Abstract: A method for attempting to fragment or comminute an object in a body using ultrasound includes producing a burst wave lithotripsy (BWL) waveform by a therapy transducer. The BWL waveform is configured to fragment or comminute the object. The BWL waveform includes a first burst of continuous ultrasound cycles and a second burst of continuous ultrasound cycles. A burst frequency corresponds to a frequency of repeating the bursts of the BWL waveform. The method also includes determining a cycle frequency f of the continuous ultrasound cycles within the first burst and the second burst based on a target fragment size D, where the cycle frequency is: f(MHz)=0.47/D(mm).
Type:
Grant
Filed:
March 7, 2019
Date of Patent:
February 21, 2023
Assignee:
University of Washington through its Center for Commercialization
Inventors:
Adam D. Maxwell, Bryan W. Cunitz, Wayne Kreider, Oleg A. Sapozhnikov, Ryan S. Hsi, Michael R. Bailey
Abstract: In one aspect, the present disclosure provides a method for identifying treatment targets relating to tumors. In another aspect, the present disclosure provides a method for identifying biomarkers and molecular features of normal and cancer cells.
Type:
Grant
Filed:
April 11, 2022
Date of Patent:
February 21, 2023
Assignee:
The Regents of the University of California
Inventors:
Jennifer A. Doudna, Chun-Hao Huang, Spencer C. Knight, Nami Saghaei
Abstract: There is provided a material comprising a multi-block thermogelling polymer, said multi-block thermogelling polymer comprising a hydrophilic polymer block; a thermosensitive polymer block; and a hydrophobic polymer block, wherein the hydrophilic polymer block, the thermosensitive polymer block and the hydrophobic polymer block are chemically coupled together by at least one of urethane/carbamate, carbonate, ester linkages or combinations thereof, and wherein the material is suitable for use as a vitreous substitute. Also provided are a method of preparing said material and a synthetic vitreous humour or part thereof comprising said material.
Type:
Grant
Filed:
February 28, 2020
Date of Patent:
February 21, 2023
Assignees:
Agency for Science, Technology and Research, National University Hospital (Singapore) Pte Ltd, National University of Singapore, Singapore Health Services Pte Ltd
Inventors:
Xian Jun Loh, Xinyi Su, Zengping Liu, Gopal Lingam, Veluchamy Amutha Barathi, Walter Hunziker
Abstract: Described herein are systems, methods and devices for implementing a temperature-aware, multi-antenna scheduler that cools mmWave devices by preventing heat buildup via switching or distributing a data stream to other redundant antennas, allowing for dissipation of heat as well as providing reliable connectivity.
Type:
Grant
Filed:
May 24, 2021
Date of Patent:
February 21, 2023
Assignee:
University of South Carolina
Inventors:
Sanjib Sur, Moh. S. Saadat, Srihari Nelakuditi
Abstract: Described herein are biomaterials, systems, and methods for guiding regeneration of an epiphyseal growth plate or similar interfacial tissue structures. In one aspect, the disclosed technology can include a biologic material that can comprise one or more of a hydrogel carrier for growth factors and MSCs, chondrogenic and immunomodulatory cytokines, microparticles for prolonged and spatially controlled growth factor delivery; and/or porous scaffold providing mechanical support. The implanted material can be applied via various different modalities depending on the nature of the physeal injury. One modality is an injectable hydrogel and another modality is an implantable hydrogel infused scaffold.
Type:
Grant
Filed:
March 3, 2017
Date of Patent:
February 21, 2023
Assignee:
University of Pittsburgh—Of The Commonwealth System of Higher Education
Abstract: An attraction loading system is provided that includes a turntable configured to rotate about a vertical axis. A ride vehicle is configured to travel along a loading path disposed about a perimeter of the turntable. A first track switch of the system is disposed along the loading path to direct the ride vehicle to a main portion of the loading path from an attraction path, or to direct the ride vehicle to the main portion of the loading path from a secondary portion of the loading path. A second track switch of the system is disposed along the loading path to direct the ride vehicle from the main portion of the loading path to the attraction path, or to direct the ride vehicle from the main portion of the loading path to the secondary portion of the loading path.
Type:
Grant
Filed:
January 13, 2020
Date of Patent:
February 21, 2023
Assignee:
Universal City Studios LLC
Inventors:
Luis Carlos Alarcon, Steven C. Blum, Michael David Russell, Jr.
Abstract: The present disclosure belongs to the technical field of new energy utilization, and provides an offshore oscillating water column wave energy conversion device with an external permeable structure. The offshore oscillating water column wave energy conversion device with the external permeable structure comprises an oscillating water column system, an anchoring fixing system and a permeable structure. According to the offshore oscillating water column wave energy conversion device with the external permeable structure provided by the present disclosure, the offshore oscillating water column wave energy conversion device and the permeable structure are effectively combined. Using an offshore floating structure, the offshore oscillating water column wave energy conversion device with the external permeable structure can be applied to deep and far sea areas with higher wave energy density, and the output power of the device can be effectively improved.
Type:
Grant
Filed:
October 18, 2021
Date of Patent:
February 21, 2023
Assignee:
Dalian University of Technology
Inventors:
Dezhi Ning, Xiangyu Zhang, Yili Wang, Rongquan Wang, Mengzhao Cheng, Yaohua He
Abstract: Described herein are functionalized garments that can be worn on the torso of a subject and can be configured with varying zones or areas of compressions and can provide increased signal-to-noise ratios and reduced motion artifacts in areas while allowing a substantially unimpeded freedom of motion.
Type:
Grant
Filed:
February 7, 2020
Date of Patent:
February 21, 2023
Assignee:
North Carolina State University
Inventors:
Jesse S. Jur, Amanda C. Myers, Allison Bowles, Raj Bhakta, Braden M. Li, Elizabeth Cobarrubias, Michael Lim
Abstract: Provided are 2-aminoimidazole-phenyl derivative compounds of Formula (I): which compounds are useful in methods of controlling microbial growth, such as by enhancing the effects of an antibiotic administered in combination with the compound. Compositions including these compounds, devices including these compounds, and methods of using the same are also provided.
Type:
Grant
Filed:
March 8, 2018
Date of Patent:
February 21, 2023
Assignee:
North Carolina State University
Inventors:
Christian Melander, David Kendall Jung, Samuel Onofre Reyes
Abstract: New organometallic complexes having bis- or tris-heteroleptic ligands and large aspect ratio in one direction and their use in OLEDs to enhance the efficiency is disclosed.
Type:
Grant
Filed:
October 21, 2020
Date of Patent:
February 21, 2023
Assignee:
Universal Display Corporation
Inventors:
Zhiqiang Ji, Lichang Zeng, Jui-Yi Tsai, Chun Lin, Chuanjun Xia, Alexey Borisovich Dyatkin, Walter Yeager
Abstract: One variation of a method for tracking objects within a surgical space during a surgery includes: based on a first image depicting the surgical space at a first time, detecting a first object and a constellation of objects in the surgical space, estimating distances from each object—in the constellation of objects—to the first object, and calculating a contamination risk of the first object based on contamination scores and distances to the first object for each object in the constellation of objects; calculating a contamination score of the first object based on a combination of the contamination risks of the first object during the surgery; and, in response to the contamination score of the first object exceeding a threshold contamination score prior to contact between the first object and a patient, serving a prompt within the surgical space to address sterility of the first object.
Type:
Grant
Filed:
August 6, 2019
Date of Patent:
February 21, 2023
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Derek F. Amanatullah, Geoffrey Appelbloom, David Zhao, Rahim Nazerali
Abstract: An electro-plasmonic array is disclosed. The electro-plasmonic array includes a substrate and a plurality of nanoantennas disposed on a surface of the substrate, each of the electro-plasmonic nanoantennas including a conductive nanodisk and a conforming biocompatible electrochromic polymer layer.
Type:
Grant
Filed:
August 10, 2020
Date of Patent:
February 21, 2023
Assignee:
The Regents of the University of California
Inventors:
Ahmet Ali Yanik, Ahsan Habib, Xiangchao Zhu
Abstract: An augmented reality (AR) device and a method of predicting a pose in the AR device is provided. In the augmented reality (AR) device inertial measurement unit (IMU) values corresponding to the movement of the AR device are obtained at an IMU rate, intermediate 6-degrees of freedom (6D) poses of the AR device are estimated based on the IMU values and images around the AR device via a visual-inertial simultaneous localization and mapping (VI-SLAM) module, and a pose prediction model for predicting relative 6D poses of the AR device is generated by performing learning by using a deep neural network.
Type:
Grant
Filed:
April 18, 2022
Date of Patent:
February 21, 2023
Assignees:
SAMSUNG ELECTRONICS CO., LTD., Korea University Research and Business Foundation
Abstract: The present disclosure is directed toward an electrodeposition-based dynamic glass element comprising an electrolyte that includes an aqueous solvent and an additive, wherein the electrolyte is stable over a temperature range that is greater than the stable temperature range of the aqueous solvent alone. In some embodiments, the freezing point of the electrolyte is lowered by its inclusion of the additive. Additives suitable for use in accordance with the present disclosure include alcohols, metal salts, sugars, cryoprotectants, and the like. In some cases, the freezing point of the aqueous-solvent-based electrolyte is lowered from 0° C. to ?40° C. by virtue of the inclusion of the additive. In some cases, the maximum stable temperature of the electrolyte is increased from 100° C. to 110° C. by virtue of the inclusion of the additive.
Type:
Grant
Filed:
November 16, 2018
Date of Patent:
February 21, 2023
Assignees:
The Board of Trustees of the Leland Stanford Junior University, Board of Regents of the Nevada System of Higher Education, on behalf of the University of Nevada, Reno
Inventors:
Christopher J. Barile, Michael David McGehee, Daniel J. Slotcavage
Abstract: A hemiplegic forearm function recovery training device includes a forearm mounting part (2) on which a forearm (S) is to be mounted. The forearm mounting part (2) includes a mounting body (20), an inner frame portion (2B), an outer frame portion (2A), and a control part. The mounting body (20) has a forearm fixing portion (22) on which the forearm (S) is mounted and a gripping mechanism (23) capable of being gripped by a hand of the forearm (S). The inner frame portion (2B) is fitted to the mounting body (20) and is rotatable around the forearm (S). The outer frame portion (2A) guides the inner frame portion (2B) in a rotation direction thereof. The control part performs a series of controls that repeatedly causes normal rotation, stop, reverse rotation, and stop of the inner frame portion (2B) while acquiring rotation angle information of the inner frame portion (2B).
Abstract: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
Type:
Grant
Filed:
August 26, 2020
Date of Patent:
February 21, 2023
Assignees:
Regents of the University of Minnesota, Intima Bioscience, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Services
Inventors:
Branden Moriarity, Beau Webber, Modassir Choudhry, R. Scott McIvor, David Largaespada, Steven A. Rosenberg, Douglas C. Palmer, Nicholas P. Restifo
Abstract: Provided are methods and compositions for generating a deletion library, and methods and compositions for generating and identifying a defective interfering particle (DIP). Also provided are transposon cassettes. A subject method can include: inserting a transposon cassette comprising a target sequence for a sequence specific DNA endonuclease into a population of circular target DNAs to generate a population of transposon-inserted circular target DNAs; contacting the population of transposon-inserted circular target DNAs with the sequence specific DNA endonuclease to generate a population of cleaved linear target DNAs; contacting the population of cleaved linear target DNAs with one or more exonucleases to generate a population of deletion DNAs; and circularizing the deletion DNAs to generate a library of circularized deletion DNAs. The population of circular target DNAs can include viral genomic DNA. Also provided are human immunodeficiency virus (HIV) deletion mutants, e.g.
Type:
Grant
Filed:
December 14, 2017
Date of Patent:
February 21, 2023
Assignees:
The J. David Gladstone Institutes, The Regents of the University of California
Abstract: A thin film transistor and a non-volatile memory device are provided. The thin film transistor comprises a gate electrode, and a metal oxide channel layer traversing the upper or lower portions of the gate electrode. The metal oxide channel layer has semiconductor properties while having bixbyite crystals. An insulating layer is disposed between the gate electrode and the metal oxide channel layer. Source and drain electrodes are electrically connected to both ends of the metal oxide channel layer, respectively.
Type:
Grant
Filed:
April 22, 2020
Date of Patent:
February 21, 2023
Assignee:
Industry-University Cooperation Foundation Hanyang University
Inventors:
Jae Kyeong Jeong, Hyun Ji Yang, Hyeon Joo Seul
Abstract: A system for network-scale parallel computing comprises a set of computer-readable instructions implementing the steps of executing a computational process from at least one client node by communicating via a content addressable service network implemented using the Tuple Space abstraction, data parallel semantics and Unidirectional Virtual Ring architecture, with any number of service computers, networks and storage to deliver lossless, non-stop services. A network-scale distributed storage system, an enhanced Domain Name System (DNS) system, a network-scale database system and a network-scale hybrid transactional analytical processing systems are also described.
Type:
Grant
Filed:
November 14, 2017
Date of Patent:
February 21, 2023
Assignee:
Temple University—Of The Commonwealth System of Higher Education
Abstract: A method of making a binder for extruded, pelleted, or agglomerated animal feed. The binder is made by treating biomass such as soybean hull or lemon peels with an aqueous acidic solution for a time, at a temperature, and at a pH sufficient to yield a first mixture containing biomass solids and partially dissolved biomass; and mechanically treating the first mixture of step to yield a first mechanically treated mixture; and then incorporating the first mechanically treated mixture as a binder in an animal feed. Also described are animal feeds made using the binder.
Type:
Grant
Filed:
January 17, 2020
Date of Patent:
February 21, 2023
Assignees:
Auburn University, The United States of America, as Represented by the Secretary of Agriculture
Inventors:
Burak Aksoy, Zhihua Jiang, Mediha Aksoy, Benjamin Beck