Abstract: Disclosed are a composition and a method for diagnosing breast cancer using extracellular vesicle-miRNA. The composition for diagnosing the breast cancer according includes an agent that measures an expression level of at least one miRNA selected from a group consisting of miR-9, MiR-16, MiR-21, and MiR-429. Furthermore, the method for diagnosing breast cancer includes measuring an expression level of at least one miRNA selected from a group consisting of MiR-9, MiR-16, MiR-21, and MiR-429 from a sample, and diagnosing the breast cancer based on the measurement result.

Abstract: An electrochemical cell includes an anode, a cathode and an electrolyte in contact with the anode and the cathode, wherein the electrolyte and at least one of the anode or the cathode includes a compound which compound includes either an amino group or a carboxyl group or both (preferably an amino acid, a peptide, or a combination thereof). Alternatively, if the anode is formed from a combination of a metal and a metal oxide, then the electrolyte and/or at least one of the anode or the cathode can include said compound (i.e. it does not have to be present on both). Use of these cells significantly reduces the overpotential of the electrochemical splitting of water, thereby enabling the production of hydrogen in a much more energy efficient manner.

Abstract: In some embodiments, initial feedback indicating threshold characteristics (under which a user sees initial stimuli presented on a user interface) may be provided to a prediction model, and a set of predicted characteristics (for a set of locations of the user interface) may be obtained via the prediction model. Based on predicted characteristics associated with one or more selected locations, stimuli may be presented at the selected locations during the visual test presentation. Visual defect information for the user may be generated based on feedback from the visual test presentation. In some embodiments, the selection of the locations to be tested during a visual test presentation may be performed based on a set of confidence scores associated with the predicted characteristics. As an example, the locations may be selected over one or more other locations of the set of locations based on the set of confidence scores.

Abstract: A compound having a formula of M(LA)x(LB)y(LC)z is provided. In the formula, each of LA, LB, and LC is a bidentate ligand; M is a metal; LA has a structure of Formula I, moiety A is a monocyclic ring or a polycyclic fused ring system; moiety B is a polycyclic ring system comprising two 6-membered rings; Z1 to Z4 are C or N; K1 and L1 are each a direct bond or a linker; each R?, R?, RA and RB is hydrogen or a General Substituent; at least one RA or RB comprises RW, where RW has a structure of Formula II, or Formula III, In formulas II and III, R1 and R2 are H, D, or F; R3 is H, D, or alkyl; and at least one of R1 or R2 is H or D. Formulations, OLEDs, and consumer products containing the compound are also provided.

Abstract: The present invention is related to a use of prochlorperazine (PCP), or analog thereof for treating a cancer in a subject by influencing membrane proteins and receptors and inducing alterations in the expressions of the surface marker on cancer cells and their derived extracellular vesicles. The invention method offers a novel approach for the treatment and diagnosis of cancer and metastasis. Specific surface markers serve as a potential candidate for cancer-associated extracellular vesicles (EVs) and have applications in diagnosis, prognosis, and therapeutic targeting.

Abstract: A complex for treating cancer includes a 2-(di-tert-butylphosphino)biphenyl ligand and a bis(diphenylphosphino)alkane ligand. The complex is dinuclear having two gold atoms, wherein the 2-(di-tert-butylphosphino)biphenyl ligand and the bis(diphenylphosphino)alkane ligand are bonded to the gold atoms, and wherein the bis(diphenylphosphino)alkane ligand is bridging the two gold atoms.

Abstract: Disclosed are example efficient circuits that produce spark discharges for hydrocarbon conversion (or treatment of other mixtures) using a high-voltage rectified DC supply to discharge a capacitor (either internal or external) across a two-electrode gap, optimized to minimize waste energy by operating in a constant current, approximately-constant current, or constant power mode. The circuits may operate off of a standard electrical supply line (e.g. 120 VAC or 240 VAC, 60 Hz, single-phase or multi-phase). The disclosed approach is scalable to any number of discharge gaps while maintaining similar pulse characteristics and electrical efficiency.

Abstract: A metal hydride storage system (MHSS) and a method for refueling the MHSS includes obtaining a parameter vector comprising a first state of a metal hydride storage system (MHSS), and a measurable output of the MHSS; sending the parameter vector to a control algorithm, wherein the control algorithm includes a first data structure and a second data structure, wherein the first data structure corresponds to a plurality of critical regions, wherein the second data structure corresponds to a plurality of piecewise affine functions, wherein the affine functions corresponds to a control action; searching the first data structure with the parameter vector; selecting a critical region based on searching the first data structure; selecting, from the second data structure, a piecewise affine function corresponding to the selected critical region; and calculating a control action based on the affine function, where the control action comprises controlling at least one controlled parameter.

Abstract: A system for navigating a virtual environment using seated walking-in-place footstep locomotion includes a virtual reality device, a first sensing device, and a second sensing device. The first sensing device senses the first footstep locomotion of one of feet of a user seated in a physical environment to generate and transmit a first stepping signal to the virtual reality device. The second sensing device senses the second footstep locomotion of another of the feet of the user seated in the physical environment to generate and transmit a second stepping signal to the virtual reality device. The virtual reality device navigates the virtual environment in a virtual locomotion mode based on a combination of the first stepping signal and the second stepping signal.

Abstract: The present disclosure describes a self-sprayer device for self-administering an animal product to an animal and providing environmental enrichment to the animal.

Abstract: An accurate and precise surgical guide for dental procedures, especially a procedure involving a subject with few or no teeth as well as methods for making and use of such guides.

Abstract: The present disclosure provides methods, uses, kits, and compositions comprising a compound of Formula (I), and either a second compound of Formula (I) or a compound of Formula (II). In one aspect, the methods are for treating a neurological disease associated with repeat expansions and/or RAN protein accumulation, reducing the level of one or more repeat associated non-AUG (RAN) proteins, and reducing the accumulation of RAN proteins in a subject and/or biological sample. Exemplary diseases associated with repeat expansions include, but are not limited to, amyotrophic lateral sclerosis (ALS), frontotemporal dementia, myotonic dystrophy type 1, myotonic dystrophy type 2, spinocerebellar ataxia, Alzheimer's disease, Huntington's disease, Fragile X Tremor Ataxia Syndrome, and Fragile XE syndrome.

Abstract: The avirulent strain A257 of the bacterial rice pathogen Burkholderia glumae is an effective priming material to reduce or suppress major diseases in rice and other plants. Protection includes that against bacterial panicle blight, sheath blight, and narrow brown leaf spot. A mutant derivative of A257, A257?qsmR, significantly reduces the risk that the priming agent might potentially revert to wild-type pathogenicity.

Abstract: A strap member is provided and includes a strap body and a plurality of hook portions. The strap member includes a first surface and a second surface. Each of the plurality of hook portions includes a hole structure and at least one hook structure. The hole structure penetrates through the strap body and includes a first opening formed on the first surface and a second opening formed on the second surface. The at least one hook structure is at least partially disposed inside the hole structure and connected to a hole wall of the hole structure. Besides, a related strap assembly is also provided.

Abstract: Provided herein are compositions and methods for preventing or reducing CARPA in a subject in need thereof. In one aspect, the composition comprises a therapeutic molecule, diagnostic molecule, molecular complex, or nanoparticle having a complement inhibitory protein attached thereto.

Abstract: In a pipeline inspection system, a hollow spherical ball has an internal ultrasonic vibration module, an internal battery for powering the vibration module, and an internal, wirelessly operated, control for controlling the vibration module while the ball is moving, with liquid, along the pipeline. Liquid, having a reduced oxygen content, is pumped through the pipeline, and filtered before returning to the pipeline. Each of a plurality of holes, connecting the interior to the exterior of the ball, is tapered proceeding in the direction from the interior to the exterior, resulting in the formation of a blade structure where the interior of each hole meets the outer surface of the ball at an inclined angle. When the blade structure is in contact with the wall of the pipe, and caused to vibrate by the vibration module, it is able to cut off scale from the interior of the pipe.

Abstract: An electronic device and method are provided. The method includes, in response to a result of a performed determination, between a processing-in-memory (PIM) operation and a non-PIM operation, being that a target operation included in an instruction set is the PIM operation, loading information regarding a PIM operation type of the target operation to a PIM operation register of an accelerator of the electronic device based on a performed determination that input data, for use in the target operation, is arranged in a memory of the accelerator according to a characteristic of the target operation, and controlling, using a PIM operation execution instruction, one or more PIM processing elements (PEs) of the memory to perform the target operation using the arranged input data and the information regarding the operation type loaded in the PIM operation register.

Abstract: A semiconductor device with multiple zero differential transconductance includes: a conductive substrate; a first insulating layer and a second insulating layer disposed on the conductive substrate; a first semiconductor and a second semiconductor disposed on first portions of the first insulating layer and the second insulating layer, respectively; a first buffer layer and a second buffer layer disposed on electrode contact areas of the first semiconductor and the second semiconductor, respectively; and an anode electrode and a cathode electrode disposed on second portions, which are different from the first portions, of the first insulating layer and the second insulating layer and on the first buffer layer and the second buffer layer, respectively, wherein the first semiconductor and the second semiconductor are disposed in parallel with each other and connected by the anode electrode and the cathode electrode.

Abstract: A method for administering a composition for exploiting natural gas hydrates. The method includes the following steps: injecting the reagent A into the tube A; injecting the reagent B into the tube B; stretching the tube A and the tube B into a hydrate reservoir by using a reagent injection instrument; regulating a flow rate according to a proportion of each component; allowing the reagents to react at a preset reservoir position; and allowing water in the reservoir to participate in the reaction at the same time, wherein a reaction product is used for supporting the reservoir.

Abstract: A far infrared (FIR)-emitting composition includes a first polymer component and a silicon dioxide composite particle which is prepared by subjecting a tetraalkoxysilane and a compound represented by Formula (A) to hydrolysis and condensation polymerization: Y—Si(ORa)3??(A), wherein each Ra independently represents a C1-4 alkyl group or a C1-4 alkanoyl group, Y represents X—R1—, a non-substituted C1-18 linear alkyl group or a non-substituted C3-18 branched alkyl group, and X and R1 are defined as set forth in the Specification and Claims. A FIR-emitting fiber including the FIR-emitting composition is also disclosed.