Patents Assigned to University of Washington
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Publication number: 20250249411Abstract: Nanoporous selective sol-gel ceramic membranes, selective-membrane structures, and related methods are described. Representative ceramic selective membranes include ion-conductive membranes (e.g., proton-conducting membranes) and gas selective membranes. Representative uses for the membranes include incorporation into fuel cells and redox flow batteries (RFB) as ion-conducting membranes.Type: ApplicationFiled: December 16, 2024Publication date: August 7, 2025Applicant: University of WashingtonInventors: Gregory M. Newbloom, Aaron F. West, Ryan Kastilani, Canfeng Wei, Jaime Rodriguez, Lilo D. Pozzo, Lauren Martin
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Patent number: 12377289Abstract: Various devices, systems, and methods for performing personalized dosimetry of a patient receiving a radiopharmaceutical are described. In an example method, anatomic data is generated by performing a computed tomography (CT) scan on the patient when they are lying down and wearing a garment. Based on the anatomic data, locations of organs of the patient are determined with respect to one or more fiducial markers integrated with the garment. Detectors for detecting photons from a radiopharmaceutical are placed on the garment based on locations of the organs. Subsequently, the patient may be administered a dose of the radiopharmaceutical. When the patient wears the garment, the detectors may detect photons released from the decaying radiopharmaceutical that is distributed in the organs. The radiation dosage to the organs may be determined based on the detected photons.Type: GrantFiled: November 5, 2021Date of Patent: August 5, 2025Assignee: University of WashingtonInventors: Larry A Pierce, II, Robert S. Miyaoka, Robert L Harrison
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Publication number: 20250244212Abstract: This disclosure relates to methods and systems for imaging biopsy samples. The system for imaging biopsy samples comprises a window and an imaging device. The window comprises an inflexible and optically clear material. The window is configured to compress a sample disposed in a biopsy needle. The imaging device is configured to maintain a constant working distance to the flattened tissue surface while scanning. The imaging device is configured to capture one or more images of the sample through the window.Type: ApplicationFiled: December 7, 2022Publication date: July 31, 2025Applicant: University of WashingtonInventors: Eric J. Seibel, Matthew Damien Carson
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Patent number: 12371734Abstract: Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.Type: GrantFiled: January 17, 2025Date of Patent: July 29, 2025Assignee: University of WashingtonInventors: Georg Seelig, Richard Muscat, Alexander B. Rosenberg
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Patent number: 12371735Abstract: Methods of uniquely labeling or barcoding molecules within a nucleus, a plurality of nuclei, a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a nucleus, a plurality of nuclei, a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs and/or cDNAs.Type: GrantFiled: February 14, 2025Date of Patent: July 29, 2025Assignee: University of WashingtonInventors: Georg Seelig, Alexander B. Rosenberg, Charles Roco
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Patent number: 12371733Abstract: Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.Type: GrantFiled: January 17, 2025Date of Patent: July 29, 2025Assignee: University of WashingtonInventors: Georg Seelig, Richard Muscat, Alexander B. Rosenberg
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Publication number: 20250237641Abstract: Systems and methods for culture of human kidney organoids as a model system for characterizing kidney pathologies and implementing therapeutics for conditions that affect the kidney. A model system for characterization of a pathophysiology includes a culture of human kidney organoids and an organoid culture medium. The organoids may include one or more genome edits as part of an approach for studying genetic factors involved with a pathological process. The culture may include one or more other factors, such as pathological agents and/or anti-pathological agents, for development and evaluation of therapeutics. The approaches may be used for implementation of compositions and methods for virally transducing the kidney or a subset of cells or cell types thereof.Type: ApplicationFiled: October 7, 2022Publication date: July 24, 2025Applicant: University of WashingtonInventors: Benjamin FREEDMAN, Louisa HELMS
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Publication number: 20250237443Abstract: A ram accelerator for accelerating a projectile is provided. The ram accelerator includes a baffle section configured to start the projectile in the ram accelerator without an obturator. The ram accelerator generally includes a tube having a projectile bore; and a baffle section operably coupled to a proximal end of the tube. The baffle section has an annular baffle wall defining a central bore axially aligned with the projectile bore; and a propellant chamber arranged adjacent to the annular baffle wall, wherein the propellant chamber is configured to enclose a propellant. The propellant can be ignited as the projectile passes through the baffle section by pressure created by the projectile, by an ignition source, or by a flame carried by the projectile to start the ram acceleration of the projectile.Type: ApplicationFiled: March 10, 2023Publication date: July 24, 2025Applicant: University of WashingtonInventors: Carl Thomas Knowlen, Brian Leege
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Publication number: 20250228899Abstract: Techniques for generating and utilizing adult hepatocyte organoids are described. An example method includes generating an organoid by culturing hepatocytes obtained from an adult donor in a hepatocyte culture medium. The hepatocyte culture medium includes a basal medium and 5 ?M of a TGF-? inhibitor.Type: ApplicationFiled: October 20, 2022Publication date: July 17, 2025Applicant: University of WashingtonInventors: Kelly Rose Stevens, Sarah Henley Saxton, Shannon Nicole Mitchell, Inkyung Kang
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Patent number: 12352754Abstract: The present invention provides, among other aspects, functionalized chromophoric polymer dots comprising a hydrophobic core and a hydrophilic cap, and bioconjugates thereof. Also provided are improved methods for preparing functionalized chromophoric polymer dots. Methods for in vivo imaging and molecular labeling are also disclosed.Type: GrantFiled: October 23, 2023Date of Patent: July 8, 2025Assignees: University of Washington, Clemson Research FoundationInventors: Daniel T. Chiu, Changfeng Wu, Jason McNeil, Jiangbo Yu
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Patent number: 12352742Abstract: The present disclosure generally relates to the methods and compositions to efficiently analyze polymer characteristics using nanopore-based assays. Specifically disclosed is a method for generating reference signals for polymer analysis in a nanopore system, wherein the nanopore system has a multi-subunit output signal resolution. The method comprises translocating a reference sequence through a nanopore to generate a plurality of reference output signals, wherein each possible multi-subunit sequence that can determine an output signal appears only once in the reference sequence. The output signals are compiled into a reference map for nanopore analysis of an analyte polymer. Also provided are methods and compositions for calibrating the nanopore system for optimized polymer analysis.Type: GrantFiled: October 12, 2023Date of Patent: July 8, 2025Assignee: University of Washington through its Center for CommercializationInventors: Jens Gundlach, Ian M. Derrington, Andrew Laszlo, Elizabeth Manrao
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Patent number: 12343274Abstract: In an embodiment, the present disclosure pertains to an organ-specific wireless optogenetic device. In some embodiments, the device includes an electronic circuit, such that the electronic circuit is configured to harvest and convert radio frequency (RF) energy into optical energy and a tether having a ?LED, where the ?LED illuminates targeted regions in the organ. In an additional embodiment, the present disclosure pertains to a method of treating obesity. In general, the method includes implanting an organ-specific wireless optogenetic device into a subject, activating an RF-power system to produce RF energy, harvesting, by the organ-specific wireless optogenetic device, the RF energy, converting, by the organ-specific wireless optogenetic device, the RF energy into optical energy, illuminating, by the ?LED, targeted regions in the stomach of the subject, and stimulating nerve endings to thereby suppress appetite in the subject.Type: GrantFiled: February 25, 2022Date of Patent: July 1, 2025Assignees: The Texas A & M University System, University of WashingtonInventors: Sung Il Park, Woo Seok Kim, Carlos Arturo Campos
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Patent number: 12329773Abstract: Methods and compositions for treating traumatic brain injury. The methods and compositions utilize a multi-functional oxygen reactive polymer (ORP) that includes repeating units that include a reactive oxygen species (ROS) scavenging group and a polyalkylene oxide group. For theranostic applications, the oxygen reactive polymer further includes a diagnostic group.Type: GrantFiled: July 19, 2021Date of Patent: June 17, 2025Assignee: University of WashingtonInventors: Patrick S. Stayton, Menko P. Ypma, Peter A. Chiarelli, Joshua Sang Hun Park, Richard G. Ellenbogen, Julia Mengyun Xu, Pierre D. Mourad, Donghoon Lee, Anthony Convertine, Forrest M. Kievit
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Publication number: 20250189251Abstract: A ram accelerator for accelerating a projectile is provided. The ram accelerator includes a first tube body having a first projectile bore, a second tube body having a second projectile bore axially aligned with the first projectile bore, and a baffle positioned between and operably coupling the first and second tube bodies. The baffle can have an annular baffle wall defining a central bore that is axially aligned with the first and second projectile bores, and a chamber arranged adjacent to the annular baffle wall. The chamber can extend radially outward from the central bore and the annular baffle wall can be configured to sweep a combustion wave relative to the projectile to prevent the combustion wave from traveling ahead of the projectile, leading to an unstart mechanism of the projectile in the ram accelerator.Type: ApplicationFiled: March 10, 2023Publication date: June 12, 2025Applicant: University of WashingtonInventors: Carl Thomas Knowlen, Andrew Jason Higgins, Brian Leege
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Publication number: 20250171827Abstract: Methods of uniquely labeling or barcoding molecules within a nucleus, a plurality of nuclei, a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a nucleus, a plurality of nuclei, a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs and/or cDNAs.Type: ApplicationFiled: February 14, 2025Publication date: May 29, 2025Applicant: University of WashingtonInventors: Georg Seelig, Alexander B. Rosenberg, Charles Roco
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Patent number: 12313519Abstract: Systems and methods for analyzing particles flowing in a channel are described. In an embodiment, the channel is configured to flow a particle through a lumen of the channel, the channel defining an interrogation window configured to allow light to pass into and out of the lumen; a light engine comprising: a first light source positioned to output first excitation light onto a first portion of the channel in the interrogation window; and a second light source positioned to output second excitation light onto a second portion of the channel in the interrogation window separate from the first portion. In an embodiment, the systems include an emission fiber bundle comprising a first emission optical fiber and a second emission optical fiber, wherein a proximal end of first emission optical fiber and second emission optical fiber are arranged in an emission fiber bundle head.Type: GrantFiled: November 10, 2021Date of Patent: May 27, 2025Assignee: University of WashingtonInventors: Daniel T. Chiu, Yifei Jiang, Mengxia Zhao, Yuanhua Cheng
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Publication number: 20250163290Abstract: Zwitterionic carboxybetaine copolymers and their use in coatings to impart non-fouling and functionality to surfaces, particularly surfaces of blood-contacting medical devices.Type: ApplicationFiled: September 12, 2023Publication date: May 22, 2025Applicant: University of WashingtonInventors: Shaoyi Jiang, Xiaojie Lin, Jonathan Himmelfarb, Buddy D. Ratner
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Publication number: 20250163495Abstract: Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.Type: ApplicationFiled: January 17, 2025Publication date: May 22, 2025Applicant: University of WashingtonInventors: Georg Seelig, Richard Muscat, Alexander B. Rosenberg
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Publication number: 20250163496Abstract: Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.Type: ApplicationFiled: January 17, 2025Publication date: May 22, 2025Applicant: University of WashingtonInventors: Georg Seelig, Richard Muscat, Alexander B. Rosenberg
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Publication number: 20250163494Abstract: Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.Type: ApplicationFiled: January 17, 2025Publication date: May 22, 2025Applicant: University of WashingtonInventors: Georg Seelig, Richard Muscat, Alexander B. Rosenberg