Patents Assigned to University of Washington
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Publication number: 20250012619Abstract: Acoustic balances configured for weighing in ultrasonic non-contact manipulators, and associated systems and methods are described. In one embodiment, a method for a non-contact acoustic determination of a mass of an object includes capturing the object within an acoustic trap of an acoustic balance. The method also includes, in response to changing at least one acoustic parameter of the acoustic balance, changing an equilibrium position of the object; and in response to changing the equilibrium position of the object, causing the object to oscillate. The method also includes determining a resonant frequency of oscillation of the object; and based on the resonant frequency of oscillation of the object, determining the mass of the object.Type: ApplicationFiled: July 3, 2024Publication date: January 9, 2025Applicant: University of WashingtonInventors: Joshua R. Smith, Jared Nakahara
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Publication number: 20250011835Abstract: Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.Type: ApplicationFiled: September 17, 2024Publication date: January 9, 2025Applicant: University of WashingtonInventors: Georg Seelig, Richard Muscat, Alexander B. Rosenberg
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Publication number: 20250011836Abstract: Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.Type: ApplicationFiled: September 17, 2024Publication date: January 9, 2025Applicant: University of WashingtonInventors: Georg Seelig, Richard Muscat, Alexander B. Rosenberg
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Publication number: 20250011837Abstract: Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.Type: ApplicationFiled: September 17, 2024Publication date: January 9, 2025Applicant: University of WashingtonInventors: Georg Seelig, Richard Muscat, Alexander B. Rosenberg
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Patent number: 12187827Abstract: Crosslinked films having electro-optic activity, compositions and compounds for making the films, methods for making the films, and devices that include the films are disclosed.Type: GrantFiled: July 1, 2020Date of Patent: January 7, 2025Assignee: University of WashingtonInventors: Delwin Elder, Huajun Xu, Bruce H. Robinson, Larry R. Dalton
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Patent number: 12191666Abstract: Embodiments of the present disclosure provide systems and methods directed to improved power system stabilization and oscillation damping control. In operation, a computing device may receive frequency data from a plurality of sensors distributed within a power system. The computing device may calculate an estimate of a speed of a center of inertia signal based at least on the frequency data. A controller may calculate a control error signal for the power system based at least on the estimated speed of the center of inertia signal. The controller may further calculate an auxiliary output signal based at least on the calculated control error. An actuator may utilize the auxiliary output signal to provide an output configured to improve the stability of the power system.Type: GrantFiled: April 17, 2020Date of Patent: January 7, 2025Assignee: University of WashingtonInventors: Daniel S. Kirschen, Payman Arabshahi, Ryan Elliott
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Patent number: 12189376Abstract: A method, apparatus, system, and computer program products for managing a set of outliers in test data. A computer system analyzes a set of features derived from the test data using different outlier detection methods to generate a result of the set of outliers identified by the different outlier detection methods. The test data is obtained from testing a physical structure. The computer system determines a causality for the set of outliers in the result. The physical structure is retested with a set of changes determined using the causality identified for the set of outliers. The retesting generates new test data for the physical structure.Type: GrantFiled: March 9, 2022Date of Patent: January 7, 2025Assignees: The Boeing Company, University of WashingtonInventors: Mohammed H. Kabir, Alan Douglas Byar, John J. Dong, Alexandru I. Stere, Todd Clayton DePauw, Christina M. Doty, Ashith Paulson Kunnel Joseph, Navid Zobeiry
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Patent number: 12191631Abstract: Within examples, a laser includes a first electrode and a second electrode; a first transport layer and a second transport layer that are between the first electrode and the second electrode; a gain layer positioned between the first transport layer and the second transport layer, where the gain layer comprises a material having a Perovskite crystal structure; and a substrate on which the first electrode, the second electrode, the first transport layer, the second transport layer, and the gain layer are formed, where a distributed feedback (DFB) waveguide is formed within the first transport layer, and where the laser is configured such that a current flowing through the gain layer between the first electrode and the second electrode causes the gain layer to emit coherent light. Examples also include methods for fabricating the laser, as well as additional lasers and methods for forming those lasers.Type: GrantFiled: May 10, 2019Date of Patent: January 7, 2025Assignee: University of WashingtonInventors: Lih-Yuan Lin, Chen Zou
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Patent number: 12180536Abstract: Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.Type: GrantFiled: December 12, 2023Date of Patent: December 31, 2024Assignee: University of WashingtonInventors: Georg Seelig, Richard Muscat, Alexander B. Rosenberg
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Patent number: 12178403Abstract: Systems and methods for capturing and rendering light fields for head-mounted displays are disclosed. A mediated-reality visualization system includes a head-mounted display assembly comprising a frame configured to be mounted to a user's head and a display device coupled to the frame. An imaging assembly separate and spaced apart from the head-mounted display assembly is configured to capture light-field data. A computing device in communication with the imaging assembly and the display device is configured to receive light-field data from the imaging assembly and render one or more virtual cameras. Images from the one or more virtual cameras are presented to a user via the display device.Type: GrantFiled: March 23, 2023Date of Patent: December 31, 2024Assignee: University of WashingtonInventors: Joshua R. Smith, Samuel R. Browd, Rufus Griffin Nicoll, James Andrew Youngquist
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Patent number: 12180374Abstract: Methods of fabricating 3D printed structures from biocompatible proteins include forming a photoreactive, proteinaceous resin, and 3D printing biocompatible structures from the resin by the patterned application of light in a select wavelength to cure the resin into the desired structures. Suitable photoreactive proteinaceous resins can be formed by reacting an aqueous solution of an acrylated or methacrylated globular protein with a photoreactive comonomer or photoinitiator. Structures printed from the photoreactive, proteinaceous resin can be photo-cured and dried to form bioplastic structures.Type: GrantFiled: June 16, 2020Date of Patent: December 31, 2024Assignee: University of WashingtonInventors: Alshakim Nelson, Siyami Millik, Ryan Thomas Shafranek, Patrick Smith
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Patent number: 12181025Abstract: The present disclosure provides a mechanical linkage device including a ground link comprising an inverse center linked to one end of the ground link. The mechanical linkage device further includes a movement link connecting the ground link to a control point. The mechanical linkage device further includes two or more linkages having a first link of the two or more linkages including a first end linked to the control point and a second link of the two or more linkages including second end linked to an end point. The end point, the control point, and the inverse center of the ground link remain co-linear. The control point and the end point have an inverse relationship such that movement of the control point is inversely translated to the end point. The ground link, the movement link, and at least one of the two or more linkages do not all he in a plane throughout an entire range of motion of the mechanical linkage device.Type: GrantFiled: April 28, 2022Date of Patent: December 31, 2024Assignee: University of WashingtonInventor: Jeffrey Lipton
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Publication number: 20240425519Abstract: Spirocyclic compounds that are KLHDC2 ligands and methods for inhibiting the enzymatic activity of KLHDC2 using the ligands.Type: ApplicationFiled: October 31, 2022Publication date: December 26, 2024Applicants: University of Washington, ACCUTAR BIOTECHNOLOGY INC.Inventors: Ning ZHENG, Domnita Valeria RUSNAC, Jie FAN, Yimin QIAN, Ke LIU
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Patent number: 12172177Abstract: Techniques for efficiently capturing targets, such as biological materials, within the air are described. A lightweight, portable device is configured to capture the targets without desiccation by flowing a mixture of air carrying the targets with liquid droplets through a nonlinear path in a partially enclosed interior of the device. For example, a method includes generating an impinging jet comprising a mixture of air, a target, and droplets. A baffle splits the impinging jet into a recirculation zone and coalesces a mixture of the target and the droplets onto an upper surface of the baffle. At least one channel receives the coalesced mixture and transports the coalesced mixture to a collection reservoir.Type: GrantFiled: September 15, 2021Date of Patent: December 24, 2024Assignee: University of WashingtonInventors: Ashleigh Brooks Theberge, Tammi van Neel, Jean Berthier, Erwin Stefan Peter Berthier, Ulri Nicole Lee
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Patent number: 12171999Abstract: A vestibular stimulation array is disclosed having one or more separate electrode arrays each operatively adapted for implantation in a semicircular canal of the vestibular system, wherein each separate electrode array is dimensioned and constructed so that residual vestibular function is preserved. In particular, the electrode arrays are dimensioned such that the membranous labyrinth is not substantially compressed. Furthermore, the electrode array has a stop portion to limit insertion of the electrode array into the semi-circular canal and is still enough to avoid damage to the anatomical structures.Type: GrantFiled: May 11, 2023Date of Patent: December 24, 2024Assignees: Cochlear Limited, University of Washington Center for CommercializationInventors: Frank Risi, Colin Irwin, Jay T. Rubinstein, Felipe Santos, James O. Phillips
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Patent number: 12167864Abstract: A method for attempting to fragment or comminute an object in a body using ultrasound includes producing a burst wave lithotripsy (BWL) waveform by a therapy transducer. The BWL waveform is configured to fragment or comminute the object. The BWL waveform includes a first burst of continuous ultrasound cycles and a second burst of continuous ultrasound cycles. A burst frequency corresponds to a frequency of repeating the bursts of the BWL waveform. The method also includes determining a cycle frequency f of the continuous ultrasound cycles within the first burst and the second burst based on a target fragment size D, where the cycle frequency is: f(MHz)=0.47/D(mm).Type: GrantFiled: January 6, 2023Date of Patent: December 17, 2024Assignee: University of Washington through its Center for CommercializationInventors: Adam D. Maxwell, Bryan W. Cunitz, Wayne Kreider, Oleg A. Sapozhnikov, Ryan S. Hsi, Michael R. Bailey
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Publication number: 20240409921Abstract: Methods and systems for characterizing the spatial genomic organization and gene expression in single cells is described. The methods described herein is used to generate spatial and transcriptomic libraries to determine the three-dimensional organization associated with the expression of nucleic acids. Implementations described herein can be used for research or diagnostic purposes.Type: ApplicationFiled: June 4, 2024Publication date: December 12, 2024Applicant: University of WashingtonInventor: Zhi-jun Duan
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Patent number: 12163189Abstract: Methods and kits for uniquely labeling nucleic acid molecules within a plurality of microbial cells are described. In an embodiment, the method comprises fixing and permeabilizing the plurality of microbial cells; dissociating microbial cell aggregates within a suspension comprising the plurality of microbial cells; reverse transcribing mRNA within the plurality of microbial cells to provide cDNA; and combinatorially labelling the cDNA to provide labelled cDNA.Type: GrantFiled: November 20, 2020Date of Patent: December 10, 2024Assignee: University of WashingtonInventors: Georg Seelig, Anna Kuchina, Leandra Brettner, William DePaolo
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Patent number: 12165387Abstract: A method of inspecting a composite structure formed of plies of tows is provided. The method involves receiving an image of an upper ply overlapping lower plies, the upper ply tow ends defining a boundary between plies, and applying extracted sub-images to a trained machine learning model to detect the upper or lower ply. Probability maps are produced in which pixels of the sub-images are associated with probabilities the pixels belong to an object class for the upper or lower ply. The method may also involve transforming the probability maps into reconstructed sub-images, stitching together a composite image, and applying the composite image to a feature detector to detect locations of tow ends of the upper ply. The method may also involve comparing the locations to as-designed locations of the tow ends, inspecting the composite structure, and indicating a result of the comparison.Type: GrantFiled: December 6, 2021Date of Patent: December 10, 2024Assignees: The Boeing Company, University of WashingtonInventors: Adriana W. Blom-Schieber, Wei Guo, Ashis G. Banerjee, Ekta U. Samani
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Patent number: 12161859Abstract: A vestibular stimulation array is disclosed having one or more separate electrode arrays each operatively adapted for implantation in a semicircular canal of the vestibular system, wherein each separate electrode array is dimensioned and constructed so that residual vestibular function is preserved. In particular, the electrode arrays are dimensioned such that the membranous labyrinth is not substantially compressed. Furthermore, the electrode array has a stop portion to limit insertion of the electrode array into the semi-circular canal and is still enough to avoid damage to the anatomical structures.Type: GrantFiled: January 31, 2023Date of Patent: December 10, 2024Assignees: Cochlear Limited, University of Washington Center for CommercializationInventors: Frank Risi, Colin Irwin, Jay T. Rubinstein, Felipe Santos, James O. Phillips