Abstract: The present disclosure provides nucleic acid compositions that incorporate one or more halouracil molecules. More specifically, the present disclosure reveals that the replacement of uracil nucleotides within a microRNA nucleotide sequence with a 5-halouracil increases the ability of the micro-RNA to inhibit cancer progression and tumorigenesis. As such, the present disclosure provides various nucleic acid (e.g., microRNA) compositions having 5-halouracil molecules incorporated in their nucleic acid sequences and methods for using the same. The present disclosure further provides pharmaceutical compositions comprising the modified nucleic acid compositions, and methods for treating cancers using the same.

Abstract: A method for making a carbon nanotube composite catalytic film includes providing a carbon nanotube film and providing a precursor solution including iron nitrate, nickel chloride, and molybdenum pentachloride. The precursor solution is placed on the carbon nanotube film, to obtain a precursor film. The precursor film defines multiple through holes spaced apart from each other. The precursor film with the multiple through holes is annealed and a sulfur power is applied during annealing the precursor film with the multiple through holes.

Abstract: A new compromise-resilient and compact cryptographic tool is provided that ensures a breach-resilient authentication and integrity of system measurements in computer systems. The described methods are forward-secure digital signatures with signature and partial public key aggregation capabilities. The methods reduce the total space overhead of signature and public key storage. The methods offer a high space efficiency for systems who has relatively low state transitions, wherein the same message is continuously signed and then followed by different messages.

Abstract: Aspects relate to patterned nanostructures having a feature size not including film thickness of below 5 microns. The patterned nanostructures are made up of nanoparticles having an average particle size of less than 100 nm. A nanoparticle composition, which, in some cases, includes a binder, is applied to a substrate. A patterned mold used in concert with electromagnetic radiation function to manipulate the nanoparticle composition in forming the patterned nanostructure. In some embodiments, the patterned mold nanoimprints a pattern onto the nanoparticle composition and the composition is cured through UV or thermal energy. Three-dimensional patterned nanostructures may be formed. A number of patterned nanostructure layers may be prepared and joined together. In some cases, a patterned nanostructure may be formed as a layer that is releasable from the substrate upon which it is initially formed.

Abstract: The present disclosure provides for compositions, methods of making compositions, and methods of using the composition. In an aspect, the composition can be a reactive material that can be used to split a gas such as water or carbon dioxide.

Abstract: A hardware memory includes at least one memory cell, peripheral circuitry and randomization circuitry. The memory cell(s) store data, which may be written to, read from and held in the hardware memory. The peripheral circuitry reads and writes data to the memory cell(s) and may perform other functions necessary for facilitating the data read, write and hold. The randomization circuitry randomizes operations performed by the peripheral circuitry to reduce a correlation between the data and the current consumed by the hardware memory.

Abstract: A control method for hybrid electromagnetic suspension. The method provides four modes for hybrid electromagnetic suspension: a comfort mode, a sport mode, a combined mode, and an energy feedback mode. A driver can switch between the four modes as desired. For the comfort, sport, and combined modes, hybrid control is adopted, and two sub-modes are provided: an active control mode and a semi-active control mode. A switching condition between the two sub-modes is determined by using a novel parameter Cact and comparing the same against a maximum equivalent electromagnetic damping coefficient Ceqmax of a linear motor. The present invention solves the problem of achieving a balance between suspension comfort and tire traction, and meets the demands of different operating conditions and users by enabling manual mode switching.

Abstract: The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.

Abstract: A radiation beam field shaping device is made from a 3D printed frame that contains and gives shape to a granular material with bulk density of at least 3 g/cm3 and composed of metal grains having a size between 1 ?m and 4 mm. The frame has a hole in the bottom with surrounding walls that defines the desired beam shape. In one implementation, the metal grains are composed of solid tungsten alloy ball bearings and/or tungsten alloy powder.

Abstract: A ride vehicle system includes a ride track and a ride vehicle. The ride track includes a vehicle rail and an accessory rail. The ride vehicle includes a ride vehicle base, a show element coupled to the ride vehicle base, and a mechanical linkage. The ride vehicle base is configured to interface with the vehicle rail of the ride track and to move along the vehicle rail of the ride track. The show element coupled to the ride vehicle base is configured to actuate with respect to the ride vehicle base. The mechanical linkage includes a first end coupled to the show element and a second end coupled to the accessory rail of the ride track. The mechanical linkage is configured to move along the accessory rail and to actuate the show element based at least in part on a position of the accessory rail with respect to the vehicle rail.

Abstract: According to an aspect, a method includes receiving data about a patient, computing geometric characterization of one or more organs at risk proximate to a target volume of a patient or vice versa, and selecting relevant treatment knowledge and experience. The method also includes generating, based on the received data, computed geometric characterization, and available knowledge and experience, a first set of radiation treatment planning parameters that will lead to a high quality plan for the patient. Further, the method includes model-based prediction, based on the data, a second set or more of radiation treatment planning parameters that will lead to alternative achievable plans with different organ sparing objectives for treating the patient. The multiple sets for parameters can be used separately or in conjunction to generate treatment plans.

Abstract: Disclosed herein are energy harvesting devices and methods of making and use thereof. The energy harvesting devices can efficiently harvest energy for motions at a frequency of 5 Hz or less.

Abstract: An amide/iminium zwitterion catalyst has a catalyst pocket size that promotes transesterification and dehydrative esterification. The amide/iminium zwitterions are easily prepared by reacting aziridines with aminopyridines. The reaction can be applied a wide variety of esterification processes including the large-scale synthesis of biodiesel. The amide/iminium zwitterions allow the avoidance of strongly basic or acidic condition and avoidance of metal contamination in the products. Reactions are carried out at ambient or only modestly elevated temperatures. The amide/iminium zwitterion catalyst is easily recycled and reactions proceed in high to quantitative yields.

Abstract: A ride system includes at least one ride vehicle. The at least one ride vehicle is configured to receive a ride passenger. The ride system includes electronic goggles configured to be worn by the ride passenger. The electronic goggles include a camera and a display. The ride system includes a computer graphics generation system communicatively coupled to the electronic goggles, and configured to generate streaming media of a real world environment based on image data captured via the camera of the electronic goggles, generate one or more virtual augmentations superimposed on the streaming media of the real world environment, and to transmit the streaming media of the real world environment along with the one or more superimposed virtual augmentations to be displayed on the display of the electronic goggles.

Abstract: A method of producing aluminum chlorohydrate comprises adding small form aluminum metal pellets to a reactant receiving space of a reactor tank to form a pellet bed; adding aqueous hydrochloric acid to the reactant receiving space of the reactor tank; and continuously circulating the aqueous hydrochloric acid through the pellet bed. In some embodiments, the continuously circulating aqueous hydrochloric acid dispels reaction gases from the pellet bed. Methods described herein can, in some cases, further comprise consecutively adding additional small form aluminum metal pellets to the reactant receiving space of the reactor tank as the small form aluminum metal pellets are consumed in the pellet bed.

Abstract: The present invention provides a comprehensive detection device and method for a cancerous region, and belongs to the technical field of deep learning. In the present invention, a cancerous region detection network is trained for preprocessed and annotated CT image data to predict bounding box coordinates of a cancerous region and a corresponding cancer confidence score; a clinical analysis network is trained for preprocessed clinical data with a cancer risk level to predict a cancer probability value of a corresponding patient; and a predicted cancer probability value is weighted to a predicted cancer confidence score to realize a comprehensive determination of the cancerous region. The present invention can detect a cancerous region with high accuracy and high performance.

Abstract: Provided is a method of preparing a pure M1 phase MoVTeNb-oxide catalyst with a high specific surface area, including S1) mixing and dissolving a molybdenum-containing compound, a vanadium-containing compound, a tellurium-containing compound, a niobium-containing compound and a protective agent to obtain a precursor-protective agent mixed solution, in which the protective agent is a surfactant or a small molecule organic acid and a salt thereof; S2) subjecting the precursor-protective agent mixed solution to a hydrothermal reaction to separate out a solid; S3) calcining the solid in an air atmosphere, followed by calcining the same in an inert gas, and then performing a hydrogen peroxide purification treatment to obtain a pure M1 phase MoVTeNb-oxide catalyst. This catalyst exhibits an excellent conversion rate, selectivity, space time yield and stability in the oxidative dehydrogenation reaction of ethane for preparing ethylene.

Abstract: Alkylamine-substituted perthiocarbamates capable of controllable release of hydropersulfides (RSSH) and carbonyl sulfide (COS) and their use in treating or preventing ischemia-reperfusion injury are described.

Abstract: A set of small molecules ER? biomodulators that kill therapy-resistant ER? positive breast, ovarian, and endometrial cancer cells. These small molecules have increased therapeutic potential because of an increased ability to kill therapy-resistant breast cancer cells compared to BHPI and other conventional therapies (endocrine therapies, tamoxifen and fulvestrant/ICI). The new compounds do not only inhibit proliferation of the cancer cells but actually kills them, which prevents reactivation of tumors years later.

Abstract: A visible-light-photocatalyzed composite light-transmitting concrete contains several bundles of optical fibers, the optical fibers are coated with a protective layer on their outer surface, the protective layer contains a visible light photocatalyst, and the concrete has several gas-permeable pores. Such concrete is prepared by mixing a visible light photocatalyst and a light-transmitting glue, applying the mixture to the surface of optical fibers to form a protective layer, and using optical fibers in the concrete. The resulting concrete has dual properties of light transmittance and photocatalytic oxidation of gas-phase pollutants under visible light irradiation. The visible-light-photocatalyzed composite light-transmitting concrete significantly breaks through the limitation of photocatalytic concrete to light sources, so that gas-phase pollutants can be removed under visible light irradiation through photocatalysis of light-transmitting concrete.