Patents Assigned to University of Utah
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Patent number: 12379266Abstract: The present disclosure describes sensor devices that can be readily integrated with prosthetic devices to provide sensing of force and torque applied to the prosthetic device during use. The sensor device includes an adaptor section that readily connects to standard prosthetic components and a base section. The base section has a deflectable portion and a fixed portion. Cantilevers in the deflectable portion house magnets and corresponding Hall effect sensors are housed in the fixed portion. When axial and/or torsional forces are applied, the cantilevers deflect relative to the fixed section and the Hall effect sensors provide a corresponding output that correlates to the axial and/or torsional forces applied.Type: GrantFiled: August 21, 2019Date of Patent: August 5, 2025Assignee: University of Utah Research FoundationInventors: Tommaso Lenzi, Lukas Gabert
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Patent number: 12357269Abstract: Systems and methods for measuring changes in smart hydrogel microresonator structures positioned in an in vivo or other environment, having an acoustic resonance frequency in an ultrasound range. The system includes a smart hydrogel microresonator structure positioned within the environment configured to exhibit a change in resonance frequency in response to interaction with one or more predefined analytes in the environment. The system includes an ultrasound transducer for querying the smart hydrogel microresonator structure at or near its resonance frequency. The system also includes a computer system configured to receive ultrasound data as provided by query of the smart hydrogel microresonator structure and to determine changes in resonance frequency, amplitude or intensity of the ultrasound query wave, or mean grayscale value (MGV) associated with the ultrasound data of the smart hydrogel microresonator structure due to the change in resonance frequency.Type: GrantFiled: March 29, 2024Date of Patent: July 15, 2025Assignee: University of Utah Research FoundationInventors: Christopher F. Reiche, Florian Solzbacher, Navid Farhoudi, Steven M. Blair, Jules J. Magda, Lars B. Laurentius, Prattay Deepta Kairy
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Patent number: 12343191Abstract: A computer system is configured to remove motion artifacts in medical images using a generative adversarial network (GAN). The computer system instantiates the GAN having one or more generative network(s) and one or more discriminative network(s) that are pitted against each other to train a generative model and a discriminative model. The training uses a training dataset including a plurality of medical images that are previously classified as without significant motion artifacts for diagnostic purposes. The discriminative model is trained to classify medical images as real or artificial. The generative model is trained to enhance the quality of a medical image and remove motion artifacts by producing a medical image directly from a post-contrast image, without using a pre-contrast mask.Type: GrantFiled: December 1, 2020Date of Patent: July 1, 2025Assignee: University of Utah Research FoundationInventors: Brendan Thomas Crabb, Frederic Nicolas Firmin Noo, Gabriel Chaim Fine
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Publication number: 20250195087Abstract: A method of preparing and/or delivering an osteochondral plug may include, positioning a tissue graft on a cutting guide, wherein the tissue graft may have been removed from a larger body of tissue to define a shaped surface. The tissue graft may include a top surface having a cartilage surface. The method may further include advancing a first cutter along a cutting direction toward the tissue graft to cut the tissue graft to form the osteochondral plug having an external wall parallel to the cutting direction and transverse to the top surface. Positioning the tissue graft on the cutting guide may include placing the shaped surface on a registration surface of the cutting guide. The registration surface may have a reference shape that corresponds to a shape of at least part of the shaped surface.Type: ApplicationFiled: November 8, 2024Publication date: June 19, 2025Applicant: University of Utah Research FoundationInventors: Zackery K. EVANS, T. Wade FALLIN, Travis G. MAAK, Charles L. SALTZMAN
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Patent number: 12290455Abstract: A semi-powered foot and ankle prosthesis (100) has a foot member (128) coupled to the ankle frame (112) and movable with respect to the ankle frame (112). A linear actuator (144) is coupled to and between the ankle frame (112) and the foot member (128) to move the foot member (128) with respect to the ankle frame (112). The linear actuator (144) has a drive motor (150). A locking mechanism (104) selectively engages the drive motor (150) to selectively lock movement of the drive motor (150) to resist a force on the foot member (128) from backdriving the linear actuator (144).Type: GrantFiled: August 7, 2024Date of Patent: May 6, 2025Assignee: University of Utah Research FoundationInventors: Tommaso Lenzi, Lukas R. Gabert, Connelly Ray Buchanan, Samuel Westgard, Minh Tran
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Patent number: 12286422Abstract: In one aspect, the invention relates to 4-substituted benzoylpiperazine-1-substituted carbonyls having a structure represented by a formula: derivatives thereof, and related compounds; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders, e.g., various tumors and cancers, associated with ?-catenin/BCL9 protein-protein interaction dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: October 18, 2022Date of Patent: April 29, 2025Assignee: University of Utah Research FoundationInventors: Haitao Ji, Min Zhang
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Publication number: 20250120755Abstract: A dynamic compression implant may be insertable into a bone, and may have a distal member with distal bone-engaging threads, a proximal member that slidably engages the distal member, and a tension member with a proximal end coupled to the proximal member, and a distal end coupled to the distal member such that, in response to motion of the distal member distally away from the proximal member, the tension member elongates and urges the distal member to move proximally toward the proximal member. The bone screw may further have an interpositional member, formed separately from the proximal member and the distal member, that cooperates with the proximal member and the distal member to form a torque transmission feature that transmits torque between the proximal member and the distal member. The dynamic compression implant may be a bone screw, intramedullary implant, or other implant that applies compression across two bone portions.Type: ApplicationFiled: December 23, 2024Publication date: April 17, 2025Applicant: University of Utah Research FoundationInventors: Colin S. GREGERSEN, T. Wade FALLIN, Charles L. SALTZMAN, Chase HAGMAN
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Patent number: 12268822Abstract: An optical filter may reduce the frequency and/or severity of photophobic responses or for modulating circadian cycles by controlling light exposure to cells in the human eye in certain wavelengths, such as 480 nm and 590 nm, and a visual spectral response of the human eye. The optical filter may disrupt the isomerization of melanopsin in the human eye reducing the availability of the active isoform, whereas the attenuation of light weighted across the action potential spectrum of the active isoform attenuates the phototransduction cascade leading to photophobic responses. Embodiments of an optical filter are described. In one embodiment an optical filter may be configured to transmit less than a first amount of light in certain wavelengths, and to transmit more than a second amount of light weighted across the visual spectral response. Methods of use and methods of manufacturing optical filters are also described.Type: GrantFiled: April 20, 2023Date of Patent: April 8, 2025Assignee: University of Utah Research FoundationInventors: Steven M. Blair, Bradley Jay Katz
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Patent number: 12239785Abstract: A ventilation system having a mask, a blowing assembly, and a processor. The mask has a mask body and a pressure sensor operatively associated with the mask body and configured to measure pressure within the mask. The mask body defines an inlet opening and a plurality of leak openings. The blowing assembly is positioned in fluid communication with the inlet opening of the mask body and configured to direct air to the inlet opening of the mask body. The processor is positioned in operative communication with the blowing assembly and the pressure sensor of the mask. The processor is configured to selectively control the blowing assembly based upon at least the measured pressure within the mask.Type: GrantFiled: August 18, 2021Date of Patent: March 4, 2025Assignee: University of Utah Research FoundationInventors: Michael Fogarty, Joseph Orr, Kai Kuck
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Patent number: 12227512Abstract: The present disclosure is concerned with benzimidazole compounds and methods of using these compounds for the treatment of hepatitis (e.g., hepatitis C), RNA virus infections (e.g., Zika virus, dengue virus, Powassan virus, Chikungunya virus, Enterovirus, respiratory syntactical virus (RSV), Rift Valley fever, Influenza virus, Tacaribe virus, Mayaro virus, West Nile virus, yellow fever virus, and coronavirus), and disorders of uncontrolled cellular proliferation (e.g., cancer). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: November 10, 2023Date of Patent: February 18, 2025Assignee: University of Utah Research FoundationInventors: Darrell Davis, Shuanghu Liu
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Patent number: 12215129Abstract: In one aspect, the invention relates to cyclopeptides and methods of using the disclosed cyclopeptides to treat bacterial infections due to, for example, Gram-negative pathogens. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: October 29, 2021Date of Patent: February 4, 2025Assignee: University of Utah Research FoundationInventors: Eric W. Schmidt, Margo Haygood, Bailey Miller
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Patent number: 12219667Abstract: Processing flows and related systems and methods are disclosed. A computing system includes one or more data interfaces, one or more other components, and a controller. The one or more data interfaces are configured to provide an interface to a data source. The one or more other components include one or more controller plugins, one or more processing nodes, or both the one or more controller plugins and the one or more processing nodes. The controller is configured to manage interactions between the one or more data interfaces and the one or more other components and enable a user to chain together the one or more data interfaces and the one or more other components according to one or more flows. The one or more controller plugins are configured to provide results of the one or more flows to one of a user interface and a system interface.Type: GrantFiled: October 30, 2020Date of Patent: February 4, 2025Assignees: Battelle Energy Alliance, LLC, University of Utah Research FoundationInventors: Aniqua Z. Baset, Christopher D. Becker, Samuel Ramirez, Sneha K. Kasera, Kurt W. Derr
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Publication number: 20250025219Abstract: A tether assembly may be attached to a bone to correct a rotational deformity. The bone may have a growth plate that separates a first section of the bone from a second section of the bone. The tether assembly may have a tether member with a first end, a second end, and a central portion extending between the first end and the second end. The first end may have a closed outer wall that defines and fully bounds a first aperture. The second end may have an open outer wall that defines and partially bounds a second aperture. The open outer wall may define a slot in communication with the second aperture. The first and second ends may be securable to the first and second sections of the bone via coupling members inserted through the first and second apertures and anchored in the first and second sections, respectively.Type: ApplicationFiled: October 3, 2022Publication date: January 23, 2025Applicant: University of Utah Research FoundationInventors: Zackery EVANS, T. Wade FALLIN, Peter M. STEVENS
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Patent number: 12186253Abstract: A trauma gurney includes a base connected to a frame by a vertical adjustment mechanism. The base is configured that it can be maneuvered over a receiving table. The frame holds a detachable platform suitable for the positioning of a patient thereon. Actuation of the adjustment mechanism allows the frame to be lowered and the patient platform to be detached. The patient platform is configured to be non-interfering with various procedures such as MRI procedures so the patient platform can remain with the patient after the patient has been transferred without adverse effects to the procedures. The patient platform can also be reattached to the frame after it has been removed. The trauma gurney beneficially allows a patient to be transferred from the gurney to another surface, such as for imaging, without requiring a conventional lateral transfer. Similarly, the trauma gurney allows a patient to be transferred back to the gurney.Type: GrantFiled: January 18, 2022Date of Patent: January 7, 2025Assignee: University of Utah Research FoundationInventors: Brandon Bruce Johnson, Charles Craig Logan
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Patent number: 12178485Abstract: A bone screw may be insertable into a bone. The bone screw may have a distal member with bone-engaging threads, a proximal member configured to slidably engage the distal member, and a tension member with a proximal end coupled to the proximal member, and a distal end coupled to the distal member such that, in response to motion of the distal member away from the proximal member, the tension member elongates and urges the distal member to move toward the proximal member.Type: GrantFiled: September 30, 2023Date of Patent: December 31, 2024Assignee: University of Utah Research FoundationInventors: Colin S. Gregersen, T. Wade Fallin, Charles L. Saltzman, Chase Hagman
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Publication number: 20240407809Abstract: A bone anchor may include a shaft having a distal end and a distal toggle element rotatably coupled to the distal end such that the distal toggle element may be rotatable between: a stowed orientation in which the distal toggle element may be insertable into a bone through an aperture formed in a cortex of the bone; and a deployed orientation in which the distal toggle element may be positioned to abut an interior surface of the cortex around the aperture. The bone anchor may also include a flange having a shoulder that may be moveable distally toward the distal toggle element to abut an exterior surface of the cortex.Type: ApplicationFiled: June 10, 2024Publication date: December 12, 2024Applicant: University of Utah Research FoundationInventors: Joseph FEATHERALL, Joel TURTLE, Colin S. GREGERSEN
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Patent number: 12163198Abstract: An alternative approach to producing iron from iron concentrates produced from low grade iron ore without going through pelletization and induration. Such a method may include providing iron ore concentrate in a small particle form, passing the iron ore concentrate through a moving bed conveyor reduction furnace with at least one of hydrogen or natural gas, wherein the concentrate is present in a layer that is no more than about 5 cm thick, the hydrogen gas or natural gas reducing the concentrate so as to remove oxygen therefrom, converting the iron ore concentrate to iron that has a composition similar to direct reduced iron (DRI) or sponge iron product, having about 90-95% iron, up to about 10% oxygen, with other trace impurities. Energy consumption is reduced by 30-50% and CO2 emissions are reduced by 60-95%, depending on whether natural gas or hydrogen is used.Type: GrantFiled: December 21, 2022Date of Patent: December 10, 2024Assignee: University of Utah Research FoundationInventors: Hong Yong R. Sohn, Syamantak Roy
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Patent number: 12156683Abstract: A bone implant system may include a plurality of bone anchors, a superior rod attachable to a superior portion of a bone via the bone anchors, and an inferior rod attachable to an inferior portion of the bone via the bone anchors. The superior rod may have a superior end, and the inferior rod may have an inferior end. The superior rod may telescopically engage the inferior rod such that a cavity is present within at least one of the superior rod and the inferior rod and such that a length of the combined superior and inferior rods, measured between the superior end and the inferior end, is adjustable. The cavity may contain a micropump and a chamber. The micropump may be configured to expel fluid into the chamber to urge the length to increase.Type: GrantFiled: August 30, 2022Date of Patent: December 3, 2024Assignee: University of Utah Research FoundationInventors: John Heflin, T. Wade Fallin, Zackery Evans
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Publication number: 20240392290Abstract: Methods of minimizing dysregulation of Staufen1-associated RNA metabolism can include introducing an amount of a Staufen1-regulating agent to a target cell sufficient to minimize the dysregulation. Therapeutic compositions for treating a neurodegenerative condition associated with Staufen1-induced dysregulation of RNA metabolism can include a therapeutically effective amount of a Staufen1-regulating agent and a pharmaceutically acceptable carrier.Type: ApplicationFiled: April 1, 2024Publication date: November 28, 2024Applicant: University of Utah Research FoundationInventors: Stefan M. Pulst, Daniel R. Scoles, Sharan Paul
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Patent number: 12150973Abstract: Disclosed herein, are compounds comprising a peptide, wherein the peptide is OCA-B or an OCA-B fragment thereof; a linker; and a cell penetrating peptide. Also described herein, are methods of administering compounds to subjects for the treatment of Type I diabetes and blocking the interaction between OCA-B and Jmjd1a.Type: GrantFiled: April 17, 2019Date of Patent: November 26, 2024Assignee: University of Utah Research FoundationInventor: Dean Tantin