Abstract: This invention provides a method and apparatus for analyzing the propagation of optical fields between arbitrarily oriented planes using full scalar diffraction theory. One aspect of the invention allows propagation between tilted planes. A second aspect allows propagation between offset planes. To analyze the propagation of an input optical field from a first plane to a second plane, the input field in the spatial domain is Fourier transformed to obtain the plane wave distribution in the spatial frequency domain. Within the spatial frequency domain the field is propagated from the first plane to the second plane by first multiplying the plane wave distribution by the spatial frequency domain phase accumulation between the first and second planes, and then converting the plane wave distribution from the coordinate system of the first plane to that of the second plane. Finally, the propagated plane wave distribution is inverse Fourier transformed to obtain the propagated optical field.

Abstract: Apparatus for assisting an operator to diagnose physical conditions in a patient by collecting and analyzing cyclical body sounds such as heart beat, peripheral vessel sounds, or breath sounds. Several cycles of data are collected and digitized. Each cycle is converted to the frequency domain and phase fixed. Then all of the frequency converted and phase fixed cycles are signal averaged together, and the results displayed to the operator. The cycles may be sorted according to respiratory cycle and averaged in two groups. The cycles may be gated according to the patients ECG. The apparatus may suggest diagnoses or further maneuvers to be performed.

Abstract: Light responsive, transmissivity variable eyewear utilizing two specifically configured liquid crystal cells and a method of making the cells is disclosed. The cell itself includes a pair of spaced apart transparent substrates in confronting parallel relationship to one another, transparent electrodes exposed over the outer surfaces of the substrates and connectable to a voltage control arrangement, a liquid crystal mixture contained between the substrates and tilted homeotropic alignment layers formed on the inner confronting surfaces of the substrates. The liquid crystal mixture contains a liquid crystal material with a negative dielectric anisotropy and dichroic dye molecules. All of which cooperate with one another such that the cell is highly transparent indoors, that is, out of the sunlight and is much less transparent, that is dark, in the sunlight.

Abstract: The present invention relates to histidine kinases, including osmosensing fungal histidine kinases. In particular, the present invention provides amino acid and nucleic acid sequences of fungal histidine kinases from organisms such as Candida (e.g., C. albicans) and Neurospora (e.g., N. crassa). The present invention further provides compositions and methods for the development of antifungal compounds.

Abstract: The present invention provides bradykin antagonists containing pentafluorophenylalanine which are therapeutically useful. Moreover, the present invention provides methods to antagonize bradykinin receptors in a mammal in need of such antagonism, comprising administering a bradykinin antagonist containing pentafluorophenylalanine. Also provided are methods to treat inflammation in a mammal in need of such inhibition, comprising administering a bradykinin antagonist containing pentafluorophenylalanine. Lastly, a method to treat cancer in a mammal in need of such inhibition, comprising administering a bradykinin antagonist containing pentafluorophenylalanine.

Abstract: A method and apparatus for assembly of liquid crystal cells with a thin (<4 pm), uniform (.+-.100 .mu.m) cell gap. The method can be used for the assembly of either individual or multiple liquid crystal cells on a single substrate. The method uses a photo-definable polymeric resin as both an edge seal and a spacer and has several important steps: spin-coating defines the cell gap, patterning defines the cell structure, and thermocompression bonding provides adhesion. The method for assembling liquid crystal cells having a thin, uniform cell gap, comprises the steps of: diluting a photo-definable polymeric resin with a solvent; applying the diluted photo-definable polymeric resin on a substrate; patterning the diluted photo-definable polymeric resin by selective exposure to a light; and selectively removing portions of the diluted photo-definable polymeric resin based upon exposure to the light resulting in a resin pattern.

Abstract: A condition sensing apparatus/method includes a sensor-fiber-grating that is subjected to a physical condition or measurand (strain/temperature/pressure) that is to be sensed. A broad-band light beam is directed into the core of the sensor grating, and the constructive-interference light beam that is reflected from this sensor grating is directed into a reference-fiber-grating. The reference grating is subjected to a servo-controlled elongation force or strain, and in this manner the length of the reference grating is varied until the reference grating operates to reflect a maximum intensity of its received light beam, and to transmit a minimum intensity of its received light beam. This maximum/minimum condition of the reference grating is sensed by detecting the minimum intensity of a light beam that is transmitted through the reference grating. The physical strain of the reference grating at which this condition occurs is used as a measure of the measurand to which the sensor grating is subjected.

Abstract: A high temperature superconductor system having the single phase composition TlBiBaCaCuO. The system exhibits a T.sub.c of at least 116 K.

Abstract: A method for making an electro-optic device or electro-optic display system having enhanced performance over conventional flat-panel displays, wherein a planarizing polymeric resin layer is spin-cast on a flat-panel backplane containing pixel circuitry. The spin-cast layer is cured to provide a flat backplane. Vias are opened in the cured polymeric resin to each pixel. Metal is deposited to fill the vias and to form a confluent, overlying metal layer on the upper surface. The metal layer is patterned and etched to form individual mirrors over each pixel. The metal acts as both a switchable electrode and as a high aperture, highly reflective mirror over each pixel. Electro-optic devices which may be made using such a process are also disclosed.

Abstract: The present invention includes the identification and isolation of a nucleic acid molecule encoding a dibasic amino acid processing endoprotease from CD4+ T-lymphocytes as well as a protein encoded by that nucleic acid molecule. The present invention also includes related nucleic acid molecules and proteins encoded by such nucleic acid molecules as well as recombinant molecules and recombinant cells that include nucleic acid molecules of the present invention. The present invention also includes use of such nucleic acid molecules and proteins to develop therapeutic compositions that enhance or inhibit dibasic amino acid processing endoprotease activity.

Abstract: Pharmaceutical compositions for the delivery of pharmacologically active proteins are provided by the present invention. The compositions of the present invention comprise a polymeric matrix having thermal gelation properties in which is incorporated a discrete suspension of at least one biologically active macromolecular polypeptide which retains greater than 90 percent of its biological activity. Furthermore, the concentration of the macromolecular polypeptide is greater than 0.5 percent by weight of the composition.

Abstract: An optical receiver suitable for use in a wavelength division multiplexing (WDM) system is able to tolerate shifts in the transmitting lasers' wavelength. During a periodically repeated wavelength synchronization phase, only a single transmitter laser is operating, and a peak finder locks onto the wavelength having greatest power and notes the corresponding detector pixel's position. Thus, the receiver knows the relative wavelength of the transmitting laser in terms of the detector pixel illuminated with the brightest light, and can store this information for later reference. The active transmitter lasers take turns synchronizing their wavelengths during successive synchronization phases. During the multi-wavelength data transmission phase, many lasers in the system transmit information at the same time, at different wavelengths.

Abstract: The present invention includes yeast vehicles and their use as delivery vehicles. Yeast vehicles include a yeast portion and a heterologous compound. Such yeast vehicles can be used to protect animals from disease and to otherwise carry compounds to given cell types. Examples of yeast vehicles include gene delivery vehicles, drug delivery vehicles, and immunomodulatory vehicles. Immunomodulatory vehicles are capable of modulating an immune response. When stimulating an immune response, such yeast vehicles effect cell-mediated as well as humoral immunity.

Abstract: A test kit for the rapid detection and drug sensitivity of malaria is presented. The test kit of the present invention comprises a unique microscope/slide incubation chamber which permits rapid detection of malaria in wet blood samples using a regular transmitted light microscope to detect opaque hemozoin particles.

Abstract: A method for increasing the production of desired hemoproteins is described in which the rate-limiting step in a heme biosynthetic pathway is deregulated to increase the quantity of the rate-limiting enzyme. In yeast, transforming cells with the HEM2 gene increases the quantity of the rate-limiting enzyme ALA dehydratase. Free heme concentrations are reduced in cells by providing heme binding agents that complexes with overproduced heme, thereby reducing or eliminating heme feedback inhibition in the cell. The present invention permits investigation of other factors effecting the heme biosynthetic pathway by reducing interference from heme feedback inhibition within that pathway.

Abstract: An anesthesia system for use in MRI suites is provided. The anesthesia system is connected between an anesthesia machine positioned outside the MRI suite and a patient positioned within the MRI suite. The anesthesia machine provides anesthesia gas mixture for anesthetizing the patient. The apparatus has a delivery mechanism for transporting the anesthesia gas mixture from the anesthesia machine to the MRI suite and a mechanism for introducing fresh room air into the anesthesia gas mixture thereby creating a combined gas mixture. A reservoir mechanism receives and stores at least a portion of the anesthesia gas mixture delivered through the delivery mechanism. A mechanism introduces fresh room air into the anesthesia gas mixture thereby creating a combined gas mixture. A ventilation mechanism receives and stores the combined gas mixture.

Abstract: A voluntary closing prosthetic prehensor includes a locking mechanism which may be locked into any position, and released with a small amount of force. With locking enabled, the prehensor opens and closes normally until the user applies sufficient tension to the prehensor cable after the prehensor has closed upon an object. Then, a lever arm attached to the cable rotates, pulling a second cable which causes an elliptical cam to rotate such that its wider portion presses against a pawl, causing the pawl to rotate into engagement with a toothed sector, locking the prehensor closed. When the user releases the force on the cable, the lever arm is biased to return to its normal position, but the prehensor stays closed because the pawl remains engaged with the sector. The cam includes a ratcheting drum which takes up the slack in the second cable. To release the prehensor, the user applies a small amount of force to the first cable, moving the lever arm and pulling the second cable, which rotates the cam.

Abstract: The present invention relates to a product and process for producing polypeptides, such products including a circular RNA having a ribosome binding site that engages an eukaryotic ribosome and cells transformed with such circular RNA. Circular RNA is produced by linking the 5' and 3' ends of a desired linear RNA sequence, and such constructs can be used to produce desired amounts of polypeptides when such constructs are translated either in vitro or in vivo. The present invention also relates to the use of circular RNA as a pharmaceutical agent to treat cells and animals involved in a disease.

Abstract: A method for inhibiting T-lymphocyte-mediated immune responses, including those directed against autologous and/or heterologous tissues, e.g., by a recipient mammal of a transplanted tissue, said method comprising providing the recipient mammal with Fas ligand. The Fas ligand may be provided to the recipient mammal by a variety of means, including by pump implantation or by transplantation of transgenic tissue expressing Fas ligand. Also provided is a method for diagnostic use of Fas ligand expression in improving transplantation success.

Abstract: The present invention discloses methods to transfect cells, comprising applying a strong magnetic field in pulses so as to affect a plurality of substance-carrying magnetic microparticles, the complexes being in physical proximity to a plurality of cells such that when the magnetic field is applied, the magnetic microparticles are pulled into the nuclei and/or cytoplasm of the cells.