Patents Assigned to University of Washington
  • Patent number: 10317602
    Abstract: The present disclosure describes luminescent solar concentrators that include photoluminescent nanoparticles. The photoluminescent nanoparticles include a semiconductor nanocrystal that sensitizes the luminescence of a defect. The defect can include, for example, an atom, a cluster of atoms, or a lattice vacancy. The defect can be incorporated into the semiconductor nanocrystal, adsorbed onto, or otherwise associated with the surface of the semiconductor nanocrystal.
    Type: Grant
    Filed: April 12, 2018
    Date of Patent: June 11, 2019
    Assignees: Western Washington University, University of Washington Through Its Center For Commercialization
    Inventors: David Patrick, John Gilbertson, Stephen McDowall, Christian Erickson, Daniel R. Gamelin, Liam Bradshaw, Emily Jane McLaurin, Kathryn E. Knowles
  • Patent number: 10307425
    Abstract: The present disclosure is directed to compositions and methods for inhibiting either Toxoplasma gondii (T. gondii) calcium dependent protein kinases (TgCDPKs) or Cryptosporidium parvum (C. parvum) and Cryptosporidium hominus (C. hominus) calcium dependent protein kinases (CpCDPKs) using pyrazolopyrimidine and/or imidazo[1,5-?]pyrazine inhibitors, of the Formula (I), wherein the variables X, Y, Z, R1, and R3 are defined herein.
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: June 4, 2019
    Assignee: University of Washington
    Inventors: Wilhelmus G. J. Hol, Eric T. Larson, Dustin James Maly, Wesley C. Van Voorhis, Ethan Merritt, Kayode K. Ojo
  • Patent number: 10307594
    Abstract: Front-end analog circuitry is described based on a sink-regulated H-bridge topology for delivery of biphasic stimulus signals that may be useful in neurostimulation. Stimulus current may be supplied using fully-integrated dynamic voltage supplies (DVSs), which may be controlled in closed-loop to have an output voltage approximately equal to the voltage of the electrode each supplies stimulus to. The stimulus waveform may be regulated by a single, low-voltage current-digital-to-analog converter (current-DAC), which can safely interface with the electrodes (which may be at high voltages) via high-voltage adapter (HVA) circuits. Example analog front-end circuitry may utilize the balancing stimulus current to discharge the electrode-tissue interface impedance (ZE). In some examples, only after full (or sufficient) ZE discharge has been detected is a DVS used to supply the remaining balancing stimulus.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: June 4, 2019
    Assignee: University of Washington
    Inventors: Eric Pepin, Jacques Christophe Rudell
  • Patent number: 10301413
    Abstract: Nonfouling copolymers and hydrogels comprising positively charged repeating units or latent positively charged repeating units and negatively charged units or latent positively charged units.
    Type: Grant
    Filed: April 28, 2015
    Date of Patent: May 28, 2019
    Assignee: UNIVERSITY OF WASHINGTON
    Inventors: Shaoyi Jiang, Shengfu Chen
  • Patent number: 10301446
    Abstract: A method for generating a microstructure that includes microcellular bubbles, in a material that includes molecules of a thermoplastic polymer, comprises: determining a size-index for the material that represents an average size of the thermoplastic polymer molecules included in the material, and in response to the determined size-index, setting a parameter of a process to generate a microstructure in the material that includes microcellular bubbles. The process to generate a microstructure in the material includes: 1) infusing into the material, during a first period, a gas that does not react with the material, 2) making the gas-infused material thermodynamically unstable.
    Type: Grant
    Filed: September 19, 2014
    Date of Patent: May 28, 2019
    Assignees: Dart Container Corporation, The University of Washington through its Center for Commercialization
    Inventors: Krishna V. Nadella, Vipin Kumar, Huimin Guo
  • Publication number: 20190158341
    Abstract: Examples described herein include backscatter devices which may transmit orthogonal frequency division multiplexing (OFDM) signals. Techniques for complex analog backscatter are described. Examples of impedance circuitry are described which may be used to provide real and imaginary components of impedance in accordance with inphase and quadrature bits.
    Type: Application
    Filed: April 4, 2017
    Publication date: May 23, 2019
    Applicant: University of Washington
    Inventors: Vamsi Talla, Joshua R, Smith, Shyamnath Gollskota, Bryce Kellogg
  • Publication number: 20190154683
    Abstract: Hierarchical films with structurally regulated functionalities through the integration of two-dimensional and three-dimensional structures to achieve ultra low nonspecific binding and high loading of molecular recognition elements, and methods for making and using the films.
    Type: Application
    Filed: July 23, 2018
    Publication date: May 23, 2019
    Applicant: University of Washington through its Center for Commercialization
    Inventors: Shaoyi Jiang, Norman David Brault, JR., Harihara S. Sundaram, Chun-Jen Huang, Qiuming Yu, Yuting Li
  • Patent number: 10293035
    Abstract: The compositions described herein include an epitope of a peptide that may elicit an immune response in a subject following administration. The compositions may comprise nucleic acids. The compositions may comprise peptides. The methods described herein include administering a composition comprising an epitope of a peptide to a subject in need thereof.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: May 21, 2019
    Assignee: University of Washington through its Center for Commercialization
    Inventors: Mary L. Disis, Denise Cecil, Meredith Slota
  • Publication number: 20190144916
    Abstract: Reagents, methods, and kits for assaying enzymes associated with lysosomal storage diseases MPS-I, MPS-II, MPS-IIIA, MPS-IIIB, MPS-IVA, MPS-VI, and MPS VII.
    Type: Application
    Filed: December 18, 2018
    Publication date: May 16, 2019
    Applicant: University of Washington through its Center for Commercialization
    Inventors: Michael H. Gelb, Arun Babu Kumar, Frances Hocutt, Zdenek Spacil, Mariana Natali Barcenas Rodriguez, Frantisek Turecek, C. Ronald Scott
  • Patent number: 10285624
    Abstract: Systems, methods, and devices are provided for estimating bilirubin levels. In one aspect, a method for estimating the level of bilirubin in a patient includes receiving image data for at least one image including a region of the patient's skin and a color calibration target. Color-balanced image data for the skin region is generated based on a subset of the image data corresponding to the color calibration target and the skin region. The bilirubin level in the patient is estimated based on the color-balanced image data for the skin region.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: May 14, 2019
    Assignee: University of Washington
    Inventors: James A. Taylor, Shwetak N. Patel, James W. Stout, Lilian De Greef, Mayank Goel, Eric C. Larson
  • Patent number: 10287631
    Abstract: Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when “deep sequencing” genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, a method Duplex Consensus Sequencing (DCS) is provided. This approach greatly reduces errors by independently tagging and sequencing each of the two strands of a DNA duplex. As the two strands are complementary, true mutations are found at the same position in both strands. In contrast, PCR or sequencing errors will result in errors in only one strand.
    Type: Grant
    Filed: July 26, 2017
    Date of Patent: May 14, 2019
    Assignee: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
    Inventors: Jesse Salk, Lawrence A. Loeb, Michael Schmitt
  • Patent number: 10272180
    Abstract: Functionalized zwitterionic and mixed charge polymers and copolymers, methods for making the polymers and copolymers, hydrogels prepared from the functionalized zwitterionic and mixed charge polymers and copolymers, methods for making and using the hydrogels, and zwitterionic and mixed charge polymers and copolymers for administration for therapeutic agents.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: April 30, 2019
    Assignee: University of Washington
    Inventors: Shaoyi Jiang, Tao Bai, Harihara Subramanian Sundaram, Andrew William Sinclair, Jean-René Ella-Menye, Priyesh Jain
  • Patent number: 10274496
    Abstract: A metabolic profiling approach for identifying biomarkers that provide highly sensitive and specific colorectal cancer (CRC) detection and monitoring using serum samples. The methods can be used for distinguishing CRC patients from both healthy controls and polyp patients, as well as to monitor disease progression or response to therapy. Receiver operator characteristic curves generated based on these models showed high sensitivities for differentiating CRC patients from healthy controls or polyp patients, good specificities, low false discovery rates, and excellent areas under the curve were obtained. Monte Carlo cross validation (MCCV) was also applied, demonstrating the robust diagnostic power of this metabolic profiling approach.
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: April 30, 2019
    Assignee: UNIVERSITY OF WASHINGTON
    Inventors: Daniel Raftery, Danijel Djukovic, Haiwei Gu, Jiangjiang Zhu
  • Patent number: 10273403
    Abstract: The present disclosure relates to a composition that includes a particle and a surface species, where the particle has a characteristic length between greater than zero nm and 100 nm inclusively, and the surface species is associated with a surface of the particle such that the particle maintains a crystalline form when the composition is at a temperature between ?180° C. and 150° C.
    Type: Grant
    Filed: May 31, 2017
    Date of Patent: April 30, 2019
    Assignees: Alliance for Sustainable Energy, LLC, University of Washington, Regents of the University of Colorado, a body corporate
    Inventors: Joseph Matthew Luther, Abhishek Swarnkar, Ashley Rae Marshall, Erin Mariko Sanehira
  • Patent number: 10273327
    Abstract: The present disclosure is directed to methods of making a polymer, including exposing a reaction mixture including a strained cyclic unsaturated monomer and an organic initiator to a stimulus to provide an activated organic initiator, whereby the activated organic initiator is effective to polymerize the strained cyclic unsaturated monomer via a 4-membered carbocyclic intermediate to provide a polymer having constitutional units derived from the strained cyclic unsaturated monomer.
    Type: Grant
    Filed: September 3, 2015
    Date of Patent: April 30, 2019
    Assignee: University of Washington
    Inventors: Andrew J. Boydston, Kelli Ogawa, Adam E. Goetz, Damian Dunford, Laura Marie Murphy Pascual
  • Publication number: 20190117243
    Abstract: Apparatus and method for improved cavitation-induced drug delivery is disclosed. In one embodiment, a method for delivering a treatment composition to a target tissue using ultrasound includes: directing ultrasound waveforms toward the target tissue of a patient; generating ultrasound shock fronts at the target tissue of a patient; generating a cavitation inside the target tissue of a patient by the ultrasound shock front; and delivering the treatment composition to the patient. Absorption of the treatment composition by the target tissue is increased by the cavitation inside the target tissue. In some embodiments, the treatment composition may be delivered within a time period of +/?1 week from generating the cavitation.
    Type: Application
    Filed: October 24, 2018
    Publication date: April 25, 2019
    Applicant: University of Washington
    Inventors: Tatiana Khokhlova, Vera Khoklova, Oleg A. Sapozhnikov, Wayne Kreider, Adam D. Maxwell, Joo Ha Hwang
  • Patent number: 10266815
    Abstract: The invention provides compositions and methods for treating celiac sprue.
    Type: Grant
    Filed: August 13, 2014
    Date of Patent: April 23, 2019
    Assignee: University of Washington Through Its Center for Commercialization
    Inventors: Justin Bloomfield Siegel, David Baker, Ingrid Swanson Pultz
  • Patent number: 10270639
    Abstract: Apparatuses, systems, ambient RF backscatter transceivers, and methods for communicating using MIMO and spread spectrum coding of backscattered ambient RF signals are described. An example system may include an ambient RF backscatter transceiver that include an antenna configured to receive a backscattered ambient radio frequency (RF) signal, and a receiver coupled to the antenna. The receiver may be configured to demodulate the backscattered ambient RF signal using one of multiple input, multiple output multiplexing demodulation or spread spectrum code demodulation to retrieve the first data. The backscattered ambient RF signal may be generated by backscattering an ambient RF signal at a first frequency. The ambient RF signal may be configured to provide other data at a second frequency.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: April 23, 2019
    Assignee: University of Washington
    Inventors: Shyamnath Gollakota, Joshua R. Smith, Aaron N. Parks, Angli Liu
  • Publication number: 20190116078
    Abstract: Apparatuses, systems, ambient RF backscatter transceivers, and methods for communicating using MIMO and spread spectrum coding of backscattered ambient RF signals are described. An example system may include an ambient RF backscatter transceiver that include an antenna configured to receive a backscattered ambient radio frequency (RF) signal, and a receiver coupled to the antenna. The receiver may be configured to demodulate the backscattered ambient RF signal using one of multiple input, multiple output multiplexing demodulation or spread spectrum code demodulation to retrieve the first data. The backscattered ambient RF signal may be generated by backscattering an ambient RF signal at a first frequency. The ambient RF signal may be configured to provide other data at a second frequency.
    Type: Application
    Filed: December 7, 2018
    Publication date: April 18, 2019
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: Shyamnath Gollakota, Joshua R. Smith, Aaron N. Parks, Angli Liu
  • Publication number: 20190106740
    Abstract: The present disclosure provides method and systems for improving nanopore-based analysis of polymers. The disclosure provides methods for selectively modifying one or more monomeric subunit(s) of a kind in a re-analyte polymer that results in a polymer analyte with a modified subunit. The polymer analyte produces a detectable signal in a nanopore-based system. The detectable signal, and/or its deviation from a reference signal, indicates the location of the modified subunit in the polymer analyte and, thus, permits the identification of the subunit at that location in the original pre-analyte polymer.
    Type: Application
    Filed: July 6, 2018
    Publication date: April 11, 2019
    Applicants: University of Washington through its Center for Commercialization, Illumina, Inc.
    Inventors: Jens H. Gundlach, Andrew Laszlo, Ian Derrington, Jeffrey G. Mandell