Abstract: An experimental setup for measuring the vacuum degree and pore pressure at a point of soil mass in vacuum consolidated state, including a connecting tube, the connecting tube includes an upper water storage tube, a middle tube, the middle tube is loaded with an upper experimental soil mass, the lower tube is loaded with a lower experimental soil mass, a water storage chamber is connected to a pumping mechanism, an intermediate inner chamber is connected to a negative pressure vacuum gauge, the inlet conduit is connected to a negative pressure vacuum gauge. Additionally, the present invention provides a test operation method. The device measures the vacuum degree of upper part of experimental soil mass by observing the reading in the negative pressure vacuum gauge.

Abstract: An example method of displaying a data visualization includes displaying a graphical user interface that includes three distinct regions, and receiving user actions to associate two different fields with two different shelves. The method also includes generating, in accordance with the received user actions, data marks to be displayed in a data visualization, each data mark corresponding to a respective retrieved tuple of data from a multidimensional database, where (i) each data mark has an x-position defined according to data for a first field in the respective tuple and (ii) each data mark has a y-position defined according to data for a second field in the respective tuple. The method also includes displaying a data visualization that includes the generated data marks.

Abstract: Disclosed herein are methods of treating a subject with an estrogen receptor-positive (ER+) breast cancer comprising obtaining a sample of the breast cancer from the subject; determining a level of E-cadherin in the sample is reduced compared to a control; and administering a therapeutically effective amount of an IGF1R pathway inhibitor and an endocrine therapeutic. Also disclosed herein are methods to treat a cancer in a subject comprising administering a therapeutically effective amount of an IGF1R pathway inhibitor and an E-cadherin inhibitor. Also disclosed are methods to predict the likelihood a subject with a breast cancer will respond therapeutically to a treatment comprising administering an IGF1R pathway inhibitor, the method comprising obtaining a sample of the cancer from the subject; and determining a level of E-cadherin in the sample.

Abstract: A sensing system, and method of operating same, can act as a highly sensitive gradiometer. A first non-magnetic element, such as a sphere, is driven at a first resonance frequency along an axis. A magnet is attached to a second non-magnetic element, such as a plate, and driven at a second resonance frequency along the axis. The first non-magnetic element and the second non-magnetic element are coupled by a force along the axis, in resonance. The gradiometer is configured to determine a gradient magnetic field acting on one or more of the first non-magnetic element and magnet based on change in at least one resonance characteristic.

Abstract: A composition for inhibiting corrosion in hydrocarbon wells includes a pyranopyrazole derivative. The pyranopyrazole derivative includes a pyrazole moiety, a dihydropyran moiety, and a phenyl moiety. The dihydropyran moiety is bound to the pyrazole moiety. The phenyl moiety is bound to the dihydropyran moiety. The composition can be flowed into a wellbore formed in a subterranean formation, thereby inhibiting corrosion in the wellbore.

Abstract: Disclosed is an electrical cell comprising a negative electrode, a positive electrode, and a deposition layer separating the positive electrode and a gas phase that supplies at least one reactive gas; wherein the deposition layer and the positive electrode are in communication with each other via electrolyte(s). Also disclosed is a battery comprising the electrical cell described above and a battery comprising: a cell comprising a negative electrode in communication with an anolyte and a positive electrode in communication with a catholyte; and a gas-liquid reactor, which is fed with the catholyte from the cell and a gas.

Abstract: Systems, devices, and methods for access point discovery in a wireless network are provided. An access point device embeds into a preamble of a transmission packet discovery information including modifications determined by passing in-phase quadrature (IQ) symbols through a finite impulse response (FIR) filter to introduce a phase shift in selected ones of the IQ symbols. The phase shifts are encoded into bits in selected ones of a plurality of subcarriers, bounded by a maximum phase shift and a maximum number of the subcarriers to limit the packet error rate. A convolutional neural network can learn channel state and other information to determine the maximum phase shift and number of subcarriers. A client device can select from among a plurality of modified transmission packets to send a discovery request.

Abstract: An organic vapor deposition device comprises a print head, comprising a source channel, in fluid communication with a flow of carrier gas and a quantity of organic source material configured to mix with the carrier gas, a nozzle having a deposition outlet, in fluid communication with the source channel, and a shutter configured at least to open and close the deposition outlet, wherein the print heat is configured to allow the flow of carrier gas and the organic source material exit the deposition outlet when the shutter is in an open position, and to prevent the flow of carrier gas and the organic source material from exiting the deposition outlet when the shutter is in a closed position. A method of manufacturing a device comprising an organic feature on a substrate is also described.

Abstract: An interleaved three-phase Y-Delta connected power converter is provided. The interleaved three-phase Y-Delta connected power converter includes an input voltage source, an input capacitor, a first converter module, a second converter module, an output circuit, and a control circuit. The control circuit calculates a phase shift amount and an operating frequency through voltage and current feedbacks to generate a plurality of switch signal groups for controlling the first converter module and the second converter module, respectively.

Abstract: Disclosed is an artificial bone structure for replacement of natural bone and comprising a solid cylindrical portion having an elongate shape. The solid cylindrical portion comprises an auxetic structure of a plurality of artificial osteons and each artificial osteon comprises a first hexagonal unit and a second hexagonal unit having corresponding edges. Furthermore, a first artificial osteon and a second artificial osteon of the plurality of artificial osteons are connected to each other using an edge of a third artificial osteon and about a central axis of each of the first artificial osteon and the second artificial osteon. Moreover, the artificial bone structure comprises a hollow cylindrical portion having an elongate shape, disposed inside of and concentrically with the solid cylindrical portion. The hollow cylindrical portion is configured to comprise an artificial bone marrow therein.

Abstract: The presently disclosed subject matter provides compositions, methods, and kits for transfecting adipose-derived mesenchymal stem cells (AMSCs) in freshly extracted adipose tissue using nanoparticles comprising biodegradable polymers self-assembled with nucleic acid molecules. The presently disclosed subject matter also provides methods for treating a neurological disease in a patient in need thereof, the method comprising administering the AMSCs transfected with the nucleic acid molecules to the patient, wherein the nucleic acid molecules encode one or more bioactive molecules functional in the treatment of a neurological disease, particularly wherein the neurological disease is a brain tumor.

Abstract: Structures for a wavelength-division multiplexing filter and methods of forming a structure for a wavelength-division multiplexing filter. A waveguide core of the wavelength-division multiplexing filter includes a first bend having a first curvature and a second bend having a second curvature different than the first curvature. The structure further includes a waveguide core region having a first end surface, a second end surface, and a bend arranged between the first and second end surfaces. The bend is positioned over the first bend of the waveguide core in an overlapping relationship.

Abstract: A smart, human-centered technique that uses artificial intelligence and mixed reality to accelerate essential tasks of the inspectors such as defect measurement, condition assessment and data processing. For example, a bridge inspector can analyze some remote cracks located on a concrete pier, estimate their dimensional properties and perform condition assessment in real-time. The inspector can intervene in any step of the analysis/assessment and correct the operations of the artificial intelligence. Thereby, the inspector and the artificial intelligence will collaborate/communicate for improved visual inspection. This collective intelligence framework can be integrated in a mixed reality supported see-through headset or a hand-held device with the availability of sufficient hardware and sensors. Consequently, the methods reduce the inspection time and associated labor costs while ensuring reliable and objective infrastructure evaluation.

Abstract: An architecture for semantic search over encrypted data that improves upon existing encrypted data search techniques by providing a solution that is space-efficient on both the cloud and client sides, considers the semantic meaning of the user's query, and returns a list of documents accurately ranked by their similarity to the query. Different search schemes are presented based on S3C architecture (namely, FKSS, SKSS, and KSWF) that are fine-tuned for different types of datasets. The system requires only a single plaintext query to be entered and is easily portable to thin-clients, making it simple and quick for users to use. The system is also shown to be secure and resistant to attacks.

Abstract: Compounds and methods for inhibiting cofilin activity or reducing total cofilin, improving motor deficits, attenuating LPS-induced microglial activation and inflammation, reducing microglial migration and proliferation, reducing TNF-?, reducing NF-?B, and improving motor deficits in a subject are described.

Abstract: Pyrazole compounds and piperazine compounds that are inhibitors of ALDH1A1 and ALDH1A2 and methods for using the pyrazole compounds and piperazine compounds in male contraceptive compositions for preventing spermatogenesis.

Abstract: A cell chip includes first, second and third elements, a dye dialysis layer, a micro-channel structure and washing solution inlet and outlet. The first element has a first hole and second holes at opposite sides of the first hole. The second element has a third hole corresponding to the first hole and fourth holes corresponding to the second holes. The dye dialysis layer is inserted between the first element and the second element and has a cell-assembly region corresponding to the first and third holes. The micro-channel structure is disposed below the cell-assembly region and between the second and the third elements. The washing solution inlet and outlet are communicatively connected to the micro-channel structure. The washing solution inlet includes the second hole and a corresponding fourth hole. A washing solution flows in the micro-channel structure through the washing solution inlet and outlet.

Abstract: A vibrational energy harvester element includes: a first electrode; a second electrode that moves in a predetermined direction with respect to the first electrode; a third electrode; a fourth electrode that moves in the predetermined direction with respect to the third electrode; and a support portion that supports the second electrode and the fourth electrode so that they are movable along the predetermined direction; and wherein: the first electrode and the third electrode are disposed along the predetermined direction; at least one of facing surfaces of the first electrode and the second electrode, and at least one of facing surfaces of the third electrode and the fourth electrode, are electrically charged; and the support portion supports the second electrode and the fourth electrode in a state in which electrostatic force between the first electrode and the second electrode, and electrostatic force between the third electrode and the fourth electrode are balanced along the predetermined direction.

Abstract: A computer-implemented method of training a neural network to improve a characteristic of a protein comprises collecting a set of amino acid sequences from a database, compiling each amino acid sequence into a three-dimensional crystallographic structure of a folded protein, training a neural network with a subset of the three-dimensional crystallographic structures, identifying, with the neural network, a candidate residue to mutate in a target protein, and identifying, with the neural network, a predicted amino acid residue to substitute for the candidate residue, to produce a mutated protein, wherein the mutated protein demonstrates an improvement in a characteristic over the target protein. A system for improving a characteristic of a protein is also described. Improved blue fluorescent proteins generated using the system are also described.

Abstract: This invention is a novel method of manufacture for hand-sanitizing lotions that retains the added benefits of prolonged effectiveness while avoiding demulsification as well as the resulting product. The invention presents a novel, more simplified process comprising a lower cooking temperature and an optimized ingredient addition protocol, designed for product stability and ingredient integrity.