Abstract: There are provided a lithography method capable of selecting best resist and a semiconductor device manufacturing method and exposure equipment based on the lithography method. The lithography method includes estimating a shape of a virtual resist pattern based on a multi-scale simulation for resist, forming a test resist pattern by performing exposure on selected resist based on the simulation result, comparing the test resist pattern with the virtual resist pattern, and forming a resist pattern on an object to be patterned by using the resist when an error between the test resist pattern and the virtual resist pattern is in an allowable range.

Abstract: A high chromium and silicon-rich corrosion resistant steel is disclosed, which comprises, in weight percent: 22-30% Cr, 2-10% Si, and the balance Fe and incidental impurities, of which a content amount of Cr and Si is less than 37%. Experimental data reveal that, samples of the high chromium and silicon-rich corrosion resistant steel all have a pitting potential greater than 0.8 V and a hardness in a range between HV170 and HV500 in the as-homogenized condition. As a result, experimental data have proved that the high chromium and silicon-rich corrosion resistant steel of the present invention can replace conventional stainless steels having poor pitting resistance like type 304 and type 316 L, and then be adopted for the applications of components and/or structural parts requiring high corrosion resistance.

Abstract: Deep learning methods and systems for detecting biomarkers within optical coherence tomography volumes using such deep learning methods and systems are provided. Embodiments predict the presence or absence of clinically useful biomarkers in OCT images using deep neural networks. The lack of available training data for canonical deep learning approaches is overcome in embodiments by leveraging a large external dataset consisting of foveal scans using transfer learning. Embodiments represent the three-dimensional OCT volume by “tiling” each slice into a single two dimensional image, and adding an additional component to encourage the network to consider local spatial structure. Methods and systems, according to embodiments are able to identify the presence or absence of AMD-related biomarkers on par with clinicians. Beyond identifying biomarkers, additional models could be trained, according to embodiments, to predict the progression of these biomarkers over time.

Abstract: Isolated polypeptides having enhanced affinity for a PDGF receptor and/or a VEGF receptor are provided. Compositions comprising the polypeptides and methods of use thereof are also provided.

Abstract: A system for assessing risks of T2DM complications includes: a data acquisition module obtaining and inputting assessment parameters of a patient with T2DM into a risk assessment module; and the risk assessment module inputting the assessment parameters into a number of risk equations and using it to calculate risk values of the complication occurring after a period of time. The risk equation for all diabetic complications (i,j) is: ra(t,i,j)=1?exp{[H(t0)?H(t1)]Ca(t,i,j)} ra(t, i, j) is the risk value for the patient to develop the complication j from the current disease i at age t. t0 is an age of one patient at a state of the disease i. t1 is an age of the patient after the period of time. t is an age between t0 and t1. H(t0) and H(t1) are hazards of the complication occurring at the age t0 and the age t1, respectively.

Abstract: A catalyst adapted for generating hydrogen peroxide induced by a temperature difference and a method for environmental disinfection using the same are provided. The catalyst includes a thermoelectric material distributed on a substrate. The thermoelectric material induces a reaction between water vapor and oxygen contained in the air through a temperature difference to generate hydrogen peroxide, to serve a sterilization function through the hydrogen peroxide generated. The method for environmental disinfection using the catalyst includes the following. The catalyst is placed in an environment with a temperature difference. The catalyst is caused to induce a reaction between water vapor and oxygen contained in air through the temperature difference to generate hydrogen peroxide without applying power, and serve a sterilization function through the hydrogen peroxide generated.

Abstract: Disclosed herein are recombinant AAV variant (e.g., variant serotype 3B (AAV3B)) capsid proteins and variant capsid protein-containing viral particles with enhanced ability to transduce hepatic cells. Viral particles containing these capsid variants are capable of evading neutralization by the host humoral immune response. The recombinant AAV3B variant proteins and viral particles disclosed herein were identified from a variant AAV3B capsid library that was engineered by making substitutions in only the variable regions of the capsid. Some embodiments of the AAV3B capsid variants disclosed herein comprise the AAV3B-G3 variant and the AAV3B-E12 variant. Compositions of these variant AAV particles are provided that are useful for transducing and delivering therapeutic transgenes to cells, such as liver cells, and thus treat diseases and disorders pertaining to these cells.

Abstract: Compositions and methods for the treatment of malignancy are disclosed.

Abstract: The present invention relates to the technical field of identification on adulterated meat, and in particular, to a method for identifying raw meat and high-quality fake meat based on a gradual linear array change of a component. The present invention spatially characterizes changing rules of featured components in the meat with the utilization of sensitivities of the visible/near-infrared spectral signals to changes of the components in the meat and the advantage that spectral scanning can acquire optical signals of the samples spatially and consecutively, further constructs the identification model according to differences in components and spectra of a region of interest in the hyperspectral image by taking a derivative for characterizing rates of change of the featured components.

Abstract: The present invention belongs to the field of array signal processing and relates to a composite tensor beamforming method for an electromagnetic vector coprime planar array. The method includes: building an electromagnetic vector coprime planar array; performing tensor modeling of an electromagnetic vector coprime planar array receiving signal; designing a three-dimensional weight tensor corresponding to a coprime sparse uniform sub-planar array; forming a tensor beam power pattern of the coprime sparse uniform sub-planar array; and performing electromagnetic vector coprime planar array tensor beamforming based on coprime composite processing of the sparse uniform sub-planar array. Starting from the principles of receiving signal tensor spatial filtering of two sparse uniform sub-planar arrays that compose the electromagnetic vector coprime planar array, the present invention forms a coprime composite processing method based on a sparse uniform sub-planar array output signal.

Abstract: The present disclosure describes a microorganism support structure, including a gas-permeable layer comprising two opposing surfaces; a microorganism adhesive coats at least one surface of the gas-permeable layer; and a microorganism disposed on the microorganism adhesive-coated surface of the layer. The microorganism adhesive enhances the adhesion of the microorganism on the layer compared to a gas-permeable layer that does not have the microorganism adhesive.

Abstract: Methods for detecting, identifying, and/or quantifying a target molecule in a complex fluid using thermal analysis are disclosed. Exemplary complex fluids include biofluids and environmental fluids. Exemplary target molecules include proteins, peptides, nucleic acids, lipids, carbohydrates, viruses, and combinations thereof. A method for using thermal analysis to determine whether purification affects one or more characteristics, such as binding characteristics, of a target molecule is also disclosed.

Abstract: Kerr and electro-optic frequency comb generation in integrated lithium niobate devices is provided. In various embodiments, a microring resonator comprising lithium niobate is disposed on a thermal oxide substrate. The microring resonator has inner and outer edges. Electrodes are positioned along the inner and outer edges of the microring resonator. The electrodes are adapted to modulate the refractive index of the microring. A pump laser is optically coupled to the microring resonator. The microring resonator is adapted to emit an electro-optical frequency comb when receiving a pump mode from the pump laser and when the electrodes are driven at a frequency equal to a free-spectral-range of the microring resonator.

Abstract: Disclosed is a system and method for verifying the authenticity of goods for sale. The system includes an authenticity device on the product which determines a code using a two step authenticity algorithm which inputs time as a variable and outputs the code. The code may be displayed on the authenticity device. The smart device contacts the manufacturer via an application and a wide area network and provides identification information regarding the product. Based on the identification information, the manufacturer finds the copy of the authenticity algorithm stored at the manufacturer, runs the algorithm, and returns the code to the smart device.

Abstract: Compositions and methods for treating a VEGF-related ophthalmic disorder in a subject in need comprising, administering intravitreally to the subject a therapeutically effective amount of an anti-VEGF agent, comprising a VEGF binding portion operatively linked to a Fc-IgG, wherein the VEGF binding portion comprises at least one VEGF binding domain that is an IgG-like domain 2 of VEGFR-1.

Abstract: System monitors and methods of monitoring a system are disclosed. In one arrangement a system monitor predicts a future state of a system. A data receiving unit receives system data representing a set of one or more measurements performed on the system. A first statistical model is fitted to the system data. The first statistical model is compared to each of a plurality of dictionary entries in a database. Each dictionary entry comprises a second statistical model. The second statistical model is of the same general class as the first statistical model and obtained by fitting the second statistical model to data representing a set of one or more previous measurements performed on a system of the same type as the system being monitored and having a known subsequent state. A prediction of a future state of the system being monitored is output based on the comparison. The first statistical model and the second statistical model are each a stochastic process or approximation to a stochastic process.

Abstract: Methods are provided for treating a subject having a MYC-driven neoplasia. Aspects of the methods include administering to the subject an amount of an inhibitor of a target gene effective to treat the subject for the MYC-driven neoplasia. Methods are also provided for identifying a MYC-dependent target gene in a MYC-driven neoplasia. Aspects of the method include identifying the MYC-dependent target gene based on a phenotype detected in a first tumor cell line conditionally expressing MYC that is absent or quantitatively different in a second tumor cell line conditionally repressing MYC when the two cell lines are contacted with a CRISPR-based gene silencing agent. Kits and cell lines for practicing the methods of the disclosure are also provided.

Abstract: Systems and methods of communicating using asymmetric polar codes are provided which overcome the codeword length constraints of systems and methods of communicating that use traditional polar codes. Used herein, asymmetric polar codes refers to a polarizing linear block code of any arbitrary length that is constructed by connecting together constituent polar codes of unequal length. Asymmetric polar codes may be known by other names. In comparison to conventional solutions for variable codeword length, asymmetric polar codes may provide more flexibility, improved performance, and/or reduced complexity of decoding, encoding, or code design. The system and method provide a flexible, universal, and well-defined coding scheme and to provide sound bit-error correction performance and low decoding latency (compared with current length-compatible methods which can be used with current hardware designs).

Abstract: A magnetic/energetic apparatus for purifying gas mixtures comprises a vortex tube and magnetic elements. Such an apparatus can include an inlet valve configured to receive a gas mixture having one or more disposed paramagnetic gas species and one or more diamagnetic gas species; a high-shear environment energetic separation chamber coupled to the inlet valve; a plurality of magnetic elements coupled to an outer wall of the high-shear environment separation chamber, wherein each of the plurality of magnetic elements are arranged so as to have a respective pole alternating in polarity with respect to an adjacently positioned magnetic element so as to induce a field gradient between each of the adjacently positioned magnetic elements and within the inner wall of the high-shear environment separation chamber; and at least one exit valve so as provide a substantially separated one or more paramagnetic gas species from the one or more diamagnetic gas species.

Abstract: The present invention generally provides methods and compositions for the treatment of Parkinson's disease and depression and/or anxiety. The invention relates to recombinant microorganisms, particularly gut-colonizing probiotics, modified to produce L-DOPA.