Abstract: This disclosure provides systems and methods for attaching nanopore-detectable tags to nucleotides. The disclosure also provides methods for sequencing nucleic acids using the disclosed tagged nucleotides.

Abstract: The present disclosure discloses an intelligent screening algorithm and automatic upgrading system for congenital heart diseases of newborns based on big data. The key point of the technical solution is as follows: The intelligent screening algorithm and automatic upgrading system includes a heart sound data module, a heart sound data processing module, a blood oxygen data module, a blood oxygen data processing module, a network upgrading module, a database, an intelligent analysis module and a congenital heart disease evaluation module; the heart sound data module is configured to acquire various data of heart sounds of a newborn for centralized processing; and the heart sound data processing module is configured to process the data in the heart sound data module and extract heart sound feature parameters.

Abstract: Provided is a switched capacitor-based electrical stimulation device which supplies a direct current (DC) power, detects a charging voltage charged in any one of a plurality of capacitors, controls the DC power supplied to a capacitor module to repeat a charging level and a resting level according to a charging pattern when the charging voltage is lower than a target voltage, and outputs an electric current to electrodes which contact a human body based on an output pattern.

Abstract: An imaging system includes a sample mount for holding a sample to be imaged, a light source configured to emit a light beam to be incident on the sample, a translation mechanism coupled to the sample mount and configured to scan the sample to a plurality of sample positions in a plane substantially perpendicular to an optical axis of the imaging system, a mask positioned downstream from the sample along the optical axis, and an image sensor positioned downstream from the mask along the optical axis. The image sensor is configured to acquire a plurality of images as the sample is translated to the plurality of sample positions. Each respective image corresponds to a respective sample position. The imaging system further includes a processor configured to process the plurality of images to recover a complex profile of the sample based on positional shifts extracted from the plurality of images.

Abstract: A catalyst structure includes: (1) a substrate; (2) a catalyst layer on the substrate; and (3) an adhesion layer disposed between the substrate and the catalyst layer. In some implementations, an average thickness of the adhesion layer is about 1 nm or less. In some implementations, a material of the catalyst layer at least partially extends into a region of the adhesion layer. In some implementations, the catalyst layer is characterized by a lattice strain imparted by the adhesion layer.

Abstract: An automatically-cleanable thickening performance evaluation instrument for drilling LCMs includes a cleaning device, a kettle body, a thickening motor, a heating component, a test ending component, a top cover, and a bottom cover, where upper and lower ends of the kettle body are both opened; the kettle body is arranged in a third bearing inner race, a third bearing outer race is connected to a first limb, and the first limb is configured to limit a position of the kettle body; and the kettle body is detachably connected to the thickening motor and driven by the thickening motor to rotate. The instrument can realize electric heating and air pressurization to simulate the underground environment, and the kettle body can be completely sealed, such that a measured thickening time is close to an actual thickening time. Moreover, the instrument can be automatically cleaned at the end of a test.

Abstract: An oral treatment protective operation device, comprising a protective cover assembly and a suspension support connected thereto. The protective cover assembly comprises a transparent protective cover; the protective cover is provided with a soft sealing sleeve in butt-joint with a patient's mouth and a connector connecting a strong suction pipe; the left side and the right side of the protective cover are provided with operation windows; the opening parts of the operation windows are provided with arc-shaped sliding plates, which are provided with circular operation holes; the operation holes are connected to soft arm sleeves; a concave part is formed on the side of the protective cover facing a doctor, and an angle-adjustable magnifying lens is arranged in the concave part; and the suspension support comprises a vertical-deflection adjusting rod, a transverse connecting rod and a connecting lock sleeve, and further comprises a stay cable or a stay bar.

Abstract: Cryptosporidium is a leading contributor to early childhood mortality, and fully effective treatment for this important infectious disease is lacking. A bicyclic azetidine compound series is disclosed having potent in vitro activity against all C. parvum isolates tested, comparable potencies against C. hominis and C. parvum, and cured cryptosporidiosis in highly susceptible immunosuppressed mice with once-daily dosing.

Abstract: The present disclosure discloses a Single-Event Transient (SET) pulse measuring circuit capable of eliminating impact thereof, and an integrated circuit chip. The SET pulse measuring circuit capable of eliminating impact thereof includes four parts: a SET pulse test chain, a latch circuit, a flip-flop test circuit, a latching self-trigger circuit. The integrated circuit chip is provided with a test chain module and two sets of SET pulse measuring circuits capable of eliminating impact thereof, and inputs of the two sets of SET pulse measuring circuits capable of eliminating impact thereof are the same and each are connected to an output terminal of the test chain module.

Abstract: This disclosure provides systems, methods, and apparatus related to graphene. In one aspect, a method includes submerging a frame support in an etching solution that is contained in a container. A growth substrate, a graphene sheet disposed on the growth substrate, and a primary support disposed on the graphene sheet is placed on a surface of the etching solution. The growth substrate is dissolved in the etching solution to leave the graphene sheet and the primary support floating on a surface of the etching solution. The etching solution in the container is replaced with a washing solution. The washing solution is removed from the container so that the graphene sheet becomes disposed on the frame support.

Abstract: A method for ambient-temperature synthesis of a catalyst for water electrolysis by dissolving an amount of an Fe2+ source and optionally an amount of a salt of another divalent cation in deionized water at ambient temperature to form a solution, placing nickel (Ni) foam into the solution, whereby the Ni foam serves as a substrate and/or a Ni source for growth of the catalyst, leaving the Ni foam in the solution at ambient temperature for a time duration in a range of from about 0.5 hour to about 4 hours to provide a treated foam, during which time duration, the catalyst is grown on the substrate, and removing the treated foam from the solution after the time duration, wherein the treated foam comprises the catalyst grown thereon.

Abstract: A nanoscale positioning system for positioning a positionable component includes a motion platform including a first end, a second end, a shuttle positioned between the first end and the second end and configured to support the positionable component, a flexure member, and a fluid passage extending through the flexure member from the first end to the second end of the motion platform, and a pressure controller coupled to the motion platform and fluidically connected to the fluid passage, wherein the pressure controller is configured to selectably provide a fluid pressure in the fluid passage to flex the flexure member whereby the shuttle is displaced along a motion axis of the motion platform.

Abstract: A three-way urology catheter stopcock includes a stopcock body defining a longitudinally extending fluid flow passage, the body having three connector mounting openings in a wall thereof, an on/off selector movably mounted within the fluid flow passage of the body, the on/off selector including a longitudinally extending, cylindrical selector body having an open end, a closed end, and three fluid flow openings in a wall of the selector body, wherein the closed second end includes one of a plurality of fluid flow indicator members and fluid flow indicia, two first connectors mounted in opposing connector mounting openings of the stopcock body, and a second connector mounted in the connector mounting opening that is between the openings in which the two first connectors are mounted.

Abstract: A hydrogel composition, a hydrogel biomedical material, a method for facilitating regeneration of a bone and a manufacturing method of a hydrogel composition are provided. The hydrogel composition includes a first deionized water, a gel powder, a transglutaminase mixture and a hyaluronic acid powder. The gel powder includes gelatin and alginic acid. The first deionized water, the gel powder, the transglutaminase mixture and the hyaluronic acid powder are evenly mixed. Based on the hydrogel composition being 100 wt %, the first deionized water is 95 wt % to 98.46 wt %, the gel powder is 1 wt % to 3 wt %, the transglutaminase mixture is 0.04 wt % to 0.15 wt %, and the hyaluronic acid powder is 0.5 wt % to 1.5 wt %.

Abstract: A pull cord type turning mechanism for a butterfly-inspired flapping-wing aerial robot includes a motor, a cord reel, a cord reel gear, a potentiometer gear, a potentiometer, a control module, and a power supply. The control module is connected to the motor and the potentiometer. A rotary shaft of the motor is connected to the cord reel, the cord reel is coaxially connected to the cord reel gear, the cord reel gear is meshed with the potentiometer gear, and the potentiometer gear is connected to a rotary shaft of the potentiometer. The cord reel gear is provided with two cord grooves and two pull cords. One ends of the two pull cords are fixed in the two cord grooves, respectively, and the other ends thereof are fixed at the tips of front wings of two sides of the butterfly-inspired flapping-wing aerial robot, respectively.

Abstract: Provided is a neuromorphic circuit including an input module configured to generate an input voltage, an output module configured to measure a current transmitted from the input module and generate an output voltage, synapse modules configured to electrically connect the input module and the output module and determine a current to be transmitted to the output module and including a memory element to which a weight is assigned, and a crossing module configured to control a direction of current flowing through the synapse modules.

Abstract: The controller comprises a displacement controller and a rotating speed controller. The displacement controller includes a vibration force compensation control module and a dead-time vibration compensation module. The vibration force compensation control module receives actual displacements and a rotor mechanical angle and outputs corresponding vibration compensation forces. The vibration force compensation control module comprises a first neural network band-pass filter, a second neural network band-pass filter, a third PID controller, and a fourth PID controller. The dead-time vibration compensation module receives a rotor electrical angle and an actual quadrature-direct axis currents and an actual direct axis current and outputs a quadrature-direct axis compensation voltages and a direct axis compensation voltage.

Abstract: The present disclosure relates to Emetine Auristatin compounds, pharmaceutical compositions and kits comprising such compounds, and methods for using such compounds or pharmaceutical compositions.

Abstract: Embodiments of the disclosed subject matter may provide a display device or display surface including at least one emissive layer and a near-infrared (NIR) emissive layer disposed in a stack arrangement between a first electrode and a second electrode, where NIR light is emitted from the NIR emissive layer through the at least one emissive layer, or visible light is emitted from the at least one emissive layer through the NIR emissive layer, and where the NIR light output by the NIR emissive layer has a peak wavelength of 740 nm-1000 nm. Embodiments of the disclosed subject matter may provide a near infrared (NIR) light source disposed behind or in front of an active-matrix organic light emitting diode (AMOLED), where the NIR light source has an area greater than 25% of an active area of the display device or display surface.

Abstract: The invention generally provides methods of treating or preventing infection and/or disease associated with different fungal pathogens in a subject in need, using an isolated antiserum generated against an immunogenic peptide of one fungal pathogen that contains antibodies that cross-protect the subject from infection and/or disease associated with one or more different fungal pathogens. The antiserum may be generated against a Kexin peptide derived from one of a Pneumocystis, Aspergillus, Candida, or Cryptococcus fungal pathogen. The resulting cross-protective, isolated antiserum may be used as a therapeutic for treating or protecting a subject who receives the antiserum against infection and/or disease associated with multiple fungal pathogens, in addition to the pathogen against which the antiserum is generated.