Patents Assigned to University of Washington
  • Publication number: 20250145926
    Abstract: Various implementations described herein relate to devices, systems, and methods for inducing and/or causing cellular migration and uses thereof. Implementations described herein can be used to cause a portion of a cell population to migrate in response to a differential stimulus. Implementations described herein can be used to isolate and characterize the portion of the cell population. Implementations described herein can be used for research, diagnostic, or therapeutic purposes.
    Type: Application
    Filed: October 31, 2024
    Publication date: May 8, 2025
    Applicant: University of Washington
    Inventors: Nathan Belliveau, Julie Theriot, Matthew Footer
  • Patent number: 12294228
    Abstract: Examples of charging systems are described which may utilize a network of resonator circuits. Control methods are described which may locate a charging location at which an electronic device is placed proximate the charging system and identify a path of resonator circuits to activate to charge the electronic device. Individual resonator circuits in the path may be activated by selecting a resonant frequency of the resonator circuit such that power may be transferred by the resonator circuit at an operating frequency.
    Type: Grant
    Filed: February 25, 2021
    Date of Patent: May 6, 2025
    Assignee: University of Washington
    Inventors: Joshua R. Smith, Xingyi Shi
  • Patent number: 12291652
    Abstract: Zwitterionic double network hydrogels, methods for making zwitterionic double network hydrogels, methods for using zwitterionic double network hydrogels, and articles made from and coated with zwitterionic double network hydrogels.
    Type: Grant
    Filed: August 14, 2019
    Date of Patent: May 6, 2025
    Assignee: University of Washington
    Inventors: Shaoyi Jiang, Hsiang-Chieh Hung, Dianyu Dong, Caroline Tsao, Chenjue Tang, Joel MacArthur
  • Publication number: 20250135016
    Abstract: The present disclosure features, inter alia, a cyclic multifunctional linker, including at least two cleavable moieties; at least two connecting chains connected to the at least two cleavable moieties to provide a cyclic structure; and at least two linking groups, each linking group being bonded at one end to a connecting chain and being located between two cleavable moieties, and each linking group having a second end configured to bond to crosslinkable moieties. In the cyclic multifunctional linker, each connecting chain has at least two ends, and at least two of the connecting chains are each connected at each end to a cleavable moiety.
    Type: Application
    Filed: November 1, 2024
    Publication date: May 1, 2025
    Applicant: University of Washington
    Inventors: Cole DeForest, Barry Badeau
  • Publication number: 20250138021
    Abstract: This application relates to oligomer barcodes for labeling extracellular vesicles (EVs). The labeled extracellular vesicles can be used to monitor EV movement for research purposes and for the development of treatments in a variety of diseases and disorders.
    Type: Application
    Filed: October 29, 2024
    Publication date: May 1, 2025
    Applicant: University of Washington
    Inventors: Elizabeth Nance, Nam Phuong H Nguyen, Shahrokh Paktinat, Lucia Vojtech, Mengying Zhang
  • Publication number: 20250136112
    Abstract: In some embodiments, a method of controlling speed of an ego vehicle in a vehicle platoon is provided. Cooperative adaptive cruise control (CACC) commands based on at least one of a vehicle-to-vehicle communication control received from a preceding vehicle and a feedback control based on a sensor output of a long-range sensor of the ego vehicle are provided to a speed controller. In response to detecting an occluded state, a minimum spacing value and a minimum relative velocity value between the ego vehicle and the preceding vehicle are determined based on information received before the detection of the occluded state; a safety speed based on the minimum spacing value and the minimum relative velocity value is determined; and an occluded adaptive cruise control command is provided to the speed controller to maintain a speed of the ego vehicle that is less than or equal to the safety speed.
    Type: Application
    Filed: September 9, 2022
    Publication date: May 1, 2025
    Applicants: University of Washington, University of Portland
    Inventors: Yudong Lin, Santosh Devasia, Brian Fabien
  • Patent number: 12285636
    Abstract: Non-planar holographic beam shaping lenses for acoustics are disclosed herein. In one embodiment, an ultrasonic therapy system that is configured to apply ultrasound to a target in a body includes: an ultrasonic transducer configured to generate the ultrasound; and a customizable holographic lens configured to focus the ultrasound onto a focal area of a target that is an object or a portion of the object in the body. The customizable holographic lens is designed and produced based on the target. Furthermore, the customizable holographic lens is curved to mate with a front surface of the ultrasonic transducer.
    Type: Grant
    Filed: August 4, 2022
    Date of Patent: April 29, 2025
    Assignee: The University of Washington
    Inventors: Michael R. Bailey, Mohamed Abdalla Ghanem, Adam D. Maxwell
  • Publication number: 20250129132
    Abstract: Described herein is a generalizable strategy to rapidly and irreversibly activate protein function with full spatiotemporal control. Through development of an exogenously triggerable self-assembling protein construct, bioactive proteins can be stably reassembled from non-functional split fragment pairs following exposure to a stimulus (e.g., light).
    Type: Application
    Filed: September 21, 2022
    Publication date: April 24, 2025
    Applicant: University of Washington
    Inventors: Cole Alexander DeForest, Emily R. Ruskowitz
  • Patent number: 12280376
    Abstract: Devices and systems for droplet generation and methods for generating droplets are described. In an embodiment, the devices and systems include a capillary configured to eject a droplet, such as in response to a voltage applied to an end of the capillary. In an embodiment, the devices and systems include a moveable stage configured to carry a multi-well plate and move the stage relative to the capillary such that the ejected droplet is selectively received by a well of the multi-well plate carried by the moveable stage.
    Type: Grant
    Filed: February 4, 2020
    Date of Patent: April 22, 2025
    Assignee: University of Washington
    Inventors: Daniel Chiu, Li Wu, Yuling Qin
  • Publication number: 20250122318
    Abstract: Crosslinked films having electro-optic activity, compositions and compounds for making the films, methods for making the films, and devices that include the films are disclosed.
    Type: Application
    Filed: December 20, 2024
    Publication date: April 17, 2025
    Applicant: University of Washington
    Inventors: Delwin Elder, Huajun Xu, Bruce H. Robinson, Larry R. Dalton
  • Publication number: 20250118545
    Abstract: A system may control a mass spectrometer to acquire, during a plurality of acquisitions constituting an acquisition cycle, a set of mass spectra of product ions derived from precursor ions isolated based on a parallel isolation window successively positioned throughout a precursor mass-to-charge ratio (m/z) range. The precursor m/z range is divided into a plurality of isolation window units. The parallel isolation window includes, for each acquisition of the acquisition cycle, a set of isolation sub-windows corresponding to a distinct set of isolation window units of the precursor m/z range. At least two adjacent isolation sub-windows of the parallel isolation window are non-contiguous. Each isolation window unit of the precursor m/z range is analyzed at least twice during the acquisition cycle. A mass spectrum for the precursor m/z range may be generated based on the set of mass spectra acquired during the acquisition cycle.
    Type: Application
    Filed: October 6, 2023
    Publication date: April 10, 2025
    Applicants: Thermo Finnigan LLC, University of Washington
    Inventors: Philip M. Remes, Michael J. MacCoss, Jarrett Egertson
  • Publication number: 20250115528
    Abstract: Embodiments of the present disclosure provide compositions and methods for increasing nutrient uptake by plants and for effecting soil remediation. Embodiments of the composition and methods comprise a hydrogel bead, a microbial consortia, and a fungi, and can additionally comprise an excipient for administration of the hydrogel bead comprising the microbial consortia and the fungi, one or more seed, water, one or more nutrients, and combinations thereof. Such composition and methods have broad application to reduce fertilizer requirements and use, and to increase plant nutrient access and uptake. The composition and methods have additional application to remediate contaminated mediums such as soil contaminated with chemicals, petroleum, and explosives.
    Type: Application
    Filed: January 5, 2023
    Publication date: April 10, 2025
    Applicant: University of Washington
    Inventors: Mari-Karoliina Henriikka Winkler, Korena Mafune
  • Patent number: 12270067
    Abstract: The present disclosure provides nanoparticle transducers and methods of use thereof for the detection of analyte concentrations in a fluid. Nanoparticle transducers can comprise a nanoparticle, such as a Pdot, coupled to an enzyme that catalyzes a reaction with the analyte. The nanoparticle transducers further comprise chromophores that emit fluorescence that varies as a function of the concentration of one of the elements of the reaction. The nanoparticle transducer thus changes fluorescence as the analyte concentration changes, transforming analyte concentration values into fluorescence intensities. The measurement of these intensities provides a measurement of the analyte concentration. The nanoparticle transducers are biocompatible, allowing for use in vivo, for the monitoring of analyte blood concentrations such as blood glucose concentrations.
    Type: Grant
    Filed: November 23, 2022
    Date of Patent: April 8, 2025
    Assignees: University of Washington, Lamprogen, Inc.
    Inventors: Daniel T. Chiu, Jiangbo Yu, Changfeng Wu, Kai Sun
  • Patent number: 12269764
    Abstract: Hydrogels for entrapment of live microorganisms and methods of their use, such as in wastewater purification, are disclosed.
    Type: Grant
    Filed: October 13, 2020
    Date of Patent: April 8, 2025
    Assignee: University of Washington
    Inventors: Raymond Redcorn, Mari-Karoliina Henriikka Winkler, Bruce Godfrey, David A. Stahl
  • Patent number: 12272468
    Abstract: The present disclosure provides organic-inorganic hybrid polymer particles, which have desirable surface chemistry and optical properties that make them particularly suitable for biological and optical applications. The present disclosure also provides methods of making organic-inorganic hybrid polymer particles. The present disclosure also provides methods of using the organic-inorganic hybrid polymer particles for biological and optical applications.
    Type: Grant
    Filed: October 11, 2023
    Date of Patent: April 8, 2025
    Assignee: University of Washington
    Inventors: Daniel T. Chiu, Jiangbo Yu, Yu Rong, Changfeng Wu
  • Patent number: 12263193
    Abstract: Compositions and method for reducing the concentration of uremic toxins in the body of a patient suffering from some degree of kidney failure are disclosed. The methods can be used to delay the need for conventional dialysis treatment or as an adjunct therapy to reduce the frequency of dialysis sessions, and in some instances, as an alternative to such dialysis sessions.
    Type: Grant
    Filed: October 14, 2019
    Date of Patent: April 1, 2025
    Assignee: University of Washington
    Inventors: Paul Yager, Jonathan Himmelfarb, Mari-Karoliina Henriikka Winkler, Erin Heiniger, Sujatha Kumar, David Stahl, Bruce Godfrey
  • Publication number: 20250101413
    Abstract: The invention provides methods for preparing DNA sequencing libraries by assembling short read sequencing data into longer contiguous sequences for genome assembly, full length cDNA sequencing, metagenomics, and the analysis of repetitive sequences of assembled genomes.
    Type: Application
    Filed: October 18, 2024
    Publication date: March 27, 2025
    Applicant: University of Washington
    Inventors: Jay Ashok Shendure, Joseph Hiatt, Rupali Patwardhan, Emily Turner
  • Patent number: 12258397
    Abstract: Aspects of the invention described herein include methods of treating, inhibiting, ameliorating and/or eliminating a virus or cancer cells in a subject utilizing genetically engineered human T-cells having receptors for a molecule presented by the virus or the cancer cells, wherein the genetically engineered T cells are isolated utilizing a two-stage MTX selection that employs increasing concentrations of MTX.
    Type: Grant
    Filed: November 12, 2020
    Date of Patent: March 25, 2025
    Assignees: Seattle Children's Hospital, University of Washington
    Inventors: Michael C. Jensen, Suzie Pun, Nataly Kacherovsky
  • Publication number: 20250094855
    Abstract: Systems and methods for optimizing data-driven decision-making in multi-agent systems are described. The system may construct an equilibrium concept to capture multi-layer and/or k-level depth reasoning by agents. The system may determine best-response type conjectures for agents to interact with one another. In some examples, the system may include a machine or an algorithm interacting with a strategic agent (e.g., a human or an entity). The system may include methods for: (1) data-driven estimation and/or learning of conjectures and associated depth; and (2) data-driven design of algorithmic mechanisms for exploring the conjectural equilibrium (CE) space by influencing the strategic agent(s) behaviors through adaptively adjusting and estimating deployed strategies.
    Type: Application
    Filed: July 20, 2022
    Publication date: March 20, 2025
    Applicant: University of Washington
    Inventors: Benjamin Chasnov, Lillian Ratliff, Samuel A Burden, Amy Orsborn, Tanner Fiez, Manchali Maneeshika Madduri, Joseph G Sullivan, Momona Yamagami
  • Patent number: 12252731
    Abstract: Methods of uniquely labeling or barcoding molecules within a nucleus, a plurality of nuclei, a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a nucleus, a plurality of nuclei, a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs and/or cDNAs.
    Type: Grant
    Filed: April 21, 2023
    Date of Patent: March 18, 2025
    Assignee: University of Washington
    Inventors: Georg Seelig, Alexander B. Rosenberg, Charles Roco