Abstract: The present disclosure provides a method for in-situ synthesizing tungsten carbide powder. In this method, cemented carbide scrap is used as an electrode and the molten salt electrolysis process is used to in-situ synthesize tungsten carbide powder, where a bidirectional pulse is used in the molten salt electrolysis process. In the method provided by the present disclosure, by using the bidirectional pulse and using the cemented carbide scrap as electrode in the molten salt medium, when the tungsten carbide scrap is oxidized, tungsten is dissolved in ionic form, deposited after the direction of current changes, and reacted with the carbon anode sludge in situ to generate tungsten carbide powder.

Abstract: An electrode includes an electrically conductive porous graphene core; a silicon layer disposed on an internal surface of the porous graphene core; and an ion-conductive hybrid silicate layer disposed on the silicon layer.

Abstract: One aspect of the disclosure relates to a cargo delivery system comprising an autophagy targeting ligand and a target-binding ligand. In one aspect of the disclosure, by comprising an autophagy targeting ligand, cargo, which is a target-binding ligand that specifically binds to a target, is delivered to the p62 protein and autophagy is activated, so that depending on the type of target-binding ligand used, a target to be degraded can be selectively and directly removed. Accordingly, the cargo delivery system according to an aspect of the disclosure may be used in pharmaceutical compositions or food compositions for preventing, alimerating, and treating various diseases.

Abstract: A biodegradable composite comprising a polymeric matrix including but not limited to poly lactide (PLA), poly (butylene succinate) 20 (PBS), poly(butylene succinate adipate) (PBSA), including bio-based PBSA (BioPBSA), poly(butylene adipate-co-terephthalate) (PBAT), polycaprolactone (PCL), polyhydroxyalkanoate (PHA(s)), poly(3-hydroxy)butyrate (PHB), poly(3-hydroxy-butyrate-hydroxyvalerate) (PHBV), copolyester of the monomers 1.4-butanediol, adipic acid and terephthalic acid (Ecoflex™) and polypropylene carbonate (PPC), and biocarbon, a.k.a. biochar or pyrolyzed biomass as a sustainable filler. The biodegradable composite achieves high oxygen barrier with balanced water barrier. Also, a method of manufacturing the biodegradable composite and articles of manufacturing comprising the biodegradable composite. The articles of manufacturing have application in limiting gas permeation into a package and extending shelf life of a material.

Abstract: The present invention relates to a method for preparing a transparent metallopolymer-based coating solution having excellent durability as well as excellent antifogging and antibacterial properties. The method for preparing a coating solution of the present invention comprises the steps of: adding an ultraviolet radical initiator, TMSH (trimethylolpropane tris(3-mercaptopropionate), and TESPMA (3-(trimethoxysilyl)propyl methacrylate) into a solvent containing ethyl acetate or acetone; irradiating the solution with ultraviolet rays to cause a polymerization reaction; and adding a metal precursor to the resulting solution, and then stirring same under a nitrogen atmosphere.

Abstract: An information processing device classifies a plurality of linear models, each of which includes one or more variables, into a plurality of groups in such a way that the linear models which include identical variables included in each of the plurality of linear models and which have identical coefficient encoding with respect to the variables are grouped in the same group, outputs a first question used in deciding degree of importance of each explanatory variable included in training data which is used in training of the plurality of linear models, and, decides on an explanatory variable about which a second question is to be asked, when a linear model in which the degree of importance is reflected is to be selected from the plurality of linear models, based on extent of decrease in number of target groups for selection according to an answer to the first question.

Abstract: With the aim of proving an antibacterial composition against oral bacteria and the like capable of inducing Th1 cell proliferation or activation in an intestinal tract, the present inventors have found out that bacteria that suppress colonization and the like of the oral bacteria and the like in the intestinal tract are present in an intestinal microbiota. Moreover, the present inventors have succeeded in isolating intestinal bacteria that suppress intestinal colonization and the like of oral bacteria and the like.

Abstract: A system and method for gene editing by using an engineered cell are provided. The system includes the engineered cell embedded with a synthetic protein receptor and a target cell. The engineered cell contains a CRISPR/CasRx system and a sgRNA gene sequence. The synthetic protein receptor includes an extracellular target cell recognition domain, a native Notch core domain, an intramembranous hydrolyzable polypeptide and effectors. The extracellular target cell recognition domain can recognize antigen molecules on the target cell surface; and the effectors act as transcription factors for CasRx enzyme and sgRNAs. CasRx and gRNA are expressed in the engineered cell for gene editing to edit mRNA of the target cell. In this way, the application range of the engineered cell is expanded, the pertinence and specificity of gene editing are improved, the off-target effect is reduced, the collective non-specific reaction is reduced, and the safety of gene editing is improved.

Abstract: Provided is a resource monitoring apparatus including a log generation unit for extracting a method requested from a hardware abstraction layer and generating a log; a log classification unit for classifying the generated log according to a type of an interface connected to the method; and a log determination unit for identifying a malicious activity from the classified log based on pattern information of the log set differently depending on the type of the interface.

Abstract: The present invention relates to a ?LED light emitting device without electrical contact based on a wavelength down-conversion. The ?LED light emitting device without electrical contact comprises ?LED crystal grains, wavelength down-conversion light emitting lavers, ate upper driving electrode and a lower driving electrode, insulators, an optical micro-structure and a control module. The upper driving electrode and the lower driving electrode are free from direct electrical contact with each of the ?LED crystal grains, the control module is electrically connected with the upper driving electrode and the lower driving electrode respectively to provide alternating driving signals to the upper driving electrode and the lower driving electrode so as to form a driving electric field, and the driving electric field controls an electron-hole recombination of the ?LED crystal grain and emits a first light source which is converted into a second light source via the wavelength down-conversion light emitting layer.

Abstract: A computer-implemented method and system for predicting orthodontic results based on landmark detection includes: acquiring a crown point cloud, a set of tooth point clouds, and tooth labels; extracting global dentition features and local tooth features, performing feature fusion on the global dentition features, tooth labels of individual teeth, and the local tooth features of the individual teeth to obtain fused features of the individual teeth, and extracting landmarks of the individual teeth and offset vectors from points in the tooth point clouds to the landmarks; fusing the landmarks of the individual teeth and the tooth point clouds, extracting tooth attention features, acquiring dentition attention features, and fusing the dentition attention features, the global dentition features, and the local tooth features to obtain a point cloud with fused landmarks; and acquiring pre- and post-treatment rigid transformation parameters, and obtaining a post-treatment crown model prediction result.

Abstract: The present disclosure relates to a light-emitting diode (LED) structure, and more particularly, to an LED structure having an asymmetric face, a method of manufacturing a direct-current-drivable LED electrode assembly using the same, and a direct-current-drivable LED electrode assembly manufactured thereby.

Abstract: A graphene and in-situ nano-ZrB2 particle-co-reinforced aluminum matrix composite (AMC) and a preparation method thereof are provided. The preparation method includes: heating an aluminum alloy for melting, adding potassium fluoroborate and potassium fluorozirconate to produce ZrB2 particles in-situ, additionally adding a mixture of pre-prepared copper-coated graphene and an aluminum powder, and stirring with an electromagnetic field for uniform dispersion; and ultrasonically treating the resulting melt to improve the dispersion of the in-situ nano-ZrB2 particles and the graphene, casting for molding to obtain a casting, and subjecting the casting to homogenization and rolling for deformation to obtain the graphene and in-situ nano-ZrB2 particle-co-reinforced AMC. The in-situ generation of the reinforcement nano-ZrB2 particles in an aluminum alloy melt increases the number of interfaces in the composite and also increases the dislocation density.

Abstract: The present disclosure belongs to the technical field of clean and efficient mining of deep unconventional or conventional resources, and discloses a pilot-scale supercritical water oxidation oil and hydrogen production system capable of realizing long-distance multi-stage heating of organic rock. The system comprises a supercritical water generator, a supercritical water pyrolysis reaction system for organic rock, an oxygen injection system and an oil-gas condensation and collection system, wherein the supercritical water generator mainly comprises a water injection system, a front-section preheating reaction system, a second-stage heating system and a third-stage heating system. The reaction system can carry out a pilot-scale simulation process of supercritical water pyrolysis for organic rock, a multi-stage heating function is realized, the maximum reaction distance is 8 m or more, and the release characteristics of oil-gas products under different reaction distances are explained.

Abstract: Among the various aspects of the present disclosure is the provision of methods for inhibiting neuronal activity in NF1 tumors. One aspect of the disclosure provides for a method of inhibiting tumor growth comprising administering a neuronal activity inhibiting agent to a subject in need thereof. Another aspect of the disclosure provides for a method of attenuating neuronal excitability, activity-regulated mitogen production, and tumor progression comprising administering a neuronal activity inhibiting agent to a subject in need thereof. Yet another aspect of the disclosure provides for a method of activating HCN channels in a subject comprising administering a neuronal activity inhibiting agent to a subject in need thereof. Yet another aspect of the disclosure provides for a method of treating brain or and nerve tumors in Neurofibromatosis type 1 (NF1) comprising administering a neuronal activity inhibiting agent to a subject in need thereof.

Abstract: Described herein are systems, methods and devices for implementing a temperature-aware, multi-antenna scheduler that cools mmWave devices by preventing heat buildup via switching or distributing a data stream to other redundant antennas, allowing for dissipation of heat as well as providing reliable connectivity.

Abstract: A distributed computation offloading method based on computation-network collaboration in a stochastic network is provided. The distributed computation offloading method includes: building a device revenue maximization problem model and a MEC server revenue maximization problem model based on a local computing model and an edge cloud computing model; building composite sets of scenarios for dwell time and waiting latency based on a random movement of a user and burst computation demands; compensating for a game strategy by using a posteriori recourse action and building a game-based stochastic programming model between the device and the MEC server; transforming a multi-stage stochastic regularization problem for both the device and the MEC server into a DEP problem by constructing a scenario tree, and solving the DEP problem to obtain an optimal task strategy for the offloading from the MEC server and an optimal offering strategy of the MEC server to the device.

Abstract: The aim is to provide a novel compound that can luminesce with high brightness and be used as a luminescent substrate in a firefly bioluminescence system. Provided is a heterocyclic compound, or salt thereof, represented by the following general formula (1): [R1, R2, and R3 are independently hydrogen or an alkyl group having a carbon number of 1-4, with provisos that R1 and R2 are optionally bonded to form a ring and that one of R1 and R2 is optionally bonded to Y1 to form a ring; X is S, O, NR4, or CH2, and Y1 and Y2 are independently N or CR4, where each R4 is independently hydrogen, an alkyl group having a carbon number of 1-4, an alkenyl group having a carbon number of 2-4, or an acyl group having a carbon number of 2-4; n is an integer of 0-4].

Abstract: The present disclosure relates to, inter alia, a method of treating cancer in a human patient in need thereof, comprising administering a therapeutically effective amount of a substrate of AKR1B1, AKR1B10, or both to said patient, wherein said patient has, or is suspected to have, cancer cells with elevated levels of AKR1B1, AKR1B10, or both, wherein said substrate is not 2-deoxy-D-glucose.

Abstract: The present invention provides a device for diagnosing and treating ocular deviation, comprising: an eye mask which is worn by an examinee, and in which an eye movement capturing means for capturing the eye movement of the examinee is provided; a temperature-regulating pipe which is inserted into the ear of the examinee and which increases or decreases the temperature inside the ear of the examinee; a heat source supply part for supplying a heat source to the temperature-regulating pipe from the outside in order to increase and decrease the temperature of the temperature-regulating pipe; a fixing main body which is worn by the examinee, and which has a mounting hole, in which the temperature-regulating pipe is mounted, in order to fix the temperature-regulating pipe inserted into the ear of the examinee; and a control part, which is connected to the eye movement capturing means and the heat source supply part, receives an image of the eye captured by the eye movement capturing means, and extracts center coord