Abstract: An electrical signal filter for processing a discrete-time real signal having a length N. In one embodiment, the filter comprising a delay line having N taps and a corresponding respective N filter coefficients. Values for the filter coefficients are determined by first shifting an impulse function of length N by a fraction of N so as to obtain a shifted impulse function. An analytic-signal-generating method is then applied to the impulse function so as to output the filter coefficient values. The values are then assigned to the N taps to complete the filter.

Abstract: A whole-body mathematical model (10) for simulating intracranial pressure dynamics. In one embodiment, model (10) includes 17 interacting compartments, of which nine lie entirely outside of intracranial vault (14). Compartments (F) and (T) are defined to distinguish ventricular from extraventricular CSF. The vasculature of the intracranial system within cranial vault (14) is also subdivided into five compartments (A, C, P, V, and S, respectively) representing the intracranial arteries, capillaries, choroid plexus, veins, and venous sinus. The body's extracranial systemic vasculature is divided into six compartments (I, J, O, Z, D, and X, respectively) representing the arteries, capillaries, and veins of the central body and the lower body. Compartments (G) and (B) include tissue and the associated interstitial fluid in the intracranial and lower regions.

Abstract: A method and apparatus for physically separating polypeptide constituents of a sample fluid by (a) providing a sample fluid comprising a mixture of polypeptides of differing physical and/or chemical properties; (b) contacting the fluid with at least two individual polymer matrix units, each polymer matrix unit preferentially accepting a different set of polypeptides on the basis of one or more physical and/or chemical properties; and (c) extracting the set of polypeptides from each polymer matrix unit.

Abstract: A breath biofeedback method and system for encouraging a subject to modify respiration. The system includes a thoracic volume input module measuring thoracic volume data of the subject and a pattern module providing target breathing patterns in communication with a display generator. The display generator producing display information representing a displayable image including a first object having a first position determined as a function of the thoracic volume data and a second object having a second position determined as a function of the target breathing pattern and the thoracic volume data. The displayable image is designed such that when displayed on the display device the displayable image encourages the subject viewing the displayable image to modify respiration.

Abstract: A launch system and method for microscopy having an optical fiber positioned proximate a sample slide with an optical fiber mounting element so as to deliver an EMR from a terminal end of the optical fiber across a surface of the sample slide to an opposing side surface at a desired incident angle.

Abstract: The invention provides methods and compositions for diagnosing and treating subjects using EBPs. Specifically disclosed are peptides and peptidomimetics that bind selectively to the extracellular domain of ErbB2. These compositions are useful in the prevention and treatment of disorders characterized by ErbB2 overexpression (e.g., breast cancer).

Abstract: This invention relates to a method for treatment of latent Toxoplasma gondii infection. The invention provides for the use of Hsp90 inhibitors for treatment of latent Toxoplasma gondii infection, particularly in an immunocompromised subject. Also provided is a screening method for identifying compounds useful for treating latent Toxoplasma gondii infection.

Abstract: An in-situ monitoring system is engaged with a mechanical system for which it is desired to assess or monitor the in-situ performance of the mechanical system. The in-situ monitoring system includes at least one input sensor and at least one output sensor for collecting data corresponding, respectively, to input into, and output from, the mechanical system. The monitoring system also includes an analyzer that utilizes the input and output data to generate an in-situ response representation of the mechanical system. The in-situ representation may be used to make a decision regarding the status of the mechanical system, e.g., to replace all or part of it, to adjust it or to do nothing. In one embodiment, the analyzer is programmed to adapt to the operating conditions of the mechanical system by automatically selecting which one of a number of target representations should be used to characterize the in-situ representation.

Abstract: The invention is based in part on the discovery that uncoupling proteins (UCPs) are expressed in the plasma membrane of rapidly dividing cells but not of growth arrested, chemotherapy resistant cells. It has also been found according to the invention that UCP is expressed in the lysosomal membrane under certain metabolic conditions. Thus the invention is methods, products, screening assays and kits relating to the manipulation of UCP expression within cellular and intracellular membranes.

Abstract: The invention relates to methods and products for treatment of a neurological defect such as a subarachnoid hemorrhage or cerebral vasospasm. Specifically, R-type voltage-gated calcium channel inhibitors and related compositions and kits are described.

Abstract: The invention relates to methods and products for treatment of hypertension, high blood pressure and vasospasm. Specifically, TRPC3 channel inhibitors and related compositions and kits are described.

Abstract: The present invention relates to methods for reducing the growth of a fungus with an anti-fungal small molecule. Methods for reducing fungal cell growth in a subject with an anti-fungal small molecule and related compositions are provided. Topical lotion formulations of an anti-fungal small molecule and a topical carrier are also provided.

Abstract: The invention provides methods and compositions for diagnosing and treating subjects using EBPs. Specifically disclosed are peptides and peptidomimetics that bind selectively to the extracellular domain of ErbB2. These compositions are useful in the prevention and treatment of disorders characterized by ErbB2 overexpression (e.g., breast cancer).

Abstract: A system and method of modeling a circulatory system including a regulatory mechanism parameter. In one embodiment, a regulatory mechanism parameter in a lumped parameter model is represented as a logistic function. In another embodiment, the circulatory system model includes a compliant vessel, the model having a parameter representing a change in pressure due to contraction of smooth muscles of a wall of the vessel.

Abstract: The invention provides methods for identifying modulators of yeast phenotypic transitions and methods for treating fungal infections with modulators of phenotypic transitions of yeast cells. These methods include methods for identifying inhibitors of the budded-to-hyphal transition of Candida albicans and methods for treating fungal infections with inhibitors of the budded-to-hyphal transition of Candida albicans.

Abstract: A system and method for referencing an objective lens to a desired plane of focus. In one embodiment, a dichroic element is utilized to reflect energy of one or more wavelengths that has passed through an objective lens to a detector for determining a position of the objective lens to a desired plane of focus. The objective lens may be manually and/or automatically focused to the desired plane of focus.

Abstract: A method of preparing mesoporous inorganic oxide spherical particles includes providing a reaction mixture capable of producing mesoporous inorganic oxide spheres; heating the reaction mixture to produce mesostructured inorganic oxide particles and removing organic material from the mesostructured inorganic oxide particles to form the mesoporous inorganic oxide spherical particles. In one embodiment a reaction mixture includes a proton donor, a source of inorganic oxide, and a source of fluoride. In another embodiment a reaction mixture includes a proton donor, a source of inorganic oxide, and an alcohol. Mesoporous inorganic oxide spheres produced by the method of the present invention are also provided.

Abstract: A system and method for measuring a pulmonary performance value of a subject. In one embodiment, a system includes one or more imaging devices, each configured to capture one or more images of a subject inside an interior chamber, such as a plethysmograph chamber. An exemplary system also includes an imaging processor in communication with the one or more imaging devices for estimating a change in volume of the subject from information about the one or more images.

Abstract: The invention relates to a method and device for recovering therapeutic and diagnostic agents from the venous outflow of a tissue or organ. A method for recovering an agent includes inserting a catheter into a vascular outflow of a tissue or organ, occluding the flow of blood/fluid through the vascular outflow, and withdrawing blood/fluid in the vascular outflow into the catheter to recover at least a portion of the agent administered to the vascular inflow of the organ or tissue.

Abstract: The present invention, in some aspects, relates to systems and methods for determining oxidized proteins, including nitrosylated proteins such as S-nitrosylated proteins. The systems and methods of the invention can be used in vitro (e.g., in cell or tissue culture) or in vivo. For instance, in some cases, the invention can be used to spatially determine the location and/or concentration of oxidized proteins within cells and/or tissues (e.g., through visual detection). In one set of embodiments, a nitrosylated or otherwise oxidized moiety on a protein may be reacted with a detection entity, which may be, for example, fluorescent, radioactive, electron-dense, able to bind to a signaling entity or a binding partner in order to produce a signal, etc. As a specific example, a nitrosothiol moiety on a nitrosylated protein may be reacted with an alkylating agent to form an alkylthio moiety; the alkylthio moiety may include a detection entity or otherwise be able to interact with a signaling entity.