Patents Assigned to University of Washington
  • Publication number: 20200253192
    Abstract: Zwitterionic microgels, zwitterionic microgel assemblies, their formulations and methods for their use.
    Type: Application
    Filed: July 20, 2017
    Publication date: August 13, 2020
    Applicant: University of Washington
    Inventors: Shaoyi Jiang, Andrew Sinclair, Mary Elizabeth O'Kelly, Tao Bai, Priyesh Jain
  • Publication number: 20200254459
    Abstract: Aniosotropic Ratchet Conveyor (“ARC”)-based biomolecule processing devices and related methods are described. The ARC-based biomolecule processing devices include (i) a substrate having an ARC track defined on or within the substrate and including a biomolecule receiving area, which is designed to receive biomolecule, and a reconstituting area, which is designed to contain dry reagents and is designed to receive a transport solution such that at the reconstituting area, dry reagents are reconstituted with transport solution; and (ii) a microheater area disposed at or near the biomolecule receiving area, fitted with a microheater, which is designed to heat biomolecule that is received through the biomolecule receiving area and designed to process heated biomolecule and dry reagents reconstituted with transport solution.
    Type: Application
    Filed: October 23, 2018
    Publication date: August 13, 2020
    Applicants: CONSERVATION X LABS, INC., UNIVERSITY OF WASHINGTON
    Inventors: David BAISCH, Hallie Ray HOLMES, Karl F. BOHRINGER
  • Patent number: 10738297
    Abstract: Hydrogel compositions including a polymer uniformly embedded with a loading agent are provided. Also provided are methods for extrusion printing hydrogel compositions to provide extruded hydrogel compositions, which can be crosslinked to provide crosslinked hydrogel structures. Also provided are methods for using crosslinked hydrogel structures in chemical processes.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: August 11, 2020
    Assignee: University of Washington
    Inventors: Rose Ann Cattolico, Chloe Ramos Deodato, Alshakim Nelson, Robert Jun Ono, Abhijit Saha, Trevor Gerald Johnston, Dylan Gary Karis
  • Patent number: 10739349
    Abstract: The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: August 11, 2020
    Assignee: University of Washington through its Center for Commercialization
    Inventors: Daniel T. Chiu, Changfeng Wu, Xuanjun Zhang, Jiangbo Yu, Fangmao Ye
  • Publication number: 20200241182
    Abstract: Disclosed herein are metasurfaces formed on a substrate from a plurality of posts. The metasurfaces are configured to be optically active at one or more wavelengths and in certain embodiments are configured to form lenses having unexpectedly strong focusing power. In particular, the metasurfaces are formed from “low-contrast” materials, including CMOS-compatible materials such as silicon dioxide or silicon nitride. Accordingly, the disclosed metasurfaces are generally CMOS compatible and therefore embody a new paradigm in metasurface design and manufacturing.
    Type: Application
    Filed: April 16, 2020
    Publication date: July 30, 2020
    Applicant: University of Washington
    Inventors: Alan Zhan, Shane Colburn, Arka Majumdar
  • Patent number: 10725053
    Abstract: Methods are provided for treating a subject with prostate cancer and/or diagnosing a subject at risk for prostate cancer, which can include measuring increased expression of at least two prostate cancer-related molecules in a sample obtained from a subject, including the prostate cancer-related molecules AGR2, AGR3, CRISP3, CCL3, CEACAM5, CEACAM6, IL24, MMP9, CXCL14, CD90, POSTN, and SFRP4. The methods can include administering at therapy to a subject with prostate cancer. Methods are provided for treating a subject with intermediate- or high-risk prostate cancer, which can include measuring increased expression of MMP9 in a sample obtained from a subject compared to a control representing expression of MMP9 expected in a sample from a subject who has low-risk prostate cancer.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: July 28, 2020
    Assignees: Battelle Memorial Institute, University of Washington
    Inventors: Wei-Jun Qian, Tujin Shi, Alvin Y. Liu
  • Patent number: 10722580
    Abstract: Methods and antibody compositions that displace mannose from the binding pocket of fimbrial adhesin FimH of enterobacteria, including uropathogenic E. coli, Klebsiella oxytoca, or Klebsiella pneumoniae, can be used to disrupt or prevent the attachment of a single layer of bacteria to a mannose-coated surface, or to disrupt or prevent the formation of a multilayer biofilm. The antibody compositions of the invention can thus be used in methods to inhibit, prevent, or reverse the colonization of a surface with enterobacteria that express the bacterial Type 1 fimbrial adhesin FimH, to inhibit or prevent infection of a cell by enterobacteria that express the bacterial Type 1 fimbrial adhesin FimH, such as, for example, uropathogenic E. coli, to treat a bacterial infection in subject in need thereof and to treat or prevent inflammatory bowel disease (IBD), among other uses.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: July 28, 2020
    Assignee: UNIVERSITY OF WASHINGTON
    Inventors: Evgeni V. Sokurenko, Dagmara Kisiela, Wendy Evelyn Thomas, Veronika L. Tchesnokova
  • Publication number: 20200231933
    Abstract: Provided herein are methods that enable the polarization of hPSC mesoderm such that closely related yet distinct cardiovascular populations can be generated efficiently without the need of post-facto enrichment.
    Type: Application
    Filed: February 26, 2020
    Publication date: July 23, 2020
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: Charles E. Murry, Lil Pabon, Nathan Palpant
  • Publication number: 20200227018
    Abstract: A method includes transmitting a focused ultrasound wave into a medium to form (i) an ultrasound intensity well within the medium that exhibits a first range of acoustic pressure and (ii) a surrounding region of the medium that surrounds the ultrasound intensity well and exhibits a second range of acoustic pressure that exceeds the first range of acoustic pressure. The method further includes confining an object within the ultrasound intensity well. Additionally, an acoustic lens is configured to be acoustically coupled to an acoustic transducer. The acoustic lens has a varying longitudinal thickness that increases proportionally with respect to increasing azimuth angle of the acoustic lens. Another acoustic lens is configured to be acoustically coupled to an acoustic transducer. The acoustic lens includes a plurality of segments. Each of the plurality of segments has a varying longitudinal thickness that increases proportionally with respect to increasing azimuth angle of the segment.
    Type: Application
    Filed: January 10, 2020
    Publication date: July 16, 2020
    Applicant: University of Washington
    Inventors: Adam D. Maxwell, Oleg A. Sapozhnikov, Wayne Kreider, Michael R. Bailey
  • Publication number: 20200224168
    Abstract: The methods and compositions as disclosed herein describe the making of mature stem cell-derived cardiomyocytes for applications such as disease modeling, cardiotoxicity screening, drug screening and identification, among other uses. The methods involve physical and biochemical cues that promote a transition of stem cell-derived cardiomyocytes from a fetal phenotype to a more mature phenotype that more closely resembles that of adult cardiomyocytes.
    Type: Application
    Filed: August 16, 2018
    Publication date: July 16, 2020
    Applicant: University of Washington
    Inventors: Deok-Ho KIM, Jesse MACADANGDANG, Alec S.T. SMITH, Hannele RUOHOLA-BAKER, Jason Wayne MIKLAS
  • Patent number: 10709791
    Abstract: Polymeric carriers for the delivery of therapeutic agents and methods for making and using the same. The polymeric carriers include copolymers, diblock copolymers, polymeric architectures that include the copolymers and diblock copolymers, and particles assemblies comprising the copolymers, diblock copolymers, and polymeric architectures that include the copolymers.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: July 14, 2020
    Assignee: University of Washington
    Inventors: Patrick S. Stayton, Anthony J. Convertine, Daniel M. Ratner, Debobrato Das, Selvi Srinivasan
  • Patent number: 10711304
    Abstract: Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when “deep sequencing” genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, a method Duplex Consensus Sequencing (DCS) is provided. This approach greatly reduces errors by independently tagging and sequencing each of the two strands of a DNA duplex. As the two strands are complementary, true mutations are found at the same position in both strands. In contrast, PCR or sequencing errors will result in errors in only one strand.
    Type: Grant
    Filed: May 13, 2019
    Date of Patent: July 14, 2020
    Assignee: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
    Inventors: Jesse Salk, Lawrence A. Loeb, Michael Schmitt
  • Patent number: 10713758
    Abstract: The present technology is generally directed to filtering systems and methods for suppression of reverberation artifacts in ultrasound images. In some embodiments, a method of obtaining a filtered ultrasound image includes taking a first ultrasound image of a target tissue using an applicator. At least a portion of the applicator is moved such that the reverberation artifact ultrasound path length changes relative to the first position of the applicator. A second ultrasound image of the target tissue is then taken. The first and second ultrasound images are synthesized using at least one filtering method. The filtering method attenuates or removes reverberation artifacts in the synthesized ultrasound image.
    Type: Grant
    Filed: February 4, 2013
    Date of Patent: July 14, 2020
    Assignee: University of Washington
    Inventors: John Kucewicz, Francesco P. Curra, Gregory P. Darlington, Lee D. Dunbar, Peter J. Kaczkowski, Justin Reed
  • Publication number: 20200216839
    Abstract: Contiguity information is important to achieving high-quality de novo assembly of mammalian genomes and the haplotype-resolved resequencing of human genomes. The methods described herein pursue cost-effective, massively parallel capture of contiguity information at different scales.
    Type: Application
    Filed: October 28, 2019
    Publication date: July 9, 2020
    Applicant: University of Washington Through Its Center for Commercialization
    Inventors: Jay Ashok Shendure, Jerrod Joseph Schwartz, Andrew Colin Adey, Cho li Lee, Joseph Brian Hiatt, Jacob Otto Kitzman, Akash Kumar
  • Patent number: 10703791
    Abstract: De novo designed polypeptides that bind to IL-2 receptor ??c heterodimer (IL-2R??c), IL-4 receptor ??c heterodimer (IL-4R??c), or IL-13 receptor ? subunit (IL-13R?) are disclosed, as are methods for using and designing the polypeptides.
    Type: Grant
    Filed: September 16, 2019
    Date of Patent: July 7, 2020
    Assignees: University of Washington, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Daniel Adriano Silva Manzano, Shawn Yu, Umut Ulge, David Baker, Kenan Christopher Garcia, Jamie Spangler, Carl Walkey
  • Patent number: 10702719
    Abstract: Methods for treating an extravascular hematoma in a patient can include liquefying a first portion of the extravascular hematoma by applying a first series of focused acoustic pulses to the extravascular hematoma at a first frequency; and liquefying a second portion of the extravascular hematoma by applying a second series of focused acoustic pulses to the extravascular hematoma at a second frequency. Liquefied remains of the extravascular hematoma can be aspirated from the patient following liquefaction and disruption.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: July 7, 2020
    Assignee: UNIVERSITY OF WASHINGTON
    Inventors: Tatiana Khokhlova, Thomas J. Matula, Wayne L. Monsky, Yak-Nam Wang
  • Publication number: 20200212956
    Abstract: Examples described herein include devices and systems utilizing backscatter communication to directly generate transmissions in accordance with wireless communication protocols that can be decoded existing devices. Examples include devices that generate 802.11b transmissions using backscatter communication. Examples of network stacks are described which may facilitate backscatter devices to coexist with other devices (e.g. in the ISM band), without incurring, or reducing a need for, the power consumption or carrier sense and medium access control operations.
    Type: Application
    Filed: August 12, 2016
    Publication date: July 2, 2020
    Applicant: University of Washington
    Inventors: Shyamnath Gollakota, Bryce Kellogg, Vamsi Talla, Joshua R. Smith
  • Publication number: 20200209115
    Abstract: Disclosed embodiments include illustrative piezoelectric element array assemblies, methods of fabricating a piezoelectric element array assembly, and systems and methods for shearing cellular material. Given by way of non-limiting example, an illustrative piezoelectric element array assembly includes at least one piezoelectric element configured to produce ultrasound energy responsive to amplified driving pulses. A lens layer is bonded to the at least one piezoelectric element. The lens layer has a plurality of lenses formed therein that are configured to focus ultrasound energy created by single ones of the at least one piezoelectric element into a plurality of wells of a microplate disposable in ultrasonic communication with the lens layer, wherein more than one of the plurality of lenses overlie single ones of the at least one piezoelectric element.
    Type: Application
    Filed: February 25, 2020
    Publication date: July 2, 2020
    Applicants: Matchstick Technologies, Inc., University of Washington
    Inventors: Karol Bomsztyk, Greg P. Darlington, Brian E. MacConaghy, Thomas J. Matula, Adam D. Maxwell
  • Patent number: 10694974
    Abstract: Example embodiments of system and method for magnetic resonance imaging (MRI) techniques for planning, real-time monitoring, control, and post-treatment assessment of high intensity focused ultrasound (HIFU) mechanical fractionation of biological material are disclosed. An adapted form of HIFU, referred to as “boiling histotripsy” (BH), can be used to cause mechanical fractionation of biological material. In contrast to conventional HIFU, which cause pure thermal ablation, BH can generate therapeutic destruction of biological tissue with a degree of control and precision that allows the process to be accurately measured and monitored in real-time as well as the outcome of the treatment can be evaluated using a variety of MRI techniques. Real-time monitoring also allow for real-time control of BH.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: June 30, 2020
    Assignees: UNIVERSITY OF WASHINGTON, KONINKLIJKE PHILIPS N.V.
    Inventors: Ari Partanen, Vera Khokhlova, Navid Farr, Donghoon Lee, Wayne Kreider, Tatiana Khokhlova, Adam Maxwell, Yak-Nam Wang, George Schade, Michael Bailey
  • Patent number: 10695574
    Abstract: Systems, methods and techniques for providing sensory input to a subject through non-invasive brain stimulation are generally described. In some examples, an input signal related to an environment may be received. In various further examples, a communication to the subject may be determined in response to the input signal. In some examples, an output signal corresponding to the determined communication may be generated. Some further examples may comprise non-invasively stimulating a portion of the subject's brain with the output signal with a stimulation subsystem positioned outside of the subject's scalp. In various examples, the stimulation of the portion of the subject's brain may be effective in producing a sensory response perceivable by the subject.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: June 30, 2020
    Assignee: UNIVERSITY OF WASHINGTON
    Inventors: Andrea Stocco, Darby Losey, Justin A. Abernethy, Rajesh Rao