Patents Assigned to University of Utah
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Patent number: 11401552Abstract: Methods are provided of identifying a male fertility condition in a subject. Methods of performing a fertility treatment and an in vitro fertilization procedure are also provided. The methods may comprise determining the DNA methylation pattern of DNA extracted from a semen sample of a subject.Type: GrantFiled: August 8, 2016Date of Patent: August 2, 2022Assignees: University of Utah Research Foundation, The University of Southern CaliforniaInventors: Douglas T. Carrell, Bradley Cairns, Kenneth I. Aston, Timothy Jenkins, Andrew David Smith, Philip James Uren, Alan Horsager
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Patent number: 11395616Abstract: An oxygen-sensing assembly for attachment to a urinary catheter may include a housing having a flow pathway extending between an inlet end and an outlet end thereof, an oxygen sensor in operable communication with the flow pathway of the housing, the oxygen sensor configured to detect oxygen levels of a fluid flowing through the flow pathway, a flowrate sensor configured to detect a flowrate of the fluid flowing through the flow pathway, and a temperature sensor configured to detect a temperature of the fluid flowing through the flow pathway.Type: GrantFiled: September 4, 2018Date of Patent: July 26, 2022Assignees: WSA Medical Ventures, LLC, University of Utah Research FoundationInventors: Kai Kuck, Natalie A. Silverton, Spencer B. Shumway, Bradley J. Stringer
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Patent number: 11373278Abstract: Technology is described for methods and systems for imaging an object (110). The method can include an image sensor (116) exposed to light (114) from an object (110) without passing the light through an image modification element. Light intensity of the light (114) can be stored as data in a medium. The image data can be analyzed at a processor (902) as a reconstructed image of the object (110).Type: GrantFiled: October 2, 2017Date of Patent: June 28, 2022Assignee: University of Utah Research FoundationInventors: Rajesh Menon, Ganghun Kim, Kyle Isaacson
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Publication number: 20220175847Abstract: The disclosure provides a salivary gland (SG) cell sheet comprising one or more layers of confluent SG cells (e.g. submandibular gland (SMG) cells). Methods of treating a wound in a salivary gland (SG), treating hyposalivation, and treating irradiation damage in an SG are also provided. The disclosure also provides a method for producing SG cell sheets comprising culturing SG cells in culture solution on a temperature-responsive polymer which has been coated onto a substrate surface of a cell culture support, wherein the temperature-responsive polymer has a lower critical solution temperature in water of 0-80° C.; adjusting the temperature of el the culture solution to below the lower critical solution temperature, whereby the substrate surface is made hydrophilic and adhesion of the cell sheet to the surface is weakened; and detaching the cell sheet from the culture support.Type: ApplicationFiled: March 5, 2020Publication date: June 9, 2022Applicant: University of Utah Research FoundationInventors: Olga Baker, Teruo Okano, Kihoon Nam, Kyungsook Kim
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Patent number: 11352315Abstract: Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, or reduce biofilms, or to inhibit or substantially prevent biofilm formation. In some aspects, the present invention relates to polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms. In some aspects, the present invention relates to compositions and methods comprising the polyamine compound. In some aspects, the compounds, compositions, and methods enhance wound healing.Type: GrantFiled: October 4, 2019Date of Patent: June 7, 2022Assignees: Curza Global, LLC, University of Utah Research FoundationInventors: Ryan E. Looper, Dustin Williams, Paul R. Sebahar, Travis J. Haussener, Hariprasada R. Kanna Reddy
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Patent number: 11351545Abstract: A method and system have been provided to perform high speed nucleic acid melting analysis while still obtaining accurate melting curve sufficient for genotyping. This rapid ability to interrogate DNA should be useful whenever time to result is important, such as in molecular point of care testing. Specifically, microfluidics enables genotyping by melting analysis at rates up to 50° C./s, requiring less than is to acquire an entire melting curve. High speed melting reduces the time for melting analysis, decreases errors, and improves genotype discrimination of small amplicons.Type: GrantFiled: July 31, 2017Date of Patent: June 7, 2022Assignees: Canon U.S.A., Inc., University of Utah Research FoundationInventors: Robert J. Pryor, Carl T. Wittwer, Scott O. Sundberg, Ivor T. Knight, Joseph T. Myrick, Robert A. Palais, Jeanette Y. Paek
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Publication number: 20220160398Abstract: An apparatus and method for external anteversion correction of an intact bone may include a first arcuate segment, a second arcuate segment rotatably coupled to the first arcuate segment, a first pin extending from the first arcuate segment to a proximal segment of the intact bone, a second pin extending from the second arcuate segment to a distal segment of the intact bone, and a control mechanism attached to the first and second arcuate segments. The control mechanism may rotate the first arcuate segment relative to the second arcuate segment to exert torsional force on the intact bone between the proximal and distal segments of the intact bone, thereby externally reducing anteversion of the intact bone.Type: ApplicationFiled: February 13, 2022Publication date: May 26, 2022Applicant: University of Utah Research FoundationInventor: Peter M. STEVENS
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Patent number: 11337610Abstract: A method, system and article of manufacture is disclosed. The method includes providing a spatial navigator outside of a thermal therapy region; receiving a plurality of analog-to-digital conversion (ADC) readouts from an MRI device at a plurality of time points, wherein the ADC readouts comprise a first ADC readout acquired at a first time point, and one or more additional ADC readouts acquired at subsequent time points; processing the ADC readouts to obtain a frequency of the spatial navigator at each of the time points; obtaining a main magnetic field (B0) drift of the MRI device based on the frequency of the spatial navigator at a particular time point and the frequency of the spatial navigator at the first time point; and obtaining the temperature change at the particular time point based on the B0 drift.Type: GrantFiled: October 1, 2018Date of Patent: May 24, 2022Assignees: Siemens Healthcare GmbH, University of Utah Research FoundationInventors: Sunil Goraksha Patil, Henrik Odeen, Bhat Himanshu, John Roberts, Dennis L. Parker
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Patent number: 11339140Abstract: The present invention presents 2-(acylamino)imidazoles with therapeutic activity, including selective activity against cancer cells, and compositions comprising them. Methods of using and preparing the 2-(acylamino)imidazoles are also presented.Type: GrantFiled: September 27, 2019Date of Patent: May 24, 2022Assignees: Curza Global, LLC, The University of UtahInventors: Ryan E. Looper, Justin M. Salvant, Emily K. Kirkeby, Wenxing Guo, Katrin P. Guillen, Bryan E. Welm
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Patent number: 11331499Abstract: A medical implant device (100) is disclosed that can protect and shield an implant (101) as the implant (101) moves through body tissue. The medical implant device (100) can comprise a main body portion (110) having a payload opening (111) to receive a payload (i.e., an implant). The medical implant device (100) can also comprise a tapered nose portion (120) at a front end (103a) of the medical implant device (100) extending from the main body portion (110) and configured to penetrate body tissue. In addition, the medical implant device (100) can comprise a payload coupling interface (130) configured to couple the implant (101) to the main body portion (110).Type: GrantFiled: July 28, 2017Date of Patent: May 17, 2022Assignee: University of Utah Research FoundationInventors: David Kluger, Gregory Clark, Douglas Hutchinson, David Page, Suzanne Wendelken
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Patent number: 11335436Abstract: Described herein are methods of identifying a plurality of polynucleotides, as well as detecting presence, absence, or abundance of a plurality of taxa in a sample. Also provided are systems for performing methods of the disclosure.Type: GrantFiled: October 4, 2017Date of Patent: May 17, 2022Assignee: University of Utah Research FoundationInventors: Steven Flygare, Keith Simmon, Chase Miller, Yi Qiao, Karen Eilbeck, Gabor Marth, Mark Yandell, Robert Schlaberg
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Patent number: 11317956Abstract: A bone screw may be insertable into a bone, and may have a proximal member, a distal member with bone-engaging threads, wherein the distal member is configured to slidably engage the proximal member such that a variable-length cavity is defined within the proximal member and the distal member, and a tension member residing at least partially within the variable-length cavity. The tension member may have a proximal end coupled to the proximal member and a distal end coupled to the distal member such that, in response to motion of the distal member away from the proximal member, the tension member elongates and urges the distal member to move toward the proximal member. The proximal member and the distal member may be interconnected to share bending loads at a bending transmission feature.Type: GrantFiled: August 26, 2021Date of Patent: May 3, 2022Assignee: University of Utah Research FoundationInventors: Colin S. Gregersen, T. Wade Fallin, Charles L. Saltzman
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Patent number: 11300449Abstract: An image capturing device (202) can include a sensor array (210), a lens (230) positioned at a first distance from an intermediate image (235), and apolychromat (220) positioned at a second distance from the lens (230). The polychromat (220) can diffract the intermediate image (235) according to a transform function (207) to produce a dispersed sensor image (215) onto the sensor array (210). The dispersed sensor image (215) can represent a spatial code of the intermediate image (235).Type: GrantFiled: March 24, 2016Date of Patent: April 12, 2022Assignee: University of Utah Research FoundationInventors: Rajesh Menon, Peng Wang
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Patent number: 11293028Abstract: The present invention relates to the effects of codon context and synonymous codon changes on mRNA translation and methods of increasing protein production.Type: GrantFiled: October 3, 2016Date of Patent: April 5, 2022Assignee: University of Utah Research FoundationInventors: Kelly T. Hughes, Fabienne Chevance
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Patent number: 11272957Abstract: An apparatus and method for external anteversion correction of an intact bone may include a first arcuate segment, a second arcuate segment rotatably coupled to the first arcuate segment, a first pin extending from the first arcuate segment to a proximal segment of the intact bone, a second pin extending from the second arcuate segment to a distal segment of the intact bone, and a control mechanism attached to the first and second arcuate segments. The control mechanism may rotate the first arcuate segment relative to the second arcuate segment to exert torsional force on the intact bone between the proximal and distal segments of the intact bone, thereby externally reducing anteversion of the intact bone.Type: GrantFiled: September 30, 2019Date of Patent: March 15, 2022Assignee: University of Utah Research FoundationInventor: Peter Stevens
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Patent number: 11266801Abstract: A ventilation system having a mask, a blowing assembly, and a processor. The mask has a mask body and a pressure sensor operatively associated with the mask body and configured to measure pressure within the mask. The mask body defines an inlet opening and a plurality of leak openings. The blowing assembly is positioned in fluid communication with the inlet opening of the mask body and configured to direct air to the inlet opening of the mask body. The processor is positioned in operative communication with the blowing assembly and the pressure sensor of the mask. The processor is configured to selectively control the blowing assembly based upon at least the measured pressure within the mask.Type: GrantFiled: October 7, 2016Date of Patent: March 8, 2022Assignee: University of Utah Research FoundationInventors: Michael Fogarty, Joseph Orr, Kai Kuck
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Patent number: 11261181Abstract: Methods of detecting a non-explosive analyte can include exposing a sensor compound to a non-explosive analyte and displaying a change in the sensor compound upon exposure of the sensor compound to the non-explosive analyte. A variety of sensor compounds for detecting a target analyte, including both explosive and non-explosive analytes, is also described. Sensor devices for detecting a target analyte can include a substrate and a sensor compound positioned on the substrate in a plurality of detection zones.Type: GrantFiled: July 11, 2016Date of Patent: March 1, 2022Assignee: University of Utah Research FoundationInventors: Ling Zang, Paul Slattum
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Patent number: 11251889Abstract: Wireless signal classifiers and systems that incorporate the same may include an energy-based detector configured to analyze an entire set of measurements and generate a first signal classification result, a cyclostationary-based detector configured to analyze less than the entire set of measurements and generate a second signal classification result; and a classification merger configured to merge the first signal classification result and the second signal classification result. Ensemble wireless signal classification and systems and devices the incorporate the same are disclosed. Some ensemble wireless signal classification may include energy-based classification processes and machine learning-based classification processes. In some embodiments, incremental machine learning techniques may be incorporated to add new machine learning-based classifiers to a system or update existing machine learning-based classifiers.Type: GrantFiled: September 12, 2019Date of Patent: February 15, 2022Assignees: Battelle Energy Alliance, LLC, University of Utah Research FoundationInventors: Kurt W. Derr, Samuel Ramirez, Sneha K. Kasera, Christopher D. Becker, Aniqua Z. Baset
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Patent number: 11248034Abstract: The present invention relates to insulin analogs, particularly insulin analogs having shortened B chains. The present invention also relates to the crystal structure of insulin from the venom of cone snails and to methods of using the crystal and related structural information to screen for and design insulin analogs that interact with or modulate the insulin receptor. The present invention also relates to therapeutic and prophylactic methods using insulin analogs.Type: GrantFiled: July 21, 2017Date of Patent: February 15, 2022Assignees: University of Utah Research Foundation, The Walter and Eliza Hall Institute of Medical ResearchInventors: John Gerbrandt Tasman Menting, Brian Smith, Danny Hung-Chieh Chou, Helena Safavi-Hemami, Michael Colin Lawrence, Baldomero M. Olivera
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Patent number: 11236408Abstract: A method of forming a functionally designed cemented tungsten carbide can include forming a particulate matrix mixture including a primary particulate tungsten carbide and a primary particulate metal binder. A particulate enhancement mixture can be formed having a secondary particulate tungsten carbide, a secondary particulate metal binder, and a particulate grain growth inhibitor, where the enhancement mixture has a finer particle size than the matrix mixture. The particulate matrix mixture can be assembled with the particulate enhancement mixture to form a structured composite where the matrix mixture forms a continuous phase and the enhancement mixture forms at least one of a dispersed granular phase and a surface layer adjacent the continuous phase to form the structured composite. This structured composite can be sintered to form the functionally designed cemented tungsten carbide having a differential grain size with the enhancement phase having a smaller grain size than the matrix phase.Type: GrantFiled: February 10, 2021Date of Patent: February 1, 2022Assignee: University of Utah Research FoundationInventors: Zhigang Zak Fang, Kyu Sup Hwang