Abstract: The invention includes, in part, methods and compounds for treating diseases and conditions characterized by elevated threonyl-tRNA synthetase (TARS) activity, which include, but are not limited to diseases and conditions in which angiogenesis is elevated as compared to normal. In some embodiments of the invention, a level of a TARS molecule is determined and compared to a control level of TARS to assess a treatment for a disease or condition characterized by elevated TARS activity.

Abstract: The present invention relates to antimicrobial polymyxin derivative compounds and their uses, and in particular to peptide polymyxin antibiotics which may be used in the treatment of bacterial infections such as Gram negative bacterial infections, particularly those caused by multidrug-resistant (MDR) Gram negative bacterial infections.

Abstract: A microfluidic solenoid point of use device for discrete quantitation of magnetized cells. The inventive device provides higher accuracy, lower cost, and less bulk than other counting devices.

Abstract: The present disclosure discloses an earthen dam structure including a core wall that includes a homogeneous mixture of clay, sand, powdered tire rubber and Portland cement. Additionally, the core wall contains the powdered tire rubber in an amount sufficient to increase a modulus of elasticity of the core wall to over 10 MPa while keeping a hydraulic conductivity of the core wall under 100 feet/year. The earthen dam structure further includes an upstream embankment portion and a downstream embankment portion, each positioned adjacent to the core wall, and a spillway configured to prevent water from overtopping a crest of the core wall.

Abstract: A computer-implemented method and system for determining a path arrangement of an infrastructure link. The method includes receiving one or more inputs each indicative of a constraint; and processing the one or more inputs and a set of data based on a path arrangement determination model. The set of data includes data representing one or more factors affecting the path arrangement. The method also includes determining, based on the processing, the path arrangement of the infrastructure link.

Abstract: The present disclosure provides an energy conversion system and method for generating electricity directly from heat by phase transformation of ferroelectric materials without any external power sources. The energy conversion system includes an electric circuit comprising a phase-changing capacitor and a charge reservoir. The phase-changing capacitor has a dielectric layer comprising a phase-transforming ferroelectric material. When the phase-changing capacitor is initialized and subjected to thermal cycles through a transformation temperature of the phase-transforming ferroelectric material, the polarization of the dielectric layer undergoes an abrupt change between a ferroelectric phase and a paraelectric phase such that a current flow between the phase-changing capacitor and the charge reservoir via a load thereby converting heat into electrical energy. The present energy conversion method does not require any external bias fields during the energy conversion.

Abstract: A system configured to facilitate virtual outfit fitting is described. The system includes a smart closet device having components including a display door and a plurality of image sensors. A first image sensor of the plurality of image sensors is configured to move across a horizontal axis and a vertical axis of enclosure of the smart closet device to capture a plurality of images of a first outfit hung on an outfit hanging column. The smart closet device also includes a computing unit to generate a three-dimensional (3D) model of the first outfit based on the plurality of images. The computing unit is further configured to update an outfit database by storing the generated 3D model of the first outfit in an outfit database. The computing unit generate an image of a user wearing the output in response to receiving a selection of the first output from the user.

Abstract: An automatic classification method of whole slide images (WSIs) for cervical tissue pathology based on confidence coefficient selection. The automatic classification method includes steps: S1: dividing the WSIs for the cervical tissue pathology into small pieces having set size, gathering the small pieces of each WSI into a packet, and removing blank pieces in the packets; S2: building a deep CNN model; S3: training the deep CNN for designated rounds; S4: performing sequential arrangement and connection to obtain feature vectors of WSIs by using the trained deep CNN as the feature extractor; S5: training a support vector machine classifier; and S6: processing the WSIs for the cervical tissue pathology, to be classified, through step S1 and step S4 to obtain the feature vectors of the images, and inputting the feature vectors into the trained support vector machine classifier to realize classification.

Abstract: A system and method for determining a sentiment, a gender and an age group of a subject in a video while the video is being played back. The video is separated into visual data and audio data, the video data is passed to a video processing pipeline and the audio data is passed to both an acoustic processing pipeline and a textual processing pipeline. The system and method performs, in parallel, a video feature extraction process in the video processing pipeline, an acoustic feature extraction process in the acoustic processing pipeline, and a textual feature extraction process in the textual processing pipeline. The system and method combines a resulting visual feature vector, acoustic feature vector, and a textual feature vector into a single feature vector, and determines the sentiment, the gender and the age group of the subject by applying the single feature vector to a machine learning model.

Abstract: A wavelength conversion system including: A. a first nonlinear optical crystal to which first pulsed laser light having a first polarization state and a first wavelength and second pulsed laser light having a second polarization state and a second wavelength are inputted and which is configured to output in response to the input the second pulsed laser light and first sum frequency light having the second polarization state and a third wavelength produced by sum frequency mixing of the first wavelength with the second wavelength; and B. a second nonlinear optical crystal to which the first sum frequency light and the second pulsed laser light outputted from the first nonlinear optical crystal are inputted and which is configured to output in response to the input third pulsed laser light having a fourth wavelength.

Abstract: Disclosed herein are octahydropyrrolo[3,4-b]pyrrole compounds of formula (I), which may be useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.

Abstract: The orthogonal space random walk (OSRW) algorithm is generalized to be the orthogonal space tempering (OST) method via the introduction of the orthogonal space sampling temperature. Moreover, a double-integration recursion method is developed to enable practically efficient and robust OST free energy calculations, and the algorithm is augmented by a novel ?-dynamics approach to realize both the uniform sampling of order parameter spaces and rigorous end point constraints. In the present work, the double-integration OST method is employed to perform alchemical free energy simulations, specifically to calculate the free energy difference between benzyl phosphonate and difluorobenzyl phosphonate in aqueous solution, to estimate the solvation free energy of the octanol molecule, and to predict the nontrivial Barnase-Barstar binding affinity change induced by the Barnase N58A mutation.

Abstract: An optoelectronic light source includes a semiconductor laser configured to produce polarized primary radiation, a converter material configured to absorb at least part of the primary radiation and convert the primary radiation into a secondary radiation of an increased wavelength, a planar multi-layered mirror located between the semiconductor laser and the converter material, the multi-layered mirror configured to transmit the primary radiation and reflect the secondary radiation, and an optical element provided between the semiconductor laser and the multi-layered mirror, wherein the optical element is configured such that the primary radiation coming from the semiconductor laser impinges on the multi-layered mirror at a Brewster angle.

Abstract: A method and an apparatus for hardware security to countermeasure side-channel attacks are provided. The method or apparatus may introduce at least one redundant or partial redundant computation having a similar power dissipation profile or an electromagnetic emission profile when compared to that of a genuine operation for cryptographic devices, and/or to reorder the iterations of operations in a different sequence. The redundant or partial redundant computation may be performed by using a different password key and/or a different raw data (e.g., plaintext). The presence of the redundant or partial redundant computation would make side-channel attacks difficult in the sense that genuine or redundant/partial redundant operations are difficult to be clearly identified, hence serving as a countermeasure for hardware security.

Abstract: The present invention relates to a drilling fluid for enhancing stratum pressure bearing capacity, and a method of preparing and using the drilling fluid. The drilling fluid comprises water, bentonite, low adhesive aggregation anionic cellulose, lignite resin, high temperature resistant and salt resistant filtrate reducer, silanol inhibitor, inorganic micrometer-nanometer rigid particles and emulsified asphalt. The bentonite is 2-9 parts by weight, the low adhesive aggregation anionic cellulose is 0.1-1 parts by weight, the lignite resin is 1-5 parts by weight, the high temperature resistant and salt resistant filtrate reducer is 0.1-2 parts by weight, the silanol inhibitor is 0.1-2 parts by weight, the inorganic micrometer-nanometer rigid particles are 0.5-5 parts by weight, and the emulsified asphalt is 1-10 parts by weight, based on 100 parts by weight of water.

Abstract: A bioreactor is provided which contains cells capable of producing cytokine inhibitors in response to cytokines, in a manner regulated by the local or systemic milieu of an individual patient and predicted by mechanistic computational simulations. The bioreactor transfers the cytokine inhibitors to a patient in need of control of the inflammation process as part of a disease or condition in the patient, such as sepsis, trauma, traumatic brain injury, or wound healing. Related methods also are provided.

Abstract: The disclosure provides a class of pH-sensitive, helix/random conformation switchable antimicrobial polypeptide (HRS-AMP) compositions as a single agent to selectively kill bacteria (e.g., H. pylori) under acidic condition in the stomach with diminished bacterial resistance compared to currently used antibiotics. Methods of treating bacterial infections in the stomach are also provided.

Abstract: The disclosed methods are utilized for recovering a high percent of platinum group metals from spent catalytic converters. The methods use an aqua regia bath and ultrasonic agitation to liberate the metals from the carrier material of the washcoat, while leaving the metal supporting structure largely intact.

Abstract: A data restoring method using compressed sensing and computer program product, the method includes (a) continuously measuring data for plural times to generate measurement results correspondingly, and processing the i-th measurement result using the compressed sensing, and starting to generate data matrix when times of measuring reaches a preset times of measurements N; (b) generating a first data matrix using the [(j+1)?N]th to the j—the measurements, and then generating a first restored data; (c) generating a second data matrix using the [(j+2)?N]th to the (j+1)—the measurements, and then generating a second restored data; (d) calculating an error between the first and the second restored data; (e) determining whether the error keeps constant for a predetermined number of times; (f) if not, repeating steps (c) to (e).

Abstract: The present invention relates to prevention and/or treatment of infection by a platelet-targeting microbe in a subject. The present invention provides for methods, combinations and pharmaceutical compositions for preventing and/or treating (and/or related uses) infection by a platelet-targeting microbe in a subject, using, inter alia, an effective amount of a nanoparticle comprising a) an inner core comprising a non-cellular material, b) an outer surface comprising a cellular membrane derived from a platelet; and optionally c) an agent for preventing said infection, treating said infection, diagnosing said infection, prognosing said infection and/or monitoring prevention or treatment of said infection. Exemplary platelet-targeting infections include infections by a bacterium, a virus, a fungus and/or a parasite.