Abstract: This disclosure relates bis-amine compounds disclosed herein and uses related to CXCR4 inhibition. In certain embodiments, the compounds have formula I, salts, derivatives, and prodrugs thereof wherein, A is an bridging aryl or heterocyclyl and R1 and R2 are further disclosed herein. In certain embodiments, the disclosure contemplates pharmaceutical compositions comprising compounds disclosed herein. In certain embodiments, the disclosure relates to methods of treating or preventing CXCR4 related diseases or conditions by administering an effective amount of a compound disclosed herein to a subject in need thereof.

Abstract: A method of removing one or more antibiotics from a dairy product, the method involve passing the dairy product comprising an antibiotic in a first amount through a bulk comprising, relative to a total bulk weight, at least 75 wt. % of titanium oxide nanostructures, to provide the dairy product comprising the antibiotic in a second, lesser amount, wherein the nanostructures have lengths at least two-fold in excess of their width and height. Bulk materials useful in this or related methods or applications may have loosely tangled, noodle-like morphologies on sub-100 nm scale, and need not employ graphene and/or polymeric support networks in columns, generally having only titanium oxides without silicon or iron oxides.

Abstract: Various embodiments of a computer-implemented framework for predicting exploitation of software vulnerabilities are disclosed.

Abstract: A method of applying a gas-impermeable coating includes forming a polyelectrolyte complex suspension. The polyelectrolyte complex suspension is applied to a substrate. The substrate having the polyelectrolyte complex applied thereon is treated. The treating reduces salt content of the polyelectrolyte complex. The treating results in a gas-impermeable coating being formed on the substrate.

Abstract: A curable composite material containing nanodiamonds, denture bases and other dental prosthetics made from the composite material and methods for treating dental stomatitis using these prosthetics.

Abstract: Disclosed is a fusion polypeptide for inhibiting neovascularization, including a peptide specifically binding to vascular endothelial growth factor (VEGF) receptors, and a hydrophilic elastin-based polypeptide (hydrophilic EBP) linked to the peptide.

Abstract: An analog neuromorphic circuit is disclosed, having input voltages applied to a plurality of inputs of the analog neuromorphic circuit. The circuit also includes a plurality of resistive memories that provide a resistance to each input voltage applied to each of the inputs so that each input voltage is multiplied in parallel by the corresponding resistance of each corresponding resistive memory to generate a corresponding current for each input voltage and each corresponding current is added in parallel. The circuit also includes at least one output signal that is generated from each of the input voltages multiplied in parallel with each of the corresponding currents for each of the input voltages added in parallel. The multiplying of each input voltage with each corresponding resistance is executed simultaneously with adding each corresponding current for each input voltage.

Abstract: A cranial bio-model including a skull layer and a dura layer and method of manufacturing a cranial bio-model. A three dimensional bio-model for simulating a simulated cranial surgical procedure, the bio-model comprises a synthetic skull layer, a synthetic dura layer under the synthetic skull layer, and a spacer layer between the synthetic skull layer and the synthetic dura layer. The bio-model may be manufactured based on medical image data using three-dimensional printing.

Abstract: Disclosed herein are anti-IgE antibodies having low binding affinity to human IgE and compositions and methods thereof. In some embodiments, the present invention provides a composition comprising one or more humanized low affinity anti-IgE antibodies (hLAAIGEs) and a pharmaceutically acceptable carrier. In some embodiments, the present invention provides a method of treating a subject for an IgE-mediated disorder, which comprises administering to the subject one or more hLAAIGEs or a composition thereof. In some embodiments, the IgE-mediated disorder is an allergic reaction.

Abstract: An ionizing radiation detector includes a first common semiconductor substrate and a first plurality of single-photon avalanche diode (SPAD) microcell structures disposed at a top face of the first common semiconductor substrate. Each SPAD microcell structure includes a first semiconductor junction that is reverse-biased beyond a first breakdown threshold. The ionizing radiation detector may also include common anode and cathode connections to each of the SPAD microcell structures that operate as an output. The ionizing radiation detector may also include control circuitry connected to the SPAD microcell structures. The control circuitry may be configured to control biasing of the SPAD microcell structures and measure electrical characteristics of a signal provided on the output. Charge drift within the first common semiconductor substrate need not be inhibited from exciting more than one of the SPAD microcell structures of the first plurality of SPAD microcell structures by isolation barriers.

Abstract: In general, the present disclosure is directed to methods for synthesizing vanadium oxide nanobelts, as well as the corresponding chemical composition of the vanadium oxide nanobelts. Also described are materials which can incorporate the vanadium oxide nanobelts, such as including the vanadium oxide nanobelts as a cathode material for use in energy storage applications (e.g., batteries). The vanadium oxide nanobelts described herein display structural characteristics that may provide improved diffusion and/or charge transfer between ions. Thus, batteries incorporating implementations of the current disclosure may demonstrate improved properties such as higher capacity retention over charge discharge cycling.

Abstract: Antibodies exhibiting a specific genetically modified signature associated with certain diseases of the central nervous system, like multiple sclerosis (MS) and clinically isolated syndrome have been identified. These antibodies recognize and bind with certain tissues in the brain and central nervous system and thus are useful as therapeutics, in the production of animal disease models, targets for therapies and as part of assays of the central nervous system.

Abstract: A contrast-enhanced digital tomosynthesis system with a source configured to emit penetrating particles toward an object, a detector configured to acquire a series of projection images of the object in response to the penetrating particles from the source, a positioning apparatus configured to position the source relative to the object and the detector, and an imaging system coupled to the source, the detector, and the positioning apparatus. The imaging system is configured to control the positioning apparatus to position the source and detector relative to the object, control the source and the detector to acquire the series of projection images, and construct a tomographic volume capable of exhibiting super-resolution morphology and contrast-enhancement arising from injection of an exogenous contrast agent from data representing the acquired series of projection images or a subset thereof.

Abstract: In one embodiment, a robotic end effector configured to mount to a robotic manipulator includes gripping elements configured to grasp objects, a drive mechanism configured to open and close the gripping elements, a central controller configured to control operation of the drive mechanism and the gripper elements, the central controller hosting a control program that enables control of the end effector independent of the robotic manipulator, and at least one of a forward-facing ultrasonic distance sensor configured to measure a distance between the gripping elements and an object to be grasped, and a forward-facing camera mounted between the gripping elements configured to capture video data of an object to be grasped.

Abstract: The present invention relates to a fault-tolerant modular permanent magnet assisted synchronous reluctance motor (PMaSynRM) and provides a modular winding connection method. The modular winding connection is to change the positions of inlet and outlet coils based on the slot electrical potential star vectogram. Then, each module has a separate set of winding and the left and right relative distribution will be adopted on the winding connection. The invention has the advantages of modularization in structure, high independence between the modules, effectively avoiding overlapping of magnetic lines between the modules, and improving fault tolerance and reliability of the motor. The invention has the advantages of modularization in structure, high independence between the modules, magnetic decoupling between the modules, and improvement of fault tolerance and reliability of the motor.

Abstract: Disclosed herein are systems and methods for modeling controversy as a combination of at least contention and importance with respect to a given population. An example system for modeling controversy within a population includes an interface, memory, and processor. The interface is configured to obtain information regarding stances of individuals in the population on a topic. The processor is configured to determine, and store in the memory, a representation of contention on the topic among individuals of the population. The representation of contention is based on the stances of individuals in the population. The processor is further configured to determine, and store in the memory, a representation of importance of the topic within the population. The processor is configured to create, and store in the memory, a model of controversy for the topic based on the representations of contention and importance.

Abstract: Provided are a method for preparing an InGaN-based epitaxial layer on a Si substrate (12), as well as a silicon-based InGaN epitaxial layer prepared by the method. The method may include the steps of: 1) directly growing a first InGaN-based layer (11) on a Si substrate (12); and 2) growing a second InGaN-based layer on the first InGaN-based layer (11).

Abstract: Natural and/or synthetic antibodies for specific proteins are adhered to nanoparticles. The nanoparticles are adhered to a substrate and the substrate is exposed to a sample that may contain the specific proteins. The substrates are then tested with surface enhanced Raman scattering techniques and/or localized surface plasmon resonance techniques to quantify the amount of the specific protein in the sample.

Abstract: A method of improving a ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCo) to have a higher protein score is disclosed. The method includes the steps of: making a modified RbcL of the RuBisCo, by, on an RbcL unit of the RuBisCo, either substituting Met for Leu, Phe, Val, or Ile or combinations thereof; substituting Lys for Arg, Thr, or His or combinations thereof; or both of these substitutions. The modified RbcL consequently modifies the RuBisCo and is added to a biomass host where it is stable for homologous recombination. Plastid and nucleus integration was observed. Example RbcL sequences are disclosed with the desirable substitutions. The improved RuBisCo can be used as an improved proteinaceous food source for humans and animals.

Abstract: A well cleanup process involves removing an impermeable filter cake from a formation face with thermochemical and chelating agents to allow formation fluids to flow from a reservoir to a wellbore. The method may be used with oil and water-based drilling fluids with varied weighting agents, e.g., bentonite, calcium carbonate, or barite. Such thermochemical agents may involve two salts, e.g., NO2? and NH4+, which, when mixed together, can generate pressure and heat, in addition to hot H2O and/or N2. For example, the thermochemical agents may comprise Na+, K+, Li+, Cs+, Mg2+, Ca2+, and/or Ba2+ with NO2? and NH4+ with F?, Cl?, Br?, I?, CO32?, NO3?, ClO4?, and/or ?OH.