Abstract: The invention relates to inhibitors of calcium-dependent protein kinase 1 (CDPK1) and pharmaceutical preparations thereof. The invention further relates to methods of treatment of parasitic infections, such as T. gondii, P. falciparum, C. hominis, or C. parvum infections, using the novel inhibitors of the invention.

Abstract: The present invention relates to compounds of Formulae (I) and (II) as defined herein, and salts and solvates thereof. The present invention also relates to pharmaceutical compositions comprising compounds of Formulae (I) and (II), and to the use of compounds of Formulae (I) and (II) in the treatment or prevention of filarial worm infection, as well as other diseases or conditions in which filarial worm infection is implicated.

Abstract: An exemplary system for generating an image(s) of a sample(s) can include, for example, an imaging arrangement that can include a superluminescent diode (SLD) configured to generate a radiation(s) to be provided to the sample(s), and a spectrometer configured to (i) sample an A-line sampling rate of at least about 200 kHz, (ii) receive a resultant radiation from the sample(s) based on the sampling rate, and (iii) generate information based on the resultant radiation, and a computer hardware arrangement configured to generate the image(s) of the sample(s) based on the information received from the spectrometer. The imaging arrangement can be an interferometric imaging arrangement, which can be an optical coherence tomography imaging (OCT) arrangement. The computer hardware arrangement can be further configured to facilitate a plurality of b-scan acquisitions of the sample(s) and facilitate the b-scan acquisitions in order to generate the image(s).

Abstract: A method of predicting joining strength of joined dissimilar materials, includes performing a joining strength test on a plurality of specimens of joined dissimilar materials each having different joining information, and acquiring force-displacement data on a basis of the joining information; constructing, in a prediction system, an artificial neural network model for predicting the force-displacement data and the joining strengths from the joining information; learning the artificial neural network model by inputting the force-displacement data to the prediction system, the force-displacement data obtained through the joining strength test; inputting joining information to be predicted to the prediction system by using a computer running a software for performing prediction for the joining strength and connected to a host computer of the prediction system through a network; and predicting, by the learned artificial neural network model, force-displacement value and joining strength.

Abstract: Natural and/or synthetic antibodies for specific proteins are adhered to nanoparticles. The nanoparticles are adhered to a substrate and the substrate is exposed to a sample that may contain the specific proteins. The substrates are then tested with surface enhanced Raman scattering techniques and/or localized surface plasmon resonance techniques to quantify the amount of the specific protein in the sample.

Abstract: A PMSM sensorless composite control method with dual sliding-mode observers is provided. In particular, two sliding-mode observers are designed, one provides an exponential piecewise sliding-mode function for observation of back electromotive force, and the other sliding-mode observer is for observation of load torque and fine-tuning parameters of a piecewise PI controller while introducing an estimated load torque onto a q-axis for feedforward compensation. A q-axis current inner loop is designed with a second-order sliding-mode controller, which can improve tracking performance of q-axis current and indirectly control an electromagnetic torque. The exponential piecewise sliding-mode function is more conductive to the observation of back electromotive force and can weaken the buffeting phenomenon. The sliding-mode observer for observing the load torque fine-tunes parameters of the piecewise PI controller while performing the feedforward compensation, the load capability of the system is improved.

Abstract: This invention relates to a systems, methods and apparatuses for controlling a sleep environment, particularly for controlling an indoor sleep environment, and to a method and system of waking a sleeping person. The invention monitors one or both of wet-bulb globe temperatures (WBGTs) within the sleep environment and outdoors with a view to either altering the WBGT within the sleep environment to mimic a nadir or inflection point typically found outdoors and/or generate an alarm when a nadir or inflection point of the WBGT outdoors is determined.

Abstract: Photovoltaic devices, and methods of fabricating photovoltaic devices. The photovoltaic devices may include a first electrode, at least one quantum dot layer, at least one semiconductor layer, and a second electrode. The first electrode may include a layer including Cr and one or more silver contacts.

Abstract: Localization and navigation systems and techniques are described. An electronic device comprises a processor configured to maintain a state vector storing estimates for a position of the electronic device at poses along a trajectory within an environment along with estimates for positions for one or more features within the environment. The processor computes, from the image data, one or more constraints based on features observed from multiple poses of the electronic device along the trajectory, and computes updated state estimates for the position of the electronic device in accordance with the motion data and the one or more computed constraints without computing updated state estimates for the features for which the one or more constraints were computed.

Abstract: Disclosed herein are nanostructured plasmonic materials. The nanostructured plasmonic materials can include a first nanostructured layer comprising: a first layer of a first plasmonic material permeated by a first plurality of spaced-apart holes, wherein the first plurality of spaced apart holes comprise a first array; and a second nanostructured layer comprising a second layer of a second plasmonic material permeated by a second plurality of spaced-apart holes, wherein the second plurality of spaced apart holes comprise a second array; wherein the second nanostructured layer is located proximate the first nanostructured layer; and wherein the first principle axis of the first array is rotated at a rotation angle compared to the first principle axis of the second array.

Abstract: A system and method for patient-adaptive hemodynamic management is described. One embodiment includes a system for hemodynamic management including transfusion, volume resuscitation with intravenous fluids, and medications, utilizing monitored hemodynamic parameters including the described dynamic predictors of fluid responsiveness, and including an intelligent algorithm capable of adaptation of the function of the device to specific patients.

Abstract: Methods are provided for treating a subject with a therapeutic dose of anti-CD47 agent by administering a primer agent prior to administering a therapeutically effective dose of an anti-CD47 agent to the subject.

Abstract: Soil contamination by heavy metals constitutes an important environmental problem, whereas field applicability of existing remediation technologies has encountered numerous obstacles, such as long operation time, high chemical cost, large energy consumption, secondary pollution, and soil degradation. A design and demonstration of a method is provided which is based on asymmetrical alternating current electrochemistry (AACE) that achieves high degrees of contaminant removal for different heavy metals (Cu, Pb, Cd) at different initial concentrations (from 100 to 10,000 ppm), all reaching corresponding regulation levels for residential scenario after rational treatment time (from 30 min to 6 h). No excessive nutrient loss in treated soil was observed and no secondary toxic product was produced. Long-term experiment and plant assay showed the high sustainability of the method and its feasibility for agricultural use.

Abstract: Various embodiments for a foldable quad-rotor (FQR) inspired by an origami mechanism are disclosed herein. The FQR can fold its arms during flight to enable aggressive turning maneuvers and operations in cluttered environments. A dynamic model of folding is built for this system with the collected data, and a feedback controller is designed to control the position and orientation of the FQR. Lyapunov stability analysis is conducted to show that the system is stable during arm folding and extension, and motion planning of the FQR is achieved based on a modified minimum-snap trajectory generation method.

Abstract: The present invention is directed to compositions including the cytokines IL-18 and IL-22 or biologically active fragments or variants thereof. In some embodiments, the compositions further include a pharmaceutically acceptable carrier. The compositions can farther include other interleukins such as IL-1?, and IL-1? can be used as a combination therapy with either IL-18 or IL-22 or biologically active fragments or variants thereof.

Abstract: The present invention provides novel methods and compositions for use in preventing infection with at least one type of influenza virus, including the use of peptides or compositions comprising a peptide comprising, consisting or consisting essentially of an amino acid sequence selected from the group of sequences as shown in SEQ ID Nos: 1 to 53, or functional derivatives or homologues thereof.

Abstract: Embodiments of the present application disclose a safety control method and a safety control system based on environmental risk assessment for an intelligent connected vehicle. The method includes: when a vehicle is in an automatic driving mode, acquiring environmental parameter information of the vehicle in a current driving environment; determining a target driving control parameter which meets a preset safe driving condition under the current environmental parameter; and managing a current automatic driving level of the vehicle by using the target driving control parameter.

Abstract: This disclosure relates to the use of kinase inhibitor to treat or prevent infectious diseases such as tuberculosis. In certain embodiments, this disclosure relates to treating or preventing an infectious disease comprising administering an effective amount of a kinase inhibitor or other compound disclosed herein to a subject in need thereof. In certain embodiments, the disclosure relates to methods of treating or preventing tuberculosis comprising administering a kinase inhibitor to a subject in need thereof. In certain embodiments, the subject is diagnosed with Mycobacterium tuberculosis (Mtb) that is resistant to multiple antibiotic agents.

Abstract: A sea wave generating device includes a floating base, a generating assembly, a driving assembly, and a guiding housing. The floating base includes a base body and a cover plate. The generating assembly is secured in the base body and includes a lower magnetic wheel and a power generator. The driving assembly includes an upper magnetic wheel and a blade wheel. The upper magnetic wheel and the lower magnetic wheel are attracted magnetically. The guiding housing is secured to the base body and rests on the cover plate. The guiding housing covers the blade wheel and the upper magnetic wheel. Thus, when the sea wave is introduced into the guiding housing, the seawater pushes the blade wheel which drives the upper magnetic wheel which drives the lower magnetic wheel which drives the power generator to generate an electric power.