounds is provided. The information acquisition method includes acquiring, by a computer, heart sound measurement data of a specific patient in real time, acquiring, by the computer, at least one processed heart sound measurement data using the heart sound measurement data in real time, extracting, by the computer, a scale factor between the processed heart sound measurement data and a cardiovascular data value, and calculating and providing, by the computer, a calculated value of specific cardiovascular information data based on the processed heart sound measurement data and the scale factor, wherein the cardiovascular information data has the same variation tendency as a variation tendency of specific processed heart sound measurement data.
    Type: Application
    Filed: January 20, 2021
    Publication date: May 13, 2021
    Applicants: THE ASAN FOUNDATION, UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
    Inventor: Sung Hoon KIM
  • Publication number: 20210128752
    Abstract: The present invention relates to a method for culturing a 3-dimensional lung cancer organoid and a method for preparing a patient-derived xenograft animal model using the same. More specifically, the present invention relates to a method for culturing a 3-dimensional lung cancer organoid, a lung cancer organoid prepared by the method, a medium composition for culturing the lung cancer organoid, a method for preparing a xenograft animal model using the lung cancer organoid, a patient-derived lung cancer organoid xenograft animal model prepared by the method, and a method for analyzing therapeutic efficacy of an anticancer agent and a method for screening an anticancer agent, using the animal model.
    Type: Application
    Filed: August 13, 2018
    Publication date: May 6, 2021
    Applicants: UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION, THE ASAN FOUNDATION
    Inventors: Se Jin JANG, Min Suh KIM, Young Ah SUH, Hye Min MUN, Ju Hee OH
  • Patent number: 10984318
    Abstract: A word semantic embedding apparatus includes: a data storing unit to store a lexical semantic network including word dictionary data and word semantic data; a word list generating unit to extract vocabularies having a predetermined part of speech from the stored word dictionary data and generate a list of words to be learned; a processing data generating unit to bring the generated list of words to be learned and the word semantic data of a word to be learned included in the list of words to be learned from the data storing unit and process the data suitable for word embedding learning to generate processing data; and a word embedding learning unit to learn the word to be learned through the word embedding learning using a learning model formed of an input/output layer and a projection layer with the generated processing data to generate a word vector.
    Type: Grant
    Filed: May 17, 2017
    Date of Patent: April 20, 2021
    Assignee: UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
    Inventors: Cheol Young Ock, Joon Choul Shin, Ju Sang Lee
  • Publication number: 20210085998
    Abstract: The present invention relates to a method, a device, and a program for calculating a brachytherapy plan, and a brachytherapy apparatus. The method comprises: a step in which a computer obtains the number of radiation irradiation spots on the basis of radiation irradiation information (a radiation irradiation spot number obtaining step (S200)); a step in which the computer obtains target area information from a body model of a patient generated on the basis of medical image data of the patient (a target area information obtaining step (S400)); and a therapy plan calculating step (S600) in which the computer calculates, on the basis of the radiation irradiation information and the target area information, the radiation irradiation spots to which radiation is irradiated and the time length of irradiation to each radiation irradiation spot.
    Type: Application
    Filed: December 3, 2020
    Publication date: March 25, 2021
    Applicants: THE ASAN FOUNDATION, UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION, NATIONAL CANCER CENTER, THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY, KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES
    Inventors: Ho Jin KIM, Jung Won KWAK, Byung Chul CHO, Sang Wook LEE, Chi Young JEONG, Young Kyung LIM, Ui Jung HWANG, Sang Hyoun CHOI
  • Patent number: 10955538
    Abstract: A positioning system according to an embodiment of the above description includes a transmitter including a first transmitting unit and a second transmitting unit for transmitting a first signal and a second signal having different velocities, respectively; and a receiver including: a first receiving unit and a second receiving unit for measuring each time of reception of the first signal and the second signal; and a position determining unit for measuring a location of the transmitter using a difference in reception time of the first signal and the second signal.
    Type: Grant
    Filed: August 17, 2016
    Date of Patent: March 23, 2021
    Assignee: UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
    Inventors: Sungoh Kwon, Baek Du Jo
  • Publication number: 20210038363
    Abstract: Provided is a medical self-expandable stent which includes a stent body that is self-stretched or expanded by heat and emits the heat, a stretchable light emitting diode (LED) that is stacked to be longitudinally spread on the stent body and emits the heat by converting electric energy into optical energy, and a thin-film formation part that includes a thin film to fix the stretchable LED to the stent body, and is self-expanded by the heat.
    Type: Application
    Filed: October 27, 2020
    Publication date: February 11, 2021
    Applicants: THE ASAN FOUNDATION, UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
    Inventor: Do Hyun PARK
  • Patent number: 10902652
    Abstract: A method of reducing an artifact by using structural similarity. The method includes at least: obtaining a plurality of input Computed Tomography (CT) images including a first CT image and a second CT image, generating an artifact map in which anatomical information is removed and artifacts information is remained, by subtracting the second. CT image from the first CT image, generating, by the computer, a structural similarity map between each CT image and the artifact map, and generating, by the computer, a final reconstructed image by comparing particular parts on images of a plurality of structural similarity maps with each other and selecting data of an input CT image which has been used to generate a particular part of a structural similarity map having a lowest degree of structural similarity, as data of a particular part on the final reconstructed image.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: January 26, 2021
    Assignees: THE ASAN FOUNDATION, UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION, KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Jung Won Kwak, Sang Wook Lee, Byung Chul Cho, Chung Hwan Lee, Seungryong Cho, Changhwan Kim