Abstract: A brain measurement apparatus includes: a static magnetic field forming unit for forming a static magnetic field in a measurement area; a gradient magnetic field coil for forming a gradient magnetic field in the measurement area; a transmission coil for transmitting a transmission pulse toward a subject in the measurement area; a detection coil for detecting a nuclear magnetic resonance signal generated in the subject by transmission of the transmission pulse; and a generator for generating an MR image based on the nuclear magnetic resonance signal detected by the detection coil.

Abstract: The present invention relates to a technique for effective intranasal delivery to the brain. More specifically, the present invention is used for diagnosing, preventing or treating central nervous system encephalopathy, neurodegenerative diseases or brain tumor by effectively delivering to the brain a pH-responsive and bioreducible PPA polymer, which can be used as a drug carrier, by means of nasal administration.

Abstract: The present invention discloses a numerical simulation method for proppant transport considering wall-retardation effect, comprising the followings: establish a physical model of laboratory experiment on proppant transport with a large flat-panel device; establish a drag coefficient model considering wall-retardation effect according to the numerical simulation experiment; establish a computational geometric model; set boundary conditions and physical parameters of the geometric model according to the two-fluid simulation method for solid proppant quasi-fluidization; verify the grid independence of the computational geometric model to obtain the transport characteristics and placement pattern of the proppant in fractures. The present invention employs a numerical simulation method to study the migration and distribution patterns of proppant under the retardation effect of narrow walls during the hydraulic fracturing.

Abstract: A method for treating a cancer of similar or same histological type is provided. The method includes administering a xenogeneic tissue cell composition to a subject in need for a treatment of the cancer of similar or same histological type. The xenogeneic tissue cell composition does not include a tumor cell, and the xenogeneic tissue cell composition is administered to the cancer of the similar or same histological type by an intralesional route.

Abstract: The invention provides a compound of formula (I): or a pharmaceutically acceptable salt, stereoisomer, solvate, or prodrug thereof, wherein R1-R6 have any of the values described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as contraceptive agents.

Abstract: A brain measurement apparatus configured to generate an MR image and a brain's magnetic field distribution of a subject includes: an MRI module having a transmission coil configured to transmit a transmission pulse toward the subject and a detection coil configured to detect a nuclear magnetic resonance signal generated in the subject by the transmission pulse; an optically pumped magnetometer configured to detect a brain's magnetic field of the subject; a generator configured to generate the MR image based on the nuclear magnetic resonance signal detected by the detection coil and generating the brain's magnetic field distribution based on the brain's magnetic field detected by the optically pumped magnetometer; a marker displayed on the MR image generated by the generator; and a helmet-type frame to which the detection coil, the optically pumped magnetometer, and the marker are attached and which is attached to a head of the subject.

Abstract: In certain embodiments a lentiviral vector for the treatment of Recombination-Activating Gene 1 Severe Combined Immunodeficiency (RAG1 SCID) is provided. In certain embodiments the vector comprises an expression cassette comprising a nucleic acid construct comprising an effective fragment of the endogenous promoter of the RAG1 gene and a nucleic acid that encodes the RAG1 protein operably linked to the effective fragment of the endogenous promoter of the RAG1 gene.

Abstract: A loading system for a Hopkinson pressure bar test under water-gas-temperature multi-field coupling action includes: a sample sealed cabin which includes sealing flanges, Y-shaped and high-temperature resistant sealing rings, and a sealed cabin body; a gas pressure loading device which includes a high-pressure gas tank, a pressure regulating valve, a second barometer, a second high-pressure valve and a first three-way valve connected in sequence; a water pressure loading device which includes an electric pressure test water pump, a water pressure gauge, an accumulator and a one-way valve connected in sequence; a temperature loading device which includes thermocouple heating rods, a temperature display and a thermocouple temperature control circuit board connected in sequence; and a dynamic and static combined loading device which includes an axial pressure loading device, an impact loading device and a Hopkinson pressure bar member.

Abstract: A system or method for compressing continuous glucose monitor (CGM) data for a subject and/or a technician, clinician, or for use with an interventional device. The system or method configures the CGM data to allow the subject, technician, clinician, or interventional device to take a physical action in response to receiving a transmission to improve the safety and/or efficacy of therapy for the subject.

Abstract: The present invention provides methods and compositions for treatment of prion disease.

Abstract: The current disclosure provides polypeptide, nucleic acid, compositions, and methods for treating or preventing CRS in patients in need thereof, particularly for those receiving an immunotherapy, such as a cancer immunotherapy, that may provoke a CRS response. Accordingly, aspects of the disclosure relate to a chimeric binding polypeptides comprising a heavy chain variable region comprising CDR1, CDR2, and CDR3 attached by a heterologous linker to a light chain variable region comprising CDR4, CDR5, and CDR6.

Abstract: Compositions that include anti-cancer, anti-tumor, and anti-microbial infection peptides are provided. In some embodiments, the compositions include 1-10 or more synthetic peptides that are between 8 and 50 amino acids long and include an amino acid sequence as disclosed herein.

Abstract: Aspects include systems having an intravenous fluid bag, a tubing line assembly including tubing connected to a connector and a purge valve assembly including a spike and an outer housing. The outer housing is connected to the spike and includes a receiving end portion configured to receive the connector. The purge valve assembly further has a check valve provided within the outer housing. Generally, the purge valve assembly interconnects the fluid bag to the fluid tubing assembly for removal of air from the fluid bag prior to connection to the tubing line assembly. Various methods and purge valve assemblies provide a rapid infusion system for use. The purge valve assemblies do not require the user to reinsert the connector or spike into the intravenous fluid bag, creating a sterile solution to preparing the intravenous fluid for rapid infusion while reducing the risk of air emboli.

Abstract: The present invention provides a method for assessing the possibility of onset or progression of chronic kidney allograft rejection or chronic kidney disease in a test subject, by using, as an indicator, the level of SYT17 protein in a urine-derived specimen collected from the test subject. The present invention also provides: a pharmaceutical composition for preventing and/or treating chronic kidney allograft rejection or chronic kidney disease, the pharmaceutical composition including at least one substance selected from the group consisting of a specific antibody to SYT17, a derivative of the specific antibody, and an inhibitory nucleic acid against SYT17; and a test kit for use in assessing the possibility of onset or progression of chronic kidney allograft rejection or chronic kidney disease, the test kit including a specific antibody to SYT17 or a derivative of the specific antibody.

Abstract: The invention concerns a software based system for computer-aided design (CAD) that includes user interface tailoring and methods for continuously evaluating the learning progress of the user and increase work productivity by searching for the patterns in the user input to predict the goal of user actions and propose next action to reach the goal in optimal way. Components of the presented invention relate to collection of the different user input including at least eye tracking and user focus and attention related features; analyzing continuously user's behavior to evaluate user learning progress and work productivity related to the computer-aided design tool; monitoring user interface components that are used by the user; searching for the patterns in user behavior; tailoring user interface controls to maximize a work productivity at the same time increasing user's qualification profile.

Abstract: A device and a method for generating a machine translation model and a machine translation device are disclosed. The device inputs a source training sentence of a source language and a dictionary data to a generator network so that the generator network outputs a target training sentence of a target language according to the source training sentence and the dictionary data. Then, the device inputs the target training sentence and a correct translation of the source training sentence to a discriminator network so as to calculate an error between the target training sentence and the correct translation according to the output of the discriminator network, and trains the generator network and the discriminator network respectively. The trained generator network is the machine translation model.

Abstract: A metal sequestering material can be contacted with a reaction mixture of a metal-catalyzed reaction to remove transition metals or transition metal complexes. The reaction mixture contains transition metals and a reaction product in solution. These transition metals may be, for example, Pd, Ir, Ru, Rh, Pt, Au, or Hg. The concentration of transition metals in the reaction mixture is reduced to less than 100 ppm or even less than 10 ppm.

Abstract: A transconductance amplifier (TCA) implemented with high electron mobility transistors (HEMTs) in a push-pull amplifier output stage provides a voltage controlled constant high output current to loads ranging from 10 m? to 1? with a bandwidth of 25 MHz. A driving stage for the HEMTs is implemented with variable gain amplifiers that amplify the input voltage signal and provide bias for the HEMTs. An automatic gain control may be connected between the TCA output and the variable gain amplifiers to ensure a constant current output for a varying load.

Abstract: The invention concerns a scalable, large-scale castanospermine preparation method that yields levels of purity greater than 98% from castanospermine-containing plant sources, such as Castanospermum australe seed material.

Abstract: A device communicates via Wi-Fi with a central function device. The function device has information regarding all the various remote controls needed by the consumer. The function device communicates wirelessly with the device and in turn then operates all of the consumer's electronic devices.