Patents Assigned to University of Utah
  • Patent number: 12290455
    Abstract: A semi-powered foot and ankle prosthesis (100) has a foot member (128) coupled to the ankle frame (112) and movable with respect to the ankle frame (112). A linear actuator (144) is coupled to and between the ankle frame (112) and the foot member (128) to move the foot member (128) with respect to the ankle frame (112). The linear actuator (144) has a drive motor (150). A locking mechanism (104) selectively engages the drive motor (150) to selectively lock movement of the drive motor (150) to resist a force on the foot member (128) from backdriving the linear actuator (144).
    Type: Grant
    Filed: August 7, 2024
    Date of Patent: May 6, 2025
    Assignee: University of Utah Research Foundation
    Inventors: Tommaso Lenzi, Lukas R. Gabert, Connelly Ray Buchanan, Samuel Westgard, Minh Tran
  • Patent number: 12286422
    Abstract: In one aspect, the invention relates to 4-substituted benzoylpiperazine-1-substituted carbonyls having a structure represented by a formula: derivatives thereof, and related compounds; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders, e.g., various tumors and cancers, associated with ?-catenin/BCL9 protein-protein interaction dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: October 18, 2022
    Date of Patent: April 29, 2025
    Assignee: University of Utah Research Foundation
    Inventors: Haitao Ji, Min Zhang
  • Publication number: 20250120755
    Abstract: A dynamic compression implant may be insertable into a bone, and may have a distal member with distal bone-engaging threads, a proximal member that slidably engages the distal member, and a tension member with a proximal end coupled to the proximal member, and a distal end coupled to the distal member such that, in response to motion of the distal member distally away from the proximal member, the tension member elongates and urges the distal member to move proximally toward the proximal member. The bone screw may further have an interpositional member, formed separately from the proximal member and the distal member, that cooperates with the proximal member and the distal member to form a torque transmission feature that transmits torque between the proximal member and the distal member. The dynamic compression implant may be a bone screw, intramedullary implant, or other implant that applies compression across two bone portions.
    Type: Application
    Filed: December 23, 2024
    Publication date: April 17, 2025
    Applicant: University of Utah Research Foundation
    Inventors: Colin S. GREGERSEN, T. Wade FALLIN, Charles L. SALTZMAN, Chase HAGMAN
  • Patent number: 12268822
    Abstract: An optical filter may reduce the frequency and/or severity of photophobic responses or for modulating circadian cycles by controlling light exposure to cells in the human eye in certain wavelengths, such as 480 nm and 590 nm, and a visual spectral response of the human eye. The optical filter may disrupt the isomerization of melanopsin in the human eye reducing the availability of the active isoform, whereas the attenuation of light weighted across the action potential spectrum of the active isoform attenuates the phototransduction cascade leading to photophobic responses. Embodiments of an optical filter are described. In one embodiment an optical filter may be configured to transmit less than a first amount of light in certain wavelengths, and to transmit more than a second amount of light weighted across the visual spectral response. Methods of use and methods of manufacturing optical filters are also described.
    Type: Grant
    Filed: April 20, 2023
    Date of Patent: April 8, 2025
    Assignee: University of Utah Research Foundation
    Inventors: Steven M. Blair, Bradley Jay Katz
  • Patent number: 12239785
    Abstract: A ventilation system having a mask, a blowing assembly, and a processor. The mask has a mask body and a pressure sensor operatively associated with the mask body and configured to measure pressure within the mask. The mask body defines an inlet opening and a plurality of leak openings. The blowing assembly is positioned in fluid communication with the inlet opening of the mask body and configured to direct air to the inlet opening of the mask body. The processor is positioned in operative communication with the blowing assembly and the pressure sensor of the mask. The processor is configured to selectively control the blowing assembly based upon at least the measured pressure within the mask.
    Type: Grant
    Filed: August 18, 2021
    Date of Patent: March 4, 2025
    Assignee: University of Utah Research Foundation
    Inventors: Michael Fogarty, Joseph Orr, Kai Kuck
  • Patent number: 12227512
    Abstract: The present disclosure is concerned with benzimidazole compounds and methods of using these compounds for the treatment of hepatitis (e.g., hepatitis C), RNA virus infections (e.g., Zika virus, dengue virus, Powassan virus, Chikungunya virus, Enterovirus, respiratory syntactical virus (RSV), Rift Valley fever, Influenza virus, Tacaribe virus, Mayaro virus, West Nile virus, yellow fever virus, and coronavirus), and disorders of uncontrolled cellular proliferation (e.g., cancer). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: November 10, 2023
    Date of Patent: February 18, 2025
    Assignee: University of Utah Research Foundation
    Inventors: Darrell Davis, Shuanghu Liu
  • Patent number: 12219667
    Abstract: Processing flows and related systems and methods are disclosed. A computing system includes one or more data interfaces, one or more other components, and a controller. The one or more data interfaces are configured to provide an interface to a data source. The one or more other components include one or more controller plugins, one or more processing nodes, or both the one or more controller plugins and the one or more processing nodes. The controller is configured to manage interactions between the one or more data interfaces and the one or more other components and enable a user to chain together the one or more data interfaces and the one or more other components according to one or more flows. The one or more controller plugins are configured to provide results of the one or more flows to one of a user interface and a system interface.
    Type: Grant
    Filed: October 30, 2020
    Date of Patent: February 4, 2025
    Assignees: Battelle Energy Alliance, LLC, University of Utah Research Foundation
    Inventors: Aniqua Z. Baset, Christopher D. Becker, Samuel Ramirez, Sneha K. Kasera, Kurt W. Derr
  • Patent number: 12215129
    Abstract: In one aspect, the invention relates to cyclopeptides and methods of using the disclosed cyclopeptides to treat bacterial infections due to, for example, Gram-negative pathogens. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: October 29, 2021
    Date of Patent: February 4, 2025
    Assignee: University of Utah Research Foundation
    Inventors: Eric W. Schmidt, Margo Haygood, Bailey Miller
  • Publication number: 20250025219
    Abstract: A tether assembly may be attached to a bone to correct a rotational deformity. The bone may have a growth plate that separates a first section of the bone from a second section of the bone. The tether assembly may have a tether member with a first end, a second end, and a central portion extending between the first end and the second end. The first end may have a closed outer wall that defines and fully bounds a first aperture. The second end may have an open outer wall that defines and partially bounds a second aperture. The open outer wall may define a slot in communication with the second aperture. The first and second ends may be securable to the first and second sections of the bone via coupling members inserted through the first and second apertures and anchored in the first and second sections, respectively.
    Type: Application
    Filed: October 3, 2022
    Publication date: January 23, 2025
    Applicant: University of Utah Research Foundation
    Inventors: Zackery EVANS, T. Wade FALLIN, Peter M. STEVENS
  • Patent number: 12186253
    Abstract: A trauma gurney includes a base connected to a frame by a vertical adjustment mechanism. The base is configured that it can be maneuvered over a receiving table. The frame holds a detachable platform suitable for the positioning of a patient thereon. Actuation of the adjustment mechanism allows the frame to be lowered and the patient platform to be detached. The patient platform is configured to be non-interfering with various procedures such as MRI procedures so the patient platform can remain with the patient after the patient has been transferred without adverse effects to the procedures. The patient platform can also be reattached to the frame after it has been removed. The trauma gurney beneficially allows a patient to be transferred from the gurney to another surface, such as for imaging, without requiring a conventional lateral transfer. Similarly, the trauma gurney allows a patient to be transferred back to the gurney.
    Type: Grant
    Filed: January 18, 2022
    Date of Patent: January 7, 2025
    Assignee: University of Utah Research Foundation
    Inventors: Brandon Bruce Johnson, Charles Craig Logan
  • Patent number: 12178485
    Abstract: A bone screw may be insertable into a bone. The bone screw may have a distal member with bone-engaging threads, a proximal member configured to slidably engage the distal member, and a tension member with a proximal end coupled to the proximal member, and a distal end coupled to the distal member such that, in response to motion of the distal member away from the proximal member, the tension member elongates and urges the distal member to move toward the proximal member.
    Type: Grant
    Filed: September 30, 2023
    Date of Patent: December 31, 2024
    Assignee: University of Utah Research Foundation
    Inventors: Colin S. Gregersen, T. Wade Fallin, Charles L. Saltzman, Chase Hagman
  • Publication number: 20240407809
    Abstract: A bone anchor may include a shaft having a distal end and a distal toggle element rotatably coupled to the distal end such that the distal toggle element may be rotatable between: a stowed orientation in which the distal toggle element may be insertable into a bone through an aperture formed in a cortex of the bone; and a deployed orientation in which the distal toggle element may be positioned to abut an interior surface of the cortex around the aperture. The bone anchor may also include a flange having a shoulder that may be moveable distally toward the distal toggle element to abut an exterior surface of the cortex.
    Type: Application
    Filed: June 10, 2024
    Publication date: December 12, 2024
    Applicant: University of Utah Research Foundation
    Inventors: Joseph FEATHERALL, Joel TURTLE, Colin S. GREGERSEN
  • Patent number: 12163198
    Abstract: An alternative approach to producing iron from iron concentrates produced from low grade iron ore without going through pelletization and induration. Such a method may include providing iron ore concentrate in a small particle form, passing the iron ore concentrate through a moving bed conveyor reduction furnace with at least one of hydrogen or natural gas, wherein the concentrate is present in a layer that is no more than about 5 cm thick, the hydrogen gas or natural gas reducing the concentrate so as to remove oxygen therefrom, converting the iron ore concentrate to iron that has a composition similar to direct reduced iron (DRI) or sponge iron product, having about 90-95% iron, up to about 10% oxygen, with other trace impurities. Energy consumption is reduced by 30-50% and CO2 emissions are reduced by 60-95%, depending on whether natural gas or hydrogen is used.
    Type: Grant
    Filed: December 21, 2022
    Date of Patent: December 10, 2024
    Assignee: University of Utah Research Foundation
    Inventors: Hong Yong R. Sohn, Syamantak Roy
  • Patent number: 12156683
    Abstract: A bone implant system may include a plurality of bone anchors, a superior rod attachable to a superior portion of a bone via the bone anchors, and an inferior rod attachable to an inferior portion of the bone via the bone anchors. The superior rod may have a superior end, and the inferior rod may have an inferior end. The superior rod may telescopically engage the inferior rod such that a cavity is present within at least one of the superior rod and the inferior rod and such that a length of the combined superior and inferior rods, measured between the superior end and the inferior end, is adjustable. The cavity may contain a micropump and a chamber. The micropump may be configured to expel fluid into the chamber to urge the length to increase.
    Type: Grant
    Filed: August 30, 2022
    Date of Patent: December 3, 2024
    Assignee: University of Utah Research Foundation
    Inventors: John Heflin, T. Wade Fallin, Zackery Evans
  • Publication number: 20240392290
    Abstract: Methods of minimizing dysregulation of Staufen1-associated RNA metabolism can include introducing an amount of a Staufen1-regulating agent to a target cell sufficient to minimize the dysregulation. Therapeutic compositions for treating a neurodegenerative condition associated with Staufen1-induced dysregulation of RNA metabolism can include a therapeutically effective amount of a Staufen1-regulating agent and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: April 1, 2024
    Publication date: November 28, 2024
    Applicant: University of Utah Research Foundation
    Inventors: Stefan M. Pulst, Daniel R. Scoles, Sharan Paul
  • Patent number: 12150973
    Abstract: Disclosed herein, are compounds comprising a peptide, wherein the peptide is OCA-B or an OCA-B fragment thereof; a linker; and a cell penetrating peptide. Also described herein, are methods of administering compounds to subjects for the treatment of Type I diabetes and blocking the interaction between OCA-B and Jmjd1a.
    Type: Grant
    Filed: April 17, 2019
    Date of Patent: November 26, 2024
    Assignee: University of Utah Research Foundation
    Inventor: Dean Tantin
  • Publication number: 20240382242
    Abstract: A bone screw may be insertable into a bone, and may have a proximal member, a distal member with bone-engaging threads, wherein the distal member is configured to slidably engage the proximal member such that a variable-length cavity is defined within the proximal member and the distal member, and a tension member residing at least partially within the variable-length cavity. The tension member may have a proximal end coupled to the proximal member and a distal end coupled to the distal member such that, in response to motion of the distal member away from the proximal member, the tension member elongates and urges the distal member to move toward the proximal member. The proximal member and the distal member may be interconnected to share bending loads at a bending transmission feature.
    Type: Application
    Filed: August 1, 2022
    Publication date: November 21, 2024
    Applicant: University of Utah Research Foundation
    Inventors: Colin S. GREGERSEN, T. Wade FALLIN, Charles L. SALTZMAN
  • Patent number: 12139724
    Abstract: Disclosed herein are methods of producing platelets and red blood cells using synthetic biology and uses thereof. The methods disclosed herein can also be used to produce platelets and red blood cells comprising a therapeutic agent. The cells produced by the methods disclosed herein can be used to treat, manage, prevent and diagnosis various diseases and disorders and be used as a research tool.
    Type: Grant
    Filed: April 15, 2022
    Date of Patent: November 12, 2024
    Assignee: University of Utah Research Foundation
    Inventor: Tara L. Deans
  • Patent number: 12117316
    Abstract: A sensor interface for a resistive sensor has an analog front end comprising. The analog front end has an analog input/output (I/O) sensor port to be coupled to the resistive sensor. An integration stage is coupled to the analog I/O sensor port to oscillate at an oscillation frequency proportional to a sensor resistance of the resistive sensor. The integration stage has a variable integrator capacitance to vary the oscillation frequency. A gain stage is coupled to the integration stage and has a variable gain to vary the oscillation frequency of the integration stage. The sensor interface also has a smart digital controller (SDC) coupled to the analog front end to compute the sensor resistance of the resistive sensor based on the oscillation frequency. In addition, the SDC automatically detects unstable oscillation in the integration stage and causes the variable gain and the variable integrator capacitance to change.
    Type: Grant
    Filed: January 26, 2023
    Date of Patent: October 15, 2024
    Assignee: University of Utah Research Foundation
    Inventors: Matthieu Couriol, Pierre-Emmanuel Gaillardon
  • Patent number: 12112820
    Abstract: Electronic devices and methods for single event effect mitigation are described. The device can include a processor, a memory cell, and an integrated particle sensor. The memory cell can comprise a substrate, a deep well coupled to the substrate, and a ground-coupled well coupled to the deep well. The integrated particle sensor can be coupled between the substrate and the deep well, and the ground-coupled well and the deep well. The integrated particle sensor can be operable to detect an ionizing particle generating the single event effect. The electronic device can be a field-programmable gate array. The method can include detecting an ionizing particle generating a single event effect at a memory cell of the electronic device, switching from the memory cell to a redundant memory cell associated with the memory cell when the single event effect is detected, and reconfiguring the memory cell based on the redundant memory cell.
    Type: Grant
    Filed: December 1, 2021
    Date of Patent: October 8, 2024
    Assignee: University of Utah Research Foundation
    Inventors: Aurelien Alacchi, Pierre-Emmanuel Gaillardon