Abstract: Systems and methods for measuring changes in smart hydrogel microresonator structures positioned in an in vivo or other environment, having an acoustic resonance frequency in an ultrasound range. The system includes a smart hydrogel microresonator structure positioned within the environment configured to exhibit a change in resonance frequency in response to interaction with one or more predefined analytes in the environment. The system includes an ultrasound transducer for querying the smart hydrogel microresonator structure at or near its resonance frequency. The system also includes a computer system configured to receive ultrasound data as provided by query of the smart hydrogel microresonator structure and to determine changes in resonance frequency, amplitude or intensity of the ultrasound query wave, or mean grayscale value (MGV) associated with the ultrasound data of the smart hydrogel microresonator structure due to the change in resonance frequency.

Abstract: An electromagnetic actuator for non-continuous rotation (cogging-torque actuator (CTA)) (100) comprises a support structure (116), an output shaft (104) rotatable about and defining an axis of rotation (X), a permanent magnet rotor (106) comprising at least two magnetic poles (108a, 108b) attached to the output shaft (104), and a stator device (110) comprising a ferromagnetic pole body (112) attached to the support structure (116) and surrounding the at least two magnetic poles (108a, 108b). The ferromagnetic pole body (112) can have at least four ferromagnetic stator poles (112a-d) each wrapped in a conductive wire (114a-d) to define a stator coil. The at least four ferromagnetic stator poles (112a-d) are sized, and spaced radially from each other, so as to define a maximum cogging torque of the electromagnetic actuator (100). The CTA (100) can operate as an actuator, an elastic spring, a clutch, and/or a load support device.

Abstract: The present invention provides methods of treating myopia comprising administering composition comprising a cop-per-containing agent to an eye of a subject in need thereof.

Abstract: Methods of minimizing dysregulation of Staufen1-associated RNA metabolism can include introducing an amount of a Staufen1-regulating agent to a target cell sufficient to minimize the dysregulation. Therapeutic compositions for treating a neurodegenerative condition associated with Staufen1-induced dysregulation of RNA metabolism can include a therapeutically effective amount of a Staufen1-regulating agent and a pharmaceutically acceptable carrier.

Abstract: A bone screw may be insertable into a bone. The bone screw may have a distal member with bone-engaging threads, a proximal member configured to slidably engage the distal member, and a tension member with a proximal end coupled to the proximal member, and a distal end coupled to the distal member such that, in response to motion of the distal member away from the proximal member, the tension member elongates and urges the distal member to move toward the proximal member.

Abstract: Technology is described for methods and systems for imaging an object (110). The method can include an image sensor (116) exposed to light (114) from an object (110) without passing the light through an image modification element. Light intensity of the light (114) can be stored as data in a medium. The image data can be analyzed at a processor (902) as a reconstructed image of the object (110).

Abstract: A system for harvesting bone material from a bone may include a rotary cutter defining a rotary cutter longitudinal axis extending between a rotary cutter proximal end and a rotary cutter distal end. The rotary cutter may have a drive shaft configured to receive input torque, and an osteochondral cutter configured to cut the tissue and receive the tissue material in response to rotation of the osteochondral cutter under pressure against the tissue. The system may further include a bone port defining a bone port longitudinal axis extending between a bone port proximal end and a bone port distal end. The bone port may have a bone port cannulation sized to closely fit over the osteochondral cutter. At least one of the bone port proximal end and the bone port distal end may be securable to the tissue. A stratiform tissue graft may be delivered through the bone port.

Abstract: Bioorthogonal molecules are disclosed and described. A bioorthogonal a molecule having a structure according to: where R2, R3, and R4 are independently selected from H, a substituted or unsubstituted C1-C4 alkyl or alkylene group, a substituted or unsubstituted aryl, COOR9, COR9, CONR9R10, CN, CF3, SO2R9, or a tether molecule; R1 is —R5, —OCOR6, —COR7, or —R8; R5 is —R8, —OH, or tosyl; R6 is a nitrophenyl ether or —R8; R7 is —R8; R8 is a payload or a molecular linker to a payload; and R9 and R10 are independently selected from H or a substituted or unsubstituted C1-C4 alkyl or alkene group.

Abstract: Methods, devices, and kits are provided for performing PCR in <20 seconds per cycle, with improved efficiency and yield.

Abstract: Technology is described for methods and systems for a diffractive optic device (525) for holographic projection. The diffractive optic device can include a lens (535) configured to convey a hologram. The lens (535) further comprises a patterned material (510) formed with an array of cells having a non-planar arrangement of cell heights extending from a surface of the patterned material. The lens further optionally comprises a filling material (530) to fill gaps on both surfaces of the patterned material.

Abstract: The disclosure provides a human umbilical cord mesenchymal stem cell sheet comprising one or more layers of confluent human umbilical cord mesenchymal stem cells (hUC-MSCs). The disclosure also provides method for producing hUC-MSC sheets comprising culturing hUC-MSCs in culture solution on a temperature-responsive polymer which has been coated onto a substrate surface of a cell culture support, wherein the temperature-responsive polymer has a lower critical solution temperature in water of 0-80° C.; adjusting the temperature of the culture solution to below the lower critical solution temperature, whereby the substrate surface is made hydrophilic and adhesion of the cell sheet to the surface is weakened; and detaching the cell sheet from the culture support.

Abstract: A system for low power chemical sensing can include a voltage shift unit which receives a voltage signal from a chemical sensor unit. The voltage signal can be determined by a concentration of an analyte. The voltage shift unit can transform the voltage signal to an input voltage signal, and send the input voltage signal to a plurality of frequency selective surface (FSS) units of an FSS array. The FSS array can communicate a radio frequency (RF) signal in an Institute of Electrical and Electronics Engineers (IEEE) S band with a resonant frequency based on the input voltage to provide the concentration of the analyte.

Abstract: A dental pulp capping composition can comprise a particulate base material which is non-toxic, and capable of forming a structural capping matrix; and a particulate setting material which is non-toxic, water-soluble, biocompatible, and capable of setting the composition. Optional growth factors can also be introduced into the composition to facilitate dental tissue repair. A complimentary method of restoring damaged tooth features can comprise removing diseased and/or damaged portions of the tooth to expose a prepared tooth region. Water can be added to the dental pulp capping composition to form a workable coherent paste. The workable coherent paste can be introduced into the prepared tooth region. The workable coherent paste can then be shaped within the prepared tooth region and then set to form a rigid biomimetic structure within the prepared tooth region.

Abstract: An ophthalmic composition or dosage form can include a therapeutically effective amount of a copper-containing agent that is sufficient to increase corneal lysyl oxidase activity in an eye of a subject in an amount sufficient to treat myopic progression and a pharmaceutically acceptable carrier. The composition or dosage form can be used to treat or prevent progression of myopia by administering a therapeutically effective amount of the composition to an eye of a subject during a treatment period.

Abstract: Methods of minimizing dysregulation of Staufen1-associated RNA metabolism can include introducing an amount of a Staufen1-regulating agent to a target cell sufficient to minimize the dysregulation. Therapeutic compositions for treating a neurodegenerative condition associated with Staufen1-induced dysregulation of RNA metabolism can include a therapeutically effective amount of a Staufen1-regulating agent and a pharmaceutically acceptable carrier.

Abstract: Methods of making permeable aerogels (100) can include providing a sol mixture (110) comprising an organic scaffold, an inorganic aerogel precursor, and a first solvent. The organic scaffold can be insoluble in the first solvent. The sol mixture can react to form a gel (120) such that an interconnected channel network is formed which is at least partially defined by the organic scaffold. The first solvent in the gel can be exchanged (130) with a second solvent. The second solvent can dissolve the organic scaffold to expose the interconnected channel network. The gel can be dried (140) to form the permeable aerogel.

Abstract: A tissue sample processing system and associated methods is disclosed and described. The tissue sample processing system (100) can include a microfluidic separating system (110). The microfluidic separating system (110) can include a fluid channel to receive a carrier fluid (104) and a tissue sample (102), and a plurality of outlets. Flow of the carrier fluid (104) and the tissue sample (102) in the fluid channel can facilitate segregation of materials in the tissue sample (102) based on size into a plurality of size fractions, such that each one of the plurality of outlets receives a different size fraction of the materials in the tissue sample. In addition, the sample processing system (100) can comprise a cryopreservation system (120) associated with at least one of the plurality of outlets to freeze the material in the tissue sample (102) associated with the at least one of the plurality of outlets.

Abstract: A differential emissivity imaging device for measuring evaporable particle properties can include a heated plate, a thermal camera, a memory device, and an output interface. The heated plate can have an upper surface oriented to receive falling evaporable particles. The evaporable particles have a particle emissivity and the upper surface has a plate surface emissivity. The thermal camera can be oriented to produce a thermal image of the upper surface. A memory device can include instructions that cause the imaging device to calculate a mass of the individual evaporable particle via heat conduction using a calculated surface area and an evaporation time.

Abstract: An imaging system that is translucent can be achieved by placing an image sensor (204) at one of more edges or periphery of a translucent window (202). A small fraction of light from the outside scene scatters off imperfections (218) in the translucent window (202) and reach the peripheral image sensor (204). Based on appropriate calibration of the response of point sources (206) from the outside scene, the full scene can be reconstructed computationally from the peripherally scattered light (210, 212). The technique can be extended to color, multi-spectral, light-field, 3D, and polarization selective imaging. Applications can include surveillance, imaging for autonomous agents, microscopy, etc.

Abstract: An oxygen-sensing assembly for attachment to a urinary catheter may include a housing having a flow pathway extending between an inlet end and an outlet end thereof, an oxygen sensor in operable communication with the flow pathway of the housing, the oxygen sensor configured to detect oxygen levels of a fluid flowing through the flow pathway and a flowrate sensor configured to detect a flowrate of the fluid flowing through the flow pathway. A risk of acute kidney injury may be determined based on the mass flowrate of oxygen through the flow pathway, determined based on the detected oxygen levels and the flowrate of the fluid through the flow pathway. Related catheter assemblies and methods are also disclosed.